ZA79268B - 9-deoxy-9a-methylene isosteres of pgi2 and process for their preparation - Google Patents

9-deoxy-9a-methylene isosteres of pgi2 and process for their preparation

Info

Publication number
ZA79268B
ZA79268B ZA79268A ZA79268A ZA79268B ZA 79268 B ZA79268 B ZA 79268B ZA 79268 A ZA79268 A ZA 79268A ZA 79268 A ZA79268 A ZA 79268A ZA 79268 B ZA79268 B ZA 79268B
Authority
ZA
South Africa
Prior art keywords
pgi2
isosteres
deoxy
methylene
preparation
Prior art date
Application number
ZA79268A
Inventor
F Faustini
R Ceserani
W Fava
C Passarotti
C Gandolfi
A Fumagalli
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of ZA79268B publication Critical patent/ZA79268B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA79268A 1978-01-26 1979-01-23 9-deoxy-9a-methylene isosteres of pgi2 and process for their preparation ZA79268B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT7819616A IT7819616A0 (en) 1978-01-26 1978-01-26 9-DEOXY-9A-METHYLENE-ISOSTERES OF PGI 2.
KR7900219A KR840000948B1 (en) 1978-01-26 1979-01-25 Process for the preparation of 9-deoxy-9a-methylene isosteres of pgi2
AU14048/83A AU556110B2 (en) 1978-01-26 1983-04-28 9-deoxy-9a-methylene isoesters of pg12

Publications (1)

Publication Number Publication Date
ZA79268B true ZA79268B (en) 1980-01-30

Family

ID=36794902

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA79268A ZA79268B (en) 1978-01-26 1979-01-23 9-deoxy-9a-methylene isosteres of pgi2 and process for their preparation

Country Status (8)

Country Link
KR (1) KR840000948B1 (en)
AU (1) AU556110B2 (en)
BE (1) BE873731A (en)
CS (2) CS215149B2 (en)
HU (1) HU182726B (en)
IT (1) IT7819616A0 (en)
SU (1) SU1360582A3 (en)
ZA (1) ZA79268B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56145239A (en) * 1980-04-11 1981-11-11 Sumitomo Chem Co Ltd Novel bicyclooctane derivative and its preparation
JPS61280294A (en) * 1985-06-04 1986-12-10 Nisshin Flour Milling Co Ltd Optically active carbacycline intermediate and production thereof
US4837342A (en) * 1986-02-28 1989-06-06 Sagami Chemical Research Center Prostacyclin analogue, and blood circulation improving agent and anti-ulcer composition containing it as active ingredient

Also Published As

Publication number Publication date
HU182726B (en) 1984-03-28
KR830000687A (en) 1983-04-18
CS215149B2 (en) 1982-07-30
BE873731A (en) 1979-07-26
AU1404883A (en) 1984-01-12
AU556110B2 (en) 1986-10-23
CS215150B2 (en) 1982-07-30
KR840000948B1 (en) 1984-07-01
SU1360582A3 (en) 1987-12-15
IT7819616A0 (en) 1978-01-26

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