ZA200610141B - Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation - Google Patents

Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation

Info

Publication number
ZA200610141B
ZA200610141B ZA200610141A ZA200610141A ZA200610141B ZA 200610141 B ZA200610141 B ZA 200610141B ZA 200610141 A ZA200610141 A ZA 200610141A ZA 200610141 A ZA200610141 A ZA 200610141A ZA 200610141 B ZA200610141 B ZA 200610141B
Authority
ZA
South Africa
Prior art keywords
entecavir
preparation
novel intermediates
via carbon
silicon oxidation
Prior art date
Application number
ZA200610141A
Inventor
Maotang X Zhou
Vemishetti Purushotham
Ambarish K Sigh
Ulhas P Dhokte
Mountford Pia
Sailes Helen
Emily A Reiff
Yadagiri R Pendri
Siva J Prasad
Qian Xinhua
Kerry B Hartung
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ZA200610141B publication Critical patent/ZA200610141B/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
ZA200610141A 2004-06-04 2006-12-04 Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation ZA200610141B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57689904P 2004-06-04 2004-06-04

Publications (1)

Publication Number Publication Date
ZA200610141B true ZA200610141B (en) 2008-09-25

Family

ID=37311738

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200610141A ZA200610141B (en) 2004-06-04 2006-12-04 Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation

Country Status (5)

Country Link
CN (2) CN1964972B (en)
AR (1) AR050339A1 (en)
PE (1) PE20060278A1 (en)
TW (1) TW200540175A (en)
ZA (1) ZA200610141B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8481728B2 (en) * 2010-02-16 2013-07-09 Scinopharm Taiwan, Ltd. Process for preparing entecavir and its intermediates
TWI668220B (en) * 2010-08-30 2019-08-11 浙江奧翔藥業股份有限公司 Synthetic method of entecavir and intermediate compounds thereof
CN102952135B (en) * 2011-08-31 2015-04-08 南京工业大学 Synthesis method for medicine entecavir for treating hepatitis B
CN103304375B (en) * 2012-03-12 2017-04-12 浙江奥翔药业股份有限公司 Synthesis intermediate of Entecavir and preparation method thereof
CN109232637B (en) * 2018-10-29 2020-11-24 常州博海威医药科技股份有限公司 Preparation method of entecavir intermediate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
AU4090697A (en) * 1996-09-03 1998-03-26 Bristol-Myers Squibb Company Improved process for preparing the antiviral agent {1s-(1alpha, 3alpha, 4beta)}-2-amino-1,9-dihydro-9-{4-hydroxy-3-(hydroxymethyl)-2 -methylenecyclopentyl}-6h-purin-6-one
ES2397104T3 (en) * 2002-12-11 2013-03-04 Bristol-Myers Squibb Company Procedure and intermediate products for the synthesis of entecavir

Also Published As

Publication number Publication date
CN101565359A (en) 2009-10-28
CN1964972A (en) 2007-05-16
PE20060278A1 (en) 2006-04-20
AR050339A1 (en) 2006-10-18
TW200540175A (en) 2005-12-16
CN1964972B (en) 2011-04-20
CN101565359B (en) 2013-05-29

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