ZA200107804B - Preparation for regulating lower bowel function. - Google Patents
Preparation for regulating lower bowel function. Download PDFInfo
- Publication number
- ZA200107804B ZA200107804B ZA200107804A ZA200107804A ZA200107804B ZA 200107804 B ZA200107804 B ZA 200107804B ZA 200107804 A ZA200107804 A ZA 200107804A ZA 200107804 A ZA200107804 A ZA 200107804A ZA 200107804 B ZA200107804 B ZA 200107804B
- Authority
- ZA
- South Africa
- Prior art keywords
- preparation
- bentonite
- aloe
- powder
- weight
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 10
- 230000003871 intestinal function Effects 0.000 title claims description 7
- 230000001105 regulatory effect Effects 0.000 title claims description 5
- 239000000843 powder Substances 0.000 claims description 17
- 239000000440 bentonite Substances 0.000 claims description 16
- 229910000278 bentonite Inorganic materials 0.000 claims description 16
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 16
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 11
- 239000005995 Aluminium silicate Substances 0.000 claims description 9
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- 238000004519 manufacturing process Methods 0.000 description 4
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
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- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Description
t t “ -1- :
PREPARATION FOR REGULATING LOWER BOWEL FUNCTION
THIS INVENTION relates to a preparation for regulating lower bowel function.
In irritable bowel syndrome (1.B.S.) the mechanical function of the colon is disrupted. The patient classically suffers from alternate bouts of . constipation and diarrhea . Flatulence, cramping and pain are also common features of this syndrome.
The consistency of the colon content is very important for normal peristaltic and mechanical movement resulting in voiding to produce a normal bowel movement with faeces the consistency of soft clay. Bowel content that is either too watery or too solid results in disruption of the colon structure, often resulting in disease conditions such as diverticulitis and ulcerative colitis.
The movement of the bowel content through the colon is facilitated by mucous which is secreted by the cells lining the lumen of the colon. If the consistency of the faecal mass is inappropriate, this lubrication effect is lost.
J
The proliferation of micro organisms in the colon is determined by many factors, such as the amount of undigested food which reaches the colon, the pH, the transit time, faecal consistency etc. Excessive bacterial or fungal activity in the colon is termed putrification and is undesirable as it can lead to bowel disease.
Many products have been formulated to treat 1.B.S. However, it has been found that, in extended studies, none are more effective than a placebo.
End stage AIDS patients suffer from diarrhea. Typically the patient at this stage of the disease will have uncontrollable diarrhea. The transit time of meals through the gastro-intestinal tract is too rapid to allow sufficient time for digestion and absorption of the nutrients in the food. The patient then loses weight, becomes very thin and eventually dies. ’
According to the present invention there is provided a preparation for regulating lower bowel function which comprises a mixture of bentonite and/or kaolin and Aloe fibres which have been reduced to the form of a dry powder.
The proportion of dry Aloe powder in the preparation can range from 10% to 90% by weight and the proportion of bentonite and/or kaolin from 90% to 10% by weight.
V
It is preferred that the proportion of fibre powder in the preparation be between 30% and 70 % and that the balance be bentonite and/or kaolin.
In the form which Applicants have found to be most effective the fibre powder constitutes 60% by weight and the balance is bentonite and/or kaolin.
Bentonite is the preferred clay as it has medicinal properties. It is best described as a native (natural) colloidal hydrated aluminium silicate of montmorillite
Al,O3, 4si0,, H,0 with trace quantities of other minerals such as magnesium and iron with some calcium carbonate. In water bentonite swells to form a colloidal gel.
The powder is preferably produced from the leaves of the Aloe Ferox plant. However, Aloe Vera or any other type of Aloe which is plentiful and robust enough to withstand sustainable harvesting can be used. Aloe Ferox is a natural dietary fibre prepared from leaves of Aloe Ferox, an abundant species growing wild in its natural habitat in the Southern Cape region of South Africa. The leaves of this species have been harvested by traditional aloe tappers for the production of crystalline Aloe Bitters, which has been exported to Europe and the East since 1763.
The traditional manner of collecting the aloin-containing bitter sap and converting it to hard crystals continues on a sustainable basis and does not present any threat to the environment.
For the production of Aloe Ferox powder, leaves already cut by the v tappers and from which the bitter sap has drained, are collected from the veld, washed and then sliced very thin. Any remaining bitter sap is removed by agitation in warm water (70°c). Finally the slices are dried in the sun and milled into a fine power. Ferox does not contain any additives. It is derived from plants that have not been artificially fertilized or sprayed with insecticides or fungicides. The only natural constituents removed from the leaves in the production process are aloin and its derivatives, as well as resins, in the bitter sap.
The Composition of Aloe Ferox per 100 g. of leaf powder, and its characteristics, are as follows:-
Total dietary fibre 43.0g
Insoluble fibre 28.79 — hemi-cellulosic polymers, mainly xylans ) - cellulose - lignin
Soluble fibre 14.3g - pectin polymers - arabinogalactan - rhamnogalacturonan
Water hydration capacity
Approximately seven times its own weight.
v -.
Viscosity 260 cps. At 20°c
Viscosity is measured as a 3% suspension of leaf powder after heating in 2% potassium citrate solution to sequestrate the polysaccharide gel from the leaf calcium.
Aloin and derivatives Absent
This is shown by a negative Borntraeger reaction
Microbial count CFU/g.
Total microbial activity 710
Pathogens absent 1 0 Moulds 50
Analysis of Particle size Sieve analysis > 500 microns 1,5 % m/m 500-125 microns 62.8 % m/m 125-45 microns 30.7 % m/m < 45 microns 5,0 % m/m
Mineral content per 100 g. of leaf powder
Calcium 4,08 ¢g
Potassium 0.08¢g
Sodium 0.18 ¢g
»
Magnesium 044g fron 34.0 mg
Copper 9.5 mg
Manganese 4.8 mg
Zinc 3.1 mg
Boron 2.5 mg
Selenium 6.3 ppm
Ash 11.8 g/100 g
Moisture 10.2 9/100 g
Carbohydrates (calculated) 50.0 g/100 g (glyco-proteins (mainly pectic polymers)
Amino acids as g. per 100 g leaf powder
Aspartic acid 0.03
Glutamic acid 0.07 16 Serine 0.08
Glycine 0.11
Histidine 0.02
Arginine 0.06
Threonine 0.11
LJ
Alanine 0.14
Proline 0.11
Tyrosine 0.06
Valine 0.11
Methionie 0.02
Cysteine 0.02
Isoleucine 0.09
Leucine 0.16
Phenylalanine 0.10
Lysine 0.08
Trypotophane not detected
The invention will now be described in detail with reference to the following example.
Two parts by weight of Aloe Ferox leaf powder was mixed with one part by weight of bentonite. A 3% suspension of the leaf powder in water has a pH of 4.9. A similar suspension of bentonite has a pH of 9.5. A 3% solution of the mixture as described has a pH of 5.2. Bentonite in water absorbs twelve times its own weight. Dry Aloe Ferox powder can absorb up to seven times its own weight.
Experimental work has shown that 10 grams of the Aloe Ferox /
v bentonite mixture absorbs water and swells, eventually achieving a mass of about 100 grams.
Kaolin, also called china clay, has properties which make it usable as a product for the treatment of humans. It can completely, or partly, replace the bentonite in the product of the present invention.
The product can be formulated as tablets or preferably granules for ease of consumption.
The following are case histories of patients on whom the product has been tested.
Patient 1
This 30 year old female was diagnosed with Irritable Bowel Syndrome five years ago at a state hospital. Her symptoms before treatment were diarrhea with cramping and pain, occasional constipation for which she took irritant laxatives which started the diarrhea phase again. She was thoroughly depressed about her condition, which included gastric hyperacidity. She reported five days after starting treatment with the bentonite / Aloe Ferox powder that her lower bowel function had improved dramatically. She reported a significant improvement in the lower bowel function, with the production of normal stools three times daily.
Claims (4)
1. A preparation for regulating lower bowel function which comprises a mixture of bentonite and/or kaolin and Aloe fibres which have been reduced to the form of a dry powder.
2. A preparation as claimed in claim 1, wherein the proportion of dry Aloe powder is between 10% to 90% by weight and the proportion of bentonite and/or kaolin from 90% to 10% by weight.
3. A preparation as claimed in claim 2, wherein the proportion of dry aloe : fibres is between 30% and 70 % and the balance is bentonite and/or kaolin.
4. A preparation as claimed in claim 3, wherein the fibre powder constitutes 60% by weight and the balance is bentonite and/or kaolin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA200107804A ZA200107804B (en) | 1999-02-24 | 2001-09-21 | Preparation for regulating lower bowel function. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA991462 | 1999-02-24 | ||
| ZA200107804A ZA200107804B (en) | 1999-02-24 | 2001-09-21 | Preparation for regulating lower bowel function. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200107804B true ZA200107804B (en) | 2002-05-23 |
Family
ID=27145199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200107804A ZA200107804B (en) | 1999-02-24 | 2001-09-21 | Preparation for regulating lower bowel function. |
Country Status (1)
| Country | Link |
|---|---|
| ZA (1) | ZA200107804B (en) |
-
2001
- 2001-09-21 ZA ZA200107804A patent/ZA200107804B/en unknown
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