ZA838058B - Controlled release theophylline tablets and a process for their preparation - Google Patents

Controlled release theophylline tablets and a process for their preparation

Info

Publication number
ZA838058B
ZA838058B ZA838058A ZA838058A ZA838058B ZA 838058 B ZA838058 B ZA 838058B ZA 838058 A ZA838058 A ZA 838058A ZA 838058 A ZA838058 A ZA 838058A ZA 838058 B ZA838058 B ZA 838058B
Authority
ZA
South Africa
Prior art keywords
weight
ratio
tablet
polymer
theophyllin
Prior art date
Application number
ZA838058A
Inventor
Joel Bougaret
Daniel Darbeau
Original Assignee
Fabre Sa Pierre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabre Sa Pierre filed Critical Fabre Sa Pierre
Publication of ZA838058B publication Critical patent/ZA838058B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

1. Pharmaceutical tablet constituted by a hydrophilic polymeric matrix permitting controlled and constant release of a unitary therapeutic dose of theophyllin during a period of approximately 12 hours, of the type comprising at least one polymer derived from cellulose and a lubricating agent, characterised in that it contains : . an effective therapeutic quantity of theophyllin ; . from 18% to 35% by weight as a ratio of the total weight of the tablet of at least one hydroxypropylmethylcellulose by way of hydrophyllic polymer, the hydroxypropylmethylcellulose(s) having a viscosity of 2% weight for weight at 20 degrees C between 10**-1 Pa s and 15 Pa .s ; . from 7.5% to 22.5% by weight as a ratio of the total weight of the tablet of lactose favouring hydration of the polymer, and . 0.5% to 1% by weight as a ratio of the total weight of the tablet of an internal hydrophobic lubricating agent, and in that the weight ratio of the theophyllin expressed in anhydrous weight as a ratio to the polymer is between 1 and 3.
ZA838058A 1982-11-03 1983-10-28 Controlled release theophylline tablets and a process for their preparation ZA838058B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8218407A FR2535202B1 (en) 1982-11-03 1982-11-03 CONTROLLED RELEASE THEOPHYLLIN TABLETS AND PROCESS FOR THEIR MANUFACTURE

Publications (1)

Publication Number Publication Date
ZA838058B true ZA838058B (en) 1984-06-27

Family

ID=9278859

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA838058A ZA838058B (en) 1982-11-03 1983-10-28 Controlled release theophylline tablets and a process for their preparation

Country Status (8)

Country Link
EP (1) EP0109320B1 (en)
AT (1) ATE20517T1 (en)
CA (1) CA1205385A (en)
DE (1) DE3364276D1 (en)
ES (1) ES8405618A1 (en)
FR (1) FR2535202B1 (en)
PT (1) PT77581B (en)
ZA (1) ZA838058B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA836031B (en) * 1983-08-16 1985-02-27 Verex Lab Constant release rate solid dosage theophylline formulation
FR2585948B1 (en) * 1985-08-06 1988-12-16 Pf Medicament PROCESS FOR THE MANUFACTURE OF INDOMETACIN TABLETS
FR2588188B1 (en) * 1985-10-04 1988-01-08 Delalande Sa PROGRAMMED RELEASE CINEPAZIDE HYDROSOLUBLE SALT (S) TABLET AND PROCESS FOR PREPARING SAME
GB8628728D0 (en) * 1986-12-02 1987-01-07 Euro Celtique Sa Spheroids
FR2618073B1 (en) * 1987-07-16 1990-09-07 Pf Medicament HYDROPHILIC MATRIX-TYPE TABLETS BASED ON SALBUTAMOL AND THEIR PREPARATION METHOD
GB8813064D0 (en) * 1988-06-02 1988-07-06 Euro Celtique Sa Controlled release dosage forms having defined water content
US5268181A (en) * 1989-04-13 1993-12-07 Upsher-Smith Laboratories, Inc. Method of using niacin to control nocturnal cholesterol synthesis
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6080428A (en) 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US5484607A (en) * 1993-10-13 1996-01-16 Horacek; H. Joseph Extended release clonidine formulation
US5393765A (en) * 1993-12-13 1995-02-28 Hoffmann-La Roche Inc. Pharmaceutical compositions with constant erosion volume for zero order controlled release
US6197340B1 (en) 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
WO2003011256A1 (en) * 2001-07-30 2003-02-13 Sun Pharmaceutical Industries Limited Oral controlled release pharmaceutical composition of a prokinetic agent
PL2168585T3 (en) * 2005-06-09 2012-05-31 Euro Celtique Sa Pharmaceutical compositions of a neuroactive steroid and uses thereof
JP2010529142A (en) 2007-06-08 2010-08-26 アドレネクス・ファーマシューティカルズ，インコーポレイテッド Sustained release formulations and methods for treating adrenergic dysregulation
EP2937096B1 (en) 2014-04-23 2019-08-21 Julius-Maximilians-Universität Würzburg Peptides derived from RS1 which down-regulate glucose absorption after a glucose rich meal and increase insulin sensitivity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2050701C3 (en) * 1969-10-17 1979-12-20 Shinetsu Chemical Co., Tokio Use of a pulverulent cellulose ether as an adjuvant for the production of easily disintegratable solid pharmaceutical forms
JPS4917565B1 (en) * 1970-12-29 1974-05-01
AT347039B (en) * 1972-11-03 1978-12-11 Ohrenberger Franz X Dr PROCESS FOR MANUFACTURING TABLETS AND DRAGEES CONTAINING TWO DIFFERENT MEDICINAL ACTIVE SUBSTANCES WITH DELAYED RELEASE OF THE ACTIVE SUBSTANCE
JPS55153715A (en) * 1979-05-18 1980-11-29 Nikken Kagaku Kk Prolonged granule of theophylline
US4259314A (en) * 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
JPS56122311A (en) * 1980-02-29 1981-09-25 Eisai Co Ltd Lasting theophylline pharmaceutical composition

Also Published As

Publication number Publication date
EP0109320A1 (en) 1984-05-23
DE3364276D1 (en) 1986-07-31
PT77581A (en) 1983-11-01
PT77581B (en) 1986-03-18
FR2535202A1 (en) 1984-05-04
FR2535202B1 (en) 1985-08-09
CA1205385A (en) 1986-06-03
ES526928A0 (en) 1984-07-01
ATE20517T1 (en) 1986-07-15
EP0109320B1 (en) 1986-06-25
ES8405618A1 (en) 1984-07-01

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