YU4792A - PROCEDURE FOR CULTIVATION OF TUMOR INFILTING LYMPHOCYTES - Google Patents

PROCEDURE FOR CULTIVATION OF TUMOR INFILTING LYMPHOCYTES

Info

Publication number
YU4792A
YU4792A YU4792A YU4792A YU4792A YU 4792 A YU4792 A YU 4792A YU 4792 A YU4792 A YU 4792A YU 4792 A YU4792 A YU 4792A YU 4792 A YU4792 A YU 4792A
Authority
YU
Yugoslavia
Prior art keywords
tumor
lymphocytes
infilting
cultivation
procedure
Prior art date
Application number
YU4792A
Other languages
Serbo-Croatian (sh)
Inventor
Hsu Dihwei
W.K. Moore
H. Spits
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of YU4792A publication Critical patent/YU4792A/en

Links

Landscapes

  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

POSTUPAK GAJENJA TUMORNIH INFILTIRAJUCIH LIMFOCITA, obezbedjen je postupak za korišćenje interleukina-10 u adoptivnoj imunoterapji raka. Populacija tumornih infiltrirajućih limfocita (TIL) i/ili limfokinski aktiviranih ćelija-ubica (LAK) ekspanduje se u kulturi u prisustvu interleukina-2 (IL-2) ili interleukina-10 (IL-10). Nakon davanja TIL i/ili LAK pacijentu, daju mu se i efikasne količine IL-2 i IL-10, kako bi se pojačala citotoksicnost TIL i/ili LAK prema ćelijama tumora i smanjila sporedna dejstva koja se javljaju zbog toga što IL-2 indukuje proizvodnju citokina u ćelijama pacijenta.PROCEDURE FOR CULTIVATION OF TUMOR INFILTING LYMPHOCYTES, a method for the use of interleukin-10 in the adoptive immunotherapy of cancer is provided. The population of tumor infiltrating lymphocytes (TIL) and / or lymphokine-activated killer cells (LAK) is expanded in culture in the presence of interleukin-2 (IL-2) or interleukin-10 (IL-10). Following administration of TIL and / or LAC to a patient, effective amounts of IL-2 and IL-10 are also administered to enhance the cytotoxicity of TIL and / or LAC to tumor cells and to reduce side effects that occur because IL-2 induces cytokine production in patient cells.

YU4792A 1991-01-16 1992-01-16 PROCEDURE FOR CULTIVATION OF TUMOR INFILTING LYMPHOCYTES YU4792A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60134291A 1991-01-16 1991-01-16

Publications (1)

Publication Number Publication Date
YU4792A true YU4792A (en) 1994-09-09

Family

ID=47470692

Family Applications (1)

Application Number Title Priority Date Filing Date
YU4792A YU4792A (en) 1991-01-16 1992-01-16 PROCEDURE FOR CULTIVATION OF TUMOR INFILTING LYMPHOCYTES

Country Status (1)

Country Link
YU (1) YU4792A (en)

Similar Documents

Publication Publication Date Title
MY108267A (en) Use of interleukin-10 in adoptive immunotherapy of cancer
IL69731A0 (en) Homogeneous human interleukin 2,its preparation and pharmaceutical compositions containing it
DK0702560T3 (en) Immune boosting by intermittent interleukin-2 treatment
Sekine et al. A feasible method for expansion of peripheral blood lymphocytes by culture with immobilized anti-CD3 monoclonal antibody and interleukin-2 for use in adoptive immunotherapy of cancer patients
DK66692A (en) A MAMMAL CYTOKIN, IL-11
DK0668781T3 (en) Lymphocyte therapy of cancer in combination with tumor antigens
Fagan et al. Immunotherapy for cancer: the use of lymphokine activated killer (LAK) cells.
Limb et al. Release of cytokines during generation of lymphokine-activated killer (LAK) cells by IL-2.
YU4792A (en) PROCEDURE FOR CULTIVATION OF TUMOR INFILTING LYMPHOCYTES
Malkovska et al. Tumour immunotherapy
Grimm et al. The lymphokine-activated killer cell phenomenon: in vitro and in vivo studies
IZUMI et al. Enhanced induction of tumor-specific Lyt-1+ 2-T cell-mediated protective immunity by in vivo administration of interleukin 1
Okamura et al. The effects of recombinant human granulocyte-macrophage colony-stimulating factor on the induction of lymphokine-activated killer cells in vitro
Whiteside The natural killer (NK) cell and synergistic antitumor effects of interferon-gamma and interleukin-2
Ikemoto et al. Combined effect of interleukin 2 and Bacillus Calmette-Guerin in the therapy of mice with transitional cell carcinoma
Booth et al. The Interleukins
SHIMIZU et al. PROLIFERATION AND CYTO-TOXICITY OF LECTIN-INDUCED LYMPHOKINE-ACTIVATED KILLER (LILAK) CELLS
Shirasaka et al. Augmentative effect of Nocardia rubra cell-wall skeleton on the induction of human lymphokine-activated killer (LAK) cells by the production of LAK cell helper factor (s)
Ben-Efraim Cancer immunotherapy: potential involvement of mediators
Simich A morphologic analysis of an in vitro model of cytotoxic antitumor activity using interleukin-2 and interferon-alpha 2a.
Leclerc et al. Regulation of IL2 production by muramyl dipeptide and derivatives
LLOYD CELL TO CELL TRANSFER OF INTERFERON-INDUCED ANTIPROLIFERATIVE ACTIVITY IN VITRO AND ANTIVIRAL ACTIVITY IN VIVO.
Ikemoto et al. Combined effect of interleukin 2 and cyclophosphamide in therapy of mice with transitional cell carcinoma
Lee et al. Changes of Interleukin-2, 4, 10 in Sarcoma 180-transplanted Mice
Sureda Estudios clinicos preliminares de la actividad antitumoral e inmunomoduladora de la proteina A estafilococica.