ZA200404149B - Substituted imidazolidines, method for the production thereof, use thereof as a drug or for diagnosis, and drug containing substituted imidazolines - Google Patents
Substituted imidazolidines, method for the production thereof, use thereof as a drug or for diagnosis, and drug containing substituted imidazolines Download PDFInfo
- Publication number
- ZA200404149B ZA200404149B ZA200404149A ZA200404149A ZA200404149B ZA 200404149 B ZA200404149 B ZA 200404149B ZA 200404149 A ZA200404149 A ZA 200404149A ZA 200404149 A ZA200404149 A ZA 200404149A ZA 200404149 B ZA200404149 B ZA 200404149B
- Authority
- ZA
- South Africa
- Prior art keywords
- ylidene
- dichlorophenyl
- compound
- medicament
- substituted
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P33/14—Ectoparasiticides, e.g. scabicides
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Description
+ WO 03/053434 ® PCT/EP02/13921
Substituted imidazolidines, method for the production thereof, use thereof as a medicament or a diagnostic tool, and medicament containing substituted imidazolidines
The invention relates to substituted imidazolidines of the formula |,
R3 X
R4 N= octal
R5 R7 R2
R6 in which
R1and R2 independently of one another are CN, (C1-Cg)-alkyl, (C2-Cg)-alkenyl, (C2-Cs)- alkynyl, (C3-Cg)-cycloalkyl or (C4-Cg)-cycloalkenyl where all carbon chains and carbon rings are unsubstituted or, independently of one another, are substituted by 1 - 11 fluorine atoms or by up to two radicals selected from the group consisting of OH,
NH2, NHCH3, N(CH3)2 and OCH3; or
R1 and R2 together with the two carbon atoms to which they are attached are a five- to eight-membered saturated or unsaturated carbon ring, but without any double bond between the two carbon atoms to which
R1 and R2 are attached, and where the ring is unsubstituted or substituted by 1 - 12 fluorine atoms or by up to two radicals selected from the group consisting of CH3 and
OCHg; ; i eo o 2
R3 is F, Cl, Br, I, (C4 -Cg4)-alkyl, (C1-C4)-alkenyl, (C3-Cg)-cycloalkyl, OH, (C1-C4)-alkoxy, Ophenyl, CN, NO2 or NH2. where phenyl is unsubstituted or substituted by up to two radicals selected from the group consisting of CH3, F, CI, Br, I, OH and OCHg3; and where the carbon chains or carbon rings are unsubstituted or substituted by 1 - 11 fluorine atoms;
R4 to R6 independently of one another are H, F, CI, Br, |, (C1-C4)-alkyl, (C1-C4)- alkenyl, (C3-Cg)-cycloalkyl, OH, (C1-C4)-alkoxy, CN, NO2, NH2, (C1-C4)- alkylamino or (C1-C4)-dialkylamino; where the carbon chains or carbon rings are unsubstituted or substituted by 1 - 11 fluorine atoms;
R7 is H, F, Cl, Br, |, (C1-C4)-alkyl, (C1-C4)-alkenyl, (C3-Cg)-cycloalkyl, OH, (C1-C4)-alkoxy, CN, NO2 or NH. where the carbon chains or carbon rings are unsubstituted or substituted by 1 - 11 fluorine atoms; and their pharmaceutically acceptable salts, and the trifluoroacetic acid salts.
Preference is given to compounds of the formula | in which
R1 and R2 independently of one another are (C1-Cg)-alkyl, (C-Cg)-alkenyt, (C2-Cs)- alkynyl, (C3-Cg)-cycloalkyl or (C4-Cg)-cycloalkenyl, where all carbon chains and carbon rings are unsubstituted or, independently of one another, substituted by 1 - 11 fluorine atoms or by up to two radicals selected from the group consisting of NHCH3,
N(CH3)2 and OCHag; or
R1 and R2 together with the two carbon atoms to which they are attached are a five- to eight-membered saturated or unsaturated carbon ring,
a ® 3 but without any double bond between the two carbon atoms to which
R1 and R2 are attached, and where the ring is unsubstituted or substituted by 1 - 12 fluorine atoms or by up to two radicals selected from the group consisting of CH3 and
OCHg;
R3 is F, Cl, Br, 1, (C4 -Cg)-alkyl, (C1-C4)-alkenyl, (C3-Cg)-cycloalkyl, OH, (C4-C4)-alkoxy, Ophenyl, CN, NO2 or NH: where phenyl is unsubstituted or substituted by up to two radicals selected from the group consisting of CH3, F, Cl, Br, OH and OCHg; and where the carbon chains or carbon rings are unsubstituted or substituted by 1 - 11 fluorine atoms;
R4 to R6 independently of one another are H, F, Cl, Br, CHa, OH, OCH3, CN, NO»o,
NH2, NHCH3, N(CH3)2; where the methyl groups are unsubstituted or substituted by 1 - 3 fluorine atoms;
R7 is H, F, Cl, Br, I, (C1-C4)-alkyl, (C1-C4)-alkenyl, (C3-Cg)-cycloalkyl, OH, (C1-Cg4)-alkoxy, CN, NO2 or NHj. where the carbon chains or rings are unsubstituted or substituted by 1 - 11 fluorine atoms; and their pharmaceutically acceptable salts, and the trifluoroacetic acid salts.
Very particular preference is given to the following compounds of the formula |: trans-(2-chloro-6-trifluoromethylphenyl)-(octahydrobenzimidazol-2-ylidene)amine hydrochloride, (S,S)-(2,6-dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt, cis-(2,6-dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt,
® 4 (R,R)-(2,6-dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt, trans-(octahydrobenzimidazol-2-ylidene)-(2-phenoxyphenyl)amine hydrochloride, trans-(2,6-dichlorophenyl)-(4,5-diisopropylimidazolidin-2-ylidene)amine hydrochloride, trans-(2,6-dichlorophenyl)-(4,5-dicyclopropylimidazolidin-2-ylidene)amine trifluoracetic acid salt, cis-(2,6-dichlorophenyl)-(4,5-dicyclopropylimidazolidin-2-ylidene)amine hydrochloride, trans-(2,6-dichlorophenyl)-(4,5-diethylimidazolidin-2-ylidene)amine hydrochloride, (2,6-dichlorophenyl)-(4,5-dimethylimidazolidin-2-ylidene)amine nitric acid salt, trans-(2,6-dichlorophenyl)-(hexahydrocyclopentaimidazol-2-ylidene)amine trifluoroacetic acid salt.
Extraordinary preference is given to the following compounds of the formula I: (S,S)-(2,6-dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt, cis-(2,6-dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt, (R,R)-(2,6-dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt, trans-(2,6-dichlorophenyl)-(4,5-diisopropylimidazolidin-2-ylidene)amine hydrochloride, trans-(2,6-dichlorophenyl)-(4,5-dicyclopropylimidazolidin-2-ylidene)amine trifluoroacetic acid salt, cis-(2,6-dichlorophenyl)-(4,5-dicyclopropylimidazolidin-2-ylidene amine hydrochloride, trans-(2,6-dichlorophenyi)-(4,5-diethylimidazolidin-2-ylidene)amine hydrochloride, (2,6-dichiorophenyl)-(4,5-dimethylimidazolidin-2-ylidene)amine nitric acid salt,trans-(2,6-dichlorophenyl)-(hexahydrocyclopentaimidazol-2-ylidene)amine trifluoroacetic acid salt.
Suitable acid addition salts are salts of all pharmacologically acceptable acids, for example halides, in particular hydrochlorides, lactates, sulfates, citrates, tartrates, acetates, phosphates, methylsulfonates, p-toluenesulfonates, adipinates, fumarates, gluconates, glutamates, glycerolphosphates, maleates and pamoates. This group also corresponds to the physiologically acceptable anions; but also trifluoroacetates.
If the compounds of the formula | contain one or more centers of asymmetry, the compounds can be both S- and R-configured. The compounds can be present as optical isomers, as diastereomers, as racemates or as mixtures thereof. 5 The compounds of the formula | can furthermore be present as tautomers or as a mixture of tautomeric structures.
This refers in particular to the following tautomers:
R3 A RSH R4 \ : N
N R4 N— ~N =~ R1
HN N R5 R7
R5 R7 RS R7 R2
R2 R2 R6
R6 R6
If R1 and R2 are different and if the nitrogen-carbon double bond has sufficient configurational stability, it is also possible for two double-bond isomers to exist:
R3 H R3 H
NN NN
Ra ST VR Ra ST V—R2
HN HN
R5 R7 R2 R5 R7 R1
R6 R6
The carbon radicals mentioned, or the partially or fully fluorinated or substituted carbon radicals, can be straight-chain or branched.
Also described are methods for preparing the compounds used.
Thus, the substances described by formula | can be prepared in a manner known to the person skilled in the art from the isothiocyanate Il parent compounds and the appropriate diamines lI.
. ® 6
R4
R5 R3
I HN R1
R7 H,N R2
The thiourea derivative which is formed as an intermediate is cyclized using methyl iodide (Synthesis, 1974, 41 — 42) or carbodiimide (Synthesis, 1977, 864 - 865) to give the corresponding imidazolidine |. if the isothiocyanates Il employed here are not commercially available, they can be prepared in a manner known from the literature from the corresponding anilines, using methods known to the person skilled in the art, for example by treatment with thiophosgene (J. Med. Chem., 1975, 18, 90-99) or thiocarbonyl! diimidazole (Justus Liebigs Ann. Chem., 1962, 657, 104).
In addition to the isothiocyanates Il described above, it is also possible to successfully react the isocyanates |V with amines of the type of formula [ll to give compounds of the formula I. Here, the urea derivative which is formed as an intermediate is cyclized using phosphorus oxychloride to give the corresponding imidazolidines of the formula
R4
XC
R6 NCO
R7
Vv
In the present invention, it was surprisingly possible to demonstrate that the compounds described are potent inhibitors of the sodium/hydrogen exchanger (NHE), in particular of NHE3.
The NHE3 inhibitors known to date are derived from compounds of the acylguanidine type (EP-A 825 178, HOE 96/F226), of the norbornylamine type (DE 199 60 204.2-
. ® 7
HMR 99 / L 073), of the 2-guanidinoquinazoline type (WO 01 79 186 A1 or of the benzamidine type (WO 01 21582 A1, WO 01 72 742 A1 ). Squalamine, which has also been described as NHE3 inhibitor (M. Donowitz et al. Am. J. Physiol. 276 (Cell Physiol. 45): C136 — C144) is, unlike the compounds of the formula |, not effective immediately but reaches its maximum potency only after one hour.
Clonidine, which is similar to the compounds described here, is known as a weak NHE inhibitor. However, its action on the NHE3 of the rat is, with an ICgq of 620 uM, extremely moderate. In contrast, it shows a certain selectivity for the NHE2, where it has an ICgq of 42 uM (J. Orlowski et al J. Biol. Chem. 268, 25536). It would therefore be more accurate to refer to clonidine as an NHE2 inhibitor. In addition to the weak
NHE action, clonidine has a high affinity for the adrenergic alpha2 receptor and the imidazoline 11 receptor, mediating a strong hypotensive action (Emsberger et al Eur. J.
Pharmacol. 134, 1, 1987).
Compounds of the formula | have increased NHE3 activity and reduced 11 and alpha2 activity.
NHE3 is found in the body of various species, preferably in the gall bladder, the intestine and the kidney (Larry Fliegel et al, Biochem. Cell. Biol. 76: 735 - 741, 1998), but can also be detected in the brain (E. Ma et al. Neuroscience 79: 591 - 603).
Owing to this unexpected property, the compounds of formula | are suitable for treating disorders caused by oxygen deficiency. As a result of their pharmacological properties, the compounds are highly suitable for use as antiarrhythmics having a cardioprotective component, for infarct prophylaxis and infarct treatment and for treatment of angina pectoris, and they also inhibit, or strongly reduce, in a preventative manner, the pathophysiological processes which contribute to ischemically induced damage, in particular those which trigger ischemically induced cardiac arrhythmias. Owing to their protective action against pathological hypoxic and ischemic situations, the compounds of the formula | according to the invention can, as inhibitors of the cellular Nat/H* exchange mechanisms, be used as medicaments for treating all acute or chronic damage caused by ischemia, or diseases induced primarily or secondarily by this
. ® 8 damage. This relates to their use as medicaments for surgical interventions, for example organ transplantations, where the compounds can be used both for protecting the organs in the donor before and during removal, for protecting organs that have been removed, for example by treatment with or storage in physiological bath fluids, and also during transfer into the recipient organism. The compounds are also useful medicaments with protective action during angioplastic surgical interventions, for example at the heart, but also in peripheral vessels. Owing to their protective action against ischemically induced damage, the compounds are also suitable for use as medicaments for treating ischemias of the nervous system, in particular of the CNS, where they can be used, for example, for treating stroke or cerebral edema. Moreover, the compounds of the formula | to be used according to the invention are also suitable for treating forms of shock, such as, for example, of allergic, cardiogenic, hypovolemic and bacterial shock.
Furthermore, the compounds induce an improvement in the respiratory drive and are therefore used for the treatment of respiratory conditions in the following clinical conditions and diseases: disturbed central respiratory drive (e.g. central sleep apnea, sudden infant death, post operative hypoxia), muscular-related respiratory disorders, respiratory disorders after long-term ventilation, respiratory disorders during adaptation in a high mountain area, obstructive and mixed forms of sleep apnea, acute and chronic lung diseases with hypoxia and hypercapnia.
The compounds additionally increase the muscle tone of the upper airways, so that snoring is suppressed.
A combination of an NHE inhibitor with a carboanhydrase inhibitor (e. g. acetazolamide), the latter producing metabolic acidosis and thereby even increasing the respiratory activity, proves to be advantageous as a result of increased action and decreased use of active compound.
It has been shown that the compounds to be used according to the invention have a mild laxative action and accordingly can be used advantageously as laxatives or in the
. ® 9 case of threatening intestinal blockage, the prevention of ischemic damage accompanying blockages in the intestinal region being particularly advantageous.
It is furthermore possible to prevent gallstone formation.
Moreover, the compounds of the formula | to be used according to the invention can exert a strong inhibitory action on the proliferation of cells, for example fibroblast cell proliferation and the proliferation of the smooth vascular muscle cells. The compounds of the formula | are therefore suitable as valuable therapeutics for diseases in which cell proliferation is a primary or secondary cause, and can therefore be used as antiatherosclerotics, agents against diabetic late complications, cancers, fibrotic disorders such as pulmonary fibrosis, liver fibrosis or kidney fibrosis, organ hypertrophy and hyperplasia, in particular in prostate hyperplasia or prostate hypertrophy.
The compounds according to the invention are effective inhibitors of the cellular sodium/proton antiporter (Na/H exchanger) which is raised in numerous disorders (essential hypertension, atherosclerosis, diabetes etc.) even in those cells which are easily accessible to measurement, such as, for example, in erythrocytes, platelets or leukocytes. The compounds to be used according to the invention are therefore suitable as outstanding and simple scientific tools, for example in their use as diagnostics for the determination and differentiation of certain forms of hypertension, but also of atherosclerosis, of diabetes, of proliferative disorders etc. Moreover, the compounds of the formula | are suitable for preventive therapy to prevent the development of high blood pressure, for example of essential hypertension.
It has moreover been found that NHE inhibitors exhibit a favorable influence on the serum lipoproteins. It is generally recognized that for the formation of artereosclerotic vascular changes, in particular of coronary heart disease, excessively high blood lipid values, ‘hyperiipoproteinemias’, are an essential risk factor. The lowering of increased serum lipoproteins is therefore of extreme importance for the prophylaxis and the regression of atherosclerotic changes. The compounds to be used according to the
) ® 10 invention can therefore be used for the prophylaxis and regression of atherosclerotic changes by excluding a causal risk factor. With this protection of the vessels against the syndrome of endothelial dysfunction, compounds of the formula | are valuable pharmaceuticals for the prevention and treatment of coronary vascular spasms, of atherogenesis and of atherosclerosis, of left-ventricular hypertrophy and of dilated cardiomyopathy, and thrombotic disorders.
The compounds mentioned are therefore advantageously used for the production of a medicament for the prevention and treatment of sleep apneas and muscular-related respiratory disorders; for the production of a medicament for the prevention and treatment of snoring, for the production of a medicament for lowering the blood pressure, for the production of a medicament having laxative action for the prevention and treatment of intestinal blockages; for the production of a medicament for the prevention and treatment of disorders which are induced by ischemia and reperfusion of central and peripheral organs, such as acute kidney failure, stroke, endogenous states of shock, intestinal disorders etc; for the production of a medicament for the treatment of hypercholesterolemia; for the production of a medicament for the prevention of atherogenesis and of atherosclerosis; for the production of a medicament for the prevention and treatment of diseases which are induced by raised cholesterol levels; for the production of a medicament for the prevention and treatment of diseases which are induced by endothelial dysfunction; for the production of a medicament for the treatment of attack by ectoparasites; for the production of a medicament for the treatment of the diseases mentioned in combination with blood pressure-lowering substances, preferably with angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor antagonists. A combination of an NHE inhibitor of the formula with an active compound lowering the blood lipid level, preferably with an HMG-CoA reductase inhibitor (e.g. lovastatin or pravastatin), the latter producing a hypolipidemic effect and thereby increasing the hypolipidemic properties of the NHE inhibitor of the formula |, proves to be a favorable combination having intensified action and decreased use of active substance.
® 11
The administration of sodium/proton exchange inhibitors of the formula | as novel pharmaceuticals for lowering raised blood lipid levels, and the combination of sodium/proton exchange inhibitors with pharmaceuticals having a blood pressure- lowering and/or hypolipidemic action is claimed.
Pharmaceuticals which contain a compound | can in this case be administered orally, parenterally, intravenously, rectally or by inhalation, the preferred administration being dependent on the particular clinical picture of the disorder. The compounds | can in this case be used on their own or together with pharmaceutical excipients, namely both in veterinary and in human medicine.
The person skilled in the art is familiar on the basis of his/her expert knowledge with excipients which are suitable for the desired pharmaceutical formulation. In addition to solvents, gel formers, suppository bases, tablet excipients and other active compound carriers, it is possible to use, for example, antioxidants, dispersants, emulsifiers, antifoams, flavor corrigents, preservatives, solubilizers or colorants.
For a form for oral administration, the active compounds are mixed with the additives suitable therefor, such as excipients, stabilizers or inert diluents, and brought by means of the customary methods into the suitable administration forms, such as tablets, coated tablets, hard gelatin capsules, aqueous, alcoholic or oily solutions. inert carriers which can be used are, for example, gum arabic, magnesia, magnesium carbonate, potassium phosphate, lactose, glucose or starch, in particular cornstarch. In this case, preparation can be carried out either as dry or as moist granules. Possible oily excipients or solvents are, for example, vegetable or animal oils, such as sunflower oil or cod-liver oils.
For subcutaneous or intravenous administration, the active compounds used are brought into solution, suspension or emulsion, if desired with the substances customary therefor such as solubilizers, emulsifiers or further excipients. Suitable solvents are, for example: water, physiological saline solution or alcohols, e.g. ethanol,
propanol, glycerol, and in addition also sugar solutions such as glucose or mannitol solutions, or alternatively a mixture of the different solvents mentioned.
Pharmaceutical formulations suitable for administration in the form of aerosols or sprays are, for example, solutions, suspensions or emulsions of the active compound of the formula | in a pharmaceutically innocuous solvent, such as, in particular, ethanol or water, or a mixture of such solvents.
If required, the formulation can also contain still other pharmaceutical excipients such as surfactants, emulsifiers and stabilizers, and a propellant. Such a preparation customarily contains the active compound in a concentration of approximately 0.1 to 10, in particular of approximately 0.3 to 3, % by weight.
The dose of the active compound of the formula | to be administered and the frequency of administration depend on the potency and duration of action of the compounds used; moreover also on the nature and severity of the disease to be treated and on the sex, age, weight and individual responsiveness of the mammal to be treated.
On average, the daily dose of a compound of the formula | in the case of a patient weighing approximately 75 kg is at least 0.001 mg/kg, preferably 0.1 mg/kg, to at most 30 mg/kg, preferably 1 mg/kg, of bodyweight. In acute episodes of the diseases, for instance, directly after a myocardial infarct, even higher and especially more frequent doses may also be necessary, e.g. up to 4 individual doses per day. In particular in the case of i.v. administration, for example in the case of an infarct patient in the intensive care unit, up to 200 mg/kg per day may be necessary.
Descriptions of the experiments and examples:
List of abbreviations used:
Rt retention time
TFA trifluoroacetic acid
LCMS liquid chromatography mass spectroscopy
MS mass spectroscopy ci chemical ionization, positive mode
ESt electrospray, positive mode
General:
The retention times (Rt) stated below are based on LCMS measurements with the following parameters:
Method A:
Stationary phase: Merck Purospher 3u 2 x 55 mm
Mobile phase: 95% H20 (0.05% TFA)— 95% acetonitrile; 4 min; 95% acetonitrile; 1.5 min — 5% acetonitrile; 1 min; 0.5 ml/min.
Method B:
Stationary phase: YMC J'sphereODS H80 2 x 33 mm
Mobile phase: 95% H20 (0.05% TFA)— 95% acetonitrile; 2.3 min; 95% acetonitrile; 1 min —» 5% acetonitrile; 0.1 min; 1 ml/min.
Preparative HPLC was carried out under the following conditions:
Stationary phase: Merck Purospher RP18 (10uM) 250 x 25 mm
Mobile phase: 90% H20 (0.05% TFA)— 90% acetonitrile; 40 min; ml/min 25 If the compounds are enantiomerically pure, the configuration and/or the sign of the optical rotation is given. If these data are missing, the compounds are racemates or not optically active.
Example 1: (S,S)-(2,6-Dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt
Cl
HN
NN Tra
Cl 2,6-Dichlorophenyl isothiocyanate (600 mg) and (1S,2S)-(+)-1,2-diaminocyclohexane (336 mg) were dissolved in toluene (30 ml) and stirred at 70°C for 3 h. The mixture was allowed to stand overnight and the solvent was then removed under reduced pressure, and ether was added to the residue. The resulting thiourea was then filtered off with suction. 840 mg of the desired product were isolated.
A fraction of the thiourea obtained in this manner (420 mg) was then admixed with toluene (15 ml) and briefly heated at reflux. N,N‘-Dicyclohexylcarbodiimide (226 mg), dissolved in toluene (5 ml), was then added dropwise, and the mixture was stirred at 70°C for 5 h. The mixture was allowed to stand overnight and the resuiting precipitate was then filtered off and the filtrate was concentrated to dryness. The residue was then purified by preparative HPLC. The pure fractions were combined, the acetonitrile was removed using a rotary evaporator and the aqueous phase was freeze-dried. This gave 70 mg of the desired compound.
LCMS-Rt: 3.69 min, (A)
MS (ES*, M+HY): 284.2
Example 2: cis-(2,6-Dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt
Cl
HN
An
H cl TFA
® 15 2,6-Dichlorophenyl isothiocyanate (600 mg) and cis-1,2-diaminocyclohexane (336 mg) were reacted and worked up as described in Example 1. From the 900 mg of thiourea obtained in the first step, 454 mg were reacted further in the next step. This gave 112 mg of the desired compound.
LCMS-Rt: 3.65 min, (A)
MS (CI, M+H*): 284.1
Example 3: (R,R)-(2,6-Dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt cl ¢)
HN
A
: . N TFA
Cl 2,6-Dicklorophenyl isothiocyanate (50 mg) and (R,R)-(-)-1,2-diaminocyclohexane (28 mg) were initially charged in toluene (1.5 ml) and heated at reflux for 15 min. N,N‘-Dicyclohexylcarbodiimide (76 mg) was then added, and the mixture was kept further at reflux. The mixture was allowed to stand overnight and the toluene was then removed and the residue was purified by preparative HPLC. Since the first purification gave only contaminated fractions, chromatography was repeated using a different column (MN Nucleosil 100-5-C18 250 x 25 mm; flow rate 20 ml/min), but with otherwise identical conditions. The pure fractions were combined, the acetonitrile was removed using a rotary evaporator and the aqueous phase was freeze-dried. This gave 10 mg of the desired compound.
LCMS-Rt: 3.70 min, (A)
MS (CI, M+H*): 284.0
: ’ ® 16
Example 4: trans-(Octahydrobenzoimidazol-2-ylidene)-(2-phenoxyphenyl)amine hydrochloride
CH O
\ 0
TO
“N a)2-Phenoxyphenyl isothiocyanate 1.96 g (0.011 mol) of thiocarbonyl diimidazole were added to a solution of 1.85 g (0.01 mol) of 2-phenoxyaniline in 50 ml of THF and the mixture was stirred at room temperature for 4 hours, giving, after removal of the solvent by distillation, the compound as a brown amorphous product. b) N-(trans-2-Aminocyclohexyl}-N'-(2-phenoxyphenyl)thiourea
A solution of 1.6 g of 2-phenoxyphenyl isothiocyanate in 10 ml of THF was added to a solution of 0.8 g of trans-1,2-diaminocyclohexane in 30 mi of THF, and the mixture was stirred at room temperature for about 4 hours. The solvent was evaporated and the residue was subsequently subjected to column chromatography on silica gel using a mixture of 10 parts of ethyl acetate, 5 parts of n-heptane, 5 parts of methylene chloride, 5 parts of methanol and 1 part of concentrated aqueous ammonia solution, giving the desired compound as an amorphous oily product. c) trans-(Octahydrobenzimidazol-2-ylidene)-(2-phenoxyphenyl)amine hydrochloride 3.4 g of methyl iodide were added to a solution of 1.03 g of N-(trans-2- aminocyclohexyl)-N‘-(2-phenoxyphenyl)thiourea in 30 mi of ethanol, and the reaction mixture was kept at reflux for 5 hours. The mixture was allowed to stand overnight and the solvent was then distilled off and the residue was treated with water and subsequently made alkaline using saturated sodium bicarbonate solution. The aqueous phase was extracted with ethyl acetate and the organic extraction phase was evaporated, and the oily residue was then chromatographed on silica gel using a
® 17 mixture of 10 parts of ethyl acetate, 5 parts of n-heptane, 5 parts of methylene chloride, 5 parts of methanol and 1 part of concentrated aqueous ammonia solution.
This gave an oily product which was dissolved in ethyl acetate and acidified using a saturated solution of HCI gas in diethyl ether. The solvent was distilled off and the residue was then dissolved in water and subjected to freeze-drying. This gave 0.49 g of a solid of m.p. 110°C.
MS (ES*, M+H*): 308.2
Example 5: trans-(2-Chloro-6-trifluoromethyiphenyl)-(octahydrobenzimidazol-2- ylidene)amine hydrochloride
N "NF
LS
CH H Cl a) N-(trans-2-Aminocyclohexyl)}-N‘-(2-chloro-6-trifluoromethylphenyl)urea
A solution of 0.46 g of trans-1,2-diaminocyclohexane in 10 mi of THF was added to a solution of 1.6 g of 2-chloro-6-trifluoromethylphenyl isocyanate in 30 ml of THF, and the mixture was stirred at room temperature for about 3 hours. The mixture was allowed to stand overnight and the solvent was then distilled off, giving 0.57 g of the desired compound as a semi-solid yellow product. b) trans-(2-Chloro-6-trifluoromethylphenyl)-(octahydrobenzimidazol-2-ylidene)amine hydrochloride 0.57 g of N-(trans-2-aminocyclohexyl)-N‘-(2-chloro-6-trifluoromethylphenyl)urea in 20 ml of phosphorus oxychloride (POCI3) was boiled at reflux for 4-5 hours. The
POCI3 was distilled off, water was added to the residue and the pH was adjusted to 7- 8 using 2N NaOH. The mixture was then extracted with ethyl acetate, the organic solvent was distilled off and the residue was chromatographed on silica gel using a i : ® 18 mixture of 20 parts of ethyl acetate, 10 parts of n-heptane and 3 parts of glacial acetic acid. After removal of the eluent by distillation, the white solid residue was dissolved in a little ethyl acetate and acidified using a saturated solution of HCI gas in diethyl! ether.
Removal of the solvent by distillation and treatment of the residue with diisopropyl ether gave 0.4 g of the desired product as a solid of m.p. 160 — 165°C.
MS (CI*, M+H*): 318.3
Example 6: trans-(4,5-Di-tert-butylimidazolidin-2-ylidene)-(2,6-dichlorophenyl)amine hydrochloride
Cl \ aye
Cl CH N 2,6-Dichlorophenyl isothiocyanate (150 mg) and trans-2,2,5,5-tetramethythexane-3,4- diamine (127 mg) — analogously to Synthesis 1999, 2, 228; in racemic form — were initially charged in toluene (1.5 ml) and heated at reflux for 15 min.
N,N‘-Dicyclohexylcarbodiimide (126 mg), dissolved in 2 ml of toluene, was then added, and the mixture was kept at reflux. After standing overnight, the toluene was removed under reduced pressure and the residue was purified by preparative HPLC. The pure fractions were combined, the acetonitrile was removed using a rotary evaporator and the aqueous phase was neutralized with saturated potassium carbonate solution and extracted three times with ethyl acetate. The combined ethyl acetate phases were washed with saturated sodium chloride solution and then dried over magnesium sulfate. The drying agent was filtered off, the mixture was concentrated and the residue was then taken up in water, 2N hydrochloric acid was added and the mixture was freeze-dried. This gave 111 mg of the desired compound.
LCMS-Rt: 4.43 min, (A)
MS (CIF, M+H*): 342.2
: ® 19
Example 7: trans-(2,6-Dichlorophenyl)-(4,5-diisopropylimidazolidin-2-ylidene)amine hydrochloride
Cl \ on A
NT
CH “ / trans-2,5-Dimethylhexane-3,4-diamine (226 mg) — analogously to Synthesis 1999, 2, 228; in racemic form — was initially charged in THF (2.5 ml), and 2,6-dichlorophenyl isothiocyanate was added a little at a time (portions of 150, 80 and 40 mg) at room temperature. N,N‘-Dicyclohexylcarbodiimide (324 mg) was then added, and the mixture was further stirred at room temperature. To complete the reaction, some more N,N‘dicyclohexylcarbodiimide was added. The mixture was allowed to stand overnight, and the resulting precipitate was then filtered off with suction and the filtrate was concentrated. The residue was purified by preparative HPLC. The pure fractions were combined, the acetonitrile was removed using a rotary evaporator and the aqueous phase was neutralized with saturated potassium carbonate solution and extracted three times with ethyl acetate. The combined ethyl acetate phases were washed with saturated sodium chloride solution and then dried over magnesium sulfate. The drying agent was filtered off and the mixture was concentrated, and the residue was then taken up in water, 2N hydrochloric acid was added and the mixture was freeze-dried. This gave 220 mg of the desired compound.
LCMS-Rt: 1.93 min, (B)
MS (ES*, M+H1): 314.1
The compounds described in the table below were synthesized according to the examples stated in each case:
Analo-
Ex- gously MS LCMS-
Salt ample to Ex- [M+H"] Rt [min] ample
Cl 309.0
TFA | 7 1.84 (B)
ZN — (ES) \ cl cl N
HN + » HCI 7 |309.1 (ES*)| 1.87 (B)
Se. N wl VER I I Th I 10 = 1.75
NN (ES*)
Cl N H 11 AY TFA | 7 [270.1 (ESY)| 1.56 (B) ca H
Cl \ 12 11 HNO3
H Cl
Pharmacological data:
Test description:
' ® 21
In this test, the recovery of the intracellular pH (pH;) after an acidification, which starts when the NHE is capable of functioning, even under bicarbonate-free conditions, was determined. For this purpose, the pH; was determined using the pH-sensitive fluorescent dye BCECF (calbiochem, the precursor BCECF-AM is employed). The cells were initially loaded with BCECF. The BCECF fluorescence was determined in a “ratio fluorescence spectrometer” (Photon Technology International, South Brunswick,
N.J., USA) with excitation wavelengths of 505 and 440 nm and an emission wavelength of 535 nm, and was converted into the pH; using calibration plots. The cells were incubated in NH4Cl buffer (pH 7.4) (NH4Cl buffer: 115 mM NaCl, 20 mM NH4Cl, 5 mM KCI, 1 mM CaCl, 1 mM MgSOg4, 20 mM Hepes, 5 mM glucose, 1 mg/ml
BSA; a pH of 7.4 is established with 1 M NaOH) even during the BCECF loading. The intracellular acidification was induced by addition of 975 ul of an NH4Cl-free buffer (see below) to 25 ul aliquots of the cells incubated in NH4Cl buffer. The subsequent rate of pH recovery was recorded in the case of NHE1 for two minutes, in the case of
NHE2 for five minutes and in the case of NHE3 for three minutes. To calculate the inhibitory power of the tested substances, the cells were initially investigated in buffers in which complete or absolutely no pH recovery took place. For complete pH recovery (100%), the cells were incubated in Na*-containing buffer (133.8 mM NaCl, 4.7 mM
KCI, 1.25 mM CaCls, 1.25 mM MgClo, 0.97 mM NagHPO4, 0.23 mM NaH2POg4, 5 mM
Hepes, 5 mM glucose, a pH of 7.0 is established with 1 M NaOH). To determine the 0% value, the cells were incubated in an Na*-free buffer (133.8 mM choline chloride, 4.7 mM KCl, 1.25 mM CaClsp, 1.25 mM MgClp, 0.97 mM KoHPO4, 0.23 mM KH2POg4, 5 mM Hepes, 5 mM glucose, a pH of 7.0 is established with 1 M KOH). The substances to be tested were made up in the Na*-containing buffer. Recovery of the intracellular pH at the tested concentration of a substance was expressed as a percentage of the maximum recovery. Using the Sigma-Plot program, the IC value of the substance in question was calculated for the individual NHE subtypes using the percentages for pH recovery.
Results:
IC50 [WM],
Example (rNHE3)
Claims (19)
1. An imidazolidine of the formula R3 \ CCE ba R5 R7 Ro R6 in which RtandR2 independently of one another are CN, (C1-Csg)-alkyl, (C2-Cs)-alkenyl, (C2-Cs)- alkynyl, (C3-Cg)-cycloalkyl or (C4-Cg)-cycloalkenyl where all carbon chains and carbon rings are unsubstituted or, independently of one another, are substituted by 1 - 11 fluorine atoms or by up to two radicals selected from the group consisting of OH, NH2, NHCH3, N(CH3)2 and OCHag; or R1 and R2 together with the two carbon atoms to which they are attached are a five- to eight-membered saturated or unsaturated carbon ring, but without any double bond between the two carbon atoms to which R1 and R2 are attached, and where the ring is unsubstituted or substituted by 1 - 12 fluorine atoms or by up to two radicals selected from the group consisting of CH3 and OCH3; R3 is F, Cl, Br, |, (C4 -C4)-alkyl, (C1-C4)-alkenyl, (C3-Cg)-cycloalkyl, OH, (C1-C4)-alkoxy, Ophenyi, CN, NO2 or NH2: where phenyl is unsubstituted or substituted by up to two radicals selected from the group consisting of CH3, F, Cl, Br, |, OH and OCH3; and od 24 where the carbon chains or carbon rings are unsubstituted or substituted by 1 - 11 fluorine atoms; R4 to R6 independently of one another are H, F, Cl, Br, |, (C1-Cg4)-alkyl, (C1-C4)- alkenyl, (C3-Cg)-cycloalkyl, OH, (C1-C4)-alkoxy, CN, NO2, NH2, (C1-C4)- alkylamino or (C4-C4)-dialkylamino; where the carbon chains or carbon rings are unsubstituted or substituted by 1 - 11 fluorine atoms; R7 is H, F, Cl, Br, |, (C1-C4)-alkyl, (C1-C4)-alkenyl, (C3-Cg)-cycloalkyl, OH, (C1-C4)-alkoxy, CN, NO2 or NH». where the carbon chains or carbon rings are unsubstituted or substituted by 1 - 11 fluorine atoms; and its pharmaceutically acceptable salts, and the trifluoroacetic acid salts.
2. A compound of the formula | as claimed in claim 1 in which R1 and R2 independently of one another are (C1-Cs)-alkyl, (C2-Cg)-alkenyl, (C2-Cs)- alkynyl, (C3-Cg)-cycloalkyl or (C4-Cg)-cycloalkenyl, where all carbon chains and carbon rings are unsubstituted or, independently of one another, substituted by 1 - 11 fluorine atoms or by up to two radicals selected from the group consisting of NHCH3, N(CH3)2 and OCHg; or R1 and R2 together with the two carbon atoms to which they are attached are a five- to eight-membered saturated or unsaturated carbon ring, but without any double bond between the two carbon atoms to which R1 and R2 are attached, and
. ' ® 25 where the ring is unsubstituted or substituted by 1 - 12 fluorine atoms or by up to two radicals selected from the group consisting of CH3 and OCHag; R3 is F, Cl, Br, I, (C4 -C4)-alkyl, (C1-C4)-alkenyl, (C3-Cg)-cycloalkyl, OH, (C1-C4)-alkoxy, Ophenyl, CN, NO or NH. where phenyl is unsubstituted or substituted by up to two radicals selected from the group consisting of CH3, F, Cl, Br, OH and OCHg3; and where the carbon chains or carbon rings are unsubstituted or substituted by 1 - 11 fluorine atoms; R4 to R6 independently of one another are H, F, Cl, Br, CH3, OH, OCH3, CN, NO», NH2, NHCH3, N(CH3)2; where the methyl groups are unsubstituted or substituted by 1 - 3 fluorine atoms; R7 is H, F, Cl, Br, |, (C1-Cg4)-alkyl, (C1-C4)-alkenyl, (C3-Cg)-cycloalkyl, OH, (C1-C4)-alkoxy, CN, NO2 or NH2. where the carbon chains or rings are unsubstituted or substituted by 1 - 11 fluorine atoms; and its pharmaceutically acceptable salts, and the trifluoroacetic acid salts.
3. A compound of the formula | as claimed in claim 1 or 2 selected from the group consisting of: trans-(2-chloro-6-trifluoromethylphenyl)-(octahydrobenzimidazol-2-ylidene)amine hydrochloride, (S,S)-(2,6-dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt, cis-(2,6-dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt, (R,R)-(2,6-dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt,
i ' ¢ 26 trans-(octahydrobenzimidazol-2-ylidene)-(2-phenoxyphenyl)amine hydrochloride, trans-(2,6-dichlorophenyl)-(4,5-diisopropylimidazolidin-2-ylidene)amine hydrochloride, trans-(2,6-dichlorophenyl)-(4,5-dicyclopropylimidazolidin-2-ylidene)amine trifluoracetic acid salt, cis-(2,6-dichlorophenyl)-(4,5-dicyclopropylimidazolidin-2-ylidene)amine hydrochloride, trans-(2,6-dichlorophenyl)-(4,5-diethylimidazolidin-2-ylidene)amine hydrochloride, (2,6-dichlorophenyl)-(4,5-dimethylimidazolidin-2-ylidene)amine nitric acid salt, trans-(2,6-dichlorophenyl)-(hexahydrocyclopentaimidazol-2-ylidene)amine trifluoroacetic acid salt.
4. A compound of the formula | as claimed in one or more of claims 1 to 3, selected from the group consisting of: (S,S)-(2,6-dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt, cis-(2,6-dichlorophenyl)-(octahydrobenzimidazol-2-ylidene)amine trifluoroacetic acid salt, (R,R)-(2,6-dichlorophenyl)-(octahydrobenzimidazol-2-ylidene )amine trifluoroacetic acid salt, trans-(2,6-dichlorophenyl)-(4,5-diisopropylimidazolidin-2-ylidene)amine hydrochloride, trans-(2,6-dichlorophenyl)-(4,5-dicyclopropylimidazolidin-2-ylidene)amine trifluoroacetic acid salt, cis-(2,6-dichlorophenytl)-(4,5-dicyclopropylimidazolidin-2-ylidene)amine hydrochloride, trans-(2,6-dichlorophenyl)-(4,5-diethylimidazolidin-2-ylidene)amine hydrochloride, (2,6-dichlorophenyl)-(4,5-dimethylimidazolidin-2-ylidene)amine nitric acid salt, trans-(2,6-dichlorophenyl)-(hexahydrocyclopentaimidazol-2-ylidene)amine trifluoroacetic acid salt.
5. The use of a compound | as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of disorders of the respiratory drive.
6. The use of a compound | as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of respiratory disorders, in particular respiratory disorders associated with sleeping, such as sleep apnea.
7. The use of a compound | as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of snoring.
8. The use of a compound | as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of acute and chronic renal diseases, in particular acute kidney failure and chronic kidney failure.
9. The use of a compound | as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of disorders of intestinal function.
10. The use of a compound | as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of disorders of gall function.
11. The use of a compound | as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of ischemic states of the peripheral and central nervous system and of stroke.
12. The use of a compound | as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of ischemic states of peripheral organs and limbs.
13. The use of a compound | as claimed in claim 1 for preparing a medicament for treating states of shock.
14. The use of a compound | as claimed in claim 1 for preparing a medicament for use in surgical operations and organ transplantations.
15. The use of a compound | as claimed in claim 1 for preparing a medicament for preserving and storing transplants for surgical interventions.
16. The use of a compound | as claimed in claim 1 for preparing a medicament for the treatment of diseases in which cell proliferation is a primary or secondary cause.
17. The use of a compound | as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of disorders of lipid metabolism.
18. The use of a compound | as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of infection by ectoparasites.
19. A medicament, comprising an effective amount of a compound | as claimed in one or more of claims 1 to 3.
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DE10163239A DE10163239A1 (en) | 2001-12-21 | 2001-12-21 | Substituted imidazolidines, process for their preparation, their use as medicaments or diagnostic agents, and medicaments containing them |
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JP (1) | JP4571803B2 (en) |
KR (1) | KR100959031B1 (en) |
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AU (1) | AU2002361990B2 (en) |
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CA (1) | CA2470856A1 (en) |
CO (1) | CO5590925A2 (en) |
DE (2) | DE10163239A1 (en) |
DK (1) | DK1461034T3 (en) |
ES (1) | ES2275945T3 (en) |
HR (1) | HRP20040573A2 (en) |
HU (1) | HUP0600836A2 (en) |
IL (2) | IL162562A0 (en) |
MA (1) | MA27149A1 (en) |
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NO (1) | NO20043009L (en) |
PE (1) | PE20030741A1 (en) |
PL (1) | PL368940A1 (en) |
RS (1) | RS53204A (en) |
RU (1) | RU2004122415A (en) |
TW (1) | TW200305408A (en) |
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DE10323701A1 (en) | 2003-05-22 | 2004-12-23 | Aventis Pharma Deutschland Gmbh | Process for the synthesis of heterocyclic compounds |
ES2545903T3 (en) | 2003-06-30 | 2015-09-16 | Sumitomo Chemical Company, Limited | Asymmetric urea compounds and process for producing asymmetric compounds by reaction of asymmetric addition of conjugate using said compounds as catalyst |
DE10341240A1 (en) * | 2003-09-08 | 2005-04-07 | Aventis Pharma Deutschland Gmbh | Substituted thienoimidazoles, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them |
RS58378B1 (en) | 2014-07-25 | 2019-04-30 | Taisho Pharmaceutical Co Ltd | Phenyl tetrahydroisoquinoline compound substituted with heteroaryl |
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US3236857A (en) * | 1961-10-09 | 1966-02-22 | Boehringer Sohn Ingelheim | 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products |
US3190802A (en) * | 1961-10-09 | 1965-06-22 | Boehringer Sohn Ingelheim | Shaving composition and method of using same |
EP0070084A3 (en) * | 1981-04-24 | 1983-02-16 | Beecham Group Plc | Imidazoline derivatives |
DE3712385A1 (en) * | 1987-04-11 | 1988-10-27 | Boehringer Ingelheim Kg | 2-(Phenylimino)imidazolidines |
GB9313330D0 (en) * | 1993-06-28 | 1993-08-11 | Fujisawa Pharmaceutical Co | New compound and its preparation |
EP0639573A1 (en) * | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Benzocondensed five membered heterocycles, process of their preparation, their use as drug, as diagnostic means and pharmaceuticals containing it |
DE4328869A1 (en) * | 1993-08-27 | 1995-03-02 | Hoechst Ag | Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
KR100257129B1 (en) * | 1993-09-11 | 2000-05-15 | 성재갑 | Novel cephalosphorine antibiotics |
US5552415A (en) * | 1993-12-21 | 1996-09-03 | Eli Lilly And Company | Method of inhibiting Alzheimer's Disease |
DE19548812A1 (en) * | 1995-12-27 | 1997-07-03 | Hoechst Ag | Use of inhibitors of the cellular Na · + · / H · + · exchanger (NHE) for the manufacture of a medicament for respiratory stimulation |
DE19633966A1 (en) * | 1996-08-22 | 1998-02-26 | Hoechst Ag | Phenyl-substituted alkenylcarboxylic acid guanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
PT966465E (en) * | 1997-03-14 | 2003-11-28 | Vertex Pharma | IMFDH ENZYME INHIBITORS |
DE19945302A1 (en) * | 1999-09-22 | 2001-03-29 | Merck Patent Gmbh | Biphenyl derivatives as NHE-3 inhibitors |
DE19950898A1 (en) * | 1999-10-22 | 2001-04-26 | Aventis Pharma Gmbh | New heteroaryl substituted fluoroalkyl-benzoylguanidine derivatives useful for treatment of e.g. ischemias, cardiac infarction, angina, shock, atherosclerosis, cancer and metabolic disorders |
DE19960204A1 (en) * | 1999-12-14 | 2001-06-28 | Aventis Pharma Gmbh | Substituted norlbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them |
DE10015248A1 (en) * | 2000-03-28 | 2001-10-04 | Merck Patent Gmbh | Bisamidino compounds as NHE-3 inhibitors |
DE10019062A1 (en) * | 2000-04-18 | 2001-10-25 | Merck Patent Gmbh | Use of known and new 2-guanidino-4-aryl-quinazoline derivatives as NHE-3 inhibitors useful for the treatment of e.g. hypertension, thrombosis, cardiac ischemia, peripheral and CNS ischemia |
DE10060292A1 (en) * | 2000-12-05 | 2002-06-20 | Aventis Pharma Gmbh | Use of substituted benzimidazoles for the manufacture of a medicament for the treatment of diseases which can be influenced by inhibition of the Na + / H + exchanger and medicament containing them |
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2001
- 2001-12-21 DE DE10163239A patent/DE10163239A1/en not_active Withdrawn
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2002
- 2002-12-09 PL PL02368940A patent/PL368940A1/en not_active Application Discontinuation
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PE20030741A1 (en) | 2003-09-29 |
JP4571803B2 (en) | 2010-10-27 |
WO2003053434A1 (en) | 2003-07-03 |
RU2004122415A (en) | 2005-03-27 |
DE50208809D1 (en) | 2007-01-04 |
CA2470856A1 (en) | 2003-07-03 |
TW200305408A (en) | 2003-11-01 |
KR20040068322A (en) | 2004-07-30 |
HRP20040573A2 (en) | 2004-10-31 |
ATE345797T1 (en) | 2006-12-15 |
CN100339079C (en) | 2007-09-26 |
BR0215154A (en) | 2004-10-19 |
MY134344A (en) | 2007-12-31 |
DK1461034T3 (en) | 2007-03-26 |
CN1606440A (en) | 2005-04-13 |
CO5590925A2 (en) | 2005-12-30 |
IL162562A0 (en) | 2005-11-20 |
AR037932A1 (en) | 2004-12-22 |
PL368940A1 (en) | 2005-04-04 |
NO20043009L (en) | 2004-07-15 |
KR100959031B1 (en) | 2010-05-20 |
JP2005516947A (en) | 2005-06-09 |
ES2275945T3 (en) | 2007-06-16 |
MA27149A1 (en) | 2005-01-03 |
EP1461034A1 (en) | 2004-09-29 |
IL162562A (en) | 2009-12-24 |
DE10163239A1 (en) | 2003-07-10 |
AU2002361990A1 (en) | 2003-07-09 |
HUP0600836A2 (en) | 2008-04-28 |
RS53204A (en) | 2006-10-27 |
EP1461034B1 (en) | 2006-11-22 |
MXPA04005388A (en) | 2004-10-11 |
AU2002361990B2 (en) | 2008-10-09 |
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