ZA805372B - New optically active 1,4-dihydropyridine compounds, their production and their medicinal use - Google Patents
New optically active 1,4-dihydropyridine compounds, their production and their medicinal useInfo
- Publication number
- ZA805372B ZA805372B ZA00805372A ZA805372A ZA805372B ZA 805372 B ZA805372 B ZA 805372B ZA 00805372 A ZA00805372 A ZA 00805372A ZA 805372 A ZA805372 A ZA 805372A ZA 805372 B ZA805372 B ZA 805372B
- Authority
- ZA
- South Africa
- Prior art keywords
- production
- optically active
- medicinal use
- dihydropyridine compounds
- new optically
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2935451A DE2935451A1 (en) | 1979-09-01 | 1979-09-01 | OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA805372B true ZA805372B (en) | 1981-09-30 |
Family
ID=6079874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA00805372A ZA805372B (en) | 1979-09-01 | 1980-08-29 | New optically active 1,4-dihydropyridine compounds, their production and their medicinal use |
Country Status (25)
Country | Link |
---|---|
US (3) | US4510310A (en) |
EP (1) | EP0026317B1 (en) |
JP (2) | JPS5636455A (en) |
AR (1) | AR228576A1 (en) |
AT (1) | ATE16101T1 (en) |
AU (1) | AU545023B2 (en) |
CA (1) | CA1142937A (en) |
CS (1) | CS228506B2 (en) |
DD (1) | DD154014A5 (en) |
DE (2) | DE2935451A1 (en) |
DK (2) | DK160549C (en) |
EG (1) | EG15011A (en) |
ES (1) | ES8104228A1 (en) |
FI (1) | FI78686C (en) |
GR (1) | GR70080B (en) |
HU (1) | HU184821B (en) |
IE (1) | IE50504B1 (en) |
IL (1) | IL60937A (en) |
NO (1) | NO159928C (en) |
NZ (1) | NZ194805A (en) |
PH (3) | PH19749A (en) |
PL (1) | PL128310B1 (en) |
PT (1) | PT71724B (en) |
SU (1) | SU932988A3 (en) |
ZA (1) | ZA805372B (en) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2935451A1 (en) * | 1979-09-01 | 1981-03-19 | Bayer Ag, 5090 Leverkusen | OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT |
JPS57200364A (en) * | 1981-06-04 | 1982-12-08 | Yoshitomi Pharmaceut Ind Ltd | 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its salt |
JPS57200386A (en) * | 1981-06-04 | 1982-12-08 | Yoshitomi Pharmaceut Ind Ltd | Novel 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its salts |
NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
GB2111978B (en) * | 1981-10-19 | 1985-05-01 | Maruko Pharmaceutical Co | 1 4-dihydropyridine compounds |
EP0096299B1 (en) * | 1982-06-03 | 1989-02-01 | Pierrel S.p.A. | Hydroxyimino and alkoxyimino derivatives of 1,4-dihydropyridine, process for the preparation thereof and pharmaceutical composition therefrom |
JPS59225162A (en) * | 1983-06-03 | 1984-12-18 | Kyowa Hakko Kogyo Co Ltd | 1,4-dihydropyridine derivative |
JPS5970667A (en) * | 1982-10-15 | 1984-04-21 | Kyowa Hakko Kogyo Co Ltd | 1,4-dihydropyridine derivative |
DE3248548A1 (en) * | 1982-12-29 | 1984-07-05 | Heinrich Mack Nachf., 7918 Illertissen | ACYL DERIVATIVES OF 1,4: 3,6-DIANHYDRO-HEXITES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
JPS60120861A (en) * | 1983-12-02 | 1985-06-28 | Otsuka Pharmaceut Co Ltd | Dihydropyridine derivative |
DE4342196A1 (en) * | 1993-12-10 | 1995-06-14 | Bayer Ag | New 4-phenyl-substituted 1,4-dihydropyridines |
IE57810B1 (en) * | 1984-03-27 | 1993-04-21 | Delagrange Lab | 1,4-dihydropyridine derivatives,their preparation and their use |
US5364872A (en) * | 1984-04-16 | 1994-11-15 | Yamanouchi Pharmaceutical Co., Ltd. | Dihydropyridine-3,5-dicarboxylic acid ester derivatives |
JPS60246313A (en) * | 1984-05-22 | 1985-12-06 | Yamanouchi Pharmaceut Co Ltd | Injection of nicardipine hydrochloride and its preparation |
USRE34618E (en) * | 1984-05-22 | 1994-05-24 | Yamanouchi Pharmaceutical Co., Ltd. | Injection of nicardinpine hydrochloride and process for the production thereof |
DE3423105A1 (en) * | 1984-06-22 | 1986-01-02 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINE |
JPS6143165A (en) * | 1984-08-07 | 1986-03-01 | Otsuka Pharmaceut Co Ltd | Preparation of dihydropyridine derivative |
DE3431152A1 (en) * | 1984-08-24 | 1986-03-06 | Cassella Ag, 6000 Frankfurt | METHOD FOR PRODUCING OPTICALLY ACTIVE, SUBSTITUTED 1,4-DIHYDROPYRIDINE AND THEIR USE AS A MEDICINAL PRODUCT |
US4975440A (en) * | 1984-09-28 | 1990-12-04 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Optically-active 1,4-dihydropyridine |
DE3447169A1 (en) * | 1984-12-22 | 1986-07-03 | Bayer Ag, 5090 Leverkusen | OPTICALLY ACTIVE NITRODIHYDROPYRIDINE, METHOD FOR THE PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS |
JPS61161263A (en) * | 1985-01-09 | 1986-07-21 | Teijin Ltd | Production of 1,4-dihydropyridine monoester monocarboxylic acid |
US4771057A (en) * | 1986-02-03 | 1988-09-13 | University Of Alberta | Reduced pyridyl derivatives with cardiovascular regulating properties |
DK142287A (en) * | 1986-03-27 | 1987-09-28 | Byk Gulden Lomberg Chem Fab | OPTIC ACTIVE 1,4-DIHYDROPYRIDINE DERIVATIVES |
JPH0686429B2 (en) * | 1986-08-27 | 1994-11-02 | 株式会社ミドリ十字 | Dihydropyridine derivative |
US4886819A (en) * | 1986-08-27 | 1989-12-12 | The Green Cross Corporation | Dihydropyridine derivatives and pharmaceutical composition thereof |
JPH0755955B2 (en) * | 1986-09-10 | 1995-06-14 | 日産化学工業株式会社 | Optically active dihydropyridine-5-phosphonate |
HU196755B (en) * | 1986-09-16 | 1989-01-30 | Gyogyszerkutato Intezet | Process for production of new substituated amilid derivatives and medical compositions containing them |
US4920225A (en) * | 1986-12-22 | 1990-04-24 | Laboratoires Syntex S.A. | Resolution of 1,4-dihydropyridine derivatives |
AU1570588A (en) * | 1987-03-27 | 1988-11-02 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New intermediate products and process |
US4994461A (en) * | 1987-03-27 | 1991-02-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | 1,4-dihydropyridine enantiomers |
US4889866A (en) * | 1987-06-11 | 1989-12-26 | Syntex (U.S.A.) Inc. | Arylsulfonyl dihydropyridine derivatives |
JPS6429359A (en) * | 1987-07-24 | 1989-01-31 | Teijin Ltd | 1,4-dihydropyridine derivative and production thereof |
DE3821334A1 (en) * | 1988-06-24 | 1989-12-28 | Bayer Ag | 1,4-DIHYDROPYRIDINE-THREONINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, INTERMEDIATE PRODUCTS AND THEIR USE AS MEDICINAL PRODUCTS |
US5158963A (en) * | 1989-08-02 | 1992-10-27 | Kaken Pharmaceutical Co., Ltd. | 1-4-dihydropyridine derivative, process for preparing the same and pharmaceutical composition containing the same |
DE4011106A1 (en) * | 1990-04-06 | 1991-10-10 | Bayer Ag | NEW HETEROCYCLIC SUBSTITUTED DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS |
DE4117750A1 (en) * | 1991-05-30 | 1992-12-24 | Bayer Ag | NEW 2-AMINO-5-CYANO-1,4-DIHYDROPYRIDINE, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS |
US5834496A (en) * | 1991-12-02 | 1998-11-10 | Sepracor, Inc. | Methods for treating hypertension using optically pure S(-) felodipine |
AT399718B (en) * | 1992-04-16 | 1995-07-25 | Lek Tovarna Farmacevtskih | INCLUSION COMPLEXES OF OPTICALLY ACTIVE AND RACEMIC 1,4-DIHYDROPYRIDINES WITH METHYL-BETA-CYCLODEXTRIN OR OTHER CYCLODEXTRINE DERIVATIVES, A METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE DIHYDROPYRIDE-DOMETHYL-DOMETHYL-DOMETHYL-DOMETHYL POWERS |
ES2096179T3 (en) * | 1992-10-30 | 1997-03-01 | Bayer Ag | DIHYDROPYRIDINES REPLACED IN POSITION 4 WITH A HETEROCICLILFENILO. |
US6001857A (en) * | 1992-10-30 | 1999-12-14 | Bayer Aktiengesellschaft | Heterocyclyl substituted dihydropyridines |
DE4236707A1 (en) * | 1992-10-30 | 1994-05-05 | Bayer Ag | 4-heterocyclyl substituted dihydropyridines |
EE03192B1 (en) * | 1993-12-10 | 1999-06-15 | Bayer Aktiengesellschaft | Isopropyl (2-methoxyethyl) -4- (2-chloro-3-cyanophenyl) -1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate, its enantiomers and intermediate, methods for their preparation and use |
DE4342193A1 (en) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Aryl substituted alkoxycarbonyl-1,4-dihydropyridine-5-carboxylic acid esters |
DE59410255D1 (en) | 1993-12-10 | 2003-04-17 | Bayer Ag | Phenyl-substituted 1,4-dihydropyridines with cerebral activity |
US5478848A (en) * | 1994-01-26 | 1995-12-26 | Bayer Corporation | Inhibition of arthritis by L-type calcium channel antagonists nimodipine, nisoldipine and nifedipine |
DE19532320A1 (en) * | 1995-09-01 | 1997-03-06 | Bayer Ag | Process for the preparation of optically active ortho-substituted 4-aryl-dihydropyridines |
JPH11106375A (en) * | 1997-08-18 | 1999-04-20 | Pfizer Pharmaceut Inc | Optically active 1,4-dihydropyridine compound as bradykinin antagonist |
US20100247646A1 (en) * | 2009-03-26 | 2010-09-30 | Ranbaxy Laboratories Limited | Extended release tablets of nisoldipine |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2117571C3 (en) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Asymmetrical 1,4-dihydropyridine-33-dicarboxylic acid esters, process for their preparation and their use as pharmaceuticals |
US3985758A (en) * | 1973-02-20 | 1976-10-12 | Yamanouchi Pharmaceutical Co., Ltd. | 1,4-Dihydropyridine derivatives |
DE2508181A1 (en) * | 1975-02-26 | 1976-09-09 | Bayer Ag | 1,4-DIHYDROPYRIDINCARBONIC ACID ARAL KYLESTER, METHOD FOR MANUFACTURING AND USING THEY AS A MEDICINAL PRODUCT |
GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
GB1591089A (en) * | 1976-12-17 | 1981-06-10 | Fujisawa Pharmaceutical Co | 1,4-dihydropyridine derivatives and process for preparation thereof |
SE429652B (en) * | 1978-06-30 | 1983-09-19 | Haessle Ab | 2,6-dimethyl-4- (2,3-dichlorophenyl) -1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-ethyl ester |
DE2935451A1 (en) * | 1979-09-01 | 1981-03-19 | Bayer Ag, 5090 Leverkusen | OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT |
-
1979
- 1979-09-01 DE DE2935451A patent/DE2935451A1/en not_active Withdrawn
-
1980
- 1980-08-15 NO NO802446A patent/NO159928C/en unknown
- 1980-08-16 EP EP80104900A patent/EP0026317B1/en not_active Expired
- 1980-08-16 DE DE8080104900T patent/DE3071186D1/en not_active Expired
- 1980-08-16 AT AT80104900T patent/ATE16101T1/en not_active IP Right Cessation
- 1980-08-22 PT PT71724A patent/PT71724B/en not_active IP Right Cessation
- 1980-08-27 SU SU802969272A patent/SU932988A3/en active
- 1980-08-28 FI FI802717A patent/FI78686C/en not_active IP Right Cessation
- 1980-08-28 DD DD80223572A patent/DD154014A5/en unknown
- 1980-08-29 DK DK368480A patent/DK160549C/en not_active IP Right Cessation
- 1980-08-29 NZ NZ194805A patent/NZ194805A/en unknown
- 1980-08-29 IE IE1820/80A patent/IE50504B1/en not_active IP Right Cessation
- 1980-08-29 IL IL60937A patent/IL60937A/en not_active IP Right Cessation
- 1980-08-29 AR AR282348A patent/AR228576A1/en active
- 1980-08-29 HU HU802135A patent/HU184821B/en not_active IP Right Cessation
- 1980-08-29 CA CA000359359A patent/CA1142937A/en not_active Expired
- 1980-08-29 CS CS805915A patent/CS228506B2/en unknown
- 1980-08-29 JP JP11856180A patent/JPS5636455A/en active Pending
- 1980-08-29 ZA ZA00805372A patent/ZA805372B/en unknown
- 1980-08-29 GR GR62770A patent/GR70080B/el unknown
- 1980-08-29 ES ES494614A patent/ES8104228A1/en not_active Expired
- 1980-08-30 EG EG80533A patent/EG15011A/en active
- 1980-08-30 PL PL1980226503A patent/PL128310B1/en unknown
- 1980-09-01 PH PH24522A patent/PH19749A/en unknown
- 1980-09-03 AU AU61982/80A patent/AU545023B2/en not_active Ceased
-
1982
- 1982-05-11 PH PH27281A patent/PH17914A/en unknown
- 1982-05-11 PH PH27282A patent/PH19006A/en unknown
- 1982-09-30 US US06/429,732 patent/US4510310A/en not_active Expired - Lifetime
-
1987
- 1987-02-09 US US07/012,515 patent/US4849433A/en not_active Expired - Fee Related
-
1989
- 1989-03-30 US US07/331,312 patent/US4988717A/en not_active Expired - Fee Related
-
1990
- 1990-10-05 DK DK241390A patent/DK164158C/en not_active IP Right Cessation
-
1991
- 1991-02-20 JP JP3047607A patent/JPH07600B2/en not_active Expired - Lifetime
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