YU48994B - N-acil-alpha-aminoacid derivatives - Google Patents

N-acil-alpha-aminoacid derivatives

Info

Publication number
YU48994B
YU48994B YU29592A YU29592A YU48994B YU 48994 B YU48994 B YU 48994B YU 29592 A YU29592 A YU 29592A YU 29592 A YU29592 A YU 29592A YU 48994 B YU48994 B YU 48994B
Authority
YU
Yugoslavia
Prior art keywords
hydrogen
group
formula
lower alkyl
amidino
Prior art date
Application number
YU29592A
Other languages
Serbo-Croatian (sh)
Other versions
YU29592A (en
Inventor
Alig Leo
Hadvary Paul
HГјrzeler Marianne
MГјller Marcel
Steiner Beat
Weller Thomas
Original Assignee
F.Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Priority to SI9210295A priority Critical patent/SI9210295B/en
Publication of YU29592A publication Critical patent/YU29592A/en
Publication of YU48994B publication Critical patent/YU48994B/en

Links

Classifications

    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1. Derivati N-acil - α- aminokiseline, formule u kojoj označavaju L grupu formule ili RВ°-NH(CH2)t L2 R amidino ili gvanidino, jedan od simbola X i Y označava CH, a drugi od ovih simbola označava CH ili N, RВ° vodonik ili amidino, t ceo broj od 2 do 6, R'm R" i R"' vodonik ili N-supstituente odnosno bočne lance (nizove) koji su uobičajeni u α-aminokarboksilnim kiselinama, pri čemu hidroksi -odnosno karboksi - grupe, koje se nalaze u supstituentima R', R" i R"', mogu biti eterifikovane odnosno esterifikovane ili amidirane, i prisutne amino-grupe mogu biti C1-6-alkanoilirane ili aroilirane, Q grupu formule ili -N(V')(CH2)v-C(V",V"')CH2OCH2COO-T ili, ako R' i R" zajedno sa N- ili C-atomom za koji su vezani, obrazuju prsten, takođe može označavati grupu formule broj 0 ili 1, Q9 n broj 0 ili 1, v ceo broj od 0 do 3, T i T"vodonik ili niži alkil (C1-6) ili fenil-niži alkil (C1-6) koji se mogu odcepiti, V do V"' vodonik ili niži alkil (C1-6), U i U' vodonik, C1-6-alkanoil ili aroil, Ar aril i R2 do R5 vodonik, niži alkil (C1-6), niži alkoksi (C1-6), halogen ili grupu -OCH2COO-T, ili R2 i R3 zajedno sa fenil-grupom za koju su vezani, obrazuju 1-naftil-grupu, kao i njihovi hidrati ili solvati i primenljive soli. Prijava sadrži još 2 nezavisna i 12 zavisnih zahteva.1. N-acyl-α-amino acid derivatives, of the formula in which they denote an L group of the formula or RV ° -NH (CH2) t L2 R amidino or guanidino, one of the symbols X and Y denotes CH and the other of these symbols denotes CH or N, RV is hydrogen or amidino, t is an integer from 2 to 6, R'm R "and R" 'are hydrogen or N-substituents or side chains (sequences) which are common in α-aminocarboxylic acids, where hydroxy -or. carboxy groups, which are present in the substituents R ', R "and R"', may be etherified or esterified or amidated, and the amino groups present may be C1-6-alkanoylated or aroylated, a Q group of formula or -N (V ') (CH2) vC (V ", V"') CH2OCH2COO-T or, if R 'and R "together with the N- or C-atom to which they are attached, form a ring, may also denote a group of formula number 0 or 1 , Q9 n number 0 or 1, v an integer from 0 to 3, T and T "hydrogen or lower alkyl (C1-6) or phenyl-lower alkyl (C1-6) which can be cleaved, V to V" 'hydrogen or lower alkyl (C1-6), U and U 'hydrogen, C1-6 alkanoyl or aroyl, Ar aryl and R2 to R5 are hydrogen, lower alkyl (C1-6), lower alkoxy (C1-6), halogen or a group -OCH2COO-T, or R2 and R3 together with the phenyl group to which they are attached form a 1-naphthyl group, as well as their hydrates or solvates and applicable salts. The application contains 2 more independent and 12 dependent requests.

YU29592A 1991-03-26 1992-03-24 N-acil-alpha-aminoacid derivatives YU48994B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SI9210295A SI9210295B (en) 1991-03-26 1992-03-24 N-acyl-alpha-aminoacids derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH91091 1991-03-26

Publications (2)

Publication Number Publication Date
YU29592A YU29592A (en) 1994-09-09
YU48994B true YU48994B (en) 2003-04-30

Family

ID=4198024

Family Applications (2)

Application Number Title Priority Date Filing Date
YU29492A YU29492A (en) 1991-03-25 1992-03-24 CONJUGATE PROTEIN TO POLYETHYLENE
YU29592A YU48994B (en) 1991-03-26 1992-03-24 N-acil-alpha-aminoacid derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU29492A YU29492A (en) 1991-03-25 1992-03-24 CONJUGATE PROTEIN TO POLYETHYLENE

Country Status (6)

Country Link
BR (2) BR9201030A (en)
LT (1) LT3681B (en)
MX (1) MX9201169A (en)
UY (1) UY23389A1 (en)
YU (2) YU29492A (en)
ZA (1) ZA922022B (en)

Also Published As

Publication number Publication date
BR1100042A (en) 2000-04-11
ZA922022B (en) 1992-11-25
LTIP861A (en) 1995-03-27
BR9201030A (en) 1992-11-24
YU29592A (en) 1994-09-09
MX9201169A (en) 1992-10-01
LT3681B (en) 1996-01-25
YU29492A (en) 1994-09-09
UY23389A1 (en) 1992-09-15

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