ZA864627B - 2-alkyl(or phenyl)thio-6-n-alkyl ergolines and 4-dialkylaminotetrahydrobenz(c,d)indoles - Google Patents

2-alkyl(or phenyl)thio-6-n-alkyl ergolines and 4-dialkylaminotetrahydrobenz(c,d)indoles

Info

Publication number
ZA864627B
ZA864627B ZA864627A ZA864627A ZA864627B ZA 864627 B ZA864627 B ZA 864627B ZA 864627 A ZA864627 A ZA 864627A ZA 864627 A ZA864627 A ZA 864627A ZA 864627 B ZA864627 B ZA 864627B
Authority
ZA
South Africa
Prior art keywords
alkyl
dialkylaminotetrahydrobenz
ergolines
indoles
thio
Prior art date
Application number
ZA864627A
Other languages
English (en)
Inventor
Bennett Coleman Laguzza
Cynthia Lynn Nichols
Nicholas James Bach
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA864627B publication Critical patent/ZA864627B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
ZA864627A 1985-06-24 1986-06-20 2-alkyl(or phenyl)thio-6-n-alkyl ergolines and 4-dialkylaminotetrahydrobenz(c,d)indoles ZA864627B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/747,753 US4683313A (en) 1985-06-24 1985-06-24 2-alkyl(or phenyl)thio-6-N alkyl ergolines and 4-dialkylaminotetrahydrobenz[c,d]indoles

Publications (1)

Publication Number Publication Date
ZA864627B true ZA864627B (en) 1988-02-24

Family

ID=25006482

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA864627A ZA864627B (en) 1985-06-24 1986-06-20 2-alkyl(or phenyl)thio-6-n-alkyl ergolines and 4-dialkylaminotetrahydrobenz(c,d)indoles

Country Status (5)

Country Link
US (1) US4683313A (xx)
EP (2) EP0207695A3 (xx)
JP (1) JPS62464A (xx)
AU (1) AU581090B2 (xx)
ZA (1) ZA864627B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801712A (en) * 1985-06-24 1989-01-31 Eli Lilly And Company 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5498727A (en) * 1994-07-19 1996-03-12 Agouron Pharmaceuticals, Inc. Preparation of benzindole compounds from naphthalene compounds
WO2014078857A1 (en) * 2012-11-19 2014-05-22 Regents Of The University Of Minnesota Ergoline derivatives as dopamine receptor modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU519636B2 (en) * 1974-07-19 1981-12-17 Sandoz Ltd. 6-methyl-8alpha-cyanomethylergoline i
US3985752A (en) * 1974-12-06 1976-10-12 Eli Lilly And Company 6-Methyl-8-(substituted) methylergolines
US4054660A (en) * 1975-04-14 1977-10-18 Eli Lilly And Company Method of inhibiting prolactin
DE2700649A1 (de) * 1977-01-08 1978-07-20 Bayer Ag Verfahren zur herstellung von naphthostyril
IT1192260B (it) * 1977-07-05 1988-03-31 Simes Derivati di ergoline-2-tioeteri e loro solfossidi
IT1193467B (it) * 1978-01-26 1988-07-08 Simes Carbammati di omolisergoli (8 beta-idrossietilergoline)
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4246265A (en) * 1979-10-01 1981-01-20 Eli Lilly And Company 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity

Also Published As

Publication number Publication date
EP0389068A2 (en) 1990-09-26
EP0389068A3 (en) 1991-10-23
AU581090B2 (en) 1989-02-09
AU5919686A (en) 1987-01-08
JPS62464A (ja) 1987-01-06
EP0207695A3 (en) 1988-01-27
US4683313A (en) 1987-07-28
EP0207695A2 (en) 1987-01-07

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