ZA200808247B - Monocyclic and bicyclic himbacine derivatives useful as thrombin receptor antagonists - Google Patents
Monocyclic and bicyclic himbacine derivatives useful as thrombin receptor antagonistsInfo
- Publication number
- ZA200808247B ZA200808247B ZA200808247A ZA200808247A ZA200808247B ZA 200808247 B ZA200808247 B ZA 200808247B ZA 200808247 A ZA200808247 A ZA 200808247A ZA 200808247 A ZA200808247 A ZA 200808247A ZA 200808247 B ZA200808247 B ZA 200808247B
- Authority
- ZA
- South Africa
- Prior art keywords
- monocyclic
- receptor antagonists
- derivatives useful
- thrombin receptor
- himbacine derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P11/06—Antiasthmatics
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- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78696106P | 2006-03-29 | 2006-03-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200808247B true ZA200808247B (en) | 2009-11-25 |
Family
ID=38561631
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200808247A ZA200808247B (en) | 2006-03-29 | 2008-09-26 | Monocyclic and bicyclic himbacine derivatives useful as thrombin receptor antagonists |
Country Status (12)
Country | Link |
---|---|
US (1) | US7888377B2 (xx) |
EP (1) | EP1999111B1 (xx) |
JP (1) | JP2009534308A (xx) |
KR (1) | KR20080104352A (xx) |
CN (1) | CN101460463A (xx) |
AR (1) | AR060095A1 (xx) |
AU (1) | AU2007243657A1 (xx) |
CA (1) | CA2647933A1 (xx) |
MX (1) | MX2008012574A (xx) |
TW (1) | TW200811107A (xx) |
WO (1) | WO2007126771A2 (xx) |
ZA (1) | ZA200808247B (xx) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8828966B2 (en) * | 2006-10-03 | 2014-09-09 | Claire Mitchell | Method for treatment of macular degeneration by modulating P2Y12 or P2X7 receptors |
US8227412B2 (en) * | 2007-03-29 | 2012-07-24 | Tsopanoglou Nikos E | Bioactive parstatin peptides and methods of use |
WO2011128421A1 (de) | 2010-04-16 | 2011-10-20 | Sanofi | Trizyklische pyridyl-vinyl-pyrrole als par1-inhibitoren |
EP2558462B1 (de) | 2010-04-16 | 2014-10-22 | Sanofi | Pyridyl-vinyl-pyrazolo-chinoline als par1-inhibitoren |
US9604971B2 (en) | 2013-07-22 | 2017-03-28 | Aralez Pharmaceuticals Trading Dac | Co-crystal of the PAR-1 receptor antagonists vorapaxar and aspirin |
CN105777681B (zh) * | 2014-12-17 | 2019-03-01 | 博瑞生物医药(苏州)股份有限公司 | 喜巴辛类似物及其中间体的制备方法 |
CN105949116A (zh) * | 2016-06-08 | 2016-09-21 | 青岛理工大学 | 酰基哌嗪类化合物及其制备方法和用途 |
CN110559294A (zh) * | 2018-06-06 | 2019-12-13 | 杨仑 | 脂肪性肝病及其相关疾病的预防和治疗性药物 |
CN116813691B (zh) * | 2018-10-29 | 2024-04-12 | 丽珠医药集团股份有限公司 | 新的二肽类化合物及其用途 |
CN110627710B (zh) * | 2019-09-29 | 2020-06-05 | 山东大学 | 一种新型par-1抑制剂及其制备方法和在预防和/或治疗血栓性疾病中的用途 |
TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
CN111879949B (zh) * | 2020-08-05 | 2021-11-09 | 中国科学院昆明动物研究所 | 检测或调控乳铁蛋白表达量的物质在制备预防和/或治疗心脑血管疾病药物或试剂盒的应用 |
CN112759548B (zh) * | 2020-12-31 | 2021-11-02 | 山东大学 | 一种par-1抑制剂及其制备方法 |
CA3216162A1 (en) | 2021-04-16 | 2022-10-20 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL106197A (en) | 1992-07-30 | 1999-11-30 | Cor Therapeutics Inc | Agagonists for the rhombin receptors and pharmaceutical preparations containing them |
US6063847A (en) * | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
US7488742B2 (en) * | 2000-06-15 | 2009-02-10 | Schering Corporation | Thrombin receptor antagonists |
ES2291323T3 (es) * | 2000-06-15 | 2008-03-01 | Schering Corporation | Antagonistas de receptores de trombina. |
KR100960170B1 (ko) | 2001-10-18 | 2010-05-26 | 쉐링 코포레이션 | 트롬빈 수용체 길항제로서의 힘바신 동족체 |
ATE498600T1 (de) * | 2003-04-15 | 2011-03-15 | Aquinox Pharmaceuticals Inc | Inden derivate als pharmazeutika |
-
2007
- 2007-03-27 EP EP07754070.6A patent/EP1999111B1/en active Active
- 2007-03-27 JP JP2009502927A patent/JP2009534308A/ja not_active Withdrawn
- 2007-03-27 AR ARP070101263A patent/AR060095A1/es not_active Application Discontinuation
- 2007-03-27 AU AU2007243657A patent/AU2007243657A1/en not_active Abandoned
- 2007-03-27 WO PCT/US2007/007497 patent/WO2007126771A2/en active Application Filing
- 2007-03-27 KR KR1020087023799A patent/KR20080104352A/ko not_active Application Discontinuation
- 2007-03-27 US US11/728,672 patent/US7888377B2/en active Active
- 2007-03-27 MX MX2008012574A patent/MX2008012574A/es unknown
- 2007-03-27 CA CA002647933A patent/CA2647933A1/en not_active Abandoned
- 2007-03-27 CN CNA2007800202800A patent/CN101460463A/zh active Pending
- 2007-03-28 TW TW096110838A patent/TW200811107A/zh unknown
-
2008
- 2008-09-26 ZA ZA200808247A patent/ZA200808247B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
TW200811107A (en) | 2008-03-01 |
WO2007126771A3 (en) | 2007-12-21 |
JP2009534308A (ja) | 2009-09-24 |
AR060095A1 (es) | 2008-05-21 |
KR20080104352A (ko) | 2008-12-02 |
WO2007126771A2 (en) | 2007-11-08 |
EP1999111B1 (en) | 2013-12-18 |
EP1999111A2 (en) | 2008-12-10 |
MX2008012574A (es) | 2008-10-10 |
US7888377B2 (en) | 2011-02-15 |
AU2007243657A1 (en) | 2007-11-08 |
US20070232635A1 (en) | 2007-10-04 |
CN101460463A (zh) | 2009-06-17 |
CA2647933A1 (en) | 2007-11-08 |
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