ZA200702605B - Method for ex-vivo purging in autologous transplantation - Google Patents

Method for ex-vivo purging in autologous transplantation

Info

Publication number
ZA200702605B
ZA200702605B ZA200702605A ZA200702605A ZA200702605B ZA 200702605 B ZA200702605 B ZA 200702605B ZA 200702605 A ZA200702605 A ZA 200702605A ZA 200702605 A ZA200702605 A ZA 200702605A ZA 200702605 B ZA200702605 B ZA 200702605B
Authority
ZA
South Africa
Prior art keywords
cells
cell
purging
patients
asct
Prior art date
Application number
ZA200702605A
Inventor
Dupuis Marc
Duchosal Michel
Greaney Peter
Original Assignee
Apoxis Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apoxis Sa filed Critical Apoxis Sa
Publication of ZA200702605B publication Critical patent/ZA200702605B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • C12N5/0093—Purging against cancer cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells

Abstract

The present invention concerns a new method for ex-vivo purging of cells in autologous transplantation, wherein the sample of taken cells is treated with a sufficient amount of a multimeric form of the soluble portion of FasL to kill malignant cells without substantially affecting viability of cells to be transplanted. Autologous stem cell transplantation (ASCT) following high-dose chemotherapy with or without radiotherapy has become the standard therapy for the majority of patients with large-cell lymphomas, multiple myeloma, and refractory/recidivating Hodgkin's disease. Such therapy is nowadays also contemplated for selected patients with low-grade lymphomas (chronic lymphocytic leukemia, follicular lymphoma, mantle cell lymphoma) and for patients with acute myeloid leukemia (AML). Current treatments for cell purging include chemotherapy and antibody cocktails. These treatments are often toxic on stem cells and not efficient in eliminating cancer cells. Thus, there is an unmet medical need for cell purging in ASCT which this project will address.
ZA200702605A 2004-10-01 2007-03-28 Method for ex-vivo purging in autologous transplantation ZA200702605B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61508404P 2004-10-01 2004-10-01

Publications (1)

Publication Number Publication Date
ZA200702605B true ZA200702605B (en) 2008-09-25

Family

ID=35414515

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200702605A ZA200702605B (en) 2004-10-01 2007-03-28 Method for ex-vivo purging in autologous transplantation

Country Status (14)

Country Link
US (1) US20080241109A1 (en)
EP (1) EP1794289B1 (en)
JP (1) JP2008514218A (en)
KR (1) KR20070083621A (en)
CN (1) CN101031642B (en)
AT (1) ATE482268T1 (en)
AU (1) AU2005291298B2 (en)
BR (1) BRPI0516723A (en)
CA (1) CA2582216A1 (en)
DE (1) DE602005023751D1 (en)
IL (1) IL182007A0 (en)
MX (1) MX2007004058A (en)
WO (1) WO2006037762A1 (en)
ZA (1) ZA200702605B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104245924B (en) * 2012-03-06 2020-05-01 塞莱克特生物疗法有限公司 Device and method for selecting anti-apoptotic signaling cells and uses thereof
US10098913B2 (en) * 2013-09-11 2018-10-16 University Of Southern California Composition of stem cells having highly expressed FAS ligand

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6383481B1 (en) * 1998-03-30 2002-05-07 Japan Immunoresearch Laboratories Co., Ltd. Method for transplantation of hemopoietic stem cells
DE19963859A1 (en) * 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- or oligomer of a di-, tri-, quattro- or pentamer of recombinant fusion proteins

Also Published As

Publication number Publication date
AU2005291298B2 (en) 2012-01-19
EP1794289A1 (en) 2007-06-13
MX2007004058A (en) 2007-05-24
AU2005291298A1 (en) 2006-04-13
WO2006037762A1 (en) 2006-04-13
CA2582216A1 (en) 2006-04-13
KR20070083621A (en) 2007-08-24
ATE482268T1 (en) 2010-10-15
CN101031642A (en) 2007-09-05
DE602005023751D1 (en) 2010-11-04
EP1794289B1 (en) 2010-09-22
BRPI0516723A (en) 2008-09-16
JP2008514218A (en) 2008-05-08
IL182007A0 (en) 2007-07-24
US20080241109A1 (en) 2008-10-02
CN101031642B (en) 2013-04-17

Similar Documents

Publication Publication Date Title
Becker et al. Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases
Tse et al. New insights into cord blood stem cell transplantation
TW200616615A (en) Compounds and methods for the treatment of cancer
SG160412A1 (en) Anti-igfr1 antibody therapeutic combinations
TW200602078A (en) Uses of anti-CTLA-4 antibodies
MX2007014132A (en) Diarylhydantoin compounds.
TNSN06059A1 (en) Use of polypeptides of the cupredoxin family in cancer therapy
Ansell Hodgkin lymphoma: MOPP chemotherapy to PD‐1 blockade and beyond
MX2021004868A (en) Bispecific cd123 x cd3 diabodies for the treatment of hematologic malignancies.
HK1124484A1 (en) Plasma-depleted, non-red blood cell-depleted cord blood compositions and methods of use
ZA200702605B (en) Method for ex-vivo purging in autologous transplantation
Shaw et al. Treatment options for the management of acute leukaemia relapsing following an allogeneic transplant
Frings et al. Elimination of the chemotherapy resistant subpopulation of 4T1 mouse breast cancer by haploidentical NK cells cures the vast majority of mice
Burroughs et al. Low-intensity allogeneic hematopoietic stem cell transplantation for myeloid malignancies: separating graft-versus-leukemia effects from graft-versus-host disease
Auberger et al. Allogeneic bone marrow vs. peripheral blood stem cell transplantation: a long‐term retrospective single‐center analysis in 329 patients
van Gorkom et al. Prospective noninterventional study on peripheral blood stem cell mobilization in patients with relapsed lymphomas
Pollack et al. Nonmyeloablative and reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation: a clinical review
Buckner Autologous bone marrow transplants to hematopoietic stem cell support with peripheral blood stem cells: a historical perspective
Magagnoli et al. Mobilizing potential of ifosfamide/vinorelbine-based chemotherapy in pretreated malignant lymphoma
Watanabe et al. The possible clinical impact of risperidone on P‐glycoprotein‐mediated transport of tacrolimus: A case report and in vitro study
Wierenga et al. Purging of acute myeloid leukaemia cells from stem cell grafts by hyperthermia: enhancement of the therapeutic index by the tetrapeptide AcSDKP and the alkyl‐lysophospholipid ET‐18‐OCH3
Gorin et al. High dose therapy for acute myelocytic leukemia treatment strategy: what is the choice?
Pham et al. Brentuximab vedotin for the treatment of Hodgkin’s lymphoma
Veroux et al. Kidney Transplantation From Hepatitis B Surface Antigen–Positive Donors Into Hepatitis B Surface Antigen–Positive Recipients: Preliminary Findings
Ford et al. Good and poor mobilizing patients differ in mobilized CD34+ cell adhesion molecule profiles