ZA200507244B - Aerosol antiperspirant with polyamide Pyrrolo-dihydroisoquinoline derivatives as PDE10 inhibitors - Google Patents
Aerosol antiperspirant with polyamide Pyrrolo-dihydroisoquinoline derivatives as PDE10 inhibitors Download PDFInfo
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- ZA200507244B ZA200507244B ZA200507244200507244A ZA200507244A ZA200507244B ZA 200507244 B ZA200507244 B ZA 200507244B ZA 200507244200507244 A ZA200507244200507244 A ZA 200507244200507244A ZA 200507244 A ZA200507244 A ZA 200507244A ZA 200507244 B ZA200507244 B ZA 200507244B
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- weight
- antiperspirant
- silicone
- polyamide
- Prior art date
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- 230000001166 anti-perspirative effect Effects 0.000 title claims description 27
- 239000003213 antiperspirant Substances 0.000 title claims description 27
- 239000000443 aerosol Substances 0.000 title claims description 24
- 239000004952 Polyamide Substances 0.000 title claims description 16
- 229920002647 polyamide Polymers 0.000 title claims description 16
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 claims description 31
- 229920001296 polysiloxane Polymers 0.000 claims description 14
- 239000003380 propellant Substances 0.000 claims description 13
- 239000002781 deodorant agent Substances 0.000 claims description 12
- 239000007789 gas Substances 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 125000002947 alkylene group Chemical group 0.000 claims description 10
- 229910052782 aluminium Inorganic materials 0.000 claims description 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 9
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 claims description 8
- -1 benzoate ester Chemical class 0.000 claims description 8
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims description 7
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 7
- 239000003205 fragrance Substances 0.000 claims description 7
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 7
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 6
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims description 6
- NPNPZTNLOVBDOC-UHFFFAOYSA-N 1,1-difluoroethane Chemical compound CC(F)F NPNPZTNLOVBDOC-UHFFFAOYSA-N 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 6
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 claims description 6
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000004599 antimicrobial Substances 0.000 claims description 6
- 239000003086 colorant Substances 0.000 claims description 6
- 229940086555 cyclomethicone Drugs 0.000 claims description 6
- 229920001971 elastomer Polymers 0.000 claims description 6
- 239000000806 elastomer Substances 0.000 claims description 6
- 239000003349 gelling agent Substances 0.000 claims description 6
- 239000004615 ingredient Substances 0.000 claims description 6
- 239000002480 mineral oil Substances 0.000 claims description 6
- 229920002050 silicone resin Polymers 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims description 5
- 150000001298 alcohols Chemical class 0.000 claims description 5
- 229940008099 dimethicone Drugs 0.000 claims description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 239000004677 Nylon Substances 0.000 claims description 4
- 150000001924 cycloalkanes Chemical class 0.000 claims description 4
- 238000004821 distillation Methods 0.000 claims description 4
- 239000003974 emollient agent Substances 0.000 claims description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 4
- 235000010446 mineral oil Nutrition 0.000 claims description 4
- 229920001778 nylon Polymers 0.000 claims description 4
- 239000003921 oil Substances 0.000 claims description 4
- 239000002304 perfume Substances 0.000 claims description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- 229940051271 1,1-difluoroethane Drugs 0.000 claims description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 3
- 239000001569 carbon dioxide Substances 0.000 claims description 3
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical class CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 claims description 3
- 229930195733 hydrocarbon Natural products 0.000 claims description 3
- 150000002430 hydrocarbons Chemical class 0.000 claims description 3
- 239000011261 inert gas Substances 0.000 claims description 3
- 239000003915 liquefied petroleum gas Substances 0.000 claims description 3
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 claims description 3
- 239000001272 nitrous oxide Substances 0.000 claims description 3
- 239000001294 propane Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 2
- 125000005910 alkyl carbonate group Chemical group 0.000 claims description 2
- 150000005215 alkyl ethers Chemical class 0.000 claims description 2
- 125000005189 alkyl hydroxy group Chemical group 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims description 2
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 150000002170 ethers Chemical class 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical class C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 2
- 239000011368 organic material Substances 0.000 claims description 2
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical compound CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 9
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 8
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical class [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 8
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical class Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 8
- ZGUQGPFMMTZGBQ-UHFFFAOYSA-N [Al].[Al].[Zr] Chemical compound [Al].[Al].[Zr] ZGUQGPFMMTZGBQ-UHFFFAOYSA-N 0.000 description 7
- WYANSMZYIOPJFV-UHFFFAOYSA-L aluminum;2-aminoacetic acid;zirconium(4+);chloride;hydroxide;hydrate Chemical compound O.[OH-].[Al+3].[Cl-].[Zr+4].NCC(O)=O WYANSMZYIOPJFV-UHFFFAOYSA-L 0.000 description 7
- 239000004471 Glycine Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 5
- 239000002585 base Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 229910052726 zirconium Inorganic materials 0.000 description 5
- 229940048506 aluminum zirconium tetrachlorohydrex gly Drugs 0.000 description 4
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- UHUFTBALEZWWIH-UHFFFAOYSA-N myristic aldehyde Natural products CCCCCCCCCCCCCC=O UHUFTBALEZWWIH-UHFFFAOYSA-N 0.000 description 3
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- YCLAMANSVUJYPT-UHFFFAOYSA-L aluminum chloride hydroxide hydrate Chemical compound O.[OH-].[Al+3].[Cl-] YCLAMANSVUJYPT-UHFFFAOYSA-L 0.000 description 2
- 229940072028 aluminum zirconium trichlorohydrex gly Drugs 0.000 description 2
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical class ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 2
- 239000001282 iso-butane Substances 0.000 description 2
- QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- NKJOXAZJBOMXID-UHFFFAOYSA-N 1,1'-Oxybisoctane Chemical compound CCCCCCCCOCCCCCCCC NKJOXAZJBOMXID-UHFFFAOYSA-N 0.000 description 1
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- BDEHGQOUMOLWCN-UHFFFAOYSA-N 16-methylheptadecyl benzoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)C1=CC=CC=C1 BDEHGQOUMOLWCN-UHFFFAOYSA-N 0.000 description 1
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- LNRUVXAPKCPQGX-UHFFFAOYSA-N 2-octyldodecyl benzoate Chemical compound CCCCCCCCCCC(CCCCCCCC)COC(=O)C1=CC=CC=C1 LNRUVXAPKCPQGX-UHFFFAOYSA-N 0.000 description 1
- XXBAQTDVRLRXEV-UHFFFAOYSA-N 3-tetradecoxypropan-1-ol Chemical compound CCCCCCCCCCCCCCOCCCO XXBAQTDVRLRXEV-UHFFFAOYSA-N 0.000 description 1
- 229920004511 Dow Corning® 200 Fluid Polymers 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- DNXNYEBMOSARMM-UHFFFAOYSA-N alumane;zirconium Chemical compound [AlH3].[Zr] DNXNYEBMOSARMM-UHFFFAOYSA-N 0.000 description 1
- 229940053431 aluminum sesquichlorohydrate Drugs 0.000 description 1
- 229940048496 aluminum zirconium pentachlorohydrex gly Drugs 0.000 description 1
- YXZZLAMCXFHTTE-UHFFFAOYSA-N aluminum;propane-1,2-diol;trihypochlorite;hydrate Chemical compound O.[Al+3].Cl[O-].Cl[O-].Cl[O-].CC(O)CO YXZZLAMCXFHTTE-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000012612 commercial material Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- LVYZJEPLMYTTGH-UHFFFAOYSA-H dialuminum chloride pentahydroxide dihydrate Chemical compound [Cl-].[Al+3].[OH-].[OH-].[Al+3].[OH-].[OH-].[OH-].O.O LVYZJEPLMYTTGH-UHFFFAOYSA-H 0.000 description 1
- XILPPDQAWPSZIL-UHFFFAOYSA-H dialuminum;dichloride;tetrahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[Al+3].[Al+3].[Cl-].[Cl-] XILPPDQAWPSZIL-UHFFFAOYSA-H 0.000 description 1
- KNXDJTLIRRQLBE-UHFFFAOYSA-H dialuminum;propane-1,2-diol;chloride;pentahydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[OH-].[OH-].[Al+3].[Al+3].[Cl-].CC(O)CO KNXDJTLIRRQLBE-UHFFFAOYSA-H 0.000 description 1
- AFABGHUZZDYHJO-UHFFFAOYSA-N dimethyl butane Natural products CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 1
- 238000007046 ethoxylation reaction Methods 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229960001679 octinoxate Drugs 0.000 description 1
- 229960003921 octisalate Drugs 0.000 description 1
- WCJLCOAEJIHPCW-UHFFFAOYSA-N octyl 2-hydroxybenzoate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1O WCJLCOAEJIHPCW-UHFFFAOYSA-N 0.000 description 1
- ADGFKRMKSIAMAI-UHFFFAOYSA-L oxygen(2-);zirconium(4+);chloride;hydroxide Chemical compound [OH-].[O-2].[Cl-].[Zr+4] ADGFKRMKSIAMAI-UHFFFAOYSA-L 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229940057874 phenyl trimethicone Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229940116987 ppg-3 myristyl ether Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- DHWLRNPWPABRBG-UHFFFAOYSA-N tridecyl 2,2-dimethylpropanoate Chemical compound CCCCCCCCCCCCCOC(=O)C(C)(C)C DHWLRNPWPABRBG-UHFFFAOYSA-N 0.000 description 1
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 description 1
- 150000003754 zirconium Chemical class 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
AEROSOL ANTIPERSPIRANT WITH POLYAMIDE
Field of the Invention ’ 5 This invention relates to aerosol compositions that have improved properties.
These improvements include easier manufacturing control and reproducibility. The manufactured products help alleviate hard packing of the antiperspirant active to the bottom of the can. This ensures that the active ingredient is dispensed evenly when the product is used.
Selected polyamides as gellants have been disclosed in previous cases owned by the same owner as this invention. It has now been found that this material can advantageously be used in aerosol compositions under certain conditions.
The invention comprises an aerosol product comprising: (a) about 2 - 20 weight % cyclomethicone (especially 5%) (particularly D5, D6 or mixtures of DS and D6); (b) about 1 - 8 weight % isopropyl palmitate (especially 2.2%); (c) about 0.5 - 3.5 weight % mineral oil (especially 0.7%); (d) about 0.3 - 4 weight % isostearyl alcohol (especially 0.6 %0); (e) about 0.1 - 1.5 weight % Nylon 611/dimethicone copolymer (especially 0.3%); (f) about 5 - 25 weight % of a solid antiperspirant active (especially 10%); (g) optionally about 0.3 - 2.0 weight % of a perfume oil (especially 1.0%); and (h) about 37- 90 weight % of a propellant gas (especially 83%); wherein the amounts are based on the total weight of the composition.
The aerosol formulation is made from: . 30 (a) a solvent system for the gellant in an amount of up to 36% of the total formula, ! wherein the solvent system is compatible with the siliconized polyamide and the ; solvent system comprises one or more members is selected from the group consisting of: (1) from 1.5 - 16% by weight based on the total weight of the composition of at least one non-silicone organic material selected from the group consisting of C12 - 36 esters (for example, tridecyl neopentanoate, ethyl oleate, dioctyl carbonate, isopropy! palmitate, octyl methoxycinnamate); extra light to heavy white mineral oils with ) viscosity ranging from 6.5 - 110 centistokes at 40 degrees C; guerbet alcohols having 8 - 30 carbons; fatty alcohols having 8 - 30 carbons; ethoxylated and propoxylated alcohols having 3 - 30 carbons (for example, PPG-14 butyl ether, and PPG-3 myristyl ether); alkyl ethers having 12 - 36 carbons (for example, dioctyl ether); C12 - 18 alkyl benzoate and benzoate ester derivatives (for example, C12-15 alkyl benzoate, isostearyl benzoate and octyl dodecyl benzoate, octyl salicylate); and paraffins having a distillation temperature in the range of 372 - 426 degrees C; isoparaffins having a distillation temperature in the range of 178 - 207 degrees C, alkyl carbonates (for example, dioctyl carbonate); (2) from 2 - 20% by weight based on the total weight of the composition of a volatile silicone selected from the group consisting of cyclomethicone and low viscosity dimethicones (for example, Dow Corning 200 Fluid/2 centistokes or less from Dow Corning, Midland, MI); and (3) from 0-10% organo-silicones such as phenyl trimethicone.
This solvent system consists of one or more of the above listed ingredients. The solvent system also allows the compositions of the invention to be processed at lower temperatures (for example, temperatures in the range of about 60 to 90 degrees C or lower). This is important in reducing the evaporation of volatile materials from the composition during manufacturing and processing. It should also be noted that many of the solvents described have emollient characteristics in the overall formula. (b) from 0.1 - 1.5% by weight based on the total weight of the composition of at least one siliconized polyamide of Formula IIIA as a gellant:
Rl RZ {COPS SICIONHY-AH
Ll
Formula ITIA
. | WO 2004/078125 PCT/US2004/006164 where: : (1) DP is a number in the range of 5-30, particularly 12-18 (especially 15); (2) n is a number selected from the group consisting of 1-500 (especially 52); (3) X is a linear or branched chain alkylene having 1-30 carbons (especially 10); (4) Y is selected from the group consisting of linear and branched chain alkylenes having 1-40 carbons (especially 6), wherein: (al) the alkylene group may optionally and additionally contain in the alkylene portion at least one of the members of a group consisting of (i) 1-3 amide linkages; (ii) C5 or C6 cycloalkane (as a cycloalkylene linkage); and (iii) phenylene optionally substituted by 1-3 members selected independently from the group consisting of C1-C3 alkyls; and (bl) the alkylene group itself may optionally be substituted by at least one member selected from the group consisting of (i) hydroxy; (ii) C3-C8 cycloalkane; (iii) 1-3 members selected independently from the group consisting of C1-C3 alkyls; phenyl optionally substituted by 1-3 members selected independently from the group consisting of C1-C3 alkyls; (iv) C1 - C3 alkyl hydroxy; and (v) C1 - C6 alkyl amine; or Y = Z* where 7? =R¥™.T-R*\. 12 wherein each of R*, R* are independently selected from the group consisting of linear and branched C1-C10 alkylenes; R* is selected from the group consisting of linear and branched C1-C10 alkanes; and T is selected from the group consisting of (i) a trivalent atom selected from N, P and Al; and (ii) -CR, where R is selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, a siloxane chain, and phenyl, wherein the phenyl may * 30 optionally be substituted by 1-3 members from the group consisting of methyl and ethyl, especially methyl and ethyl and most especially methyl; and (5) each of R'-R%is independently selected from the group consisting of methyl, ethyl, propyl, isopropyl, a siloxane chain, and phenyl, wherein the phenyl may optionally be substituted by 1-3 members from the group consisting of methyl and ethyl
(with more particular values for R'-R* being selected from methyl and ethyl and especially methyl); wherein the polyamide of Formula IIIA has: (i) a silicone portion in the acid side of the polyamide;
S) (i1) an average molecular weight of at least 30,000 daltons with at least 95% of the polyamide having a molecular weight greater than 4,000 daltons; and (iii) a polydispersity of less than 20; (The polyamide material is supplied by Dow Corning Corp., Midland MI, as Dow
Corning ®2-8178 Gellant. The INCI Name is Nylon-611/Dimethicone copolymer, but the commercial version of the product conveniently used here has abut 10 weight %
PPG-3 myristal ether. Thus, the PPG-3 myristal ether can also be in the final composition if this commercial material is used. For the final composition, the amount of PPG myristal ether can be in the range of about 0.01 — 0.15 weight %.) (c) an antiperspirant active used in an amount to have a deodorant and/or antiperspirant effect (for example, 5 - 25 weight % based on the entire weight of the composition) for example Reach®103 an activated antiperspirant or Reheis Microdry ® ACH a non- activated aluminum chlorohydrate ("ACH") (from Reheis Incorporated, Berkeley
Heights, NJ), wherein the amounts are in percent by weight based on the total weight of the composition. It is preferred to add the antiperspirant active as a dry powder to obtain a product with better efficacy and aesthetics. Solutions of the antiperspirant salt can also be used. These solutions can be solutions in water, glycols, alcohols and mixtures of the above. The solution concentrations can be from 5 - 50% ACH in the solvent. (d) the propellant gas can be chosen from the group singly or in combinations from the following; (1) compressed gas propellants selected from the group consisting of the industry standard inert gases carbon dioxide, nitrous oxide, and nitrogen; (2) liquefied gas propellants selected from the groups consisting of: (a) hydrocarbons, for example liquefied petroleum gases such as propane, isobutane, n-butane, isopentane and n-pentane; (b) fluorocarbons, for example 1,1Difluoroethane (152a) and 1,1,1,2
Tetrafluoroethane (134a); (c) ethers, for example, dimethyl ether; and (d) mixtures of the foregoing (a)-(c).
i WO 2004/078125 PCT/US2004/006164
Optional ingredients may also be added to the composition of the invention.
These optional ingredients include additional emollients (0-20%), silicone gums (0- . 20%), elastomers (0-20%), silicone resins (0-20%), colorants (0-1%), fragrances (0- 3%), antimicrobials (0-2%), surfactants (0-10%), and inert particulates (0-30%) to : S achieve better structural integrity, stability or aesthetics.
A variety of aluminum salts can be used in the invention such as is known in the art. While several specific aluminum salts have been described, it is currently believed than any aluminum salt known to be useful in antiperspirant/deodorant products may be used with the invention. While the use of antiperspirant salts containing zirconium (for example, tri and tetra salts of aluminum and zirconium with glycine) are currently not permitted to be used in aerosol products in many geographies including the United
States, there is no technical reason why such salts cannot be used in the invention.
A comprehensive list of both aluminum and aluminum/zirconium salts include the following. These include conventional aluminum and aluminumy/zirconium salts, as well as aluminum/zirconium salts complexed with a neutral amino acid such as glycine, as known in the art. See each of European Patent Application Number. 512,770 Al and PCT case WO 92/19221. Suitable materials include (but are not limited to) aluminum chlorides (various types including, for example, anhydrous form, hydrated form, etc.), basic aluminum chlorides, basic aluminum chlorides combined with zirconyl oxychlorides and hydroxychlorides, and organic complexes of each of basic aluminum chlorides with or without zirconyl oxychlorides and hydroxychlorides and mixtures of any of the foregoing. These include, by way of example (and not of a limiting . nature), aluminum chlorohydrate, aluminum chloride, aluminum sesquichlorohydrate, aluminum chiorohydrol-propylene glycol complex, zirconyl hydroxychloride, aluminum-zirconium glycine complex (for example, aluminum zirconium trichlorohydrex gly, aluminum zirconium pentachlorohydrex gly, aluminum zirconium tetrachlorohydrex gly and aluminum zirconium octochlorohydrex gly), . aluminum dichlorohydrate, aluminum chlorohydrex PG, aluminum chlorohydrex PEG, aluminum dichlorohydrex PG, aluminum dichlorohydrex PEG, aluminum zirconium * trichlorohydrex gly propylene glycol complex, aluminum zirconium trichlorohydrex gly dipropylene glycol complex, aluminum zirconium tetrachlorohydrex gly propylene glycol complex, aluminum zirconium tetrachlorohydrex gly dipropylene glycol complex, and mixtures of any of the foregoing.
If aluminum/zirconium salts are used, particular antiperspirant actives that can be incorporated in the compositions of the present invention include the enhanced efficacy aluminum salts and the enhanced efficacy aluminum/zirconium salt-glycine materials, having enhanced efficacy due to improved molecular distribution, known in the art and discussed, for example, in PCT No. W(092/19221. Particular actives include Westchlor A2Z 4105 aluminum zirconium tetrachlorohydrex gly propylene glycol complex, (from Westwood Chemical Corporation, Middletown, NY); Westchlor
ZR 35B aluminum zirconium tetrachlorhydrex gly, and Rezal 36 GP and AZP 902 aluminum zirconium tetrachlorhydrex gly both from Reheis, Berkeley Heights, NJ as well as Rezal AZZ 908 from Reheis. In general, the metal:chloride mole ratio is in the range of 2.1-0.9:1 for such salts.
Another particular group of actives of special interest because they form low RI solutions include: Westchlor Zr 35BX3 (30-35% actives in water) from Westwood
Chemical Company, Middletown, NY; Rezal 36G (46% in water) from Reheis Inc,,
Berkeley Heights, NJ; Summit AZG-368 (28-32% in water) from Summit Research
Labs, Huguenot, NY; Reach 301 (39% in water) from Reheis Inc.; and aluminum chloride (28% in water) which may be obtained from several sources. In general, the metal:chloride mole ratio is approximately 1.4:1 for such salts.
If an aluminum zirconium salt is used, one particular type of salt of interest is an aluminum zirconium tetra salt with glycine is used wherein aluminum zirconium tetrachlorohydrex glycine salt having a metal to chloride ratio in the range of 0.9-1.2:1 (especially in the range of 0.9-1.1:1 and, more particularly in the range of 0.9-1.0:1); and a glycine:zirconium mole ratio greater than 1.3:1, particularly greater than 1.4:1.
For commercial purposes, currently the particular embodiments of interest contain only aluminum salts and do not contain zirconium. ) Other embodiments are free of silicone gums, elastomers, silicone resins, colorants, fragrances, antimicrobials, surfactants, and inert particulates.
. | WO 2004/078125 PCT/US2004/006164
The following Examples are offered as illustrative of the invention and are not to be construed as limitations thereon. In the Examples and elsewhere in the description of the invention, chemical symbols and terminology have their usual and 9 customary meanings. In the Examples as elsewhere in this application values for n, m, etc. in formulas, molecular weights and degree of ethoxylation or propoxylation are averages. Temperatures are in degrees C unless otherwise indicated. The amounts of the components are in weight percents based on the standard described; if no other standard is described then the total weight of the composition is to be inferred. Various names of chemical components include those listed in the CTFA International
Cosmetic Ingredient Dictionary (Cosmetics, Toiletry and Fragrance Association, Inc., 7™ ed. 1997).
Example 1: Aerosol Product
Base Formula - An aerosol base is produced by combining 23.4g cyclopentasiloxane, 14.0g isopropyl palmitate, 6.8g mineral oil, 3.8g isostearyl alcohol, 2g nylon 611/dimethicone copolymer (also referred to herein as "selected polyamide") together with stirring and heating to a temperature of about 90 degrees C until all of the selected polyamide is dissolved. The mixture is cooled to room temperature. Next, 50g of antiperspirant active are added and dispersed into the resultant gel. A thick antiperspirant base with a viscosity in the range of 3,500-12,000 centipoise as determined by using a Brookfield RTV viscometer. The measurement is taken using
Spindle D at 10 RPM with the Helipath attachment.
Filling the Aerosol Cans - The amount of base formula used depends on the final concentration of aluminum active salt required for the final product. The current formula requires 16g of the aerosol base and 1g of perfume oil. These ingredients are placed in a conventional 150 ml tin plated, three piece steel aerosol can (obtained from
CCL, Harrisonburg, VA). A steel plated aerosol valve (obtained from Seaquist
Perfect, Carey IL.) is crimped to the top of the can using a Single Head Pneumatic
Aerosol Valve Crimper (from Nalbach Engineering Inc., Country Side IL). The can is ) 30 then charged with 83g of propellant A-46, a mixture of 21.91% propane, 46.84% n- butane, and 30.84% isobutane, using an aerosol burette. An actuator and a hood are ) than placed over the valve and the product is ready for use.
Claims (9)
- Claims What is claimed is: L An aerosol antiperspirant/deodorant product comprising: (a) a solvent system for the gellant in an amount of up to 36% of the total formula, wherein the solvent system is compatible with a siliconized polyamide of Formula IIIA and comprises one or more members is selected from the group consisting of: (1) from 1.5 - 16% by weight based on the total weight of the composition of at least one non-silicone organic material selected from the group consisting of C12 - 36 esters; extra light to heavy white mineral oils with viscosity ranging from 6.5 - 110 centistokes at 40 degrees C; guerbet alcohols having 8 - 30 carbons; fatty alcohols having 8 - 30 carbons; ethoxylated and propoxylated alcohols having 3 - 30 carbons; alkyl ethers having 12 - 36 carbons; C12 - 18 alkyl benzoate and benzoate ester derivatives; paraffins having a distillation temperature in the range of 372 - 426 degrees C; 1soparaffins having a distillation temperature in the range of 178 - 207 degrees C; and alkyl carbonates; (2) from 2 - 20% by weight based on the total weight of the composition ofa volatile silicone selected from the group consisting of cyclomethicone and low viscosity dimethicones; and (3) from 0-10% organo-silicones; (b) from 0.1 - 1.5% by weight based on the total weight of the composition of at least one siliconized polyamide of Formula IIIA as a gellant: R1 R2 {C(0)-X-[SiOlppSi-X-C(O)NH-Y-NH],- . 05 RS R4 Formula ITA where: (1) DP is a number in the range of 5-30; (2) n is a number selected from the group consisting of 1-500;(3) X is a linear or branched chain alkylene having 1-30 carbons; (4) Y is selected from the group consisting of linear and branched chain alkylenes having 1-40 carbons, wherein: (al) the alkylene group may optionally and additionally contain in the alkylene portion at least one of the members of a group consisting of (i) 1-3 amide linkages; (ii) C5 or C6 cycloalkane as a cycloalkylene linkage; and (iii) phenylene optionally substituted by 1-3 members selected independently from the group consisting of C1-C3 alkyls; and (b1) the alkylene group itself may optionally be substituted by at least one member selected from the group consisting of (i) hydroxy; (ii) C3-C8 cycloalkane; (iii) 1-3 members selected independently from the group consisting of C1-C3 alkyls; phenyl optionally substituted by 1-3 members selected independently from the group consisting of C1-C3 alkyls; (iv) C1 - C3 alkyl hydroxy; and (v) C1 - C6 alkyl amine; or Y = Z* where 7? =R¥TR" . 22 wherein each of R?®, R*! are independently selected from the group consisting of linear and branched C1-C10 alkylenes; R* is selected from the group consisting of linear and branched C1-C10 alkanes; and T is selected from the group consisting of (i) a trivalent atom selected from N, P and Al; and (i1) -CR, where R is selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, a siloxane chain, and phenyl, wherein the phenyl may optionally be substituted by 1-3 members from the group consisting of methyl and ethyl; and (5) each of R1 - R4 is independently selected from the group consisting of methyl, ethyl, propyl, isopropyl, a siloxane chain, and phenyl, wherein the phenyl may . 30 optionally be substituted by 1-3 members from the group consisting of methyl and ethyl;wherein the polyamide of Formula IITA has: (i) a silicone portion in the acid side of the polyamide; ‘ (i1) an average molecular weight of at least 30,000 daltons with at least 95% of the polyamide having a molecular weight greater than 4,000 hd 5 daltons; and (111) a polydispersity of less than 20; (c) an antiperspirant active used in an amount to have a deodorant and/or antiperspirant effect; and (d propellant gas selected from the group consisting of: (1) compressed gas propellants selected from the group consisting of inert gases, carbon dioxide, nitrous oxide, and nitrogen; (2) liquefied gas propellants selected from the groups consisting of: (i) hydrocarbons selected from the group consisting of liquefied petroleum gases; (11) fluorocarbons selected from the group consisting of 1,1difluoroethane (152a) and 1,1,1,2 tetrafluoroethane (134a); (iii) ethers; and (iv) mixtures of the foregoing (i)-(ii1).
- 2. An aerosol antiperspirant/deodorant product comprising: (a) about 2 - 20 weight % cyclomethicone; (b) about 1 - 8 weight % isopropyl palmitate; (c) about 0.5 - 3.5 weight % mineral oil; (d) about 0.3 - 4 weight % isostearyl alcohol; (e) about 0.1 - 1.5 weight % Nylon 611/dimethicone copolymer; (f) about 5 - 25 weight % of a solid antiperspirant active; (g) optionally about 0.3 - 2.0 weight % of a perfume oil; and (h) about 37- 90 weight % of a propellant gas; wherein the amounts are based on the total weight of the composition.
- 3. An aerosol antiperspirant/deodorant product according to Claim 2 wherein the i cyclomethicone is D5, D6 or mixtures of D5 and D6 cyclomethicones.© WO 2004078125 PCT/US2004/006164
- 4. An aerosol antiperspirant/deodorant product according to Claim 2 comprising; (a) about 5 weight % cyclomethicone; (b) about 2.2 weight % isopropyl palmitate; (c) about 0.7 weight % mineral oil; 9S (d) about 0.6 weight % isostearyl alcohol; (e) about 0.3 weight % Nylon 611/dimethicone copolymer; (f) about 5 - 25 weight % of a solid antiperspirant active (especially 10%); (g) optionally about 0.3 - 2.0 weight % of a perfume oil (especially 1.0%); and (h) about 37- 90 weight % of a propellant gas (especially 83%); wherein the amounts are based on the total weight of the composition.
- 5. An aerosol antiperspirant/deodorant product according to Claim 2 wherein the propellant gas is one or more gasses selected from the group consisting of: (a) compressed gas propellants selected from the group consisting of the industry standard inert gases carbon dioxide, nitrous oxide, and nitrogen; and (b) liquefied gas propellants selected from the groups consisting of: (1) hydrocarbons which are liquefied petroleum gases selected from the group consisting of propane, isobutene, n-butane, is pentane and n- pentane; (2) fluorocarbons selected from the group consisting of 1,1-difluoroethane (152a) and 1,1,1,2-tetrafluoroethane (134a); (3) diethyl ether; and (4) mixtures of any of the foregoing.
- 6. An aerosol antiperspirant/deodorant product according to Claim 1 further comprising one or more additional ingredients selected from the group consisting of: emollients, silicone gums, elastomers, silicone resins, colorants, fragrances, antimicrobials, surfactants, and inert particulates.
- 7. An aerosol antiperspirant/deodorant product according to Claim 2 further comprising one or more additional ingredients selected from the group consisting of: emollients, silicone gums, elastomers, silicone resins, colorants, fragrances, antimicrobials, surfactants, and inert particulates.
- 8. An aerosol antiperspirant/deodorant product according to Claim 1 which is free of silicone gums, elastomers, silicone resins, colorants, fragrances, antimicrobials, surfactants, and inert particulates.. * WOL064/078125 PCT/US2004/006164
- 9. An aerosol antiperspirant/deodorant product according to Claim 1 which is free . of silicone gums, elastomers, silicone resins, colorants, fragrances, antimicrobials, : surfactants, and inert particulates. Cw
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45128203P | 2003-03-04 | 2003-03-04 | |
| EP03014425 | 2003-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200507244B true ZA200507244B (en) | 2006-11-29 |
Family
ID=40490868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200507244200507244A ZA200507244B (en) | 2003-03-04 | 2005-11-16 | Aerosol antiperspirant with polyamide Pyrrolo-dihydroisoquinoline derivatives as PDE10 inhibitors |
Country Status (1)
| Country | Link |
|---|---|
| ZA (1) | ZA200507244B (en) |
-
2005
- 2005-11-16 ZA ZA200507244200507244A patent/ZA200507244B/en unknown
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