YU47530B - 6-SUBSTITUTED-HEXAHIDROBENZ CD INDOLES AND PROCEDURE FOR THEIR DETECTION - Google Patents

6-SUBSTITUTED-HEXAHIDROBENZ CD INDOLES AND PROCEDURE FOR THEIR DETECTION

Info

Publication number
YU47530B
YU47530B YU32691A YU32691A YU47530B YU 47530 B YU47530 B YU 47530B YU 32691 A YU32691 A YU 32691A YU 32691 A YU32691 A YU 32691A YU 47530 B YU47530 B YU 47530B
Authority
YU
Yugoslavia
Prior art keywords
alkyl
substituted
hydrogen
phenyl
aryl
Prior art date
Application number
YU32691A
Other languages
Serbo-Croatian (sh)
Other versions
YU32691A (en
Inventor
T.J. Kress
M.R. Leanna
M.J. Martinelli
B.C. Peterson
M.E. Flaugh
M.M. Foreman
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/482,811 external-priority patent/US5204340A/en
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of YU32691A publication Critical patent/YU32691A/en
Publication of YU47530B publication Critical patent/YU47530B/en

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  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

6-SUPSTITUISANI-HEKSAHIDROBENZ CD INDOLI I POSTUPAK ZA NJIHOVO DOBIJANJE, jedinjenje formule: naznačen time, što: R1 je vodonik, C1-C4 alkil, C3-C4 alkenil, ciklopropilmetil, fenil-supstituisani C1-C4 alkil, -COR4, -(CH2)nS(C1-C4 alkil) ili -(CH2)nCONR9R10; R2 je vodonik, C1-C4 alkil, C3-C4 alkenil, ili ciklopropilmetil; Q je OR3, SR3, NR5R6, ili vodonik; R3 je C1-C8 alkil, supstituisani C1-C8 alkil, aril, supstituisani aril, aril (C1-C4 alkil), supstituisani aril (C1-C4 alkil), ili C3-C7 cikloalkil; n je 1-4 R4 je vodonik C1-C4 alkil, C1-C4 haloalkil, C1-C4 alkoksi ili fenil; R5 i R6 su nezavisno vodonik, C1-C4 alkil, C1-C4 alkil supstituisan sa fenil grupom, fenil ili zajedno formiraju C3-C5 heterociklični prsten, pod uslovom da R5 i R6 nisu oba vodonik; R9 i R10 su nezavisno vodonik, C1-C4 alkil, ili C5-C8 cikloalkil; B je vodonik, C1-C4 alkil, ili aminoblokirajuća grupa; X je kiseonik ili sumpor; ili njegova farmaceutski prihvatljiva so. Prijava sadrži još 1 nezavisan i 15 zavisnih zahteva.6-SUBSTITUTED-HEXAHIDROBENZ CD INDOLES AND PROCEDURE FOR THEIR PREPARATION, Compound of Formula: wherein: R1 is hydrogen, C1-C4 alkyl, C3-C4 alkenyl, cyclopropylmethyl, phenyl-substituted C1-C4 alkyl, -CC4 alkyl, -COR4 CH2) nS (C1-C4 alkyl) or - (CH2) nCONR9R10; R 2 is hydrogen, C 1 -C 4 alkyl, C 3 -C 4 alkenyl, or cyclopropylmethyl; Q is OR3, SR3, NR5R6, or hydrogen; R3 is C1-C8 alkyl, substituted C1-C8 alkyl, aryl, substituted aryl, aryl (C1-C4 alkyl), substituted aryl (C1-C4 alkyl), or C3-C7 cycloalkyl; n is 1-4 R4 is hydrogen C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy or phenyl; R 5 and R 6 are independently hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkyl substituted with a phenyl group, phenyl or together form a C 3 -C 5 heterocyclic ring, provided that R 5 and R 6 are not both hydrogen; R 9 and R 10 are independently hydrogen, C 1 -C 4 alkyl, or C 5 -C 8 cycloalkyl; B is hydrogen, C1-C4 alkyl, or an aminoblocking group; X is oxygen or sulfur; or a pharmaceutically acceptable salt thereof. The application contains 1 more independent and 15 dependent requests.

YU32691A 1990-02-26 1991-02-25 6-SUBSTITUTED-HEXAHIDROBENZ CD INDOLES AND PROCEDURE FOR THEIR DETECTION YU47530B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48519490A 1990-02-26 1990-02-26
US07/482,811 US5204340A (en) 1989-04-11 1990-02-26 Tetrahydrobenz(c,d)indole serotonin agonists
US56798690A 1990-08-15 1990-08-15

Publications (2)

Publication Number Publication Date
YU32691A YU32691A (en) 1994-01-20
YU47530B true YU47530B (en) 1995-10-03

Family

ID=27048278

Family Applications (1)

Application Number Title Priority Date Filing Date
YU32691A YU47530B (en) 1990-02-26 1991-02-25 6-SUBSTITUTED-HEXAHIDROBENZ CD INDOLES AND PROCEDURE FOR THEIR DETECTION

Country Status (2)

Country Link
CN (1) CN1032202C (en)
YU (1) YU47530B (en)

Also Published As

Publication number Publication date
CN1032202C (en) 1996-07-03
YU32691A (en) 1994-01-20
CN1054419A (en) 1991-09-11

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