ZA889709B - Dopamine-beta-hydroxylase inhibitors - Google Patents

Dopamine-beta-hydroxylase inhibitors

Info

Publication number
ZA889709B
ZA889709B ZA889709A ZA889709A ZA889709B ZA 889709 B ZA889709 B ZA 889709B ZA 889709 A ZA889709 A ZA 889709A ZA 889709 A ZA889709 A ZA 889709A ZA 889709 B ZA889709 B ZA 889709B
Authority
ZA
South Africa
Prior art keywords
dopamine
beta
hydroxylase inhibitors
hydroxylase
inhibitors
Prior art date
Application number
ZA889709A
Other languages
English (en)
Inventor
Lawrence Ivan Kruse
Ivan Kruse Lawrence
Stephen Torey Ross
Torey Ross Stephen
Eliot Howard Ohlstein
Howard Ohlstein Eliot
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of ZA889709B publication Critical patent/ZA889709B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA889709A 1987-12-29 1988-12-29 Dopamine-beta-hydroxylase inhibitors ZA889709B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/139,217 US4882348A (en) 1987-12-29 1987-12-29 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors

Publications (1)

Publication Number Publication Date
ZA889709B true ZA889709B (en) 1989-12-27

Family

ID=22485613

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA889709A ZA889709B (en) 1987-12-29 1988-12-29 Dopamine-beta-hydroxylase inhibitors

Country Status (6)

Country Link
US (1) US4882348A (de)
EP (1) EP0323148A1 (de)
JP (1) JPH03502690A (de)
AU (1) AU2936889A (de)
WO (1) WO1989006127A1 (de)
ZA (1) ZA889709B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2003283A1 (en) * 1988-12-05 1990-06-05 C. Anne Higley Imidazoles for the treatment of atherosclerosis
US5183810A (en) * 1990-02-13 1993-02-02 Merck & Co., Inc. Imidazole angiotensin II antagonists incorporating a substituted benzyl element
GB9005966D0 (en) * 1990-03-16 1990-05-09 May & Baker Ltd New compositions of matter
FR2675503B1 (fr) * 1991-04-19 1994-02-18 Roussel Uclaf Nouveaux derives soufres de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
IL98319A (en) * 1990-07-05 1997-04-15 Roussel Uclaf Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them
FR2664271B1 (fr) * 1990-07-05 1994-02-18 Roussel Uclaf Nouveaux derives soufres de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
CN1172727C (zh) * 1996-12-16 2004-10-27 Icu医学有限公司 正向流动阀
US9567316B2 (en) 2012-03-07 2017-02-14 The Mclean Hospital Corporation Aminoquinoline derivatives and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334112A (en) * 1964-05-07 1967-08-01 American Cyanamid Co Aminoalkylenethioimidazoline derivatives
BE688585A (de) * 1965-10-21 1967-04-20
US4532331A (en) * 1983-04-12 1985-07-30 Smithkline Beckman Corporation 1-Benzyl-2-aminomethyl imidazole derivatives
PT78388B (en) * 1983-04-12 1986-09-15 Smithkline Beckman Corp Dopamine-beta-hydroxylase inhibitors
FI833794A0 (fi) * 1983-10-18 1983-10-18 Farmos Oy Substituerade 2-merkapto-imidazoler
US4600430A (en) * 1985-02-22 1986-07-15 Eli Lilly And Company Pyridinylimidazolidinone compounds
US4719223A (en) * 1985-10-31 1988-01-12 Smithkline Beckman Corporation Imidazolethiol dopamine-beta-hydroxylase inhibitors
US4743613A (en) * 1986-04-08 1988-05-10 Smithkline Beckman Corporation Ester prodrugs of dopamine-β-hydroxylase, inhibitors, composition containing them, and method of using them to inhibit dopamine-β-hydroxylase activity
NZ221427A (en) * 1986-08-18 1990-12-21 Smithkline Beckman Corp 2-mercaptoimidazole derivatives and pharmaceutical compositions
US4762850A (en) * 1987-03-24 1988-08-09 Smithkline Beckman Corporation Dopamine-beta-hydroxylase inhibitors
US4835154A (en) * 1987-06-01 1989-05-30 Smithkline Beckman Corporation 1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors

Also Published As

Publication number Publication date
JPH03502690A (ja) 1991-06-20
EP0323148A1 (de) 1989-07-05
WO1989006127A1 (en) 1989-07-13
US4882348A (en) 1989-11-21
AU2936889A (en) 1989-08-01

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