ZA200202603B - Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase. - Google Patents
Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase. Download PDFInfo
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- ZA200202603B ZA200202603B ZA200202603A ZA200202603A ZA200202603B ZA 200202603 B ZA200202603 B ZA 200202603B ZA 200202603 A ZA200202603 A ZA 200202603A ZA 200202603 A ZA200202603 A ZA 200202603A ZA 200202603 B ZA200202603 B ZA 200202603B
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- South Africa
- Prior art keywords
- compound
- alkyl
- cycloalkyl
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- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title claims description 9
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 title claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 title description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title description 7
- 239000003112 inhibitor Substances 0.000 title description 3
- 125000003282 alkyl amino group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 75
- 125000000217 alkyl group Chemical group 0.000 claims description 66
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 53
- 229910052739 hydrogen Inorganic materials 0.000 claims description 31
- 239000001257 hydrogen Substances 0.000 claims description 31
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 29
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 23
- 125000003118 aryl group Chemical group 0.000 claims description 22
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 22
- 125000000623 heterocyclic group Chemical group 0.000 claims description 22
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 20
- 150000002431 hydrogen Chemical class 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
- 125000001188 haloalkyl group Chemical group 0.000 claims description 17
- 125000001072 heteroaryl group Chemical group 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- 238000011282 treatment Methods 0.000 claims description 15
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 13
- 125000004475 heteroaralkyl group Chemical group 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 9
- 125000002947 alkylene group Chemical group 0.000 claims description 8
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 claims description 8
- 125000005357 cycloalkylalkynyl group Chemical group 0.000 claims description 8
- 125000001475 halogen functional group Chemical group 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000000304 alkynyl group Chemical group 0.000 claims description 6
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- 230000002452 interceptive effect Effects 0.000 claims description 6
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 5
- 206010003246 arthritis Diseases 0.000 claims description 5
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16080499P | 1999-10-21 | 1999-10-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200202603B true ZA200202603B (en) | 2003-07-03 |
Family
ID=30442382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200202603A ZA200202603B (en) | 1999-10-21 | 2002-04-03 | Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase. |
Country Status (2)
| Country | Link |
|---|---|
| RU (1) | RU2264404C2 (ru) |
| ZA (1) | ZA200202603B (ru) |
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2000
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-
2002
- 2002-04-03 ZA ZA200202603A patent/ZA200202603B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2264404C2 (ru) | 2005-11-20 |
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