ZA200705151B - G-protein coupled receptor (GPR116) and agonists use thereof for treating obesity and diabetes - Google Patents

G-protein coupled receptor (GPR116) and agonists use thereof for treating obesity and diabetes

Info

Publication number
ZA200705151B
ZA200705151B ZA200705151A ZA200705151A ZA200705151B ZA 200705151 B ZA200705151 B ZA 200705151B ZA 200705151 A ZA200705151 A ZA 200705151A ZA 200705151 A ZA200705151 A ZA 200705151A ZA 200705151 B ZA200705151 B ZA 200705151B
Authority
ZA
South Africa
Prior art keywords
gpr116
diabetes
coupled receptor
protein coupled
treating obesity
Prior art date
Application number
ZA200705151A
Inventor
Fyfe Matthew Colin Thor
Thomas Gerard Hugh
Bertram Lisa Sarah
Williams Geoffrey Martyn
Original Assignee
Prosidion Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prosidion Ltd filed Critical Prosidion Ltd
Publication of ZA200705151B publication Critical patent/ZA200705151B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200705151A 2004-12-24 2007-06-21 G-protein coupled receptor (GPR116) and agonists use thereof for treating obesity and diabetes ZA200705151B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0428212A GB0428212D0 (en) 2004-12-24 2004-12-24 Compounds

Publications (1)

Publication Number Publication Date
ZA200705151B true ZA200705151B (en) 2008-10-29

Family

ID=34113150

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200705151A ZA200705151B (en) 2004-12-24 2007-06-21 G-protein coupled receptor (GPR116) and agonists use thereof for treating obesity and diabetes

Country Status (3)

Country Link
CN (1) CN101123964B (en)
GB (1) GB0428212D0 (en)
ZA (1) ZA200705151B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104761540A (en) * 2015-03-12 2015-07-08 佛山市赛维斯医药科技有限公司 Compound containing structures of nicotinamide and piperidine and application thereof
CN104725309A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 PTP1B inhibitor containing nicotinic acid amide structure and use thereof
CN104725354A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 Compound containing nicotinic acid amide and piperidine structures and use thereof
CN104725353A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 PTP1B inhibitor containing nicotinic acid amide and piperidine structures and use thereof
CN104788424A (en) * 2015-03-12 2015-07-22 佛山市赛维斯医药科技有限公司 PTP1B inhibitors containing nicotinamide and piperidine structure, and preparation method and use thereof
CN104725308A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 PTP1B inhibitor containing nicotinic acid amide structure and preparation method and use thereof
CN104788425A (en) * 2015-03-12 2015-07-22 佛山市赛维斯医药科技有限公司 PTP1B inhibitors containing nicotinamide and piperidine structure, and preparation method and use thereof
CN106831559A (en) * 2015-03-12 2017-06-13 佛山市赛维斯医药科技有限公司 A kind of PTP1B inhibitor, preparation method and its usage containing niacin hydroxyacyl amine structure
CN106748999A (en) * 2015-03-12 2017-05-31 佛山市赛维斯医药科技有限公司 PTP1B inhibitor, preparation method and its usage of one class containing niacin hydroxyacyl amine structure
CN104725311A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 PTP1B inhibitor containing nicotinic acid amide structure and use thereof
CN106831561A (en) * 2015-03-12 2017-06-13 佛山市赛维斯医药科技有限公司 A kind of PTP1B inhibitor containing niacin hydroxyacyl amine and aniline structure, its preparation and purposes
CN104725355A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 PTP1B inhibitor containing nicotinic acid amide and piperidine structures and use thereof
CN104725310A (en) * 2015-03-12 2015-06-24 佛山市赛维斯医药科技有限公司 PTP1B inhibitor containing nicotinic acid amide and aniline structures and use thereof
CN114404597A (en) * 2022-01-10 2022-04-29 中国人民解放军海军军医大学第一附属医院 Medicine and pharmaceutical composition for treating lung injury or acute respiratory distress syndrome

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20084540B (en) * 2003-01-14 2008-11-25 Arena Pharm Inc 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
WO2005061489A1 (en) * 2003-12-24 2005-07-07 Prosidion Limited Heterocyclic derivatives as gpcr receptor agonists

Also Published As

Publication number Publication date
CN101123964A (en) 2008-02-13
GB0428212D0 (en) 2005-01-26
CN101123964B (en) 2012-11-28

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