YU4792A - PROCEDURE FOR CULTIVATION OF TUMOR INFILTING LYMPHOCYTES - Google Patents

PROCEDURE FOR CULTIVATION OF TUMOR INFILTING LYMPHOCYTES

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Publication number
YU4792A
YU4792A YU4792A YU4792A YU4792A YU 4792 A YU4792 A YU 4792A YU 4792 A YU4792 A YU 4792A YU 4792 A YU4792 A YU 4792A YU 4792 A YU4792 A YU 4792A
Authority
YU
Yugoslavia
Prior art keywords
tumor
lymphocytes
infilting
cultivation
procedure
Prior art date
Application number
YU4792A
Other languages
Serbo-Croatian (sh)
Inventor
Hsu Dihwei
W.K. Moore
H. Spits
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of YU4792A publication Critical patent/YU4792A/en

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Abstract

POSTUPAK GAJENJA TUMORNIH INFILTIRAJUCIH LIMFOCITA, obezbedjen je postupak za korišćenje interleukina-10 u adoptivnoj imunoterapji raka. Populacija tumornih infiltrirajućih limfocita (TIL) i/ili limfokinski aktiviranih ćelija-ubica (LAK) ekspanduje se u kulturi u prisustvu interleukina-2 (IL-2) ili interleukina-10 (IL-10). Nakon davanja TIL i/ili LAK pacijentu, daju mu se i efikasne količine IL-2 i IL-10, kako bi se pojačala citotoksicnost TIL i/ili LAK prema ćelijama tumora i smanjila sporedna dejstva koja se javljaju zbog toga što IL-2 indukuje proizvodnju citokina u ćelijama pacijenta.PROCEDURE FOR CULTIVATION OF TUMOR INFILTING LYMPHOCYTES, a method for the use of interleukin-10 in the adoptive immunotherapy of cancer is provided. The population of tumor infiltrating lymphocytes (TIL) and / or lymphokine-activated killer cells (LAK) is expanded in culture in the presence of interleukin-2 (IL-2) or interleukin-10 (IL-10). Following administration of TIL and / or LAC to a patient, effective amounts of IL-2 and IL-10 are also administered to enhance the cytotoxicity of TIL and / or LAC to tumor cells and to reduce side effects that occur because IL-2 induces cytokine production in patient cells.

YU4792A 1991-01-16 1992-01-16 PROCEDURE FOR CULTIVATION OF TUMOR INFILTING LYMPHOCYTES YU4792A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60134291A 1991-01-16 1991-01-16

Publications (1)

Publication Number Publication Date
YU4792A true YU4792A (en) 1994-09-09

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ID=47470692

Family Applications (1)

Application Number Title Priority Date Filing Date
YU4792A YU4792A (en) 1991-01-16 1992-01-16 PROCEDURE FOR CULTIVATION OF TUMOR INFILTING LYMPHOCYTES

Country Status (1)

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YU (1) YU4792A (en)

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