ZA200605610B - Device for dosing a product that is intended to be applied to the skin - Google Patents
Device for dosing a product that is intended to be applied to the skin Download PDFInfo
- Publication number
- ZA200605610B ZA200605610B ZA200605610A ZA200605610A ZA200605610B ZA 200605610 B ZA200605610 B ZA 200605610B ZA 200605610 A ZA200605610 A ZA 200605610A ZA 200605610 A ZA200605610 A ZA 200605610A ZA 200605610 B ZA200605610 B ZA 200605610B
- Authority
- ZA
- South Africa
- Prior art keywords
- compartments
- contain
- medication
- silkis
- area
- Prior art date
Links
- 239000003814 drug Substances 0.000 claims description 29
- 229940079593 drug Drugs 0.000 claims description 29
- GMRQFYUYWCNGIN-ZVUFCXRFSA-N 1,25-dihydroxy vitamin D3 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-ZVUFCXRFSA-N 0.000 claims description 18
- 201000004681 Psoriasis Diseases 0.000 claims description 4
- 239000002537 cosmetic Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- 230000000875 corresponding effect Effects 0.000 claims 7
- 239000003086 colorant Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 239000006071 cream Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000004705 lumbosacral region Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229940126702 topical medication Drugs 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D40/00—Casings or accessories specially adapted for storing or handling solid or pasty toiletry or cosmetic substances, e.g. shaving soaps or lipsticks
- A45D40/26—Appliances specially adapted for applying pasty paint, e.g. using roller, using a ball
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
oo EE
Device for metering a product intended for application to the skin
The present invention concerns the metering of a product for topical application such as a medication. The in vention is intended to provide a new dewice for metering products intended to be applied to the skin, in particular pharmaceutical or cosmetic products. The invention welates more particularly to a device taking the form of an applicator stick, the graduations of which allow users to determine the precise quantity of medication to be applie d to the skin as a function of the surface are a to be treated.
With regard to medication intended to be applied to the skin, it iss known that the efficacy of topical medication depends inter alia on their dosage. W hether formulated as a cream, ointment, foam, liquid, or as adhesives such as patche=s, the medication intended for topical application is not packed in a device allowing optimum metering.
Thus when the medication intended for topical application is packed in the form of a tube or simple bottle, the precise dose to be applied of said drug carnot be calibrated by the user.
There are however numerous metering distributors. Some have a ssiphon-like device which require pumping-like. manipulation by the user; they often comprise a high number of parts which makes production difficult. Other metering dis tributors are fitted with a piston-type devicee but as the quantity of product supplied is a function of the pressure exerted by the u ser, these are not reliable.
Furthermore these meteri ng distributors are fitted with a system allow ing issue of only a single dose of the product.
To remedy the above dra wbacks, the applicant has now developed aan optimum device for metering a medicatio n intended to be applied to the skin, whe re the quantity of medication applied is pre cise and can be modulated as a function of the surface of the skin to be treated; this allows better efficacy of the treatment.
This aim is achieved tharks to a device for metering a product interded to be applied to the skin, in particular a pharmaceutical or cosmetic composition, comprising an applicator stick with a longitudinal groove along which is defined a series of compartments, said groo ve being able to hold a quantity of medication corresponding to a defined surface area of the skin to be treated, the quantity being defined by one or more compartments.
. oo 2
SRR IER F-
Advantageously the applicator is fitted with graduations which, from one end of the groove corresponding to the start of the first compartment and for the following compartments, define the quantity of medication in the compartments of the groove.
Following a particular method of implementation, the device of the present invention comprises at least two, preferably at least three and most preferably four compartments.
Said compartments may have the same or different dimension and in the latter case compartments of increasing dimension are preferred. The term dimension here preferably means the length of the compartment but a variant of the invention consists of varying the depth or width of the groove continuously or from one compartment to the other.
Preferably the graduation of the applicator stick is selected from a graduated scale, protuberances, notches, a set of «olours or a combination thereof. The graduation of the applicator stick may be arranged inside and/or outside the groove.
According to a particular method of implementation, the device preferably comprises at least at one end of the applicator stick, a surface designed for manipulation. This may for example be a flared portion at one end of the applicator stick.
According to preferred embodimerats of the invention: - the first compartment is able ®o contain a quantity of medication corresponding approximately to an area of 0.8 to 1.2% of the total surface of the body, preferably around 1% of the total surface of the body; - the first and second compartm ents are able to contain a quantity of medication corresponding approximately to ara area of 2.4 to 3.6% of the total surface of the body, preferably around 3% of the total s urface of the body; - the first, second and third compartments are able to contain a quantity of medication corresponding approximately to arm area of 4.8 to 7.1% of the total surface of the body, preferably around 6% of the total s urface of the body; - the first, second, third and fourth compartments are able to contain a quantity of medication corresponding approxirmately to an area of 7.2 to 10.8% of the total surface of the body, preferably 9% of the total surface of the body.
Lo. I ’ 3 oo SEEN a ' E i} EE CA
The device according to the invention is remarkable in that it can be re-used by the patient, it is adapted to any form of presentation of the drugs for topical apeplication, for example liquid, semi-liquid, gel, ointment, cream or powder.
The device according to the invention can be made of any impermeamble material meeting hygiene requirements, such as glass, metal, flexible or rigid plastics.
A specific application of the de vice according to the invention relates to metering of a drug intended to treat psoriasis, said drug preferably being Silkis. For this as pplication: - the first compartment is able to contain a quantity of Silkis of around «0.35 to 0.54 grams (g), preferably 0.45 grams; - the first and second compartments are able to contain a quantity of Silkzis of around 1.08 to 1.62 grams, preferably 1.30 grams; - the first, second and third compartments are able to contain a quantity of Silkis of around 2.16 to 3.20 grams, preferably 2.60 grams; - the first, second, third and fou rth compartments are able to contain a qua ntity of Silkis of around 3.24 to 4.86 grams, preferably 3.90 grams;
Other advantages and features of the invention will appear from the example below concerning a device for metering Silkis for the treatment of psoriasis, given as an illustrative example and not to be interpreted as limiting the scope of the in vention, and in which reference will be made to the attached drawings in which: - Figure 1 shows an oblique top view of the metering device. - Figure 2 shows a top view of the metering device. - Figure 3 shows a profile view of the metering device. - Figure 4 shows a vertical section through the metering device.
Figures 1, 2 and 3 represent a metering device according to the inventiorn comprising an applicator stick (1) of oblong shape provided with graduations formed by protuberances (4). The applicator stick comprises a longitudinal groove (22 fitted with a series of compartments (3) and having at one end a flared circular pat (5), which facilitates handling of said applicator stick.
In the present example the applicator stick (1) is of oblong shape meastaring 158mm long, 32mm wide at the level of the end with the circular portion (5) and 1° 7mm wide at the other end. The groove (22), of width 7mm and depth 2mm, externds along a
. | | 4
FEAL) longitudinal axis over 126mm. This groove iss divided into four compartments (3a, 3b, 3c and 3d) by protuberances (4). The first cosmpartment (3a) defines a volume of 7mm width, 2mm depth and 14mm length. The se=cond compartment (3b) defines a volume of 7mm width, 2mm depth and 28mm Rength. The third (3c) and fourth (3d)
La) compartment each define a volume of 7mm wwvidth, 2mm depth and 42mm length.
Figures 3 and 4 show a metering device according to the invention with a longitudinal bulge (6) on the lower face of the applicator stick (1), which constitutes the base of the groove (2) or a means allowing inclination of fhe device when flat.
Example 1 1) Definition of body surfaces to be treated
To define the body surfaces to be treated ir the treatment of psoriasis, the applicant uses a proposition derived from Wallace's 9%% rule. The applicant has thus determined the following body surface area percentages (expressed in relation to the total surface area of the body): - inguinal fold: between abdomen and thigh = 1% - gluteal fold = 1% (3% of back) - lumbar region = 3% - face = 9%: 1% per ear, 1% per eyebrow, 1%% chin, 1% per nasal fold, 2% forehead 2) Determination of Silkis dose
Given that the maximum dose of Silkis that can be used per day is 30 grams in two applications and the maximum treatable surface area of the body is 35% of the total body surface, the applicant has established the optimum dose of Silkis as 30/2/35% or 0.43 grams per percentage body surface to b e treated per application.
Table 1 shows the correlation between the percentage of body surface to be treated and the Silkis dose.
Err CR ER CON CR
Table 1
Claims (26)
1. Metering device for a product intended to be applied to the skin, characterised i nN that it comprises an applicator stick with a longitudinal groove along which i-S defined a series of compartments, said groove being able to accommodate & quantity of medication corresponding to a defined surface area of the skin to bea treated, this quantity being defined by ome or more compartments.
2. Device according to claim 1, characterised in that the product is a pharmaceutical or cosmetic composition.
3. Device according to either claims 1 or 2, characterised in that the applicator stick is fitted with graduations which, from one= end of the groove corresponding to the start of a first compartment and for follow ing compartments, define the quantity of medication in the compartments of the groove.
4. Device according to any one of the pre=ceding claims, characterised in that it comprises at least two compartments.
5. Device according to claim 4, characterised in that it comprises at least three compartments.
6. Device according to claim 5, characterised in that it comprises four compartments.
7. Device according to any one of claims 3 to 6, characterised in that the graduation of the applicator stick is selected from: a graduated scale, protuberances, notches, and a set of colours or a combinati on thereof.
8. Device according to any one of claims 3 to 7, characterised in that the first compartment is able to contain a quantity of” medication corresponding to an area of 0.8 to 1.2% of the total surface of the body.
9. Device according to claim 8, characterised ir that the first compartment is able to contain a quantity of medication correspording to an area of 1% of the total surface of the body. AMENDED SHEET
SE 6
10. Device according to any one of claims 3 to 9, characterised in that tlhe first and a second compartments are able to contain a quantity of medication ceorresponding to an area of 2.4 to 3.6% of the total surface of the body.
11. Device according to claim 10, characterised in that the first and second compartments are able to contain a quantity of medication corresponding to 3% of the total surface of the body.
12. Device according ®o any one of claims 3 to 11, characterised in that the first, the second and a thir d compartments are able to contain a quantity of medication corresponding to aan area of 4.8 to 7.1% of the total surface of the body.
13. Device according -to claim 12, characterised in that the first, the second and the third compartmentss are able to contain a quantity of medication corr-esponding to 6% of the total surface of the body.
14. Device according fo any one of claims 3 to 13, characterised in that: the first, the second, the third and a fourth compartments are able to contain a quantity of medication correspoonding to an area of 7.2 to 10.8% of the total s urface of the body.
15. Device according to claim 14, characterised that the first, the second, the third and the fourth compartments are able to contain a quantity of medication corresponding to aan area of 9% of the total surface of the body.
16. Device for meterimg a drug intended to be applied to the skin according to any one of claims 3 tom 15, characterised in that said medication is intemnded to treat psoriasis.
17. Device according t o claim 16, characterised in that the medication is Silkis.
18. Device according ®o claim 17, characterised in that the first compartment is able to contain a quanti-ty of 0.36g to 0.54g of Silkis. AMENDED SHEET
-L .
19. Device according to claim 18, characterised in that the first cormnpartment is able to contain a quantity of 0.45g of Silkis.
20. Device according to claim 17, characterised in that the first and the second compartments are able to contain a quantity of 1.08g to 1.62g of Silkis.
21. Device accordings to claim 20, characterised in that the first and the second compartments are able to contain a quantity of 1.30g of Silkis.
22. Device according to claim 17, characterised in that the first, the second and the third compartmen ts are able to contain a quantity of 2.16g to 3.2 Og of Silkis.
23. Device according to claim 22, characterised in that the first, the second and the third compartmen ts are able to contain a quantity of 2.60g of Silkis.
24. Device accordings to any one of the preceding claims, characterised in that the first, the second, the third and fourth compartments are able to contain a quantity of 3.24g to 4.86g of Silkis.
25. Device according to claim 24, characterised in that the first, the second, the third and fourth compaartments are able to contain a quantity of 3.90g of Silkis.
26. Metering device for a product intended to be applied to the skin as claimed in claim 1, substan-tially as herein described and illustrated with reference to any one of Figures 1 ®&o 4 of the drawings. AMENDED SHEET
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0314335A FR2863174B1 (en) | 2003-12-08 | 2003-12-08 | DEVICE FOR DETERMINING A PRODUCT INTENDED TO BE APPLIED ON THE SKIN |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200605610B true ZA200605610B (en) | 2007-11-28 |
Family
ID=34586356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200605610A ZA200605610B (en) | 2003-12-08 | 2006-07-07 | Device for dosing a product that is intended to be applied to the skin |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7727204B2 (en) |
| EP (1) | EP1696892A1 (en) |
| JP (1) | JP2007517546A (en) |
| KR (1) | KR101187232B1 (en) |
| CN (1) | CN1889936A (en) |
| AU (1) | AU2004296576B2 (en) |
| BR (1) | BRPI0416431A (en) |
| CA (1) | CA2547673C (en) |
| FR (1) | FR2863174B1 (en) |
| MX (1) | MXPA06006359A (en) |
| RU (1) | RU2349307C2 (en) |
| WO (1) | WO2005055992A1 (en) |
| ZA (1) | ZA200605610B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100100060A1 (en) * | 2008-10-17 | 2010-04-22 | Novartis Ag | Applicator for pharmaceutical product and method of using same |
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| GB0102701D0 (en) * | 2001-02-05 | 2001-03-21 | Midland Cosmetic Sales Plc | Device |
| US7117874B2 (en) * | 2001-08-17 | 2006-10-10 | E-L Management Corp. | Case for presenting and using cosmetic powders |
| DE10246206A1 (en) * | 2002-04-17 | 2003-11-06 | Mvb Gmbh | Topical composition, useful e.g. for treating skin diseases, pruritis or eczema, comprises agglomerated smoke obtained from smouldering newspaper |
| AU2003223005A1 (en) * | 2002-05-06 | 2003-11-17 | Vectura Limited | Application device for topical administration of pharmaceutical agents |
| US7122712B2 (en) * | 2002-12-02 | 2006-10-17 | Lutri Thomas P | Surgical bandage and methods for treating open wounds |
-
2003
- 2003-12-08 FR FR0314335A patent/FR2863174B1/en not_active Expired - Fee Related
-
2004
- 2004-12-02 JP JP2006541978A patent/JP2007517546A/en active Pending
- 2004-12-02 WO PCT/FR2004/003100 patent/WO2005055992A1/en active Application Filing
- 2004-12-02 BR BRPI0416431-8A patent/BRPI0416431A/en not_active IP Right Cessation
- 2004-12-02 CN CNA2004800364515A patent/CN1889936A/en active Pending
- 2004-12-02 CA CA2547673A patent/CA2547673C/en not_active Expired - Fee Related
- 2004-12-02 RU RU2006124565/15A patent/RU2349307C2/en not_active IP Right Cessation
- 2004-12-02 AU AU2004296576A patent/AU2004296576B2/en not_active Ceased
- 2004-12-02 MX MXPA06006359A patent/MXPA06006359A/en active IP Right Grant
- 2004-12-02 US US10/582,214 patent/US7727204B2/en not_active Expired - Fee Related
- 2004-12-02 KR KR1020067011290A patent/KR101187232B1/en not_active IP Right Cessation
- 2004-12-02 EP EP04805619A patent/EP1696892A1/en not_active Withdrawn
-
2006
- 2006-07-07 ZA ZA200605610A patent/ZA200605610B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2863174A1 (en) | 2005-06-10 |
| KR101187232B1 (en) | 2012-10-02 |
| FR2863174B1 (en) | 2006-11-24 |
| EP1696892A1 (en) | 2006-09-06 |
| BRPI0416431A (en) | 2007-02-21 |
| JP2007517546A (en) | 2007-07-05 |
| US7727204B2 (en) | 2010-06-01 |
| AU2004296576A1 (en) | 2005-06-23 |
| RU2349307C2 (en) | 2009-03-20 |
| CA2547673C (en) | 2013-07-02 |
| RU2006124565A (en) | 2008-01-20 |
| WO2005055992A1 (en) | 2005-06-23 |
| KR20060123276A (en) | 2006-12-01 |
| US20070191792A1 (en) | 2007-08-16 |
| AU2004296576B2 (en) | 2010-08-05 |
| MXPA06006359A (en) | 2006-08-23 |
| CA2547673A1 (en) | 2005-06-23 |
| CN1889936A (en) | 2007-01-03 |
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