ZA909350B - 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders - Google Patents

1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders

Info

Publication number
ZA909350B
ZA909350B ZA909350A ZA909350A ZA909350B ZA 909350 B ZA909350 B ZA 909350B ZA 909350 A ZA909350 A ZA 909350A ZA 909350 A ZA909350 A ZA 909350A ZA 909350 B ZA909350 B ZA 909350B
Authority
ZA
South Africa
Prior art keywords
substituted
phenyl
alkyl
carbons
hydroxy
Prior art date
Application number
ZA909350A
Other languages
English (en)
Inventor
Daniel Wilbur Mcpherson
Wilbur Mcpherson Daniel
John Paul Carter
Paul Carter John
Original Assignee
Marion Merrell Dow Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US07/372,009 priority Critical patent/US5001160A/en
Priority to AT90312632T priority patent/ATE127117T1/de
Priority to ES90312632T priority patent/ES2079449T3/es
Priority to DE69022058T priority patent/DE69022058T2/de
Priority to CA002030397A priority patent/CA2030397C/fr
Priority to EP90312632A priority patent/EP0486734B1/fr
Application filed by Marion Merrell Dow Inc filed Critical Marion Merrell Dow Inc
Priority to ZA909350A priority patent/ZA909350B/xx
Priority to AU67005/90A priority patent/AU634604B2/en
Priority to JP2321328A priority patent/JPH0764833B2/ja
Publication of ZA909350B publication Critical patent/ZA909350B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
ZA909350A 1988-04-28 1990-11-21 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders ZA909350B (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US07/372,009 US5001160A (en) 1988-04-28 1989-06-27 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders
AT90312632T ATE127117T1 (de) 1988-04-28 1990-11-20 1-aryl-1-hydroxy-1-substituierte-3-(4- substituierte-1-piperazinyl)-2-propanone und ihre verwendung bei der behandlung von blasenstörungen neurologischen ursprungs.
ES90312632T ES2079449T3 (es) 1988-04-28 1990-11-20 1-aril-1-hidroxi-1-sustituido-3-(4-sustituido-1-piperazinil)-2-propanonas y su utilizacion en el tratamiento de los trastornos neurogenicos de la vejiga.
DE69022058T DE69022058T2 (de) 1988-04-28 1990-11-20 1-Aryl-1-hydroxy-1-substituierte-3-(4-substituierte-1-piperazinyl)-2-propanone und ihre Verwendung bei der Behandlung von Blasenstörungen neurologischen Ursprungs.
CA002030397A CA2030397C (fr) 1988-04-28 1990-11-20 Les 1-aryl-hydroxy-1-substituant-3-(4-substituant- 1-piperazinyl)-2-propanones et leur utilisation pour le traitement de troubles nevralgiques de la vessie
EP90312632A EP0486734B1 (fr) 1988-04-28 1990-11-20 1-Aryl-1-hydroxy-1-substitué-3-(4-substitué-1-pipérazinyl)-2-propanones et leur utilisation dans le traitement des troubles neurogéniques de la vessie
ZA909350A ZA909350B (en) 1988-04-28 1990-11-21 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders
AU67005/90A AU634604B2 (en) 1988-04-28 1990-11-26 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1- piperazinyl-2-propanones and their use in treatment of neurogenic bladder disorders
JP2321328A JPH0764833B2 (ja) 1988-04-28 1990-11-27 １―アリール―１―ヒドロキシ―１―置換―３―（４―置換―１―ピペラジニル）―２―プロパノン

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18764988A 1988-04-28 1988-04-28
US07/372,009 US5001160A (en) 1988-04-28 1989-06-27 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders
ZA909350A ZA909350B (en) 1988-04-28 1990-11-21 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders
AU67005/90A AU634604B2 (en) 1988-04-28 1990-11-26 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1- piperazinyl-2-propanones and their use in treatment of neurogenic bladder disorders

Publications (1)

Publication Number Publication Date
ZA909350B true ZA909350B (en) 1991-09-25

Family

ID=40149700

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA909350A ZA909350B (en) 1988-04-28 1990-11-21 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders

Country Status (9)

Country Link
US (1) US5001160A (fr)
EP (1) EP0486734B1 (fr)
JP (1) JPH0764833B2 (fr)
AT (1) ATE127117T1 (fr)
AU (1) AU634604B2 (fr)
CA (1) CA2030397C (fr)
DE (1) DE69022058T2 (fr)
ES (1) ES2079449T3 (fr)
ZA (1) ZA909350B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001160A (en) * 1988-04-28 1991-03-19 Marion Laboratories, Inc. 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders
US6482837B1 (en) 1998-04-24 2002-11-19 University Of Rochester Antimuscarinic compounds and methods for treatment of bladder diseases
JP2004043433A (ja) * 2002-04-26 2004-02-12 Kitai Kagi Kofun Yugenkoshi モルフォリノケトン誘導体及びその用途
AU2002345266B2 (en) 2002-07-08 2009-07-02 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
CA2513188A1 (fr) * 2003-01-16 2004-08-05 University Of Rochester Composes antimuscariniques quaternaires destines au traitement de maladies vesicales
US7488748B2 (en) * 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2004089898A1 (fr) * 2003-04-09 2004-10-21 Ranbaxy Laboratories Limited Derives d'azabicyclo hexane substitues en tant qu'antagonistes de recepteurs muscariniques
US20070021487A1 (en) * 2003-04-11 2007-01-25 Mohammad Salman Azabicyclo derivatives as muscarinic receptor antagonists
WO2006005980A1 (fr) * 2004-06-16 2006-01-19 Ranbaxy Laboratories Limited Derives de xanthine utilises en tant qu'antagonistes du recepteur muscarinique
WO2006018708A2 (fr) * 2004-08-19 2006-02-23 Ranbaxy Laboratories Limited Derives de pyrrolidine utilises en tant qu'antagonistes des recepteurs muscariniques
EP1794161A2 (fr) * 2004-09-24 2007-06-13 Ranbaxy Laboratories Limited Antagonistes des recepteurs muscariniques
US20090105221A1 (en) * 2004-09-29 2009-04-23 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
WO2006054162A1 (fr) * 2004-11-19 2006-05-26 Ranbaxy Laboratories Limited Antagonistes azabicycliques des recepteurs muscariniques
US20100035954A1 (en) * 2004-12-15 2010-02-11 Mohammad Salman Acid addition salts of muscarinic receptor antagonists
WO2006117754A1 (fr) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Derives d'azabicyclo [3.1.0] hexane 3,6-disubstitues utilises comme antagonistes du recepteur muscarinique
RU2008119323A (ru) 2005-10-19 2009-11-27 Рэнбакси Лабораториз Лимитед (In) Фармацевтические композиции мускаринового рецептора
US20090010923A1 (en) * 2007-04-24 2009-01-08 University Of Maryland, Baltimore Treatment of cancer with anti-muscarinic receptor agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3125577A (en) * 1964-03-17 N-substttuted piperazinoalkyl
US2835676A (en) * 1953-07-14 1958-05-20 Merck & Co Inc Gamma-keto-tertiary amines and derivatives thereof
US3073842A (en) * 1957-07-22 1963-01-15 Endo Lab 1, 1 diphenyl-1-hydrocarbonoxy, 4-tertiary amino 2-butanones
US3157656A (en) * 1960-07-20 1964-11-17 Olin Mathieson Heterocyclic compounds
US3073854A (en) * 1960-11-28 1963-01-15 California Research Corp Trimethyllead methyl thioglycolate
US3395146A (en) * 1965-02-11 1968-07-30 Warner Lambert Pharmaceutical 4-substituted-2-benzhydryl-2-butanol derivatives
US3873546A (en) * 1974-02-06 1975-03-25 Abbott Lab Catalytic reduction of 4-methyl-{62 ,{62 -diphenyl-1-piperazine ethanol
NL8202636A (nl) * 1982-06-29 1984-01-16 Gist Brocades Nv Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten.
US5001160A (en) * 1988-04-28 1991-03-19 Marion Laboratories, Inc. 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders

Also Published As

Publication number Publication date
CA2030397C (fr) 1996-06-11
JPH05125068A (ja) 1993-05-21
US5001160A (en) 1991-03-19
ATE127117T1 (de) 1995-09-15
EP0486734B1 (fr) 1995-08-30
JPH0764833B2 (ja) 1995-07-12
ES2079449T3 (es) 1996-01-16
DE69022058D1 (de) 1995-10-05
AU634604B2 (en) 1993-02-25
CA2030397A1 (fr) 1992-05-21
EP0486734A1 (fr) 1992-05-27
DE69022058T2 (de) 1996-04-25
AU6700590A (en) 1992-06-11

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