ZA200906916B - Use of 4-(Nitrooxy)-butyl-(S)-2-(6-methoxy-2-naphtyl)-propanoate for treating pain and inflammation - Google Patents

Use of 4-(Nitrooxy)-butyl-(S)-2-(6-methoxy-2-naphtyl)-propanoate for treating pain and inflammation

Info

Publication number
ZA200906916B
ZA200906916B ZA200906916A ZA200906916A ZA200906916B ZA 200906916 B ZA200906916 B ZA 200906916B ZA 200906916 A ZA200906916 A ZA 200906916A ZA 200906916 A ZA200906916 A ZA 200906916A ZA 200906916 B ZA200906916 B ZA 200906916B
Authority
ZA
South Africa
Prior art keywords
nitrooxy
naphtyl
propanoate
inflammation
methoxy
Prior art date
Application number
ZA200906916A
Inventor
Pottumarthi V Prasad
Manlio Bolla
Marianna Armogida
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of ZA200906916B publication Critical patent/ZA200906916B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200906916A 2007-04-25 2009-10-05 Use of 4-(Nitrooxy)-butyl-(S)-2-(6-methoxy-2-naphtyl)-propanoate for treating pain and inflammation ZA200906916B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90797007P 2007-04-25 2007-04-25

Publications (1)

Publication Number Publication Date
ZA200906916B true ZA200906916B (en) 2010-06-30

Family

ID=39638863

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200906916A ZA200906916B (en) 2007-04-25 2009-10-05 Use of 4-(Nitrooxy)-butyl-(S)-2-(6-methoxy-2-naphtyl)-propanoate for treating pain and inflammation

Country Status (14)

Country Link
US (1) US20080269323A1 (en)
EP (1) EP2148665A1 (en)
JP (1) JP2010525005A (en)
KR (1) KR20100015744A (en)
CN (1) CN101686953A (en)
AR (1) AR071726A1 (en)
AU (1) AU2008244441A1 (en)
BR (1) BRPI0809544A2 (en)
CA (1) CA2683488A1 (en)
IL (1) IL201280A0 (en)
MX (1) MX2009011502A (en)
RU (1) RU2009139180A (en)
WO (1) WO2008132025A1 (en)
ZA (1) ZA200906916B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20080325A1 (en) * 2008-06-20 2009-12-21 Nicox Sa METHOD FOR PURIFYING 4- (NITROOSIS) BUTYL (2S) -2- (6-METHOXY-2-NAFTYL) PROPANOATE
US20100240745A1 (en) * 2009-03-20 2010-09-23 Nicox S.A. Method of treatment of inflammation in hypertensive patients
US20110054020A1 (en) * 2009-05-05 2011-03-03 Auspex Pharmaceuticals, Inc. Napthylene inhibitors of cyclooxygenase
IT1402177B1 (en) 2010-09-07 2013-08-28 Rottapharm Spa NITROESTERS OF 1,5-DIARYL-2-ALCHIL-PYRROL-3-SUBSTITUTES, SELECTIVE INHIBITORS OF COX-2 AND DONORS OF NITROSUS OXIDE
JP6983070B2 (en) * 2015-02-03 2021-12-17 ユニヴァーシティー コート オブ ザ ユニヴァーシティー オブ セント アンドリューズ NO-containing composition
EP4103171A1 (en) * 2020-02-10 2022-12-21 Nicox S.A. Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE432258T1 (en) * 2003-03-05 2009-06-15 Merck Frosst Company NITROGEN MONOXIDE RELEASING PRODRUGS OF DIARYL-2-(5H)-FURANONES AS INHIBITORS OF CYCLOOXYGENASE-2
US7622502B2 (en) * 2004-01-27 2009-11-24 Merck Frosst Canada & Co. Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors

Also Published As

Publication number Publication date
IL201280A0 (en) 2010-05-31
CN101686953A (en) 2010-03-31
JP2010525005A (en) 2010-07-22
MX2009011502A (en) 2009-11-09
AU2008244441A1 (en) 2008-11-06
EP2148665A1 (en) 2010-02-03
US20080269323A1 (en) 2008-10-30
RU2009139180A (en) 2011-05-27
CA2683488A1 (en) 2008-11-06
BRPI0809544A2 (en) 2014-09-16
AR071726A1 (en) 2010-07-14
KR20100015744A (en) 2010-02-12
WO2008132025A1 (en) 2008-11-06

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