YU48721B - PROCESS FOR THE PRAPARATION OF 1ß-ETHYL-1α-(HYDROXYMETHYL)-1,2,3,4,6,7,12,12bα-OCTAHYDRO-INDOLO (2,3-a)QUINOLIZYNE AND NOVEL INTERMEDIATES - Google Patents

PROCESS FOR THE PRAPARATION OF 1ß-ETHYL-1α-(HYDROXYMETHYL)-1,2,3,4,6,7,12,12bα-OCTAHYDRO-INDOLO (2,3-a)QUINOLIZYNE AND NOVEL INTERMEDIATES

Info

Publication number
YU48721B
YU48721B YU188791A YU188791A YU48721B YU 48721 B YU48721 B YU 48721B YU 188791 A YU188791 A YU 188791A YU 188791 A YU188791 A YU 188791A YU 48721 B YU48721 B YU 48721B
Authority
YU
Yugoslavia
Prior art keywords
ethyl
indolo
hydroxymethyl
formula
hexahydro
Prior art date
Application number
YU188791A
Other languages
Serbo-Croatian (sh)
Other versions
YU188791A (en
Inventor
Janos Dr. Kreidl
Laszlo dr. Czibula
Gyorgy hem.ing. Visky
Maria nee Kirjak hem.ing. Farkas
Katalin Dr. Nogradi
Ida Nee Juhasz Hem. Deutsch
Judit dr. Brill
Original Assignee
Richter Gedeon Vegyeszeti Gyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.
Priority to YU188791A priority Critical patent/YU48721B/en
Priority to HRP920776 priority patent/HRP920776A2/en
Publication of YU188791A publication Critical patent/YU188791A/en
Publication of YU48721B publication Critical patent/YU48721B/en

Links

Abstract

Postupak za dobijanje (-)-1Гџ-etil-1α-(hidroksimetil)-1,2,3,4,6,7,12,12bα-oktahidroindolo(2,3-a)hinolizin formule (I) naznačen time, što reaguje 1-etil-2,3,4,6,7,12-heksahidro-indolo(2,3-a)hinolizin formule (II) sa oko ekvimolamom količinom formaldehida ili sa njegovom polimerizovanom formom i posle izolovanja ako je potrebno novi racemski 1-etil-1-(hidroksimetil)-1,2,3,4,6,7-heksahidro-12H-indolo-(2,3-a)hinolizin formule (III) tretira se sa agensom razdvajanja u količini manjoj od ekvimolarne količine i novi dobijeni 1Гџ-etil-1α-(hidroksimetil)-1,2,3,4,6,7-heksahidro-12H-indolo-(2,3-a)hinolizin-5-jum soli formule (IV) gde X- predstavlja ostatak optički aktivne kiseline, redukuje se i ako je potrebno dobija slobodna baza formule (I). - Prijava sadrži još 6 nezavisnih i 3 zavisna zahteva.A process for the preparation of (-) - 1G-ethyl-1α- (hydroxymethyl) -1,2,3,4,6,7,12,12bα-octahydroindolo (2,3-a) quinolizine of formula (I), characterized in that reacts 1-ethyl-2,3,4,6,7,12-hexahydro-indolo (2,3-a) quinolysin of formula (II) with about an equimolam amount of formaldehyde or with its polymerized form and after isolation if a new racemic is required 1-Ethyl-1- (hydroxymethyl) -1,2,3,4,6,7-hexahydro-12H-indolo- (2,3-a) quinolysin of formula (III) is treated with a separation agent in an amount less than equimolar quantities and newly obtained 1G-ethyl-1α- (hydroxymethyl) -1,2,3,4,6,7-hexahydro-12H-indolo- (2,3-a) quinolizin-5-yl salt of formula (IV) wherein X- represents the residue of the optically active acid, reduced and if necessary obtained the free base of formula (I). - The application contains 6 more independent and 3 dependent requests.

YU188791A 1991-12-03 1991-12-03 PROCESS FOR THE PRAPARATION OF 1ß-ETHYL-1α-(HYDROXYMETHYL)-1,2,3,4,6,7,12,12bα-OCTAHYDRO-INDOLO (2,3-a)QUINOLIZYNE AND NOVEL INTERMEDIATES YU48721B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
YU188791A YU48721B (en) 1991-12-03 1991-12-03 PROCESS FOR THE PRAPARATION OF 1ß-ETHYL-1α-(HYDROXYMETHYL)-1,2,3,4,6,7,12,12bα-OCTAHYDRO-INDOLO (2,3-a)QUINOLIZYNE AND NOVEL INTERMEDIATES
HRP920776 HRP920776A2 (en) 1991-12-03 1992-10-01 PROCESS FOR OBTAINING 1 BETA-ETHYL-1 ALPHA(HYDROXYMETHYL)-1,2,3,4,6,7,12,12b ALPHA-OCTAHYDRO-INDOLO (2,3-a) QUINOLIZINE AND NEW INTERMEDIATES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU188791A YU48721B (en) 1991-12-03 1991-12-03 PROCESS FOR THE PRAPARATION OF 1ß-ETHYL-1α-(HYDROXYMETHYL)-1,2,3,4,6,7,12,12bα-OCTAHYDRO-INDOLO (2,3-a)QUINOLIZYNE AND NOVEL INTERMEDIATES

Publications (2)

Publication Number Publication Date
YU188791A YU188791A (en) 1994-06-10
YU48721B true YU48721B (en) 1999-07-28

Family

ID=25556002

Family Applications (1)

Application Number Title Priority Date Filing Date
YU188791A YU48721B (en) 1991-12-03 1991-12-03 PROCESS FOR THE PRAPARATION OF 1ß-ETHYL-1α-(HYDROXYMETHYL)-1,2,3,4,6,7,12,12bα-OCTAHYDRO-INDOLO (2,3-a)QUINOLIZYNE AND NOVEL INTERMEDIATES

Country Status (2)

Country Link
HR (1) HRP920776A2 (en)
YU (1) YU48721B (en)

Also Published As

Publication number Publication date
YU188791A (en) 1994-06-10
HRP920776A2 (en) 1994-08-31

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