YU49442B - PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE - Google Patents
PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDEInfo
- Publication number
- YU49442B YU49442B YU15195A YU15195A YU49442B YU 49442 B YU49442 B YU 49442B YU 15195 A YU15195 A YU 15195A YU 15195 A YU15195 A YU 15195A YU 49442 B YU49442 B YU 49442B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- formula
- ribofuranosylselenazole
- added
- anhydro
- methanol
- Prior art date
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Postupak za dobijanje 2-β-D-ribofuranozilselenazol-4-karboksiamida, formule I, naznačen time, što reaguje 2,3-anhidro-3,4,6-tri-O-benzoil-D-alononitril formule II sa natrijum-metoksidom u metanolu na temperaturi od 35-45 В°C u atmosferi azota, dodaje metilen hlorid i dobija kristalni metil-2,5-anhidro-2-D-alonimidat formule III koji se dodaje u ekvimolarnom odnosu u smešu etanola ohladjenog na -20В°C i vodonik-selenida, na temperaturi od 0 do 5 В°C i dobija selenoamid formue IV koji se ne izoluje, nego in situ reaguje sa etil-α-bromopiruvatom i dobija etil 2-D-ribofuranozilselenazol-4-karboksilat formule V koji se, rastvoren u metanolu i ohladjen na 0 В°C, zasiti amonijakom i prevodi u 2-D-ribofuranozilselenazol-4-karboksiamida formule I. Prijava sadrži još 3 zavisna patentna zahteva.A process for the preparation of 2-β-D-ribofuranosylselenazole-4-carboxyamide of formula I by reacting with 2,3-anhydro-3,4,6-tri-O-benzoyl-D-alononitrile formula II with sodium methoxide in methanol at a temperature of 35-45 V ° C under a nitrogen atmosphere, methylene chloride is added and crystalline methyl-2,5-anhydro-2-D-alonimidate of formula III is added which is added in equimolar ratio to a mixture of ethanol cooled to -20V ° C and hydrogen selenide, at a temperature of from 0 to 5 V ° C, gives a selenoamide of formula IV which is not isolated but in situ reacted with ethyl α-bromopyruvate to give ethyl 2-D-ribofuranosylselenazole-4-carboxylate of formula V which , dissolved in methanol and cooled to 0 ° C, is saturated with ammonia and converted to 2-D-ribofuranosylselenazole-4-carboxamide of formula I. The application contains 3 more dependent claims.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
YU15195A YU49442B (en) | 1995-03-07 | 1995-03-07 | PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE |
US08/603,106 US5907036A (en) | 1995-02-17 | 1996-02-20 | Procedures for obtaining ribo-C-nucleosides |
PCT/US1996/002512 WO1996026212A1 (en) | 1995-02-17 | 1996-02-20 | Procedures for obtaining ribo-c-nucleosides |
EP96909514A EP0804447A1 (en) | 1995-03-07 | 1996-02-20 | Procedures for obtaining ribo-c-nucleosides |
SK1202-97A SK120297A3 (en) | 1995-03-07 | 1996-02-20 | Procedures for obtaining ribo-c-nucleosides |
AU52980/96A AU5298096A (en) | 1995-02-17 | 1996-02-20 | Procedures for obtaining ribo-c-nucleosides |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
YU15195A YU49442B (en) | 1995-03-07 | 1995-03-07 | PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE |
Publications (2)
Publication Number | Publication Date |
---|---|
YU15195A YU15195A (en) | 1998-07-10 |
YU49442B true YU49442B (en) | 2006-03-03 |
Family
ID=25548578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU15195A YU49442B (en) | 1995-02-17 | 1995-03-07 | PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0804447A1 (en) |
SK (1) | SK120297A3 (en) |
YU (1) | YU49442B (en) |
-
1995
- 1995-03-07 YU YU15195A patent/YU49442B/en unknown
-
1996
- 1996-02-20 EP EP96909514A patent/EP0804447A1/en not_active Withdrawn
- 1996-02-20 SK SK1202-97A patent/SK120297A3/en unknown
Also Published As
Publication number | Publication date |
---|---|
SK120297A3 (en) | 1998-01-14 |
EP0804447A1 (en) | 1997-11-05 |
YU15195A (en) | 1998-07-10 |
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