ZA881811B - Process for the manufacture of isoquinolines - Google Patents

Process for the manufacture of isoquinolines

Info

Publication number
ZA881811B
ZA881811B ZA881811A ZA881811A ZA881811B ZA 881811 B ZA881811 B ZA 881811B ZA 881811 A ZA881811 A ZA 881811A ZA 881811 A ZA881811 A ZA 881811A ZA 881811 B ZA881811 B ZA 881811B
Authority
ZA
South Africa
Prior art keywords
isoquinolines
manufacture
formula
image
solution
Prior art date
Application number
ZA881811A
Inventor
Peter Philippe
Original Assignee
F. Hoffmann-La Roche & Co. Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche & Co. Aktiengesellschaft filed Critical F. Hoffmann-La Roche & Co. Aktiengesellschaft
Publication of ZA881811B publication Critical patent/ZA881811B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

Abstract

Process for the preparation of isoquinolines of the formula <IMAGE> in which R is methyl or benzyl and R' is phenyl, p-hydroxyphenyl or p-methoxyphenyl, characterised in that a solution of an enamine of the formula <IMAGE> in which R and R' have the above meaning, is reacted in a hydrocarbon with an anhydrous solution of p-toluenesulphonic acid in toluene or xylene at elevated temperature.
ZA881811A 1987-03-20 1988-03-14 Process for the manufacture of isoquinolines ZA881811B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH106487 1987-03-20

Publications (1)

Publication Number Publication Date
ZA881811B true ZA881811B (en) 1988-09-20

Family

ID=4201606

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA881811A ZA881811B (en) 1987-03-20 1988-03-14 Process for the manufacture of isoquinolines

Country Status (12)

Country Link
EP (1) EP0283848B1 (en)
JP (1) JP2507523B2 (en)
AT (1) ATE63545T1 (en)
AU (1) AU613605B2 (en)
CA (1) CA1310012C (en)
DE (1) DE3862787D1 (en)
DK (1) DK168625B1 (en)
HU (1) HU203876B (en)
IE (1) IE61069B1 (en)
NZ (1) NZ223879A (en)
PH (1) PH25036A (en)
ZA (1) ZA881811B (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE834103C (en) * 1950-01-03 1952-03-17 Bayer Ag Process for the preparation of 1-benzyl-1, 2, 3, 4, 5, 6, 7, 8, -octahydroisoquinoline
DE908138C (en) * 1951-01-16 1954-04-01 Hoffmann La Roche Process for the preparation of 1-benzyl-2-alkyl-1,2,3,4,5,6,7,8, -octa-hydroisoquinolines and their salts
DE1003211B (en) * 1952-06-16 1957-02-28 Hoffmann La Roche Process for the preparation of 1-benzyl-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinolines optionally substituted in the benzyl radical and their salts
DE955769C (en) * 1953-08-13 1957-01-10 Hoffmann La Roche Process for the racemization of optically active 1- (p-methoxybenzyl) -2-methyl-octahydroisoquinolines

Also Published As

Publication number Publication date
EP0283848A1 (en) 1988-09-28
ATE63545T1 (en) 1991-06-15
PH25036A (en) 1991-01-28
DK168625B1 (en) 1994-05-09
NZ223879A (en) 1991-01-29
DE3862787D1 (en) 1991-06-20
CA1310012C (en) 1992-11-10
JP2507523B2 (en) 1996-06-12
DK102388D0 (en) 1988-02-26
HU203876B (en) 1991-10-28
AU613605B2 (en) 1991-08-08
HUT49123A (en) 1989-08-28
JPS63238062A (en) 1988-10-04
IE61069B1 (en) 1994-09-21
DK102388A (en) 1988-09-21
AU1307488A (en) 1988-09-22
IE880805L (en) 1988-09-20
EP0283848B1 (en) 1991-05-15

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