ZA200605341B - Sulfonamide derivatives for the treatment of diseases - Google Patents

Info

Publication number

ZA200605341B

ZA200605341B ZA200605341A ZA200605341A ZA200605341B ZA 200605341 B ZA200605341 B ZA 200605341B ZA 200605341 A ZA200605341 A ZA 200605341A ZA 200605341 A ZA200605341 A ZA 200605341A ZA 200605341 B ZA200605341 B ZA 200605341B

Authority

ZA

South Africa

Prior art keywords

hydroxy

amino

phenyl

ethyl

acetamide

Prior art date

2004-01-22

Links

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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 34
• 201000010099 disease Diseases 0.000 title claims description 28
• 238000011282 treatment Methods 0.000 title claims description 26
• 229940124530 sulfonamide Drugs 0.000 title description 5
• 150000003456 sulfonamides Chemical class 0.000 title description 5
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 217
• 150000001875 compounds Chemical class 0.000 claims description 159
• -1 CFs Chemical group 0.000 claims description 77
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 62
• 239000000203 mixture Substances 0.000 claims description 55
• 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 52
• 238000000034 method Methods 0.000 claims description 49
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 48
• 150000003839 salts Chemical class 0.000 claims description 42
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• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 39
• 125000000217 alkyl group Chemical group 0.000 claims description 34
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 34
• 239000002904 solvent Substances 0.000 claims description 31
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 30
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• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 24
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• 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 claims description 4
• FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 claims description 3
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