YU55095A - Opioid peptides for the treatment of pain and the use thereof - Google Patents

Opioid peptides for the treatment of pain and the use thereof

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Publication number
YU55095A
YU55095A YU55095A YU55095A YU55095A YU 55095 A YU55095 A YU 55095A YU 55095 A YU55095 A YU 55095A YU 55095 A YU55095 A YU 55095A YU 55095 A YU55095 A YU 55095A
Authority
YU
Yugoslavia
Prior art keywords
peptides
pain
opioid
treatment
present
Prior art date
Application number
YU55095A
Other languages
Serbo-Croatian (sh)
Inventor
William Brown
John Diamio
Peter Schiller
Rene Martel
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Priority to YU55095A priority Critical patent/YU55095A/en
Publication of YU55095A publication Critical patent/YU55095A/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Ovaj se pronalazak odnosi na niz novih opioidnih peptida za lečenje bola i na farmaceutski prihvatljive preparate koji sadrže te peptide. Pronalazak takodje daje postupke za suzbijanje bola kod pacijenata koji koriste preparate prema pronalasku. Peptidi prema ovom pronalasku imaju veliki stepen selektivnosti za .Вµ..-opioidni receptor. Ovi peptidi su veoma lipofilni. Uprkos njihovog lipofilnog karaktera, ne prolaze lako kroz barijeru krv-mozak (blood brain barrier - BBB). Peptidi prema prikazanom pronalasku posebno su pogodni kao analgetički agensi koji u suštini deluju na periferne .Вµ..-opioidne receptore. Zbog toga što ovi peptidi deluju periferno, oni u suštini izbegavaju izazivanje sporednih dejstava normalno povezanih sa centralnim analgetičkim delovanjem.The present invention relates to a series of novel opioid peptides for the treatment of pain and to pharmaceutically acceptable preparations containing these peptides. The invention also provides methods of pain management for patients using the compositions of the invention. The peptides of this invention have a high degree of selectivity for the .Vµ ..- opioid receptor. These peptides are very lipophilic. Despite their lipophilic character, they do not easily cross the blood brain barrier (BBB). The peptides of the present invention are particularly suitable as analgesic agents that substantially affect peripheral .Vµ ..- opioid receptors. Because these peptides act peripherally, they essentially avoid causing side effects normally associated with central analgesic activity.

YU55095A 1995-08-17 1995-08-17 Opioid peptides for the treatment of pain and the use thereof YU55095A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
YU55095A YU55095A (en) 1995-08-17 1995-08-17 Opioid peptides for the treatment of pain and the use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU55095A YU55095A (en) 1995-08-17 1995-08-17 Opioid peptides for the treatment of pain and the use thereof

Publications (1)

Publication Number Publication Date
YU55095A true YU55095A (en) 1998-08-14

Family

ID=47598477

Family Applications (1)

Application Number Title Priority Date Filing Date
YU55095A YU55095A (en) 1995-08-17 1995-08-17 Opioid peptides for the treatment of pain and the use thereof

Country Status (1)

Country Link
YU (1) YU55095A (en)

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