YU47885B - HYALURONIC ACID COMPLEXES, PROCEDURE FOR THEIR PREPARATION AND THEIR USE - Google Patents
HYALURONIC ACID COMPLEXES, PROCEDURE FOR THEIR PREPARATION AND THEIR USEInfo
- Publication number
- YU47885B YU47885B YU67190A YU67190A YU47885B YU 47885 B YU47885 B YU 47885B YU 67190 A YU67190 A YU 67190A YU 67190 A YU67190 A YU 67190A YU 47885 B YU47885 B YU 47885B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- hyaluronic acid
- periodic table
- preparation
- deprotonized
- periods
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
KOMPLEKSI HIJALURONSKE KISELINE, POSTUPAK ZA NJIHOVO PRIPREMANJE I NJIHOVA UPOTREBA, kompleksi hijaluronske kiseline sa jonovima 3 d metala, četvrte periode Periodnog sistema. Kozmetički preparat, naznačen time, što kao aktivni sastojak sadrži delotvornu količinu kompleksa deprotonizovane hijaluronske kiseline sa jonovima 3 d metala, četvrte periode Periodnog sistema, a prema potrebi i druge aditive. Postupak za pripremanje novih kompleksa deprotonizovane hijaluronkse kiseline sa jonovima 3 d metala, četvrte periode Period-nog sistema, naznačen time, što se sastoji u sledećem: a) dodavanju vodenog rastvora, koji sadrži ekvivalentnu količinu soli, prednost je hlorida, jednog od jonova 3 d metala, četvrte periode Periodnog sistema, u vodeni rastvor natrijum-hijaluronata, ili koje druge soli, kao alkalnog ili zemnoalkalnog metala, eventualno soli srebro-hijaluronata; ili b) rastvaranju kompleksa, dobijenog od hijaluronske kiseline i kvaternerne amonijumove soli u vodenoj suspenziji, u paru rastvarača koji sadrži vodeni rastvor jona 3 d metala, četvrte periode Periodnog sistema i rastvarač koji se delimično meša sa vodom, prednost je n-butanol; a zatim se - na poznat način taloži kompleks, dobijen od deprotonizovane hijaluronske kiseline sa jonom 3 d metala, četvrte periode Periodnog sistema, pomoću alkanola ili alkanona, ili se - odvaja talog od rastvora, pa se, ako se želi - suži, pod blagim uslovima. Postupak za pripremanje farmaceutskih preparata, naznačen time, što se meša, ili rastvara, kao aktivni sastojak, kompleks deprotonizovane hijaluronske kiseline sa jonovima 3 d metala, četvrte periode Periodnog sistema, pripremljen na osnovu postupka prema zahtevu 6, sa uobičajeno korišćenim nosačima, razredjivačima, a prema potrebi i sa izotonizujućim sredstvom, ili sa drugim aditivima, pa se prevodi u farmaceutski preparat. Prijava sadrži još 9 zavisnih zahteva.HYALURONIC ACID COMPLEXES, PROCEDURE FOR THEIR PREPARATION AND USE, Hyaluronic acid complexes with 3 d metal ions, fourth periods of the Periodic Table. A cosmetic composition comprising as an active ingredient an effective amount of a deprotonized hyaluronic acid complex with 3 d metal ions, the fourth period of the Periodic Table, and, if necessary, other additives. A process for the preparation of novel deprotonized hyaluronic acid complexes with 3 d metal ions, the fourth period of the Periodic Table, comprising: a) adding an aqueous solution containing an equivalent amount of salt, preferably chloride, of one of the ions 3 d metal, fourth periods of the Periodic Table, into an aqueous solution of sodium hyaluronate, or any other salts, such as alkali or alkaline earth metal, optionally salts of silver hyaluronate; or b) dissolving the complex derived from hyaluronic acid and quaternary ammonium salt in aqueous suspension in a solvent vapor containing an aqueous 3 d metal ion solution, fourth periods of the Periodic Table, and a partially miscible water solvent, preferably n-butanol; and then the complex, obtained from deprotonized hyaluronic acid with 3 d metal ion, is then deposited in a known manner, for the fourth period of the Periodic System, by alkanols or alkanones, or - is separated from the solution and, if desired, narrowed under gentle conditions. conditions. A process for the preparation of pharmaceutical preparations, which is miscible or dissolved, as an active ingredient, a deprotonized hyaluronic acid complex with 3 d metal ions, fourth periods of the Periodic Table prepared according to the method of claim 6, with commonly used carriers, diluents, and, if necessary, with an isotonizing agent or other additives, it is then converted into a pharmaceutical preparation. The application contains 9 more dependent requests.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU67190A YU47885B (en) | 1990-04-05 | 1990-04-05 | HYALURONIC ACID COMPLEXES, PROCEDURE FOR THEIR PREPARATION AND THEIR USE |
| SI9010671A SI9010671B (en) | 1990-04-05 | 1990-04-05 | Novel compositions containing complexes of the hyaluronic acid and the procedure for their preparation |
| HR930063 HRP930063B1 (en) | 1990-04-05 | 1993-02-01 | Novel compositions containing hyaluronic acid associates and a process for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU67190A YU47885B (en) | 1990-04-05 | 1990-04-05 | HYALURONIC ACID COMPLEXES, PROCEDURE FOR THEIR PREPARATION AND THEIR USE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU67190A YU67190A (en) | 1992-09-07 |
| YU47885B true YU47885B (en) | 1996-05-20 |
Family
ID=25550934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU67190A YU47885B (en) | 1990-04-05 | 1990-04-05 | HYALURONIC ACID COMPLEXES, PROCEDURE FOR THEIR PREPARATION AND THEIR USE |
Country Status (2)
| Country | Link |
|---|---|
| SI (1) | SI9010671B (en) |
| YU (1) | YU47885B (en) |
-
1990
- 1990-04-05 YU YU67190A patent/YU47885B/en unknown
- 1990-04-05 SI SI9010671A patent/SI9010671B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI9010671A (en) | 1997-06-30 |
| SI9010671B (en) | 1999-08-31 |
| YU67190A (en) | 1992-09-07 |
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