ZA201307645B - Tetrahydroquinoline derivatives useful as bromodomain inhibitors - Google Patents
Tetrahydroquinoline derivatives useful as bromodomain inhibitorsInfo
- Publication number
- ZA201307645B ZA201307645B ZA2013/07645A ZA201307645A ZA201307645B ZA 201307645 B ZA201307645 B ZA 201307645B ZA 2013/07645 A ZA2013/07645 A ZA 2013/07645A ZA 201307645 A ZA201307645 A ZA 201307645A ZA 201307645 B ZA201307645 B ZA 201307645B
- Authority
- ZA
- South Africa
- Prior art keywords
- derivatives useful
- bromodomain inhibitors
- tetrahydroquinoline derivatives
- tetrahydroquinoline
- bromodomain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201106743A GB201106743D0 (en) | 2011-04-21 | 2011-04-21 | Novel compounds |
| PCT/EP2012/057111 WO2012143413A1 (en) | 2011-04-21 | 2012-04-19 | Tetrahydroquinoline derivatives useful as bromodomain inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201307645B true ZA201307645B (en) | 2015-04-29 |
Family
ID=44147335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2013/07645A ZA201307645B (en) | 2011-04-21 | 2013-10-14 | Tetrahydroquinoline derivatives useful as bromodomain inhibitors |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9029395B2 (en) |
| EP (1) | EP2699550B1 (en) |
| JP (1) | JP5840763B2 (en) |
| KR (1) | KR101896599B1 (en) |
| CN (1) | CN103619820B (en) |
| AU (1) | AU2012244759B2 (en) |
| BR (1) | BR112013026834A2 (en) |
| CA (1) | CA2832763C (en) |
| EA (1) | EA022341B1 (en) |
| ES (1) | ES2544302T3 (en) |
| GB (1) | GB201106743D0 (en) |
| IL (1) | IL228707A (en) |
| MX (1) | MX338515B (en) |
| SG (1) | SG194469A1 (en) |
| WO (1) | WO2012143413A1 (en) |
| ZA (1) | ZA201307645B (en) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201107325D0 (en) | 2011-05-04 | 2011-06-15 | Glaxosmithkline Llc | Novel compounds |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
| MX2015007921A (en) | 2012-12-21 | 2016-03-03 | Zenith Epigenetics Corp | Novel heterocyclic compounds as bromodomain inhibitors. |
| ES2704048T3 (en) * | 2013-03-14 | 2019-03-14 | Glaxosmithkline Ip No 2 Ltd | Derivatives of 1-acyl-4-amino-1,2,3,4-tetrahydroquinoline-2,3-disubstituted and their use as bromodomain inhibitors |
| WO2014143768A1 (en) | 2013-03-15 | 2014-09-18 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
| BR112015031073B1 (en) | 2013-06-21 | 2022-11-29 | Zenith Epigenetics Ltd | BICYCLIC BROMODIMANIUM INHIBITORS AND PHARMACEUTICAL COMPOSITION CONTAINING SAID COMPOUNDS |
| JP6599852B2 (en) | 2013-06-21 | 2019-10-30 | ゼニス・エピジェネティクス・リミテッド | Novel substituted bicyclic compounds as bromodomain inhibitors |
| AR096837A1 (en) | 2013-07-08 | 2016-02-03 | Incyte Corp | TRICYCLIC HETEROCICLES AS BET PROTEIN INHIBITORS |
| EA201690087A1 (en) | 2013-07-31 | 2016-08-31 | Зенит Эпидженетикс Корп. | NEW QUINAZOLINONS AS BROMOMODENIAL INHIBITORS |
| WO2015081189A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| US9399640B2 (en) | 2013-11-26 | 2016-07-26 | Incyte Corporation | Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors |
| US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| WO2015120393A1 (en) | 2014-02-10 | 2015-08-13 | Concert Pharmaceuticals, Inc. | Substituted triazolobenzodiazepines |
| FI3674302T3 (en) | 2014-04-23 | 2023-04-27 | Incyte Holdings Corp | 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins |
| KR102633122B1 (en) * | 2014-08-01 | 2024-02-05 | 누에볼루션 에이/에스 | Compounds active towards bromodomains |
| CA2958159A1 (en) | 2014-09-12 | 2016-03-17 | Glaxosmithkline Intellectual Property (No. 2) Limited | Tetrahydroquinoline derivatives as bromodomain inhibitors |
| ES2855225T3 (en) | 2014-09-15 | 2021-09-23 | Incyte Corp | Tricyclic heterocycles for use as BET protein inhibitors |
| KR20170055549A (en) * | 2014-10-02 | 2017-05-19 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | Compound |
| WO2016087936A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Corp. | Substituted pyridinones as bromodomain inhibitors |
| US10179125B2 (en) | 2014-12-01 | 2019-01-15 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| JP2017537946A (en) | 2014-12-11 | 2017-12-21 | ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． | Substituted heterocycles as bromodomain inhibitors |
| CN107406438B (en) | 2014-12-17 | 2021-05-14 | 恒翼生物医药科技(上海)有限公司 | Inhibitors of bromodomains |
| GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
| WO2016203335A1 (en) | 2015-06-18 | 2016-12-22 | Pfizer Inc. | Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors |
| TW201722966A (en) | 2015-10-29 | 2017-07-01 | 英塞特公司 | Amorphous solid form of a BET protein inhibitor |
| EP3472157B1 (en) | 2016-06-20 | 2023-04-12 | Incyte Corporation | Crystalline solid forms of a bet inhibitor |
| ES2937307T3 (en) | 2016-07-26 | 2023-03-27 | Univ Southern California | Selective bromodomain inhibition of fungal BDF1 |
| WO2018111805A1 (en) * | 2016-12-13 | 2018-06-21 | St. Jude Children's Research Hospital | Tetrahydroquinoline-based bromodomain inhibitors |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| AU2004287261B8 (en) | 2003-11-03 | 2011-01-27 | Glaxo Group Limited | A fluid dispensing device |
| JP2008156311A (en) | 2006-12-26 | 2008-07-10 | Institute Of Physical & Chemical Research | Brd2 bromodomain binder |
| JP5478262B2 (en) | 2007-12-28 | 2014-04-23 | 田辺三菱製薬株式会社 | Anticancer drug |
| JP5572154B2 (en) * | 2009-03-31 | 2014-08-13 | 興和株式会社 | A prophylactic and / or therapeutic agent for anemia comprising a tetrahydroquinoline compound as an active ingredient |
| GB0919431D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919432D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Use |
| GB0919434D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| EP2955524A3 (en) * | 2009-11-05 | 2016-03-23 | GlaxoSmithKline LLC | Novel process |
| GB201106750D0 (en) * | 2011-04-21 | 2011-06-01 | Glaxosmithkline Llc | Novel compounds |
| GB201107325D0 (en) * | 2011-05-04 | 2011-06-15 | Glaxosmithkline Llc | Novel compounds |
| WO2013033268A2 (en) * | 2011-08-29 | 2013-03-07 | Coferon, Inc. | Bivalent bromodomain ligands, and methods of using same |
-
2011
- 2011-04-21 GB GB201106743A patent/GB201106743D0/en not_active Ceased
-
2012
- 2012-04-19 JP JP2014505610A patent/JP5840763B2/en not_active Expired - Fee Related
- 2012-04-19 EA EA201391285A patent/EA022341B1/en not_active IP Right Cessation
- 2012-04-19 MX MX2013012190A patent/MX338515B/en active IP Right Grant
- 2012-04-19 AU AU2012244759A patent/AU2012244759B2/en not_active Ceased
- 2012-04-19 WO PCT/EP2012/057111 patent/WO2012143413A1/en active Application Filing
- 2012-04-19 US US14/111,580 patent/US9029395B2/en not_active Expired - Fee Related
- 2012-04-19 EP EP12716378.0A patent/EP2699550B1/en active Active
- 2012-04-19 BR BR112013026834A patent/BR112013026834A2/en not_active Application Discontinuation
- 2012-04-19 SG SG2013076146A patent/SG194469A1/en unknown
- 2012-04-19 ES ES12716378.0T patent/ES2544302T3/en active Active
- 2012-04-19 CA CA2832763A patent/CA2832763C/en not_active Expired - Fee Related
- 2012-04-19 KR KR1020137030972A patent/KR101896599B1/en active IP Right Grant
- 2012-04-19 CN CN201280029939.XA patent/CN103619820B/en not_active Expired - Fee Related
-
2013
- 2013-10-03 IL IL228707A patent/IL228707A/en active IP Right Grant
- 2013-10-14 ZA ZA2013/07645A patent/ZA201307645B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012244759A1 (en) | 2013-10-31 |
| EA022341B1 (en) | 2015-12-30 |
| CN103619820A (en) | 2014-03-05 |
| EP2699550B1 (en) | 2015-06-10 |
| JP2014511891A (en) | 2014-05-19 |
| AU2012244759B2 (en) | 2016-03-03 |
| MX2013012190A (en) | 2014-01-31 |
| EP2699550A1 (en) | 2014-02-26 |
| CA2832763C (en) | 2019-09-24 |
| EA201391285A1 (en) | 2014-04-30 |
| BR112013026834A2 (en) | 2016-12-27 |
| US9029395B2 (en) | 2015-05-12 |
| CN103619820B (en) | 2015-08-19 |
| MX338515B (en) | 2016-04-20 |
| US20140039006A1 (en) | 2014-02-06 |
| ES2544302T3 (en) | 2015-08-28 |
| CA2832763A1 (en) | 2012-10-26 |
| JP5840763B2 (en) | 2016-01-06 |
| IL228707A (en) | 2016-09-29 |
| IL228707A0 (en) | 2013-12-31 |
| WO2012143413A1 (en) | 2012-10-26 |
| KR101896599B1 (en) | 2018-09-07 |
| SG194469A1 (en) | 2013-12-30 |
| KR20140025484A (en) | 2014-03-04 |
| GB201106743D0 (en) | 2011-06-01 |
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