ZA200702321B - Novel gene disruptions, compositions and methods relating thereto - Google Patents

Novel gene disruptions, compositions and methods relating thereto

Info

Publication number
ZA200702321B
ZA200702321B ZA200702321A ZA200702321A ZA200702321B ZA 200702321 B ZA200702321 B ZA 200702321B ZA 200702321 A ZA200702321 A ZA 200702321A ZA 200702321 A ZA200702321 A ZA 200702321A ZA 200702321 B ZA200702321 B ZA 200702321B
Authority
ZA
South Africa
Prior art keywords
compositions
methods relating
novel gene
gene disruptions
disruptions
Prior art date
Application number
ZA200702321A
Other languages
English (en)
Inventor
Brennan Jane
Sauvage Frederic J De
Edwards Joel
Huang Wenhu
Montgomery Charles
Payne Bobby Joe
Shi Zheng-Zheng
Sparks Mary Jean
Vogel Peter
Ye Weilan
Original Assignee
Genentech Inc
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Lexicon Pharmaceuticals Inc filed Critical Genentech Inc
Publication of ZA200702321B publication Critical patent/ZA200702321B/xx

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    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276Knock-out vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
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    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
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    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
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    • A61P37/02Immunomodulators
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    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
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    • A61P9/00Drugs for disorders of the cardiovascular system
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
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    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases

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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Environmental Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
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ZA200702321A 2004-08-25 2005-08-23 Novel gene disruptions, compositions and methods relating thereto ZA200702321B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60432304P 2004-08-25 2004-08-25

Publications (1)

Publication Number Publication Date
ZA200702321B true ZA200702321B (en) 2009-09-30

Family

ID=35677379

Family Applications (9)

Application Number Title Priority Date Filing Date
ZA200702321A ZA200702321B (en) 2004-08-25 2005-08-23 Novel gene disruptions, compositions and methods relating thereto
ZA200802563A ZA200802563B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802556A ZA200802556B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802560A ZA200802560B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802557A ZA200802557B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802558A ZA200802558B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802559A ZA200802559B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802561A ZA200802561B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802562A ZA200802562B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto

Family Applications After (8)

Application Number Title Priority Date Filing Date
ZA200802563A ZA200802563B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802556A ZA200802556B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802560A ZA200802560B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802557A ZA200802557B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802558A ZA200802558B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802559A ZA200802559B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802561A ZA200802561B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto
ZA200802562A ZA200802562B (en) 2004-08-25 2008-03-19 Novel gene disruptions, compositions and methods relating thereto

Country Status (7)

Country Link
US (2) US7956237B2 (xx)
EP (1) EP1781824A2 (xx)
JP (1) JP2008510488A (xx)
AU (1) AU2005280266A1 (xx)
CA (1) CA2577102A1 (xx)
WO (1) WO2006026222A2 (xx)
ZA (9) ZA200702321B (xx)

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* Cited by examiner, † Cited by third party
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US7981420B2 (en) 2000-12-22 2011-07-19 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Therapeutic use of antibodies directed against repulsive guidance molecule (RGM)
JP2009510002A (ja) 2005-09-30 2009-03-12 アボット ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 反発誘導分子(rgm)タンパク質ファミリーのタンパク質の結合ドメイン、及びその機能的断片、及びそれらの使用
JP2009544324A (ja) * 2006-07-28 2009-12-17 ジェネンテック・インコーポレーテッド 遺伝子破壊、それに関連する組成物および方法
WO2009037295A1 (en) * 2007-09-18 2009-03-26 Commissariat A L'energie Atomique Method for testing psoriasis susceptibility
CA2715628A1 (en) 2008-02-21 2009-08-27 Dexcom, Inc. Systems and methods for processing, transmitting and displaying sensor data
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
MX2012006560A (es) 2009-12-08 2012-10-05 Abbott Gmbh & Co Kg Anticuerpos monoclonales contra la proteina rgm a para utilizarse en el tratamiento de degeneracion de capa de fibra de nervio retinal.
EP2750662A4 (en) 2011-08-31 2015-06-24 Univ Georgia NANOPARTICLES TARGETING APOPTOSIS
PL2807192T3 (pl) 2012-01-27 2019-02-28 Abbvie Deutschland Kompozycja oraz sposób diagnostyki i leczenia chorób związanych ze zwyrodnieniem neurytów
ES2669561T3 (es) 2012-02-17 2018-05-28 University Of Georgia Research Foundation, Inc. Nanopartículas para el transporte mitocondrial de agentes
WO2015138992A1 (en) 2014-03-14 2015-09-17 University Of Georgia Research Foundation, Inc. Mitochondrial delivery of 3-bromopyruvate
CN111778284B (zh) * 2020-06-24 2023-09-22 西安医学院 通过ctrp6介导的动脉粥样化动物模型及其建立方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053753A2 (en) 1999-03-08 2000-09-14 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization
US6057435A (en) * 1997-09-19 2000-05-02 Genentech, Inc. Tie ligand homologues
US7378507B2 (en) * 1997-09-18 2008-05-27 Genentech, Inc. PRO217 polypeptides
CA2372511C (en) * 1999-06-15 2011-11-22 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7390879B2 (en) * 1999-06-15 2008-06-24 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2002040662A2 (en) * 2000-11-15 2002-05-23 Deltagen, Inc. Transgenic mice containing targeted gene disruptions
ZA200801231B (en) 2003-12-16 2009-05-27 Genentech Inc Novel gene disruptions, compositions and methods relating thereto
ZA200606461B (en) 2004-02-12 2008-02-27 Lexicon Pharmaceuticals Inc Gene disruptions, compositions and methods relating thereto
ZA200608527B (en) * 2004-05-12 2007-12-27 Genentech Inc Novel gene disruptions, compositions and methods relating thereto

Also Published As

Publication number Publication date
CA2577102A1 (en) 2006-03-09
ZA200802562B (en) 2010-02-24
ZA200802558B (en) 2010-01-27
US20110061114A1 (en) 2011-03-10
US20080160034A1 (en) 2008-07-03
ZA200802563B (en) 2010-02-24
WO2006026222A3 (en) 2006-06-01
ZA200802560B (en) 2009-05-27
EP1781824A2 (en) 2007-05-09
ZA200802557B (en) 2010-01-27
WO2006026222A2 (en) 2006-03-09
ZA200802561B (en) 2010-02-24
ZA200802556B (en) 2010-02-24
AU2005280266A1 (en) 2006-03-09
US7956237B2 (en) 2011-06-07
JP2008510488A (ja) 2008-04-10
ZA200802559B (en) 2009-05-27

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