ZA8410029B - Photostabilisation of molsidomine - Google Patents
Photostabilisation of molsidomineInfo
- Publication number
- ZA8410029B ZA8410029B ZA8410029A ZA8410029A ZA8410029B ZA 8410029 B ZA8410029 B ZA 8410029B ZA 8410029 A ZA8410029 A ZA 8410029A ZA 8410029 A ZA8410029 A ZA 8410029A ZA 8410029 B ZA8410029 B ZA 8410029B
- Authority
- ZA
- South Africa
- Prior art keywords
- beta
- atoms
- denotes
- see diagramm
- denotes hydrogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, NL Photostabilised mixture of molsidomine, one or several photostabilisers, and, if appropriate, further mixing components, characterised in that the photostabilisers are compounds of the general formula I see diagramm : EP0147811,P13,F4 wherein Y denotes a hydroxyl group, alkoxy having 1 or 2 C atoms or beta-hydroxyethoxy and Z denotes a group of the formula see diagramm : EP0147811,P13,F5 or Y and Z together denote a structural element of the formula II or III see diagramm : EP0147811,P13,F6 see diagramm : EP0147811,P13,F7 in which the free oxygen valency is attached in the Y-position and the free carbon valency is attached in the Z-position and R**1 denotes hydrogen or a radical G, R**2 denotes hydrogen, alkyl having 1 or 2 C atoms or beta-hydroxyethyl, R**3 denotes hydrogen, alkyl having 1 or 2 C atoms or beta-hydroxyethyl, R**4 denotes hydrogen, alkyl having 1 or 2 C atoms, beta-hydroxyethyl or a radical G and G is the radical of a monosaccharide or disaccharide, or esters of these compounds with pharmacologically acceptable acids and also, if appropriate, a salt thereof with pharmacologically acceptable bases. 1. Claims for the Contracting State : AT Process for photostabilising molsidomine and mixtures of molsidomine with mixing components, characterised in that there are added, respectively to the molsidomine and its mixtures, as photostabilisers, one or several compounds of the general formula I see diagramm : EP0147811,P15,F1 wherein Y denotes a hydroxyl group, alkoxy having 1 or 2 C atoms or beta-hydroxyethoxy and Z denotes a group of the formula see diagramm : EP0147811,P15,F2 or Y and Z together denote a structural element of the formula II or III see diagramm : EP0147811,P15,F3 see diagramm : EP0147811,P15,F4 in which the free oxygen valency is attached in the Y-position and the free carbon valency is attached in the Z-position and R**1 denotes hydrogen or a radical G, R**2 denotes hydrogen, alkyl having 1 or 2 C atoms or beta-hydroxyethyl, R**3 denotes hydrogen, alkyl having 1 or 2 C atoms or beta-hydroxyethyl, R**4 denotes hydrogen, alkyl having 1 or 2 C atoms, beta-hydroxyethyl or a radical G and G is the radical of a monosaccharide or disaccharide, or esters of these compounds with pharmacologically acceptable acids and also, if appropriate, a salt thereof with pharmacologically acceptable bases.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833346638 DE3346638A1 (en) | 1983-12-23 | 1983-12-23 | PHOTOSTABILIZATION OF MOLSIDOMIN |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA8410029B true ZA8410029B (en) | 1985-08-28 |
Family
ID=6217839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA8410029A ZA8410029B (en) | 1983-12-23 | 1984-12-21 | Photostabilisation of molsidomine |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0147811B1 (en) |
JP (1) | JPS60156678A (en) |
KR (1) | KR850004394A (en) |
AT (1) | ATE45496T1 (en) |
CA (1) | CA1232275A (en) |
DE (2) | DE3346638A1 (en) |
ES (1) | ES8602775A1 (en) |
FI (1) | FI844973L (en) |
GR (1) | GR82583B (en) |
HU (1) | HU191734B (en) |
PT (1) | PT79717B (en) |
ZA (1) | ZA8410029B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3522191A1 (en) * | 1985-06-21 | 1987-01-15 | Cassella Ag | PHOTOSTABILIZATION OF SYDNONIMINES |
US4603046A (en) * | 1985-08-23 | 1986-07-29 | Charles Of The Ritz Group Ltd. | Improved sunscreen or sunblock composition |
HU211648A9 (en) * | 1990-03-28 | 1995-12-28 | Chinoin Gyogyszer Es Vegyeszet | Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same |
DE59408793D1 (en) * | 1993-05-11 | 1999-11-11 | Hoechst Ag | Galenic preparations from Molsidomin |
DE4443105C2 (en) * | 1994-12-03 | 1997-03-13 | Hoechst Ag | Process for the production of tablets containing molsidomine |
AT501682A1 (en) | 2005-01-14 | 2006-10-15 | Hermine Dr Engl | METHOD FOR PRODUCING AN ACTIVE SUBSTANCE MIXTURE |
KR20090057440A (en) * | 2006-09-15 | 2009-06-05 | 아스텔라스세이야쿠 가부시키가이샤 | Solid pharmaceutical composition for oral administration comprising optically stable ramosetron |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3136282A1 (en) * | 1981-09-12 | 1983-03-24 | Hoechst Ag | "METHOD FOR STABILIZING PHOTO-UNSTABLE MEDICINAL PRODUCTS AND STABILIZED MEDICAL PREPARATIONS" |
DE3230273A1 (en) * | 1982-08-14 | 1984-02-16 | Bayer Ag, 5090 Leverkusen | LIGHT-STABILIZED CHINOXALINE DI-N-OXIDES |
DK243084A (en) * | 1983-05-26 | 1984-11-27 | Takeda Chemical Industries Ltd | PERCUTANEOUS PHARMACEUTICAL PREPARATIONS FOR EXTERNAL USE |
-
1983
- 1983-12-23 DE DE19833346638 patent/DE3346638A1/en not_active Withdrawn
-
1984
- 1984-12-17 FI FI844973A patent/FI844973L/en not_active Application Discontinuation
- 1984-12-20 PT PT79717A patent/PT79717B/en unknown
- 1984-12-20 EP EP84116004A patent/EP0147811B1/en not_active Expired
- 1984-12-20 HU HU844747A patent/HU191734B/en unknown
- 1984-12-20 AT AT84116004T patent/ATE45496T1/en not_active IP Right Cessation
- 1984-12-20 DE DE8484116004T patent/DE3479396D1/en not_active Expired
- 1984-12-21 GR GR82583A patent/GR82583B/en unknown
- 1984-12-21 ZA ZA8410029A patent/ZA8410029B/en unknown
- 1984-12-21 JP JP59268743A patent/JPS60156678A/en active Pending
- 1984-12-21 ES ES538959A patent/ES8602775A1/en not_active Expired
- 1984-12-21 CA CA000470804A patent/CA1232275A/en not_active Expired
- 1984-12-22 KR KR1019840008265A patent/KR850004394A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FI844973L (en) | 1985-06-24 |
DE3479396D1 (en) | 1989-09-21 |
EP0147811A2 (en) | 1985-07-10 |
DE3346638A1 (en) | 1985-07-04 |
ES538959A0 (en) | 1985-11-01 |
HUT37039A (en) | 1985-11-28 |
FI844973A0 (en) | 1984-12-17 |
PT79717B (en) | 1989-01-05 |
ATE45496T1 (en) | 1989-09-15 |
GR82583B (en) | 1985-04-23 |
EP0147811B1 (en) | 1989-08-16 |
KR850004394A (en) | 1985-07-15 |
CA1232275A (en) | 1988-02-02 |
JPS60156678A (en) | 1985-08-16 |
HU191734B (en) | 1987-04-28 |
EP0147811A3 (en) | 1986-12-30 |
PT79717A (en) | 1985-01-01 |
ES8602775A1 (en) | 1985-11-01 |
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