ZA200606072B - Dental-bleaching compositions and methods with reduced peroxide concentration - Google Patents
Dental-bleaching compositions and methods with reduced peroxide concentration Download PDFInfo
- Publication number
- ZA200606072B ZA200606072B ZA200606072A ZA200606072A ZA200606072B ZA 200606072 B ZA200606072 B ZA 200606072B ZA 200606072 A ZA200606072 A ZA 200606072A ZA 200606072 A ZA200606072 A ZA 200606072A ZA 200606072 B ZA200606072 B ZA 200606072B
- Authority
- ZA
- South Africa
- Prior art keywords
- peroxide
- compound
- composition
- calcium
- tooth
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 262
- 238000000034 method Methods 0.000 title claims description 78
- 150000002978 peroxides Chemical class 0.000 title description 28
- 238000004061 bleaching Methods 0.000 title description 6
- 150000001875 compounds Chemical class 0.000 claims description 116
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 105
- -1 peroxide compound Chemical class 0.000 claims description 103
- 230000002087 whitening effect Effects 0.000 claims description 66
- 230000000052 comparative effect Effects 0.000 claims description 46
- 239000011575 calcium Substances 0.000 claims description 35
- 229910052791 calcium Inorganic materials 0.000 claims description 35
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 29
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 27
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 22
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 22
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 22
- 230000007794 irritation Effects 0.000 claims description 21
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 18
- WUGQZFFCHPXWKQ-UHFFFAOYSA-N Propanolamine Chemical compound NCCCO WUGQZFFCHPXWKQ-UHFFFAOYSA-N 0.000 claims description 18
- 239000000551 dentifrice Substances 0.000 claims description 18
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims description 18
- 239000011591 potassium Substances 0.000 claims description 18
- 229910052700 potassium Inorganic materials 0.000 claims description 18
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 15
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 14
- 230000009977 dual effect Effects 0.000 claims description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 13
- 239000011734 sodium Substances 0.000 claims description 13
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims description 12
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 12
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 12
- 239000001099 ammonium carbonate Substances 0.000 claims description 12
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 12
- XXQBEVHPUKOQEO-UHFFFAOYSA-N potassium superoxide Chemical compound [K+].[K+].[O-][O-] XXQBEVHPUKOQEO-UHFFFAOYSA-N 0.000 claims description 12
- 229910052708 sodium Inorganic materials 0.000 claims description 12
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 12
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 10
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims description 8
- 239000005770 Eugenol Substances 0.000 claims description 8
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- 229960002217 eugenol Drugs 0.000 claims description 8
- 239000000377 silicon dioxide Substances 0.000 claims description 8
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 7
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 7
- 235000010216 calcium carbonate Nutrition 0.000 claims description 7
- 239000011736 potassium bicarbonate Substances 0.000 claims description 7
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 7
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 7
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 7
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 claims description 7
- LCPVQAHEFVXVKT-UHFFFAOYSA-N 2-(2,4-difluorophenoxy)pyridin-3-amine Chemical compound NC1=CC=CN=C1OC1=CC=C(F)C=C1F LCPVQAHEFVXVKT-UHFFFAOYSA-N 0.000 claims description 6
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 6
- IOAOAKDONABGPZ-UHFFFAOYSA-N 2-amino-2-ethylpropane-1,3-diol Chemical compound CCC(N)(CO)CO IOAOAKDONABGPZ-UHFFFAOYSA-N 0.000 claims description 6
- UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 claims description 6
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 claims description 6
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 6
- 239000004342 Benzoyl peroxide Substances 0.000 claims description 6
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 6
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 claims description 6
- 239000004343 Calcium peroxide Substances 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 6
- NHHJEVOQZGSLEB-UHFFFAOYSA-J [Ca+2].[Ca+2].[O-]S(=O)(=O)OOS([O-])(=O)=O.[O-]S(=O)(=O)OOS([O-])(=O)=O Chemical compound [Ca+2].[Ca+2].[O-]S(=O)(=O)OOS([O-])(=O)=O.[O-]S(=O)(=O)OOS([O-])(=O)=O NHHJEVOQZGSLEB-UHFFFAOYSA-J 0.000 claims description 6
- RSRJCYZEMGBMDE-UHFFFAOYSA-J [K+].[K+].[K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O.[O-]S(=O)(=O)OOS([O-])(=O)=O Chemical compound [K+].[K+].[K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O.[O-]S(=O)(=O)OOS([O-])(=O)=O RSRJCYZEMGBMDE-UHFFFAOYSA-J 0.000 claims description 6
- 235000012538 ammonium bicarbonate Nutrition 0.000 claims description 6
- 235000012501 ammonium carbonate Nutrition 0.000 claims description 6
- 239000000908 ammonium hydroxide Substances 0.000 claims description 6
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 6
- 235000012745 brilliant blue FCF Nutrition 0.000 claims description 6
- 239000004161 brilliant blue FCF Substances 0.000 claims description 6
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 6
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 6
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 6
- 239000000920 calcium hydroxide Substances 0.000 claims description 6
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 6
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 claims description 6
- 235000019402 calcium peroxide Nutrition 0.000 claims description 6
- 239000004202 carbamide Substances 0.000 claims description 6
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 claims description 6
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 6
- BHDAXLOEFWJKTL-UHFFFAOYSA-L dipotassium;carboxylatooxy carbonate Chemical compound [K+].[K+].[O-]C(=O)OOC([O-])=O BHDAXLOEFWJKTL-UHFFFAOYSA-L 0.000 claims description 6
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 claims description 6
- JRBPAEWTRLWTQC-UHFFFAOYSA-N dodecylamine Chemical compound CCCCCCCCCCCCN JRBPAEWTRLWTQC-UHFFFAOYSA-N 0.000 claims description 6
- IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical group [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 claims description 6
- 235000012732 erythrosine Nutrition 0.000 claims description 6
- 239000004174 erythrosine Substances 0.000 claims description 6
- 229940011411 erythrosine Drugs 0.000 claims description 6
- 229940051147 fd&c yellow no. 6 Drugs 0.000 claims description 6
- 230000001965 increasing effect Effects 0.000 claims description 6
- QWDJLDTYWNBUKE-UHFFFAOYSA-L magnesium bicarbonate Chemical compound [Mg+2].OC([O-])=O.OC([O-])=O QWDJLDTYWNBUKE-UHFFFAOYSA-L 0.000 claims description 6
- 239000002370 magnesium bicarbonate Substances 0.000 claims description 6
- 235000014824 magnesium bicarbonate Nutrition 0.000 claims description 6
- 229910000022 magnesium bicarbonate Inorganic materials 0.000 claims description 6
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 6
- 239000001095 magnesium carbonate Substances 0.000 claims description 6
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 6
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 6
- 239000000347 magnesium hydroxide Substances 0.000 claims description 6
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 6
- OOHAUGDGCWURIT-UHFFFAOYSA-N n,n-dipentylpentan-1-amine Chemical compound CCCCCN(CCCCC)CCCCC OOHAUGDGCWURIT-UHFFFAOYSA-N 0.000 claims description 6
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 claims description 6
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 6
- 235000011181 potassium carbonates Nutrition 0.000 claims description 6
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 6
- 229960001922 sodium perborate Drugs 0.000 claims description 6
- 229940045872 sodium percarbonate Drugs 0.000 claims description 6
- PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 claims description 6
- CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 claims description 6
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 claims description 6
- WSTYDEJXBVROKI-UHFFFAOYSA-J tetrasodium sulfonatooxy sulfate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O.[O-]S(=O)(=O)OOS([O-])(=O)=O WSTYDEJXBVROKI-UHFFFAOYSA-J 0.000 claims description 6
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 6
- CGORWLLFUJDORA-UHFFFAOYSA-N 3-(2,3-dihydroxypropylperoxy)propane-1,2-diol Chemical compound OCC(O)COOCC(O)CO CGORWLLFUJDORA-UHFFFAOYSA-N 0.000 claims description 5
- SAIKULLUBZKPDA-UHFFFAOYSA-N Bis(2-ethylhexyl) amine Chemical compound CCCCC(CC)CNCC(CC)CCCC SAIKULLUBZKPDA-UHFFFAOYSA-N 0.000 claims description 5
- RZSYLLSAWYUBPE-UHFFFAOYSA-L Fast green FCF Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC(O)=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 RZSYLLSAWYUBPE-UHFFFAOYSA-L 0.000 claims description 5
- 230000003247 decreasing effect Effects 0.000 claims description 5
- 235000019240 fast green FCF Nutrition 0.000 claims description 5
- WWOYCMCZTZTIGU-UHFFFAOYSA-L magnesium;2-carboxybenzenecarboperoxoate;hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].OOC(=O)C1=CC=CC=C1C([O-])=O.OOC(=O)C1=CC=CC=C1C([O-])=O WWOYCMCZTZTIGU-UHFFFAOYSA-L 0.000 claims description 5
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 5
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 claims description 4
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims 4
- 150000008041 alkali metal carbonates Chemical class 0.000 claims 4
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 4
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims 4
- 238000011282 treatment Methods 0.000 description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
- 201000002170 dentin sensitivity Diseases 0.000 description 10
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 10
- 230000036347 tooth sensitivity Effects 0.000 description 10
- 238000000338 in vitro Methods 0.000 description 8
- 239000003082 abrasive agent Substances 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- 229920001983 poloxamer Polymers 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000001506 calcium phosphate Substances 0.000 description 6
- 229940078916 carbamide peroxide Drugs 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 229920001992 poloxamer 407 Polymers 0.000 description 6
- 229920001223 polyethylene glycol Polymers 0.000 description 6
- 229960003975 potassium Drugs 0.000 description 6
- 239000002202 Polyethylene glycol Substances 0.000 description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
- 239000000975 dye Substances 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 235000010333 potassium nitrate Nutrition 0.000 description 5
- 239000004323 potassium nitrate Substances 0.000 description 5
- 235000011121 sodium hydroxide Nutrition 0.000 description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 3
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 3
- 229940038472 dicalcium phosphate Drugs 0.000 description 3
- 150000002222 fluorine compounds Chemical class 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 150000001451 organic peroxides Chemical class 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
- 235000019204 saccharin Nutrition 0.000 description 3
- 229940081974 saccharin Drugs 0.000 description 3
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920002582 Polyethylene Glycol 600 Polymers 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 235000013877 carbamide Nutrition 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 239000003975 dentin desensitizing agent Substances 0.000 description 2
- 239000012933 diacyl peroxide Substances 0.000 description 2
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- AYRBHTOSHJHALD-UHFFFAOYSA-N 1-amino-2-methylpropan-1-ol Chemical compound CC(C)C(N)O AYRBHTOSHJHALD-UHFFFAOYSA-N 0.000 description 1
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- OALHHIHQOFIMEF-UHFFFAOYSA-N 3',6'-dihydroxy-2',4',5',7'-tetraiodo-3h-spiro[2-benzofuran-1,9'-xanthene]-3-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 OALHHIHQOFIMEF-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
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- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
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- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 1
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- 239000013522 chelant Substances 0.000 description 1
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- 235000017803 cinnamon Nutrition 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
- DGTVXEHQMSJRPE-UHFFFAOYSA-M difluorophosphinate Chemical compound [O-]P(F)(F)=O DGTVXEHQMSJRPE-UHFFFAOYSA-M 0.000 description 1
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 1
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 1
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
- 235000019820 disodium diphosphate Nutrition 0.000 description 1
- GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
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- OMRRUNXAWXNVFW-UHFFFAOYSA-N fluoridochlorine Chemical compound ClF OMRRUNXAWXNVFW-UHFFFAOYSA-N 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- COHYTHOBJLSHDF-BUHFOSPRSA-N indigo dye Chemical compound N\1C2=CC=CC=C2C(=O)C/1=C1/C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-BUHFOSPRSA-N 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
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- SBOJXQVPLKSXOG-UHFFFAOYSA-N o-amino-hydroxylamine Chemical class NON SBOJXQVPLKSXOG-UHFFFAOYSA-N 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 150000004965 peroxy acids Chemical class 0.000 description 1
- 125000000864 peroxy group Chemical group O(O*)* 0.000 description 1
- 125000005342 perphosphate group Chemical group 0.000 description 1
- 229960004838 phosphoric acid Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
- 229940094025 potassium bicarbonate Drugs 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 229960002816 potassium chloride Drugs 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
- 229940099402 potassium metaphosphate Drugs 0.000 description 1
- 229940098424 potassium pyrophosphate Drugs 0.000 description 1
- FJOUFWIJPPFZEI-UHFFFAOYSA-M potassium sodium hydroxide nitrate Chemical compound [N+](=O)([O-])[O-].[K+].[OH-].[Na+] FJOUFWIJPPFZEI-UHFFFAOYSA-M 0.000 description 1
- 239000001472 potassium tartrate Substances 0.000 description 1
- 229940111695 potassium tartrate Drugs 0.000 description 1
- 235000011005 potassium tartrates Nutrition 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000008262 pumice Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229960004029 silicic acid Drugs 0.000 description 1
- 229940083037 simethicone Drugs 0.000 description 1
- 229940080314 sodium bentonite Drugs 0.000 description 1
- 229910000280 sodium bentonite Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
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- 239000010409 thin film Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/38—Percompounds, e.g. peracids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Description
DENTAL-BLEACHING COMPOSITIONS AND METHODS WITH REDUCED
PEROXIDE CONCENTRATION
[0001] This application relates generally to dental-whitening methods and compositions and, more particularly, to dental-bleaching methods and compositions based upon peroxide compounds.
[0002] Tooth whitening methods currently offered in dental practices often involve the use of take-home whitening kits containing a peroxide gel or paste. In one type of kit, the peroxide product is placed in a pre-fabricated tray and worn by the patient for 1-2 weeks in daily application times ranging from 30 minutes to overnight. In an attempt to obtain faster whitening, products containing high concentrations up to 22% carbamidc peroxide are now ] available. Nevertheless, such products with high peroxide concentrations can often produce greater tooth and gingival irritation. Thus, there remains a continuing need for new peroxide- based tooth-whitening products.
[0003] Accordingly, the present inventors have succeeded in developing methods and compositions for enhancing tooth-whitening with peroxide compounds that accelerate the tooth-whitening process, increase the whitening activity of the peroxide compounds and decrease oral irritation. The methods and compositions are based upon a tooth-whitening composition comprising a peroxide compound and one or more abrasive compounds, said composition having a pH of 9.0 or greater. Any one or more of an increased rate of tooth- whitening, increased effectiveness of tooth-whitening and decreased oral irritation are produced in comparison to that produced by a tooth-whitening composition containing the same or greater concentration of the peroxide compound at a pH of 7.0 or less in absence of the one or more abrasive compounds. The methods can involve increasing the pH of the peroxide-containing tooth-whitening composition from a pH of 7.0 or less to a pH to 9.0 or greater by combining, in a dual component system, a first component comprising the peroxide compound in an aqueous vehicle at a pH of about 7 or less and adding a second component comprising an alkaline compound produce a mixture having a pH of about 9 or greater. It is also possible to initially preparing the composition containing both the peroxide compound and the alkaline compound such that the composition has a pH of about 9 or greater. The presence of the one or more abrasive compounds further increases the effectiveness of the composition. As a result, the whitening process is accelerated whitening at a lower concentration of the peroxide compound and with less oral irritation than that produced by a peroxide-containing composition having a pH of about 7 or less in absence of the one or more abrasive compounds.
[0004] Thus, in various embodiments, the present invention can involve a dual component dentifrice system comprising first and second components. The first component can comprise a peroxide compound and a peroxide-compatible abrasive compound. The second component can comprise an alkaline compound. Combining the first and second components in a mixture produces a dentifrice composition having a pH of about 9 or greater is produced. By combining the first and second components it is meant that the first and second components are mixed in their entireties or that predetermined portions of the first and second components are mixed, such as, for example, the first and second components can be combined in a 1:1 ratio by either weight or volume. The pH of the first component can be in a range of from about 4 to about 7 and the pH of the second component can be in a pH range of from at least about 9 to about 13. The peroxide compound in the dentifrice composition can be at a hydrogen-peroxide-equivalent concentration of not greater than about 5% by weight or at a hydrogen-peroxide-equivalent concentration of not greater than about 3.5% by weight.
[0005] In various embodiments, the present invention can also include dentifrice compositions comprising a peroxide compound and a peroxide-compatible abrasive compound. The pH of the composition can be 9.0 or greater and the concentration of the peroxide compound can be at a hydrogen-peroxide-equivalent concentration of not greater than about 5% by weight or at a hydrogen-peroxide-equivalent concentration of not greater than about 3.5% by weight. The composition can produces a tooth-whitening effect equal to or greater than that of a comparative tooth-whitening composition having a hydrogen peroxide concentration of about 7% or greater by weight.
[0006] In various embodiments, the present invention can also include methods for whitening a tooth in a mammal. The methods can comprise contacting the tooth for an effective tooth-whitening period with a tooth-whitening composition. The tooth-whitening composition can comprises a peroxide compound and a peroxide-compatible abrasive compound. The pH of the tooth-whitening composition can be at least about 9 and the peroxide compound can be at a hydrogen-peroxide-equivalent concentration of not greater than about 5% by weight or at a hydrogen-peroxide-equivalent concentration of not greater than about 3.5% by weight. In various aspects, the composition can be prepared from a dual component system comprising a first component comprising a peroxide compound and a peroxide-compatible abrasive compound and a second component comprising an alkaline compound. The contacting is for a period of time which is effective in whitening the tooth, i.e. an effective tooth-whitening period, which is less than that required for a comparative composition comprising hydrogen peroxide at a concentration of about 7% by weight or greater and a pH of about 7.0 or less. Such effective tooth-whitening period of the tooth- whitening compositions of the present invention can be not more than about 15 minutes or not more than about 20 minutes and that of comparative composition can be about 30 minutes or greater.
[0007] The present invention, in various embodiments, can also include methods for decreasing whitening time, increasing whitening effectiveness or decreasing oral irritation in a tooth-whitening process. The methods can comprise contacting a tooth for an effective tooth-whitening period with a tooth-whitening composition comprising a peroxide compound and a peroxide-compatible abrasive compound. The pH of the tooth-whitening composition can be at least about 9 and the peroxide compound can be present at a hydrogen-peroxide- equivalent concentration of not greater than about 5% by weight or at a hydrogen-peroxide- equivalent concentration of not greater than about 3.5% by weight. The tooth-whitening composition produces a decrease in whitening time, an increase in whitening effectiveness or a decrease in oral irritation or any combination thereof in comparison to a reference composition having a peroxide compound concentration of about 7% by weight or greater and a pH of about 7.0 or less. In various aspects of this embodiment, the contacting can be for an effective tooth-whitening period which is less than that required for a comparative composition comprising hydrogen peroxide at a concentration of about 7% by weight or greater and a pH of about 7.0 or less. For example, the effective tooth-whitening period of the tooth-whitening composition can be not more than about 15 minutes or not more than about minutes and that of comparative composition can be about 30 minutes or greater. In various aspects of this embodiment, the tooth-whitening composition can be prepared from a dual component system comprising first and second components in which the first component can comprise a peroxide compound and a peroxide-compatible abrasive compound and the second component can comprise an alkaline compound.
[0008] In various aspects of the embodiments of the present invention involving a dual component system, the first and second components can combine not more than about minutes, not more than about 10 minutes, not more than about 5 minutes or not more than about 2 minutes prior contacting a tooth with the composition to produce tooth whitening.
[0009] In various of the embodiments of the present invention, the peroxide compound can be hydrogen peroxide, an organic peroxide compound, a hydrogen peroxide generating compound or combinations thereof. Such organic peroxide compound can be, for example, urea hydrogen peroxide, glyceryl peroxide, benzoyl peroxide, monoperoxyphthalate or combinations thereof. The hydrogen peroxide generating compound can be, for example, sodium persulfate, sodium dipersulfate, sodium percarbonate, sodium perphosphate, sodium perborate, sodium persilicate, potassium persulfate, potassium dipersulfate, potassium percarbonate, potassium perphosphate, potassium perborate, potassium persilicate, calcium persulfate, calcium dipersulfate, calcium percarbonate, calcium perphosphate, calcium perborate, calcium persilicate, sodium peroxide, potassium peroxide and calcium peroxide or combinations thereof.
[0010] In various of the embodiments of the present invention the peroxide- compatible abrasive comprises one or more calcium phosphate salts including, for example calcium pyrophosophate. The peroxide-compatible abrasive can be present in the tooth- whitening composition or in the dentifrice composition at a concentration of at least about 10% by weight or at a concentration of at least about 20% by weight.
[0011] In various embodiments of the present invention, an alkaline compound can be present. Such alkaline compound can be, for example, sodium hydroxide, potassium hydroxide, ammonium hydroxide, calcium hydroxide, magnesium hydroxide, sodium carbonate, potassium carbonate, ammonium carbonate, calcium carbonate, magnesium carbonate, sodium bicarbonate, potassium bicarbonate, ammonium bicarbonate, calcium bicarbonate, magnesium bicarbonate, urea, monoethanolamine, diethanolamine, triethanolamine, mono(iso)propanolamine, di(iso)propanolamine, tri(iso)propanolamine, 2-
S amino-2-methylpropanol, 2-amino-2-methyl- 1,3-propanediol, 2-amino-2-ethyl-1,3- propanediol, tris(hydroxymethyl)aminomethane, N,N,N’N’-tetrakis(2- hydroxypropyl)ethylenediamine, di(2-ethylhexyl)amine, triamylamine, dodecylamine, morpholine or combinations thereof.
[0012] In various embodiments of the present invention involving a dual component system, the second component can also comprise an abrasive compound. The abrasive compound in the second component can be one or more peroxide-incompatible abrasive compounds, such as, for example a silica compound or an alumina compound or one or more peroxide-compatible abrasive compounds, such as, for example one or more calcium phosphate salts including calcium pyrophosphate as well as a combination of one or more peroxide-incompatible and/or peroxide-compatible abrasive compounds. The total concentration of abrasive compounds in the tooth-whitening compositions or the dentifrice compositions can be at least 10% by weight or at least 20% by weight.
[0013] In various embodiments of the present invention involving a dual component system, the second component can also comprise a color indicator such as, for example, group consisting of FD&C Red No. 3, FD&C Yellow No. 5, FD&C Yellow No. 6, FD&C
Green No. 3, FD&C Blue No. 1 and combinations thereof. In addition, either or both of the first or second components can further comprise a tooth-desensitizing compound such as, for example, a potassium salt of a weak acid or eugenol.
[0014] Figure 1 illustrates the in vitro treatment of extracted human teeth for 28 treatment periods using the composition of Example 1 for 20 minute treatment periods; comparative example C1 for 30 minute treatment periods; and comparative example C2 for minute treatment periods.
[0015] Figure 2 illustrates the in vitro treatment of extracted human teeth for 14 or greater treatments using the compositions of Example 1 for 20 minute treatment periods; the composition of Example 5 for 15 minute treatment periods; comparative example C1 for 30 minute treatment periods; and comparative example C2 for 30 minute treatment periods.
[0016] The present invention, in various embodiments, can involve methods and compositions for enhancing tooth-whitening with compositions containing one or more peroxide compounds and one or more abrasive compounds, wherein the compositions can have a pH of at least about 9.0. Such compositions can accelerate the tooth-whitening process, increase the whitening activity of the peroxide compounds and decrease oral irritation,
[0017] Reference herein to “a tooth” is intended to include the singular (tooth) and the plural (teeth). The tooth-whitening effect of the compositions is detectable by visual observation or by measurement using any of various instruments following a given application period or following successive application periods of the same duration.
[0018] The enhanced whitening effect of the compositions of the present invention, can be achieved at a reduced concentration of peroxide compounds compared to concentrations normally used. Concentrations of peroxide compounds normally used can be, for example, 7% hydrogen peroxide by weight or 7.5% hydrogen peroxide by weight or an amount of a peroxide compound other than hydrogen peroxide in which the peroxide compound delivers a hydrogen peroxide ion or an organic peroxide ion in an amount equivalent to the hydrogen peroxide ion delivered by 7% by weight hydrogen peroxide or 7.5% by weight hydrogen peroxide under the same conditions of temperature, exposure to light or other radiation, agitation and the like. Such equivalence is sometimes referenced herein as hydrogen-peroxide-equivalent concentration for a given peroxide compound.
[0019] Thus, concentrations of peroxide compounds as used herein refer concentrations that deliver the amount of bleaching activity equal to that delivered by hydrogen peroxide at the stated concentration. In various embodiments, the compounds deliver an amount of peroxide ion equal to that delivered by hydrogen peroxide at the stated concentration. For example, carbamide peroxide at a concentration of 10% by weight in an aqueous solution is generally considered to deliver the same amount of hydrogen peroxide ion as an aqueous solution of hydrogen peroxide at a concentration of about 3% by weight.
Thus, for carbamide peroxide, a hydrogen-peroxide-equivalent concentration of 3.5% by weight is intended to mean a carbamide peroxide concentration of about 12% by weight, a hydrogen-peroxide-equivalent concentration of 5% by weight is intended to mean a carbamide peroxide concentration of about 17% by weight and a hydrogen-peroxide- equivalent concentration of 7% by weight is intended to mean a carbamide peroxide concentration of about 22% by weight.
[0020] All amounts in the specification and claims are by weight unless otherwise indicated. Reference herein to amounts by weight can also be expressed as (w/w) which intended to mean the ratio of the number of grams of a particular component of a composition to the total number of grams of that composition.
[0021] The terms “comparative composition” and “reference composition” are used interchangeably herein. Concentrations of the comparative or reference compositions as used herein is intended to mean the concentrations that deliver an amount of peroxide ion equal to that delivered by hydrogen peroxide at the stated concentration. In various embodiments, the reference or comparative composition can be hydrogen peroxide. Other comparative compositions can, however, be used and in such instances, the concentrations of the comparative compositions are intended to mean the hydrogen-peroxide-equivalent concentrations of the comparative compositions. The comparative compositions can be at a hydrogen-peroxide-equivalent concentration of about 3.5% by weight or greater, about 5% by weight or greater, about 7% by weight or greater, about 7.5% by weight or greater, about 10% by weight or greater, or about 13% by weight or greater.
[0022] The hydrogen-peroxide-equivalent concentrations of the peroxide compounds of the present invention, show an enhanced whitening effect at hydrogen-peroxide-equivalent concentrations of not more than 3% by weight, not more than 3.5% by weight, not more than 4% by weight, not more than 4.5% by weight, not more than 5% by weight, not more than 5.5% by weight, not more than 6% by weight, and not more than 6.5% by weight.
[0023] In various embodiments of the present invention, the concentration of the peroxide compound can be viewed as a reduced concentration compared to the reference composition, i.e. the methods in certain embodiments, can involve a reduction in the concentration of the peroxide compound necessary to achieve the same whitening effect in duration of whitening period, effectiveness of whitening and degree of absence of oral irritation.
[0024] The peroxide compound can be any of a variety of peroxide-based bleaching agents, which deliver a hydrogen peroxide ion or an organic peroxide ion. Such compound include, for example, hydrogen peroxide, organic peroxide compounds, hydrogen peroxide generating compounds, organic peroxide generating compounds and combinations thereof.
[0025] Organic peroxide compounds include, for example, urea hydrogen peroxide (carbamide peroxide), glyceryl hydrogen peroxide as well as groups of peroxides classified according to the number and kind of organic functional groups attached to the oxygen atoms, such as, for example, alkyl hydrogen peroxide (R-O-O-H), dialkyl hydrogen peroxide (R-O-
O-R") peroxy acids (RCO-O-O-H), peroxy esters (RCO-OOR), and diacyl peroxides (R-CO-
0-0-CO-R'). Among such peroxides used in dental whitening are the diacyl peroxide, benzoyl peroxide and the peroxy acid monoperoxyphthalate.
[0026] The hydrogen peroxide generating compound can be, for example, alkali metal and alkaline-earth metal persulfate, dipersulfate, percarbonate, perphosphate, perborate, and persilicate salts such as, for example, sodium persulfate, sodium dipersulfate, sodium percarbonate, sodium perphosphate, sodium perborate, sodium persilicate, potassium persulfate, potassium dipersulfate, potassium percarbonate, potassium perphosphate, potassium perborate, potassium persilicate, calcium persulfate, calcium dipersulfate, calcium percarbonate, calcium perphosphate, calcium perborate, calcium persilicate salts as well as sodium peroxide, potassium peroxide and calcium peroxide and combinations of all of the above hydrogen peroxide generating compounds.
[0027] The enhanced whitening effect is achieved at least in part due to the high pH of the tooth-whitening composition which is, in turn achieved by the presence of at least one alkaline compound in the composition. In dual component systems, the alkaline compound can be present in one component and the peroxide compound, in the other component such that upon combination prior to use, the tooth-whitening mixture has a pH of at least about 9 or greater.
[0028] The alkaline compound can be, for example, an alkali metal, ammonium or alkaline earth metal compound such as, for example, sodium hydroxide, potassium hydroxide, ammonium hydroxide, calcium hydroxide, magnesium hydroxide, sodium carbonate, potassium carbonate, ammonium carbonate, calcium carbonate, magnesium carbonate, sodium bicarbonate, potassium bicarbonate, ammonium bicarbonate, calcium bicarbonate, magnesium bicarbonate or combinations thereof; an organic amine such as urea, alkanolamines such as monoethanolamine, diethanolamine, triethanolamine, mono(iso)propanolamine, di(iso)propanolamine, tri(i so)propanolamine or 2-amino-2-
methylpropanol; alkanediolamines such as 2-amino-2-methyl-1,3-propanediol or 2-amino-2- ethyl-1,3-propanediol; alkanepolyamines such as tris(hydroxymethyl)aminomethane or
N,N,N’N’-tetrakis(2-hydroxypropyl)ethylenediamine; alkylamines such as di(2- ethylhexyl)amine, triamylamine or dodecylamine; or amino ethers such as morpholine.
[0029] The alkaline compound can be at a concentration of from about 0.1% by weight to about 30% by weight, from about 0.2% by weight to about 10% by weight, from about 0.5% by weight to about 2% by weight or from about 0.5% by weight to about 0.75% by weight.
[0030] One or more abrasive compounds can be included in the tooth-whitening compositions of the present invention. Such compounds impart cleaning and polishing “functions to the composition. In addition to such actions, the abrasive compounds can enhance the whitening effect of peroxide compounds.
[0031] The method of incorporating the abrasive compound into the tooth-whitening composition can depend upon the type of abrasive compound. For example, certain abrasive compounds can be considered incompatible with peroxide based bleaching compounds because they tend to produce a decomposition of the peroxide compound. This can result not only in a reduced efficacy, but also in premature gas evolution resulting in swelling and/or bursting of tubes containing products made up of a peroxide compound and a peroxide- incompatible abrasive.
[0032] Peroxide-compatible abrasives, i.e. abrasive compounds not considered to cause substantial decomposition of peroxide compounds, include calcium phosphate abrasive compounds (see for example, U.S. Patent No. 5,171,564, which is incorporated in its entirety by reference). Examples of such peroxide compatible abrasives include dicalcium phosphate dihydrate, anhydrous dicalcium phosphate, calcium pyrophosphate and mixtures thereof.
[0033] Peroxide-incompatible abrasives include silica compounds and alumina compounds. Such silica compounds include for example, hydrated silica, such as Sorbosil
AC-35, marketed by INEOS Silicas Ltd (Warrington, UK; formerly Crosfield Chemicals), or
Zeodent 115 from Huber Company (Edison, N.J.). Alumina compounds can include, for example, alumina trihyhydrate, aluminum silicate, calcined alumina and mixtures thereof.
[0034] Other abrasives can also be included in the compositions of the present invention, such as, for example, hydroxyapatite, sodium metaphosphate, potassium metaphosphate, tricalcium phosphate, calcium carbonate, sodium bicarbonate, bentonite, and mixtures thereof.
[0035] Peroxide-incompatible abrasives can be combined with peroxide compounds immediately prior to use without producing substantial decomposition of the peroxide compounds. Such mixtures can produce an enhanced whitening activity of the peroxide compound (see for example, U.S. Patent No. 5,766,574 which is incorporated in its entirety by reference).
[0036] Thus, in various embodiments, the tooth-whitening compositions of the present invention can be in the form of a dual component system. The first component can comprise the peroxide compound and the second component can comprise the alkaline compound. In certain embodiments, the second component can also comprise a peroxide- incompatible abrasive compound. A peroxide-compatible abrasive compound can be incorporated into either or both of the first or second components. In particular, the first component of a two component system of the present invention can comprise a peroxide compound and a calcium phosphate abrasive compound such as calcium pyrophosphate and the second component can comprise an alkaline compound. In various embodiments, the second component can also contain either or both of a peroxide-incompatible abrasive compound and a peroxide-compatible abrasive compound.
[0037] The first and second components can, independently, be in the form of a liquid or a semi-solid liquid such as a gel or paste.
[0038] The dual component system can be in the form of a kit which includes the first and second components along with instructions for combining the first and second components and/or instructions as to the method of use of the first and second components "and the a mixture thereof. Such instructions as to the method of use can include the amount to be used, time period for applying the compositions, schedule for repeated application and the like.
[0039] Typically, equal amounts of the first component and the second component are combined in such a manner to effect mixing. Such mixing results in an increase in the pH of the mixture to about 9 or greater, about 9.5 or greater, or about 10 or greater, or about 11 or greater, or about 12 or greater up to a pH of about 13 or greater.
[0040] The time period for applying the compositions of the present invention to achieve tooth-whitening is sometimes referenced herein as “effective tooth-whitening period.” This represents the time period during which the compositions contact the tooth during a single application. An “effective tooth-whitening period” can be about 10 minutes or less, about 15 minutes or less, about 20 minutes or less, about 25 minutes or less or about 30 minutes or less or more than about 30 minutes.
[0041] The tooth whitening composition can be applied in a single application or in repeated application. Such repeated or successive applications can be performed one or more times during the day such as, for example, once a day, twice a day or three times a day or less frequently such as, for example once every two days, once every three days or once a week.
The application period can continue, for example for about one week, about two weeks, about three weeks, or about four weeks or longer.
[0042] The compositions of the present invention, including the tooth-whitening compositions and the first and second component compositions of two-component systems, can, in various embodiments, contain a thickening agent which imparts a high viscosity to the composition. Typically the compositions have a viscosity of from less than about 200 CPS up to about 10,000 or greater or from about 1000 cps up to about 9000 cps or from about 4000 to about 6000 cps. In certain embodiments, the thickening agent can be a hydrophilic block copolymer of polyethylene oxide and polypropylene oxide such as a Pluronic® compound, for example Pluronic® F127 which is a trade name of BASF obtained therefrom (BASF
Corporation, Mount Olive, New Jersey). Pluronic® F127 has a molecular weight of about 4000. This substance can be present in the compositions at a concentration of about 5% by weight about 10% by weight, about 15% by weight, about 20% by weight, about 25% by weight, about 30% by weight or greater. In particular, the Pluronic® F127 concentration in the first component containing the peroxide compound can be about 20% by weight, in the second component containing the alkaline compound, the concentration can be about 17% by weight and in the tooth-whitening mixture of the two, the concentration can be about 18.5% by weight.
[0043] Polyethylene oxide of high molecular weight can also be used in the compositions of the present invention as thickening agents. Such polyetheylene oxide thickeners have a number average molecular weight, a viscosity average molecular weight, a weight average molecular weight or a Z-average molecular weight of about 50,000 to about 5,000,000. One or more high molecular weight polyethylene oxide can be present in a concentration range of from about 0% to about 30% by weight, from about 10% by weight to about 25% by weight or from about 15% by weight to about 20% by weight.
[0044] One or more of glycerin, sorbitol and low molecular weight polyethylene glycol can also be included in the compositions as carrier materials which can also impart effects on viscosity. The polyethylene glycol is a nonionic polymer of ethylene oxide. The polyethylene glycol when present in the compositions of the present invention can have a number average, weight average, or Z average molecular weight of from about 200 to about 1000, from about 400 to about 800 or about 600. The glycerin, sorbitol and polyethylene glycol can each independently be present in amounts of from about 0% to about 30% by weight, from about 5% by weight to about 25% by weight, from about 10% by weight to about 20% by weight, or from about 15% by weight to about 20% by weight. Typically, glycerin and polyethylene glycol (600) are present in amounts of about 5% by weight and about 15% by weight, respectively in the first component composition, in amounts of about 5% by weight and about 10% by weight, respectively in the second component composition and in amounts of about 5% by weight and about 12.5% by weight, respectively in the tooth- whitening composition.
[0045] The compositions of the present invention can also contain added water in an amount of from about 5% by weight to about 40% by weight, from about 10% by weight to about 30% by weight or from about 5% by weight to about 20% by weight. [0046) Surfactants can also be included in the compositions of the present invention as solubilizing, dispersing and/or emulsifying agents. Such surfactants can include nonionic surfactants such as, for example, Tween 20 or anionic surfactants such as, for example, sodium lauryl sulfate or sodium dodecyl sulfate.
[0047] The compositions of the present invention can also contain flavoring substances at a concentration of from about 0.05% by weight to about 5% by weight. Such flavoring substances include, for example, an essential oil, extract or flavoring aldehyde, ester or alcohol that imparts a flavor of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit, orange, apple, pear, peach,
strawberry, cherry, apricot, watermelon, banana, coffee, cocoa, menthol, carvone, anethole or combinations thereof.
[0048] One or more sweetening agents can also be included in the compositions of the present invention. Such sweetening agents can include sodium saccharin, sodium cyclamate, zylitol, aspartame and the like in a concentration of from about 0.01% by weight to about 1.0% by weight.
[0049] The compositions of the present invention can also be formulated to contain one or more desensitizing agents to reduce tissue sensitivity and irritation upon application of the tooth-whitening compositions. Such sensitizers include, for example, potassium salts of weak acids, such as potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate as well as strontium salts and eugenol (4- allyl-2-methoxyphenol). One or more of the sensitizers can be present in the compositions of the present invention at a concentration of from about 0.05% by weight to about 0.5% by weight or from about 0.1% by weight to about 0.25% by weight for eugenol and from about 1% by weight to about 10% by weight or from about 3% by weight to about 6% by weight for potassium salts of weak acids such as, for example potassium nitrate.
[0050] One or more redox color indicators that are oxidized by hydrogen peroxide, can also be included in the second component of the dual-component system. The color indicator can be a dye suitable for use in an tooth-bleaching composition such as, for food color additives certified under the Food Drug & Cosmetic Act for use in food and ingested drugs, including dyes such as FD&C Red No. 3 (sodium salt of tetraiodofluorescein), FD&C
Yellow No. § (sodium salt of 4-p-sulfophenylazo-1-p-sulfophenyl-5-hydroxypyrazole-3 carboxylic acid), FD&C Yellow No. 6 (sodium salt of p-sulfophenylazo-B-naphtol-6- monosulfonate), FD&C Green No. 3 (disodium salt of 4-{[4-(N-ethyl-p-sulffobenzylamino)- phenyl]-(4-hydroxy-2-sulfoniumphenyl)-mewthylene }-[1-(N-ethyl-N-p-sulfobenzyl)-A-3,5-
cyclohexadienimine], FD&C Blue No. 1 (disodium salt of dibenzyldiethyldiaminotriphenylcarbinol trisulfonic acid of indigotin). The dyes change colors upon contacting the peroxide compound, thereby signaling the user when the effective whitening period is completed. The second component composition can contain one or more dyes at a concentration of from about 0.005% by weight to about 0.5% by weight or from about 0.025% by weight to about 0.15% by weight.
[0051] Agents that chelate metal ions can also be present in the compositions of the present invention. Such chelating agents include sodium acid pyrophosphate, disodium calcium ethylene diamine tetraacetic acid, phosphoric acid, citric acid, sodium citrate, potassium citrate, sodium pyrophosphate, potassium pyrophosphate, disodium ethylenediamine tetraacetic acid and the like. The chelating agents can be incorporated into the compositions of the present invention in an amount of from about 0.1% by weight to about 8% by weight or from about 0.5% by weight to about 3.0% by weight.
[0052] Fluoride compounds having anti-caries activity can also be incorporated in the compositions of the present invention. These substances release fluoride ions in an aqueous environment. Such fluoride compounds include salts such as, for example, sodium fluoride, potassium fluoride, cuprous fluoride, stannous fluoride, stannous chlorofluoride, sodium fluorosilicate, ammonium fluorosilicate, sodium monofluorophosphate, alumina mono- fluorophosphate and alumina difluorophosphate. The fluoride compounds, when present, can be at a concentration sufficient to release fluoride ion in an amount of from about 15 to about 1500 ppm.
[0053] Anti-forming agents such as simethicone can also be present in the compositions of the present invention at a concentration of from about 0% by weight to about 0.1% by weight.
[0054] Tooth whiteness can be visually observed or measured by any of various instruments measured. One such instrument can be a colorimetry such as, for example, a
Minolta portable Chroma-meter such as model CR-400 (Minolta Corp. Ramsey, New Jersey).
This colorimeter can be programmed to measure Hunter lab values of “L”, “a” and “b” in which “L” values represent lightness and "a" and "b" values represent the chromaticity coordinates. Lightness “L” values can represent dark to light color in which a value of 0 represents black and a value of 100 represents white. Green to red can be expressed by the "a" value, the more positive value represented more red, and the more negative value represented more green color (-80 represents green and 100 represents red). Blue to yellow can be expressed by the "b" value, a more positive value represented more yellow color in the sample (-80 represents blue and 70 represents yellow). Typically “L” values are used to measure tooth-whiteness.
[0055] The invention can be further understood by reference to the examples which follow.
EXAMPLE 1 {0056] This Example illustrates a two component tooth-whitening system in which the concentration of the peroxide compound in the tooth-whitening composition formed by combining the two components is about 3.5% by weight.
[0057] The composition of the first, peroxide component, and the second alkaline component are as shown in Table 1.
Table 1. Tooth-Whitening Composition having 3.5% H,0,.
A B
Component Peroxide Component Alkaline Component
Ingredients Weight % Weight %
Deionized Water 14.3 31
Hydrogen peroxide 20 (35% solution) --
Potassium Nitrate -- 6
Glycerin 5 5
Polyethylene glycol 600 15 10
Pluronic F-127 20 17
Saccharin 0.2 --
Sodium hydroxide -- 0.5-0.75
FD+C Yellow #6 -- 0.025 -0.15
Eugenol 0.25 --
Calcium pyrophosphate 25 30
Sodium lauryl sulfate -- 0.4
Flavor 0.25 -
[0058] Components A and B were prepared in a Ross mixer (Charles Ross & Son
Company, Hauppauge, NY) as follows.
Component A: Water, saccharin and 30% of the total volume of 35% hydrogen peroxide were stirred in a beaker until the saccharin dissolves. PEG 600 and glycerin were added and the mixture was placed in the Ross mixer along with Pluronic F127 and stirred at high speed under vacuum until a clear gel formed (approximately 45 minutes). Calcium pyrophosphate was added and the mixture stirred at medium speed for another 10 minutes under vacuum.
The remaining 70% of the peroxide volume was added and stirred 10 minutes at medium speed. Next, the flavor was added and the mixture was stirred 5 minutes at low speed. An extrudible paste having a pH of 6.0 was obtained.
Component B: Water, sodium hydroxide potassium nitrate and FD+C Green #3 dye were mixed in a beaker until the potassium nitrate dissolved. PEG 600 and glycerin were added to the aqueous phase and the mixture was placed in the Ross mixing pot along with Pluronic
F127. The mixture was stirred at high speed under vacuum until a clear gel formed (approximately 45 minutes). Calcium pyrophosphate, sodium lauryl sulfate, sodium bicarbonate and sodium hydroxide were added and the mixture stirred at medium speed for another 10 minutes under vacuum. An extrudable paste having a pH of 9.6 was obtained.
EXAMPLE 2
[0059] This example illustrates the in vitro whitening effect of the tooth-whitening composition of Example 1 containing peroxide compound at a concentration of 3.5% by weight and calcium pyrophosphate at a concentration of 27.5%.
[0060] Three compositions were tested. The composition of Example 1 was prepared by mixing component A with component B in approximately equal proportions. Comparative composition designated “C” was a simple pluronic gel prepared at approximately the same pH and peroxide concentration as the composition of Example 1, but having water in place of the calcium pyrophosphate. Comparative composition designated “C1” was a commercially available whitening composition comprised of a thickened Pluronic gel containing about 7% hydrogen peroxide at a pH of about 5.8 in addition to calcium pyrophosphate and dicalcium phosphate.
[0061] Extracted, naturally-stained human teeth were pumiced and initial color determined using a Minolta Chromameter CR-241. Three teeth each were immersed for minutes at 37 °C in each of the three tooth-whitening compositions. These 15 minute- treatments were repeated 8 times for a total contact time of 2 hours. Tooth shade was measured midway and at the end of the total treatment period. The increase in tooth whiteness, represented as AE values was calculated using the following formula:
AE = [AL]? + (Aa)* + (Ab)]"? wherein “L”, “a” and “b” are Hunter lab values in which “L” values represent lightness and "a" and "b" values represent the chromaticity coordinates as described above. Higher values of AE, indicate higher levels of tooth whiteness achieved. Results are shown in Table 2 below.
Table 2. In vitro Immersion Study et [os wom [sme = a
Example C
Example C1
[0062] As shown in the table, the tooth-whitening effect of the composition of
Example 1 was greater than that of comparative composition C at both measurement points.
The comparative composition C contained 3.5% by weight hydrogen peroxide as did the composition of Example 1, however, the composition of Example 1 also contained calcium pyrophosphate at a concentration 27.5%. This suggests that the calcium pyrophosphate contributed to the tooth-whitening effect of the composition of Example 1. Since the majority of the extrinsic staining was removed from the sample teeth with pumice, the improved whitening produced by calcium pyrophosphate is believed to result from removal of intrinsic tooth stain. Thus, the data above show that the calcium pyrophosphate provided a beneficial whitening benefit in addition to its effect on surface polishing and extrinsic stain removal.
[0063] The whitening effect produced by the composition of Example 1 was greater than that produced by comparative composition, C1, which contained hydrogen peroxide at a concentration of about 7% and a pH of about 9.
EXAMPLE 3
[0064] This example illustrates the long-term in vitro effectiveness of the tooth- whitening composition of Example 1 containing peroxide compound at a concentration of 3.5% by weight and calcium pyrophosphate at a concentration of 27.5%.
[0065] Three compositions were tested. The composition of Example 1 was prepared by mixing component A with component B in approximately equal proportions. Comparative composition designated “C1” was a commercially available whitening composition comprised of a thickened Pluronic gel containing about 7% hydrogen peroxide at a pH of about 5.8 in addition to calcium pyrophosphate and dicalcium phosphate. Comparative composition “C2” was a commercially available whitening composition comprising a thickened Pluronic gel which contained about 7.5% hydrogen peroxide at a pH of about 9 and no added abrasive compounds.
[0066] Five human extracted teeth each were repeatedly treated with comparative composition “C1” for a periods of 30 minutes per treatment; or comparative composition “C2” for periods of 30 minutes per treatment. Another five human extracted teeth were treated with the composition of Example 1 for periods of 20 minutes per treatment.
[0067] The study was carried out to 28 treatments, which is equivalent to 14 days of twice daily treatments (a typical treatment regimen for at-home whitening). Shade readings were taken at various intervals with the Minolta Chromameter. Results are shown in Figure 1.
As seen in the Figure 1, the tooth-whitening composition of Example 1 achieved whitening comparable to that of comparative composition C1 in half the number of treatments compared to that of the composition of Example 1. In addition, the composition of Example
1 achieved whitening comparable to that of comparative composition C2 which contained more than twice the level of hydrogen peroxide at a concentration of 7.5% compared to 3.5% for the composition of Example 1.
EXAMPLE 4
[0068] This example illustrates the in vivo testing of the tooth-whitening composition of Example 1 containing peroxide compound at a concentration of 3.5% by weight and calcium pyrophosphate at a concentration of 27.5%.
[0069] The whitening efficacy of the composition of Example 1 was also compared to comparative composition C1 in a 2-week clinical study. One cell used comparative composition C1 30 minutes twice daily and the other cell used the composition of Example 1 for 20 minutes once daily. Tooth shade was evaluated after 14 days using a Vita shade guide.
The results are summarized in the Table 2.
Table 3: Clinical Testing of Composition of Example 1
Composition Hydrogen No. of Subjects | Total Wear Shade Change
Peroxide Time
Concentration
Comparative 7.5% 10 14.0 hrs. 4.56 £2.65
Example C1
[0070] As shown in the Table, there was no significant difference between tooth shade changes. Thus the composition of Example 1 provides the same whitening effect as comparative example C1, but at half the peroxide level and 1/3 the total wear time. In addition, subjects using comparative composition C1 reported significantly (p=0.038) more gum irritation than those using the composition of Example 1.
EXAMPLE 5
[0071] This Example illustrates a two component tooth-whitening system in which the concentration of the peroxide compound in the tooth-whitening composition formed by combining the two components is about 5% by weight.
[0072] The composition of the first, peroxide component, and the second alkaline component are as shown in Table 4.
Table 4. Tooth-Whitening Composition having 5% H.0,
A B
Component Peroxide Component Alkaline Component
Ingredients Weight % Weight %
Deionized Water 24 30.2
Hydrogen peroxide 10 -
Potassium Nitrate -- 10
Polyox (PEG 2M) h) --
Glycerin 5 25
Polyethylene glycol 600 10 3
Xanthan -- 0.7
Na carboxymethyl cellulose -- 0.5
Pluronic F-127 20 2
Sodium saccharin -- 0.2
Titanium dioxide -- 1
Sodium hydroxide (50%) - 1
TiO, -- 1
FD+C Green #3 -- 0.025
Zeodent 115 (silica abrasive) -- 17.5
Zeodent 165 (silica thickener) -- 3
Sodium bicarbonate -- 5
Calcium pyrophosphate 25 --
Sodium lauryl sulfate - 0.4
Flavor 0.5 0.5
Components A and B were prepared as described above in Example 1.
EXAMPLE 6
[0073] This example illustrates the in vitro whitening effect of the tooth-whitening composition of Example 5 containing peroxide compound at a concentration of 5% by weight and calcium pyrophosphate at a concentration of 12.5%.
[0074] In Vitro assessment of stain removal by the tooth-whitening composition of
Example 5 was determined by an in vitro study procedure using human extracted teeth as described above in Example 2. The teeth were polished with a prophy paste to remove any surface stain. The root portions of five teeth were placed in a row and immersed in an impression compound. To mimic in vivo use, a tray for the sample teeth was prepared by placing a piece of tray material in a tray former and heated until the material began to soften.
The softened tray material was then pulled down over the five teeth using a vacuum and allowed to harden to entrap the teeth in the hardened tray material.
[0075] Baseline Chromameter readings were taken of the teeth using a Minolta
Chromameter CR-241. Next, small dots of the tooth-whitening composition of Example 5 composed of equal weight amounts of component A and B, so that the peroxide content was 5% by weight, were placed in each tooth well in a dental tray. The tray was weighed and then placed over the teeth so that a thin film of the composition of Example 5 covered each tooth. The tray covered teeth were placed in a 37°C incubator for 15 minute intervals and thereafter removed, rinsed and measured with the Chromameter. This process was repeated for each time point. The AE values were determined for each time point as described above.
[0076] For purposes of comparison, the single component peroxide paste similar to component A alone but containing hydrogen peroxide at a concentration of 3.5% and designated composition “Cl1A” as described above was evaluated for tooth whitening efficacy following the procedure of the Example 3 above. The AE values of the tray covered teeth were measured at 30 minute intervals for composition C1A. For purposes of further comparison, a commercially available professional tooth whitening composition was also evaluated for tooth whitening efficacy with chromameter measurements being performed also at 30 minute intervals. The commercial whitening composition, designated composition “C7” as described above was a thickened Pluronic gel which contained 7.5% peroxide at a of about pH 9. No abrasives were present in the gel. The whitening study was carried out to 14 treatments, which is equivalent to a typical home whitening regimen of twice daily treatments over a one week period. Results are shown in Table 5.
Table S. Tooth Whitening Efficacy of Composition Containing 5% H;0,. a Js [12 Jia
Example C1A
Example C2
[0077] The results recorded in Table 5 indicate that although the treatment time (15 minutes) using the composition of Example 5 was half the treatment time (30 minutes) of comparative composition C2, the composition of Example 5 achieved faster maximum whitening in half the number of treatments and half the application time in spite of the fact that the composition C2 contained 33% more peroxide whitening agent than that of the composition of Example 5 (7.5% v. 5.0%).
[0078] These results are further illustrated in Figure 2 which shows the comparisons above and in addition, the whitening effects of the composition of Example 1.
[0079] While not intending to be bound by any theory, the unexpected enhancement in whitening efficacy produced by the compositions of Examples 1 and § in comparison to the comparative composition C2 may be due to the presence in the composition of calcium pyrophosphate and silica abrasives which serve to aid in extrinsic stain removal and, boost the effective peroxide concentration delivered inside the tooth by the increased density and solid content of the compositions of Example 1 and 5 as compared to the comparative composition C2. Thus, larger amounts of peroxide are believed to have been delivered by the compositions of Examples 1 and 5 to the teeth per unit weight of paste. In addition, the peroxide ingredient in the compositions of Example 1 and 2 are believed to have been concentrated into the water soluble portion of the composition and it is believed that this concentrated portion may have diffused into the teeth to remove intrinsic stain.
EXAMPLE 7
[0080] This example illustrates the in vivo assessment of whitening efficacy of the composition of Example 5.
[0081] The composition of Example 5 was prepared by combining equal weight amounts of Components A and B. Whitening efficacy of the composition was also compared to that of comparative composition C2 in a two week human clinical study wherein one cell of 9 subjects used composition C2 thirty minutes twice daily according to the manufacturer’s instruction. The other cell with 12 patients used the composition of Example 5 for fifteen minutes once daily. Tooth shade was evaluated after 0, 5, 7 and 14 days using a value- ordered Vita shade guide. The results are summarized in Table 6.
Table 6. In vivo Whitening Efficacy of Composition Containing 5% H,0,.
Shade Guide Change
Average
Average Shade Guide
Average Shade Guide Change
Shade at (Day) (Day)
Composition | Baseline — rs 1 7 Tas] 7 |14]
Examples | D3 | 767 | 615 | 488 |358| 492 [6.19]
Comparative D3 8.06 6.11 422 | 228 3.92 5.66
Example C2
[0082] The results recorded in Table 6 indicate that the overall whitening efficacy of the composition of Example 5 was directionally better than comparative composition C2 and statistically better at 5 days (p=0.025) evidencing faster whitening efficacy since both the application time and number of treatments using the composition of Example 5 was one quarter that of comparative composition C2 (15 minutes once daily versus 30 minutes twice daily).
[0083] In addition to enhanced efficacy, the patients in the tooth whitening study using the composition of Example 5 as described above reported less gingival irritation and tooth sensitivity than patients using comparative composition C2. The patients involved in the study rated their tooth sensitivity and gingival irritation on a scale of zero (none) to 5, the higher the number, the greater the tooth sensitivity and gingival irritation experienced by the patient involved in the study. Patient rated their perception of tooth sensitivity and gingival irritation using this scale before using the product (baseline) and after using the product for 7 days and 14 days. The patient ratings of gum irritation and tooth sensitivity minus the baseline ratings are recorded in Table 7 below.
Table 7. Sensitivity and Irritation Study with Composition of Example 5.
A Gum Irritation * A Tooth Sensitivity**
C= a Wl tl ll
Err a a Ea
Example C2 * Change in gum irritation from baseline ** Change in tooth sensitivity from baseline
[0084] Ratings for gum irritation and tooth sensitivity were lower for the composition of Example 5 compared to that of comparative composition C2 at 7 and 14 days. The levels of tooth sensitivity reported for the composition of Example 5 at 7 and 14 days were negative (lower than the reported baseline values), suggesting that the desensitizing agent present in the composition reduced tooth sensitivity over the treatment period.
[0085] Copending Application No. 10/065,244 filed September 27, 2002 is hereby incorporated in its entirety by reference.
[0086] The description of the invention is merely exemplary in nature and, thus, variations that do not depart from the gist of the invention are intended to be within the scope of the invention. Such variations are not to be regarded as a departure from the spirit and scope of the invention.
Claims (93)
1. A dual component dentifrice system comprising a first component comprising a peroxide compound and a peroxide-compatible abrasive compound and a second component comprising an alkaline compound, wherein upon combining the first and second components, a dentifrice composition having a pH of about 9.0 or greater is produced.
2. A system according to claim 1, wherein the first component has a pH of from about 4 to about 7 and the second component has a pH of from about 9 to about 13.
3. A system according to claim 1, wherein the peroxide compound is selected from the group consisting of hydrogen peroxide, an organic peroxide compound, a hydrogen peroxide generating compound and combinations thereof.
4. A system according to claim 1, wherein the peroxide compound is an organic peroxide compound selected from the group consisting of urea hydrogen peroxide, glyceryl peroxide, benzoyl peroxide, monoperoxyphthalate and combinations thereof.
5. A system according to claim 1, wherein the peroxide compound is a hydrogen peroxide generating compound selected from the group consisting of sodium persulfate, sodium dipersulfate, sodium percarbonate, sodium perphosphate, sodium perborate, sodium persilicate, potassium persulfate, potassium dipersulfate, potassium percarbonate, potassium perphosphate, potassium perborate, potassium persilicate, calcium persulfate, calcium dipersulfate, calcium percarbonate, calcium perphosphate, calcium perborate, calcium persilicate, sodium peroxide, potassium peroxide and calcium peroxide and combinations thereof.
6. A system according to claim 1 wherein, upon combining the first and second components the peroxide compound is present in the dentifrice composition at a hydrogen- peroxide-equivalent concentration of not greater than about 5.0% by weight.
7. A system according to claim 6, wherein upon combining the first and second components the peroxide compound is present in the dentifrice composition at a hydrogen- peroxide-equivalent concentration of not greater than about 3.5% by weight.
8. A system according to claim 1, wherein the peroxide-compatible abrasive comprises one or more calcium phosphate salts.
9. A system according to claim 8, wherein the peroxide-compatible abrasive comprises calcium pyrophosophate.
10. A system according to claim 1, wherein upon combining the first and second components, the peroxide-compatible abrasive is present in the dentifrice composition at a concentration of at least about 10% by weight.
11. A system according to claim 10, wherein upon combining the first and second components, the peroxide-compatible abrasive is present in the dentifrice composition at a concentration of at least about 20% by weight.
12. A system according to claim 1, wherein the alkaline compound is an alkali metal hydroxide or an alkali metal carbonate salt.
13. A system according to claim 1, wherein the alkaline compound is selected from the group consisting of sodium hydroxide, potassium hydroxide, ammonium hydroxide, calcium hydroxide, magnesium hydroxide, sodium carbonate, potassium carbonate, ammonium carbonate, calcium carbonate, magnesium carbonate, sodium bicarbonate, potassium bicarbonate, ammonium bicarbonate, calcium bicarbonate, magnesium bicarbonate, urea, monoethanolamine, diethanolamine, triethanolamine, mono(iso)propanolamine, di(iso)propanolamine, tri(iso)propanolamine, 2-amino-2- methylpropanol, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-ethyl-1,3-propanediol, tris(hydroxymethyl)aminomethane, N.N N’N’-tetrakis(2-hydroxypropyl)ethylenediamine, di(2-ethylhexy!)amine, triamylamine, dodecylamine, morpholine and combinations thereof.
14. A system according to claim 1, wherein the second component further comprises a second abrasive compound.
15. A system according to claim 14, wherein the second component comprises a peroxide-incompatible abrasive compound.
16. A system according to claim 15, wherein the peroxide-incompatible abrasive compound is a silica compound or an alumina compound.
17. A system according to claim 14, wherein the second abrasive compound comprises one or more calcium phosphate salts.
18. A system according to claim 17, wherein the second abrasive compound comprises calcium pyrophosphate.
19. A system according to claim 14, wherein upon combining the first and second components, the total concentration of abrasive compounds in the dentifrice composition is at least about 20% by weight.
20. A system according to claim 1, wherein the second component further comprises a color indicator.
21. A system according to claim 20, wherein the color indicator is selected from the group consisting of FD&C Red No. 3, FD&C Yellow No. 5, FD&C Yellow No. 6, FD&C Green No. 3, FD&C Blue No. 1 and combinations thereof.
22. A system according to claim 1, wherein either or both of the first or second components further comprise a tooth-desensitizing compound.
23. A system according to claim 22, wherein the tooth-desensitizing compound is a potassium salt of a weak acid or eugenol.
24. A dentifrice composition comprising a peroxide compound at a hydrogen- peroxide-equivalent concentration of not greater than about 5.0% by weight and a peroxide- compatible abrasive compound, wherein said composition has a pH of about 9.0 or greater.
25. A composition according to claim 24, wherein the peroxide compound is at a hydrogen-peroxide-equivalent concentration of not more than about 3.5% by weight.
26. A composition according to claims 24 or 25, wherein the composition produces a tooth-whitening effect equal to or greater than that of a comparative tooth-whitening composition having a hydrogen peroxide concentration of 7% by weight or greater.
27. A composition according to claims 24 or 25, wherein the peroxide compound is selected from the group consisting of hydrogen peroxide, an organic peroxide compound, a hydrogen peroxide generating compound and combinations thereof.
28. A composition according to claims 27, wherein the peroxide compound is an organic peroxide compound selected from the group consisting of urea hydrogen peroxide, glyceryl peroxide, benzoyl peroxide, monoperoxyphthalate and combinations thereof.
29. A composition according to claim 27, wherein the peroxide compound is a hydrogen peroxide generating compound selected from the group consisting of sodium persulfate, sodium dipersulfate, sodium percarbonate, sodium perphosphate, sodium perborate, sodium persilicate, potassium persulfate, potassium dipersulfate, potassium percarbonate, potassium perphosphate, potassium perborate, potassium persilicate, calcium persulfate, calcium dipersulfate, calcium percarbonate, calcium perphosphate, calcium perborate, calcium persilicate, sodium peroxide, potassium peroxide and calcium peroxide and combinations thereof.
30. A composition according to claims 24 or 25, wherein the peroxide-compatible abrasive comprises one or more calcium phosphate salts.
31. A composition according to claim 30, wherein the peroxide-compatible abrasive comprises calcium pyrophosophate.
32. A composition according to claims 24 or 25. wherein the peroxide-compatible abrasive is present in the dentifrice composition at a concentration of at least about 10% by weight.
33. A composition according to claim 32, wherein the peroxide-compatible abrasive is present in the dentifrice composition at a concentration of at least about 20% by weight.
34. A composition according to claims 24 or 25, wherein the composition comprises an alkaline compound that is an alkali metal hydroxide or an alkali metal carbonate salt.
35. A composition according to claims 24 or 25, wherein the composition comprises an alkaline compound selected from the group consisting of sodium hydroxide, potassium hydroxide, ammonium hydroxide, calcium hydroxide, magnesium hydroxide, sodium carbonate, potassium carbonate, ammonium carbonate, calcium carbonate, magnesium carbonate, sodium bicarbonate, potassium bicarbonate, ammonium bicarbonate, calcium bicarbonate, magnesium bicarbonate, urea, monoethanolamine, diethanolamine, triethanolamine, mono(iso)propanolamine, di(iso)propanolamine, tri(iso)propanolamine, 2- amino-2-methylpropanol, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-ethyl-1,3- propanediol, tris(hydroxymethyl)aminomethane, N,N,N’N’-tetrakis(2-
hydroxypropyl)ethylenediamine, di(2-ethylhexyl)amine, triamylamine, dodecylamine, morpholine and combinations thereof.
36. A composition according to claims 24 or 25, further comprising an abrasive which is a silica compound or an alumina compound.
37. A composition according to claim 36, wherein the total concentration of abrasive compounds is at least about 20% by weight.
38. A composition according to claims 24 or 25, wherein said composition is a tooth- whitening composition which is prepared not more than about 15 minutes prior to application to a tooth.
39. A composition according to claim 38, further comprising a color indicator.
40. A composition according to claim 39, wherein the color indicator is selected from the group consisting of FD&C Red No. 3, FD&C Yellow No. 5, FD&C Yellow No. 6, FD&C Green No. 3, FD&C Blue No. 1 and combinations thereof.
41. A composition according to claims 24 or 25, further comprising a tooth- desensitizing compound.
42. A composition according to claim 41, wherein the tooth-desensitizing compound is a potassium salt of a weak acid or eugenol.
43. A method for whitening a tooth in a mammal, the method comprising contacting the tooth for an effective tooth-whitening period with a tooth-whitening composition that comprises a peroxide compound at a hydrogen-peroxide-equivalent concentration of not greater than about 5% by weight and a peroxide-compatible abrasive compound, said composition having a pH of at least about 9.
44. A method according to claim 43 wherein the peroxide compound is at a hydrogen- peroxide-equivalent concentration of not greater than about 3.5% by weight.
45. A method according to claims 43 or 44, wherein the composition is prepared from a dual component system comprising a first component comprising a peroxide compound and a peroxide-compatible abrasive compound and a second component comprising an alkaline compound.
46. A method according to claim 45, wherein the composition is prepared not more than 15 minutes prior said contacting.
47. A method according to claims 43 or 44, wherein the contacting is for an effective tooth-whitening period which is less than that required for a comparative composition comprising hydrogen peroxide at a concentration of 7% by weight or greater and a pH of 7.0 or less.
48. A method according to claim 47 wherein the effective tooth-whitening period of the tooth-whitening composition is not more than about 20 minutes and that of comparative composition is about 30 minutes or greater.
49. A method according to claims 43 or 44, wherein the peroxide compound is selected from the group consisting of hydrogen peroxide, an organic peroxide compound, a hydrogen peroxide generating compound and combinations thereof.
50. A method according to claims 49, wherein the peroxide compound is an organic peroxide compound selected from the group consisting of urea hydrogen peroxide, glyceryl peroxide, benzoyl peroxide, monoperox yphthalate and combinations thereof.
51. A method according to claim 49, wherein the peroxide compound is a hydrogen peroxide generating compound selected from the group consisting of sodium persulfate, sodium dipersulfate, sodium percarbonate, sodium perphosphate, sodium perborate, sodium persilicate, potassium persulfate, potassium dipersulfate, potassium percarbonate, potassium perphosphate, potassium perborate, potassium persilicate, calcium persulfate, calcium dipersulfate, calcium percarbonate, calcium perphosphate, calcium perborate, calcium persilicate, sodium peroxide, potassium peroxide and calcium peroxide and combinations thereof.
52. A method according to claims 43 or 44, wherein the peroxide-compatible abrasive comprises one or more calcium phosphate salts.
53. A method according to claim 52, wherein the peroxide-compatible abrasive comprises calcium pyrophosophate.
54. A method according to claims 43 or 44, wherein the peroxide-compatible abrasive is present in the tooth-whitening composition at a concentration of at least about 10% by weight.
55. A method according to claim 54, the peroxide-compatible abrasive is present in the tooth-whitening composition at a concentration of at least about 20% by weight.
56. A method according to claim 45, wherein the alkaline compound is an alkali metal hydroxide or an alkali metal carbonate salt.
57. A method according to claim 45, wherein the alkaline compound is an alkaline compound selected from the group consisting of sodium hydroxide, potassium hydroxide, ammonium hydroxide, calcium hydroxide, magnesium hydroxide, sodium carbonate, potassium carbonate, ammonium carbonate, calcium carbonate, magnesium carbonate, sodium bicarbonate, potassium bicarbonate, ammonium bicarbonate, calcium bicarbonate, magnesium bicarbonate, urea, monoethanolamine, diethanolamine, triethanolamine, mono(iso)propanolamine, di(iso)propanolamine, tri(iso)propanolamine, 2-amino-2- methylpropanol, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-ethyl-1,3-propanediol, tris(hydrox ymethyl)aminomethane, N,N,N’N’-tetrakis(2-hydroxypropyl)ethylenediamine, di(2-ethylhexyl)amine, triamylamine, dodecylamine, morpholine and combinations thereof.
58. A method according to claim 45, wherein the second component of the two component system further comprises a second abrasive compound.
59. A method according to claim 58, wherein the second abrasive compound is a peroxide-incompatible abrasive compound.
60. A method according to claim 59, wherein the peroxide-incompatible abrasive compound comprises a silica compound or an alumina compound.
61. A method according to claim 58, wherein the second abrasive compound comprises one or more calcium phosphate salts.
62. A method according to claim 61, wherein the one or more calcium phosphate salts comprises calcium pyrophosphate.
63. A method according to claim 58, wherein the tooth-whitening composition has a total concentration of abrasive compounds in the dentifrice composition is at least about 20% by weight.
64. A method according to claim 45, wherein the second component further comprises a color indicator.
65. A method according to claim 64, wherein the color indicator is selected from the group consisting of FD&C Red No. 3, FD&C Yellow No. §, FD&C Yellow No. 6, FD&C Green No. 3, FD&C Blue No. 1 and combinations thereof.
66. A method according to claim 45, wherein either or both of the first or second components further comprise a tooth-desensitizing compound.
67. A method according to claim 66, wherein the tooth-desensitizing compound is a potassium salt of a weak acid or eugenol.
68. A method for decreasing whitening time, increasing whitening effectiveness or decreasing oral irritation in a tooth-whitening process, the method comprising contacting a tooth for an effective tooth-whitening period with a tooth-whitening composition comprising a peroxide compound at a hydrogen-peroxide-equivalent concentration of not greater than about 5% by weight and a peroxide-compatible abrasive compound, said tooth-whitening composition having a pH of at least about 9.0.
69. A method according to claim 68, wherein the tooth-whitening composition comprises the peroxide compound at a concentration of not more than about 3.5% by weight.
70. A method according to claims 68 or 69, wherein the tooth-whitening composition produces a decrease in whitening time, an increase in whitening effectiveness or a decrease in oral irritation or any combination thereof in comparison to a reference composition having a peroxide compound concentration of about 7% by weight or greater and a pH of 7.0 or less.
71. A method according to claims 68 or 69, wherein the tooth-whitening composition is prepared from a dual component system comprising a first component comprising a peroxide compound and a peroxide-compatible abrasive compound and a second component comprising an alkaline compound.
72. A method according to claim 71, wherein the tooth-whitening composition is prepared not more than 15 minutes prior said contacting. :
73. A method according to claims 68 or 69, wherein the contacting is for an effective tooth-whitening period which is less than that required for a comparative composition comprising hydrogen peroxide at a concentration of 7% by weight or greater and a pH of 7.0 or less.
74. A method according to claim 73 wherein the effective tooth-whitening period of the tooth-whitening composition is not more than about 20 minutes and that of comparative composition is about 30 minutes or greater.
75. A method according to claims 68 or 69, wherein the peroxide compound is selected from the group consisting of hydrogen peroxide, an organic peroxide compound, a hydrogen peroxide generating compound and combinations thereof.
76. A method according to claims 75, wherein the peroxide compound is an organic peroxide compound selected from the group consisting of urea hydrogen peroxide, glyceryl peroxide, benzoyl peroxide, monoperoxyphthalate and combinations thereof.
77. A method according to claim 75, wherein the peroxide compound is a hydrogen peroxide generating compound selected from the group consisting of sodium persulfate, sodium dipersulfate, sodium percarbonate, sodium perphosphate, sodium perborate, sodium persilicate, potassium persulfate, potassium dipersulfate, potassium percarbonate, potassium perphosphate, potassium perborate, potassium persilicate, calcium persulfate, calcium dipersulfate, calcium percarbonate, calcium perphosphate, calcium perborate, calcium persilicate, sodium peroxide, potassium peroxide and calcium peroxide and combinations thereof.
78. A method according to claims 68 or 69, wherein the peroxide-compatible abrasive comprises one or more calcium phosphate salts.
79. A method according to claim 78, wherein the one or more calcium phosphate salts comprise calcium pyrophosophate.
80. A method according to claims 68 or 69, wherein the peroxide-compatible abrasive is present in the tooth-whitening composition at a concentration of at least about 10% by weight.
81. A method according to claim 80, wherein the peroxide-compatible abrasive is present in the tooth-whitening composition at a concentration of at least about 20% by weight. :
82. A method according to claim 71, wherein the alkaline compound is an alkali metal hydroxide or an alkali metal carbonate salt.
83. A method according to claim 71, wherein the alkaline compound is an alkaline compound selected from the group consisting of sodium hydroxide, potassium hydroxide, ammonium hydroxide, calcium hydroxide, magnesium hydroxide, sodium carbonate, potassium carbonate, ammonium carbonate, calcium carbonate, magnesium carbonate,
sodium bicarbonate, potassium bicarbonate, ammonium bicarbonate, calcium bicarbonate, magnesium bicarbonate, urea, monoethanolamine, diethanolamine, triethanolamine, mono(iso)propanolamine, di(iso)propanolamine, tri(iso)propanolamine, 2-amino-2- methylpropanol, 2-amino-2-methyl-1 ,3-propanediol, 2-amino-2-ethyl-1,3-propanediol, tris(hydrox ymethyl)aminomethane, N,N, N’N’-tetrakis(2-hydrox ypropyl)ethylenediamine, di(2-ethylhexyl)amine, triamylamine, dodecylamine, morpholine and combinations thereof.
84. A method according to claim 71, wherein the second component of the two component system further comprises a second abrasive compound.
85. A method according to claim 84, wherein the second abrasive comprises a peroxide-incompatible abrasive compound.
86. A method according to claim 85, wherein the peroxide-incompatible abrasive comprises a silica compound or an alumina compound.
87. A method according to claim 84, wherein the second abrasive compound comprises one or more calcium phosphate salts.
88. A method according to claim 87, wherein the one or more calcium phosphate salts comprise calcium pyrophosphate.
89. A method according to claim 84, wherein the tooth-whitening composition has a total concentration of abrasive compounds in the dentifrice composition is at least about 20% by weight.
90. A method according to claim 71, wherein the second component further comprises a color indicator.
91. A method according to claim 90, wherein the color indicator is selected from the group consisting of FD&C Red No. 3, FD&C Yellow No. 5, FD&C Yellow No. 6, FD&C Green No. 3, FD&C Blue No. 1 and combinations thereof.
92. A method according to claim 71, wherein either or both of the first or second components further comprise a tooth-desensitizing compound.
93, A method according to claim 92, wherein the tooth-desensitizing compound is a potassium salt of a weak acid or eugenol.
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ZA200606072A ZA200606072B (en) | 2004-01-26 | 2006-07-21 | Dental-bleaching compositions and methods with reduced peroxide concentration |
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Country | Link |
---|---|
EP (1) | EP1718368A1 (en) |
CN (1) | CN1933800A (en) |
AR (1) | AR047457A1 (en) |
AU (1) | AU2005209271A1 (en) |
BR (1) | BRPI0507098A (en) |
CA (1) | CA2553672A1 (en) |
RU (1) | RU2391964C2 (en) |
TW (1) | TW200534874A (en) |
WO (1) | WO2005072692A1 (en) |
ZA (1) | ZA200606072B (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010132126A1 (en) * | 2009-05-14 | 2010-11-18 | Nuvora, Inc. | Flavored tooth-whitening composition in the form of a sustained release matrix |
US20150342839A1 (en) | 2010-04-21 | 2015-12-03 | Oraceutica LLC | Compositions and methods for whitening teeth |
EP2561447A2 (en) * | 2010-04-21 | 2013-02-27 | Discus Dental, LLC | Method of simultaneously cleaning and whitening teeth |
US8888489B2 (en) | 2012-10-23 | 2014-11-18 | Oraceutical Llc | Method of simultaneously cleaning and whitening teeth |
AU2012395816B2 (en) * | 2012-11-30 | 2015-09-03 | Colgate-Palmolive Company | Color-stable oral care compositions |
AU2012397231B2 (en) * | 2012-12-21 | 2015-10-22 | Colgate-Palmolive Company | Controlled delivery whitening compositions |
US9320580B2 (en) | 2013-04-21 | 2016-04-26 | Oraceutical Llc | Hand-held tooth whitening instrument with applicator reservoir for whitening composition and methods of using same |
RU2664940C2 (en) * | 2013-05-24 | 2018-08-23 | Солвей Са | Non-oxidizing particles |
WO2015084296A1 (en) * | 2013-12-02 | 2015-06-11 | Colgate-Palmolive Company | Two part oxidizing system for oral care compositions |
CA2945215C (en) | 2014-05-15 | 2019-09-17 | The Procter & Gamble Company | Oral care compositions containing polyethylene glycol for physical stability |
CN106456459B (en) * | 2014-05-15 | 2020-09-04 | 宝洁公司 | Oral care compositions comprising polyethylene glycol to provide physical stability |
MX2019004739A (en) | 2016-10-26 | 2019-09-26 | Procter & Gamble | Electromagnetic radiation source and multi-phase oral composition for oral care use. |
EP3811922A1 (en) * | 2019-10-24 | 2021-04-28 | Koninklijke Philips N.V. | Kit, system and method for preparing and use of a peroxide-containing composition |
EP3881677A1 (en) * | 2020-03-18 | 2021-09-22 | Corticalis AS | A multi-functional cleaning and/or debridement composition |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5648064A (en) * | 1995-07-07 | 1997-07-15 | Gaffar; Abdul | Oral compositions having accelerated tooth whitening effect |
US5849269A (en) * | 1996-11-26 | 1998-12-15 | The Procter & Gamble Company | Oral compositions containing fluoride, pyrophosphate, peroxide, and nonionic and/or amphoteric surfactants |
WO1998031331A1 (en) * | 1997-01-15 | 1998-07-23 | Unilever N.V. | A method for whitening teeth |
US5928628A (en) * | 1997-10-23 | 1999-07-27 | Pellico; Michael A. | Two-component dental bleaching system and method |
US20040062723A1 (en) * | 2002-09-27 | 2004-04-01 | Zaidel Lynette A. | Dual component tooth whitening dentifrice |
-
2005
- 2005-01-25 RU RU2006130793/15A patent/RU2391964C2/en not_active IP Right Cessation
- 2005-01-25 EP EP05711997A patent/EP1718368A1/en not_active Withdrawn
- 2005-01-25 CN CNA2005800089349A patent/CN1933800A/en active Pending
- 2005-01-25 TW TW94102074A patent/TW200534874A/en unknown
- 2005-01-25 BR BRPI0507098-8A patent/BRPI0507098A/en not_active IP Right Cessation
- 2005-01-25 AR ARP050100250A patent/AR047457A1/en unknown
- 2005-01-25 WO PCT/US2005/002332 patent/WO2005072692A1/en not_active Application Discontinuation
- 2005-01-25 CA CA002553672A patent/CA2553672A1/en not_active Abandoned
- 2005-01-25 AU AU2005209271A patent/AU2005209271A1/en not_active Abandoned
-
2006
- 2006-07-21 ZA ZA200606072A patent/ZA200606072B/en unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0507098A (en) | 2007-06-19 |
TW200534874A (en) | 2005-11-01 |
CA2553672A1 (en) | 2005-08-11 |
WO2005072692A1 (en) | 2005-08-11 |
AU2005209271A1 (en) | 2005-08-11 |
AR047457A1 (en) | 2006-01-18 |
CN1933800A (en) | 2007-03-21 |
RU2391964C2 (en) | 2010-06-20 |
RU2006130793A (en) | 2008-03-10 |
EP1718368A1 (en) | 2006-11-08 |
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