ZA895710B - The use of imexon as immune suppressive and pharmaceutical compositions containing imexon - Google Patents

The use of imexon as immune suppressive and pharmaceutical compositions containing imexon

Info

Publication number
ZA895710B
ZA895710B ZA895710A ZA895710A ZA895710B ZA 895710 B ZA895710 B ZA 895710B ZA 895710 A ZA895710 A ZA 895710A ZA 895710 A ZA895710 A ZA 895710A ZA 895710 B ZA895710 B ZA 895710B
Authority
ZA
South Africa
Prior art keywords
imexon
pharmaceutical compositions
compositions containing
immune suppressive
cell
Prior art date
Application number
ZA895710A
Inventor
Dieter Dr Herrmann
Herrmann Dr Dieter
Rainer Dr Haag
Haag Dr Rainer
Elmar Dr Gosies
Gosies Dr Elmar
Uwe Prof Bicker
Bicker Prof Uwe
Wolfgang Dr Kampe
Kampe Dr Wolfgang
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of ZA895710B publication Critical patent/ZA895710B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The present invention relates to the use of 4-imino-1,3-diazabicyclo[3.1.0]hexan-2-one (imexon) as an immunosuppressive agent. Imexon selectively suppresses beta -lymphocyte activation and can be employed for the treatment of B-cell or plasma-cell leukaemia and neoplasms. Imexon is used in the treatment of those disorders in which polyclonal B-cell proliferation is of pathophysiological, symptomatic or clinical relevance such as, for example, for autoimmune diseases.
ZA895710A 1988-07-28 1989-07-27 The use of imexon as immune suppressive and pharmaceutical compositions containing imexon ZA895710B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3825667A DE3825667A1 (en) 1988-07-28 1988-07-28 USE OF IMEXON AS IMMUNOSUPPRESSIVE

Publications (1)

Publication Number Publication Date
ZA895710B true ZA895710B (en) 1990-04-25

Family

ID=6359767

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA895710A ZA895710B (en) 1988-07-28 1989-07-27 The use of imexon as immune suppressive and pharmaceutical compositions containing imexon

Country Status (14)

Country Link
EP (1) EP0352652B1 (en)
JP (1) JP2848634B2 (en)
KR (1) KR0135757B1 (en)
AT (1) ATE117551T1 (en)
AU (1) AU619027B2 (en)
CA (1) CA1333771C (en)
DE (2) DE3825667A1 (en)
DK (1) DK175199B1 (en)
HU (1) HU206827B (en)
IE (1) IE66680B1 (en)
IL (1) IL91138A (en)
PH (1) PH26684A (en)
PT (1) PT91293B (en)
ZA (1) ZA895710B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2548491A1 (en) * 2003-12-08 2005-06-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Synergistic anti-cancer compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2528460A1 (en) * 1975-06-26 1977-01-13 Boehringer Mannheim Gmbh 1-Carbamoyl 2-cyano aziridine as immunostimulant - for therapy of bacterial and viral infections
DE2530398A1 (en) * 1975-07-08 1977-01-27 Boehringer Mannheim Gmbh ORGANIC CONNECTION
DE2736296A1 (en) * 1977-08-12 1979-02-22 Boehringer Mannheim Gmbh USE OF 2-CYAN-AZIRIDINE AND ITS DERIVATIVES FOR IMMUNESTIMULATION

Also Published As

Publication number Publication date
PT91293B (en) 1995-03-01
EP0352652A3 (en) 1991-09-04
ATE117551T1 (en) 1995-02-15
DE3825667A1 (en) 1990-03-15
IE66680B1 (en) 1996-01-24
HU206827B (en) 1993-01-28
IE892448L (en) 1990-01-28
KR0135757B1 (en) 1998-04-23
CA1333771C (en) 1995-01-03
PT91293A (en) 1990-02-08
AU619027B2 (en) 1992-01-16
HUT52378A (en) 1990-07-28
PH26684A (en) 1992-09-15
DE3825667C2 (en) 1991-06-27
DE58908926D1 (en) 1995-03-09
DK363389D0 (en) 1989-07-21
EP0352652B1 (en) 1995-01-25
AU3887789A (en) 1990-02-01
DK363389A (en) 1990-01-29
JP2848634B2 (en) 1999-01-20
IL91138A0 (en) 1990-03-19
EP0352652A2 (en) 1990-01-31
DK175199B1 (en) 2004-07-05
JPH0288521A (en) 1990-03-28
IL91138A (en) 1994-10-21
KR900001369A (en) 1990-02-27

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