ZA707997B - Substituted nitroimidazoles useful against tripanosomiasis - Google Patents

Substituted nitroimidazoles useful against tripanosomiasis

Info

Publication number
ZA707997B
ZA707997B ZA707997A ZA707997A ZA707997B ZA 707997 B ZA707997 B ZA 707997B ZA 707997 A ZA707997 A ZA 707997A ZA 707997 A ZA707997 A ZA 707997A ZA 707997 B ZA707997 B ZA 707997B
Authority
ZA
South Africa
Prior art keywords
tripanosomiasis
useful against
nitroimidazoles
substituted
substituted nitroimidazoles
Prior art date
Application number
ZA707997A
Inventor
P Kulsa
C Rooney
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA707997B publication Critical patent/ZA707997B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA707997A 1970-01-07 1970-11-25 Substituted nitroimidazoles useful against tripanosomiasis ZA707997B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US130770A 1970-01-07 1970-01-07

Publications (1)

Publication Number Publication Date
ZA707997B true ZA707997B (en) 1972-07-26

Family

ID=21695371

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA707997A ZA707997B (en) 1970-01-07 1970-11-25 Substituted nitroimidazoles useful against tripanosomiasis

Country Status (11)

Country Link
US (1) US3711495A (en)
JP (1) JPS511717B1 (en)
CA (1) CA988089A (en)
CH (1) CH555852A (en)
DE (1) DE2100242C2 (en)
FR (1) FR2081416B1 (en)
GB (1) GB1316221A (en)
NL (1) NL7018072A (en)
OA (1) OA03554A (en)
ZA (1) ZA707997B (en)
ZM (1) ZM14570A1 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3915978A (en) * 1970-01-07 1975-10-28 Merck & Co Inc Nitroimidazoles
DE2229223C3 (en) * 1971-07-30 1975-12-18 Gruppo Lepetit S.P.A., Mailand (Italien) 2-Nitro-S-imidazole derivatives and processes for their preparation
US4010176A (en) * 1972-10-27 1977-03-01 Merck & Co., Inc. Isoxazole substituted nitroimidazoles
US4080340A (en) * 1975-07-30 1978-03-21 Merck & Co., Inc. Nitroimidazoles
DE2613167A1 (en) * 1976-03-27 1977-10-06 Bayer Ag OXIME CARBAMATES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE AS INSECTICIDES, ACARICIDES AND NEMATOCIDES
US4268674A (en) * 1977-11-14 1981-05-19 The Dow Chemical Company Preparation of substituted oxatriazoles
DE2862035D1 (en) * 1977-11-30 1982-11-04 Merck & Co Inc Substituted nitroimidazoles, process for their preparation and compositions containing them
US4144345A (en) * 1977-11-30 1979-03-13 Merck & Co., Inc. Dihydroxybenzisoxazolin-3-yl-substituted-5-nitroimidazoles as antibacterials and antiprotozoals
US4269830A (en) * 1979-05-17 1981-05-26 Merck & Co., Inc. Compositions and methods for the treatment of chronic trypanosomiasis infections
GB2101886B (en) * 1981-05-22 1985-07-31 Merck & Co Inc Compositions for the treatment of chronic trypanosomiasis infections
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
US4767866A (en) * 1987-04-10 1988-08-30 Pennwalt Corporation 3-Phenyl-3-(1H-1,2,4-triazol-1-ylmethyl)-2-methyl-5-alkylisoxazolidines
US4767867A (en) * 1987-04-10 1988-08-30 Pennwalt Corporation 5-(alkoxyalkyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines
US4719306A (en) * 1986-08-27 1988-01-12 Pennwalt Corporation Substituted 3,5-diphenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines
US4769471A (en) * 1987-04-10 1988-09-06 Pennwalt Corporation Substituted 3,5-diphenyl-3-(1H-1,2,4-triazol-1-yl-methyl)-2-methylisoxazolidines
US4727156A (en) * 1986-08-27 1988-02-23 Pennwalt Corporation 3-(Substituted phenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-{[(substituted phenyl)thio]me}isoxazolidine derivatives
US4767868A (en) * 1987-04-10 1988-08-30 Pennwalt Corporation 3-Phenyl-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-[(phenylamino)methyl]isoxazolidines
US4723021A (en) * 1986-08-27 1988-02-02 Pennwalt Corporation Substituted 5-(phenoxyalkyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines
US4769468A (en) * 1987-04-10 1988-09-06 Penwalt Corporation 5-(acyloxyalkyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines
US4727157A (en) * 1986-08-27 1988-02-23 Pennwalt Corporation 3-(Substituted phenyl)-3-(1H-1,2,4-triazol-1-yl)methyl-2-methyl-5-[(substituted phenoxy)methyl]isoxazolidine derivatives
US4831154A (en) * 1987-04-10 1989-05-16 Pennwalt Corporation 5-alkyl(or alkenyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines
US4769470A (en) * 1987-10-02 1988-09-06 Pennwalt Corporation 5-(phenyl or phenoxyalkyl)-3-(2-thienyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines
US4769469A (en) * 1987-04-10 1988-09-06 Pennwalt Corporation 5-(phenyl or phenoxyalkyl)-3-(2-furanyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines
US4777262A (en) * 1987-10-02 1988-10-11 Pennwalt Corporation 5-(substituted thiomethyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine derivatives
US4749793A (en) * 1987-10-02 1988-06-07 Pennwalt Corporation 5-substituted-3-phenyl-3-[1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl]-2-benzylisoxazolidines (ir 3011)
US4785117A (en) * 1987-10-02 1988-11-15 Pennwalt Corporation 5,5-disubstituted-3-phenyl-3-phenyl-3-[(1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl)]-2-methylisoxazolidine derivatives (IR 3012)
US4777263A (en) * 1987-10-02 1988-10-11 Pennwalt Corporation 5-substituted-3-(2-naphthalenyl)-3-((1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl))-2-methylisoxazolidines
US4754042A (en) * 1987-10-02 1988-06-28 Pennwalt Corporation 5-{[naphthyl(or 2-oxo-1,3-benzoxathiol-6-yl)oxy]methyl}-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines
US4777264A (en) * 1987-10-02 1988-10-11 Pennwalt Corporation 5-carbonyl derivatives of 3-phenyl-3-(1H-imadazol-1-ylmethyl)-2-methylisoxazolidines and related compounds thereof
US4835283A (en) * 1988-03-07 1989-05-30 Pennwalt Corporation 3,5-diphenyl-3-[(1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl)]-2
US6072057A (en) * 1996-06-06 2000-06-06 Gliatech Inc. 1H-4(5)-cyclo-substituted imidazole derivatives as histamine H3 receptor agents
US6329342B1 (en) 1997-08-19 2001-12-11 Eli Lilly And Company Treatment of congestive heart failure with growth hormone secretagogues
EP1060179A1 (en) * 1998-02-25 2000-12-20 PHARMACIA & UPJOHN COMPANY Substituted aminomethyl isoxazoline derivatives useful as antimicrobials
US6639076B1 (en) 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
US6828331B1 (en) * 1999-02-19 2004-12-07 Eli Lilly And Company Growth hormone secretagogues
US7125840B2 (en) * 2001-10-09 2006-10-24 Eli Lilly And Company Substituted dipeptides as growth hormone secretagogues
US20060167268A1 (en) * 2002-04-09 2006-07-27 Eli Lilly And Company, Patent Division, Growth hormone secretagogues
DE60306636T2 (en) * 2002-04-09 2007-07-05 Eli Lilly And Co., Indianapolis WACHSTUMHORMONSEKRETIONSFÖRDERER

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1162257A (en) * 1965-09-22 1969-08-20 Danippon Pharmaceutical Co Ltd 3-(5-Nitro-2-Furyl) Isoxazole Derivatives and methods of preparation thereof
FR1510315A (en) * 1966-02-03 1968-01-19 Ciba Geigy Process for the preparation of 4-diaza-cyclo-alkano-pyrazoles substituted in position 1 by bicyclic heterocyclic residues
US3452035A (en) * 1966-12-23 1969-06-24 American Cyanamid Co 2 - amino - 5 - (5 - nitro - 1 - substituted-2 - imidazolyl) - 1,3,4 - thiadiazoles and oxadiazoles

Also Published As

Publication number Publication date
GB1316221A (en) 1973-05-09
JPS511717B1 (en) 1976-01-20
CA988089A (en) 1976-04-27
DE2100242C2 (en) 1984-07-19
FR2081416B1 (en) 1974-09-27
ZM14570A1 (en) 1972-08-21
NL7018072A (en) 1971-07-09
OA03554A (en) 1971-03-30
DE2100242A1 (en) 1971-07-15
US3711495A (en) 1973-01-16
FR2081416A1 (en) 1971-12-03
CH555852A (en) 1974-11-15

Similar Documents

Publication Publication Date Title
ZA707997B (en) Substituted nitroimidazoles useful against tripanosomiasis
HK42177A (en) Azapurinones
IL36363A (en) 5-azapyrimidine-nucleosides
JPS5636468A (en) 44hydroxyy66arylpyrimidines
JPS5182632A (en) Seidensenzono ekitaigenzosochi
HK13477A (en) Arylalkylsulphoxides
IL38178A (en) 1-phenyl-3-acyl-thioureas
IL36191A0 (en) Disc-brakes
JPS56156207A (en) Tickicide
JPS5123747A (en) Seidensenzono ekitaigenzosochi
JPS5168563A (en) Isoindorinjudotaino seiho
IL37883A0 (en) Alpha-6-deoxytetracyclines
IE35693L (en) 1 - phenoxy - 2 - hydroxy - 3 - hydroxyalkyl-aminopropanes
HK86379A (en) 3-fluoroalanines
IL36155A (en) 3-amino-1-phenoxy-propan-2-olderivatives
IL36747A0 (en) 3-sulfonamido-4-hydroxyphenyl-2-piperidylcarbinols
ZA713158B (en) Imidazole derivatives
JPS5136411A (en) Jukikagobutsuno seizohoho
IL43774A0 (en) 4-benzyloxy-ureidoacetophenones
MY7400161A (en) Copocymers
GB1364569A (en) Cinecamera
IL36630A (en) 2-naphthyl-quinazolinones
ZA713113B (en) Substituted octahydroquinazoline-diones
ZA717873B (en) Novel imidazole compounds
AU4883172A (en) Stick-classifying