ZA200803367B - Methods for treatment and prevention of otitis media using chemical penetration enhancers to facilitate transmembrane drug delivery into the middle ear - Google Patents

Methods for treatment and prevention of otitis media using chemical penetration enhancers to facilitate transmembrane drug delivery into the middle ear

Info

Publication number
ZA200803367B
ZA200803367B ZA200803367A ZA200803367A ZA200803367B ZA 200803367 B ZA200803367 B ZA 200803367B ZA 200803367 A ZA200803367 A ZA 200803367A ZA 200803367 A ZA200803367 A ZA 200803367A ZA 200803367 B ZA200803367 B ZA 200803367B
Authority
ZA
South Africa
Prior art keywords
prevention
treatment
methods
drug delivery
penetration enhancers
Prior art date
Application number
ZA200803367A
Other languages
English (en)
Inventor
Neil E Paulsen
Roland H Johnson
William R Campbell
Original Assignee
Piedmont Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Piedmont Pharmaceuticals Llc filed Critical Piedmont Pharmaceuticals Llc
Publication of ZA200803367B publication Critical patent/ZA200803367B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
ZA200803367A 2005-09-26 2006-08-24 Methods for treatment and prevention of otitis media using chemical penetration enhancers to facilitate transmembrane drug delivery into the middle ear ZA200803367B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72053505P 2005-09-26 2005-09-26

Publications (1)

Publication Number Publication Date
ZA200803367B true ZA200803367B (en) 2009-09-30

Family

ID=37900207

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200803367A ZA200803367B (en) 2005-09-26 2006-08-24 Methods for treatment and prevention of otitis media using chemical penetration enhancers to facilitate transmembrane drug delivery into the middle ear

Country Status (11)

Country Link
US (2) US20080269187A1 (xx)
EP (1) EP1928439A4 (xx)
JP (1) JP2009509955A (xx)
CN (1) CN101272772A (xx)
AU (1) AU2006295236A1 (xx)
BR (1) BRPI0616363A2 (xx)
CA (1) CA2622001A1 (xx)
EA (1) EA200800949A1 (xx)
IL (1) IL190080A0 (xx)
WO (1) WO2007037874A2 (xx)
ZA (1) ZA200803367B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190026056A (ko) 2008-04-21 2019-03-12 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
AU2009246870B2 (en) 2008-05-14 2013-08-01 Otonomy, Inc. Controlled release corticosteroid compositions and methods for the treatment of otic disorders
US8648119B2 (en) 2008-05-23 2014-02-11 Otonomy, Inc. Controlled release immunomodulator compositions and methods for the treatment of otic disorders
US8846770B2 (en) 2008-06-18 2014-09-30 Otonomy, Inc. Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders
US8349353B2 (en) 2008-06-27 2013-01-08 Otonomy, Inc. Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders
WO2010011466A2 (en) 2008-06-27 2010-01-28 Otonomy, Inc. Controlled-release cns modulating compositions and methods for the treatment of otic disorders
US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
US8399018B2 (en) 2008-07-21 2013-03-19 Otonomy, Inc. Controlled release ion channel modulator compositions and methods for the treatment of otic disorders
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
CA2731769C (en) 2008-07-21 2013-09-10 Otonomy, Inc. Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders
KR20160047490A (ko) 2013-08-27 2016-05-02 오토노미, 인코포레이티드 소아 귀 질환의 치료
EP3512513A4 (en) 2016-09-16 2020-04-15 Otonomy, Inc. GEL FORMULA FOR THE EAR FOR TREATING OTITIS EXTERNA
US11484515B2 (en) 2017-12-12 2022-11-01 University of Pittsburgh—of the Commonwealth System of Higher Education Thermoresponsive hydrogel containing polymer microparticles for controlled drug delivery to the ear
CN116265023A (zh) * 2021-12-16 2023-06-20 北京远大九和药业有限公司 一种预防和/或治疗耳部感染的药物组合物及其制备方法和用途

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3128227A (en) * 1954-06-17 1964-04-07 American Cyanamid Co Antibiotic intramuscular composition
US3549770A (en) * 1963-12-09 1970-12-22 Crown Zellerbach Corp Therapeutic administration of effective amounts of dimethyl sulfoxide to human and animal subjects
US5231112A (en) * 1984-04-12 1993-07-27 The Liposome Company, Inc. Compositions containing tris salt of cholesterol hemisuccinate and antifungal
US4761288A (en) * 1984-09-24 1988-08-02 Mezei Associates Limited Multiphase liposomal drug delivery system
US4897269A (en) * 1984-09-24 1990-01-30 Mezei Associates Limited Administration of drugs with multiphase liposomal delivery system
CA1234717A (en) * 1985-06-28 1988-04-05 Leslie F. Knebl Moist chewing gum composition
US4710390A (en) * 1986-07-07 1987-12-01 Warner-Lambert Company Ingestible, high density, compressed-tablet fruit fiber composition
DE3936328A1 (de) * 1989-10-27 1991-05-02 Schering Ag Pharmazeutische praeparate
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5540930A (en) * 1993-10-25 1996-07-30 Pharmos Corporation Suspension of loteprednol etabonate for ear, eye, or nose treatment
ES2088742B1 (es) * 1994-06-29 1997-03-16 Salvat Lab Sa Composicion antibiotica de aplicacion otica.
CA2201134A1 (en) * 1994-10-10 1996-04-18 Alfred Sallmann Ophthalmic and aural compositions containing diclofenac potassium
US5843930A (en) * 1995-06-06 1998-12-01 Bayer Corporation Method of treating otitis with ciprofloxacin-hydrocortisone suspension
US5735603A (en) * 1996-05-03 1998-04-07 Littleford Day, Inc. Horizontal mixer apparatus and method with improved shaft and seal structure
US6344222B1 (en) * 1998-09-03 2002-02-05 Jsr Llc Medicated chewing gum delivery system for nicotine
US6740664B2 (en) * 1998-09-30 2004-05-25 Alcon, Inc. Methods for treating otic and ophthalmic infections
US6716830B2 (en) * 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
US6093417A (en) * 1999-01-11 2000-07-25 Advanced Medical Instruments Composition to treat ear disorders
US6723714B2 (en) * 1999-07-06 2004-04-20 Blansett Pharmacal Co., Inc. Aqueous solvent for corticosteroids
MXPA03002342A (es) * 2000-09-25 2004-10-15 Bayer Healthcare Llc Combinaciones microbianas opticas para el tratamiento de animales con la membrana timpanica rota.
US6716813B2 (en) * 2000-11-28 2004-04-06 House Ear Institute Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
US6613346B2 (en) * 2001-06-28 2003-09-02 Wm. Wrigley, Jr. Company Chewable product including active ingredient
US6763085B2 (en) * 2001-10-22 2004-07-13 Cleaner Food, Inc. Irradiation apparatus and method
US6672252B2 (en) * 2002-01-31 2004-01-06 Sergeant's Pet Products, Inc. Pet chew
US7220431B2 (en) * 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
JP2006510657A (ja) * 2002-12-06 2006-03-30 アライバ ファーマシューティカルズ，インコーポレイティド 中耳炎の処置のための方法および組成物
EP1438942A1 (en) * 2003-01-17 2004-07-21 Schering Oy An otorhinological drug delivery device
DK1610613T3 (en) * 2003-04-04 2017-02-27 Merial Inc TOPICAL ANTHELMINTIC VETERINARY FORMULATIONS
US20050058673A1 (en) * 2003-09-09 2005-03-17 3M Innovative Properties Company Antimicrobial compositions and methods

Also Published As

Publication number Publication date
JP2009509955A (ja) 2009-03-12
US20080269187A1 (en) 2008-10-30
US20070218050A1 (en) 2007-09-20
EP1928439A2 (en) 2008-06-11
WO2007037874B1 (en) 2008-02-28
IL190080A0 (en) 2008-12-29
EA200800949A1 (ru) 2008-08-29
CN101272772A (zh) 2008-09-24
CA2622001A1 (en) 2007-04-05
AU2006295236A1 (en) 2007-04-05
BRPI0616363A2 (pt) 2011-06-14
WO2007037874A3 (en) 2007-11-08
EP1928439A4 (en) 2009-04-29
WO2007037874A2 (en) 2007-04-05

Similar Documents

Publication Publication Date Title
ZA200803367B (en) Methods for treatment and prevention of otitis media using chemical penetration enhancers to facilitate transmembrane drug delivery into the middle ear
IL190079A0 (en) Methods for treatment and prevention of otitis media using nonionic surfactants to facilitate transmembrane drug delivery into the middle ear
GB2434604B (en) Porous composites containing hydrocarbon-soluble well treatment agents and methods for using the same
HK1200373A1 (en) Transdermal therapeutic system for administering the active substance buprenorphine
EP1861161A4 (en) APPARATUS AND METHOD FOR DISPENSING THERAPEUTIC AND / OR OTHER AGENTS IN THE INTERNAL EAR AND OTHER FABRICS
EP2209371A4 (en) COMPOSITIONS AND METHODS OF TREATING DIABETIC RETINOPATHY
GB0906225D0 (en) Magnectic carrier and medical prepartion for controllable delivery and release of active substances, a method of production and method of treatment using ther
ZA200610576B (en) Ablation apparatus and system to limit nerve condition
EP2271300A4 (en) Swallowing air pulse therapy mouthpiece and method for the use thereof
EP1784164A4 (en) PROCESS FOR TRANSMEMBRANE TREATMENT AND PREVENTION OF OTITIS MEDIA
HK1124321A1 (en) Substituted 4-phenyltetrahydroisoquinolines, method of producing them, their use as medicament, and also medicament containing them
IL207558A0 (en) Pharmaceutical solutions, process of prepartion and therapeutic uses
EP1876178A4 (en) CYANOPYRIDINE DERIVATIVE AND THE USE THEREOF AS A MEDICAMENT
HK1136955A1 (en) Drug solution having reduced dissolved oxygen content, method of producing the same and drug solution containing unit having reduced dissolved oxygen content
EP1849448A4 (en) SYRINGE DEVICE AND METHOD FOR PREPARING A MEDICAMENT USING THE DEVICE
ZA201007059B (en) Quinoxalinone derivatives as insulin secretion stimulators,methods for obtaining them and use thereof for the treatment of diabetes
IL212880A0 (en) Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
HRP20190178T1 (hr) Farmaceutski sastav za liječenje disglikemije i izleta glukoze
GB2465814B (en) Method,composition and device for the treatment of enzymes and saccharides disorders
WO2006116311A3 (en) Opioid receptor agonist compounds and their use in treatment of pain
IL198395A0 (en) Methods for treatment of cochlear and vestibular disorders
EP2007790A4 (en) COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN
GB0821501D0 (en) Method, composition, and device, for the treatment of enzymes and saccharides disorder
HUP0500975A2 (en) Process for producing of extract of sour cherry seed, use of extract for producing of medicament and medicaments consist extract
EP2066171A4 (en) ADMINISTERING A TREATMENT SUBSTANCE TO POROUS ELEMENTS