YU49442B - PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE - Google Patents

PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE

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Publication number
YU49442B
YU49442B YU15195A YU15195A YU49442B YU 49442 B YU49442 B YU 49442B YU 15195 A YU15195 A YU 15195A YU 15195 A YU15195 A YU 15195A YU 49442 B YU49442 B YU 49442B
Authority
YU
Yugoslavia
Prior art keywords
formula
ribofuranosylselenazole
added
anhydro
methanol
Prior art date
Application number
YU15195A
Other languages
Serbo-Croatian (sh)
Other versions
YU15195A (en
Inventor
dr. Vjera Pejanović
Jadranka Vojmirović
Original Assignee
Galenika A.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galenika A.D. filed Critical Galenika A.D.
Priority to YU15195A priority Critical patent/YU49442B/en
Priority to US08/603,106 priority patent/US5907036A/en
Priority to PCT/US1996/002512 priority patent/WO1996026212A1/en
Priority to EP96909514A priority patent/EP0804447A1/en
Priority to SK1202-97A priority patent/SK120297A3/en
Priority to AU52980/96A priority patent/AU5298096A/en
Publication of YU15195A publication Critical patent/YU15195A/en
Publication of YU49442B publication Critical patent/YU49442B/en

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Postupak za dobijanje 2-β-D-ribofuranozilselenazol-4-karboksiamida, formule I, naznačen time, što reaguje 2,3-anhidro-3,4,6-tri-O-benzoil-D-alononitril formule II sa natrijum-metoksidom u metanolu na temperaturi od 35-45 В°C u atmosferi azota, dodaje metilen hlorid i dobija kristalni metil-2,5-anhidro-2-D-alonimidat formule III koji se dodaje u ekvimolarnom odnosu u smešu etanola ohladjenog na -20В°C i vodonik-selenida, na temperaturi od 0 do 5 В°C i dobija selenoamid formue IV koji se ne izoluje, nego in situ reaguje sa etil-α-bromopiruvatom i dobija etil 2-D-ribofuranozilselenazol-4-karboksilat formule V koji se, rastvoren u metanolu i ohladjen na 0 В°C, zasiti amonijakom i prevodi u 2-D-ribofuranozilselenazol-4-karboksiamida formule I. Prijava sadrži još 3 zavisna patentna zahteva.A process for the preparation of 2-β-D-ribofuranosylselenazole-4-carboxyamide of formula I by reacting with 2,3-anhydro-3,4,6-tri-O-benzoyl-D-alononitrile formula II with sodium methoxide in methanol at a temperature of 35-45 V ° C under a nitrogen atmosphere, methylene chloride is added and crystalline methyl-2,5-anhydro-2-D-alonimidate of formula III is added which is added in equimolar ratio to a mixture of ethanol cooled to -20V ° C and hydrogen selenide, at a temperature of from 0 to 5 V ° C, gives a selenoamide of formula IV which is not isolated but in situ reacted with ethyl α-bromopyruvate to give ethyl 2-D-ribofuranosylselenazole-4-carboxylate of formula V which , dissolved in methanol and cooled to 0 ° C, is saturated with ammonia and converted to 2-D-ribofuranosylselenazole-4-carboxamide of formula I. The application contains 3 more dependent claims.

YU15195A 1995-02-17 1995-03-07 PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE YU49442B (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
YU15195A YU49442B (en) 1995-03-07 1995-03-07 PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE
US08/603,106 US5907036A (en) 1995-02-17 1996-02-20 Procedures for obtaining ribo-C-nucleosides
PCT/US1996/002512 WO1996026212A1 (en) 1995-02-17 1996-02-20 Procedures for obtaining ribo-c-nucleosides
EP96909514A EP0804447A1 (en) 1995-03-07 1996-02-20 Procedures for obtaining ribo-c-nucleosides
SK1202-97A SK120297A3 (en) 1995-03-07 1996-02-20 Procedures for obtaining ribo-c-nucleosides
AU52980/96A AU5298096A (en) 1995-02-17 1996-02-20 Procedures for obtaining ribo-c-nucleosides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU15195A YU49442B (en) 1995-03-07 1995-03-07 PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE

Publications (2)

Publication Number Publication Date
YU15195A YU15195A (en) 1998-07-10
YU49442B true YU49442B (en) 2006-03-03

Family

ID=25548578

Family Applications (1)

Application Number Title Priority Date Filing Date
YU15195A YU49442B (en) 1995-02-17 1995-03-07 PROCESS FOR OBTAINING 2-β-D-RIBOFURANOSYLSELENOAZOLE-4-CARBOXYLAMIDE

Country Status (3)

Country Link
EP (1) EP0804447A1 (en)
SK (1) SK120297A3 (en)
YU (1) YU49442B (en)

Also Published As

Publication number Publication date
SK120297A3 (en) 1998-01-14
EP0804447A1 (en) 1997-11-05
YU15195A (en) 1998-07-10

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