YU46420B - PROCESS FOR PREPARATION OF CYCLODEXTRIN CLATRATE OF CARBACYCLINE DERIVATIVES - Google Patents

PROCESS FOR PREPARATION OF CYCLODEXTRIN CLATRATE OF CARBACYCLINE DERIVATIVES

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Publication number
YU46420B
YU46420B YU36987A YU36987A YU46420B YU 46420 B YU46420 B YU 46420B YU 36987 A YU36987 A YU 36987A YU 36987 A YU36987 A YU 36987A YU 46420 B YU46420 B YU 46420B
Authority
YU
Yugoslavia
Prior art keywords
group
atoms
cyclodextrin
general formula
free
Prior art date
Application number
YU36987A
Other languages
Serbo-Croatian (sh)
Other versions
YU36987A (en
Inventor
W. Skuballa
H. VORBRГњGGEN
H. Dahl
C.S. STГњRZEBECHER
K.H. Thierauch
Original Assignee
Schering Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19863608086 external-priority patent/DE3608086A1/en
Application filed by Schering Ag. filed Critical Schering Ag.
Publication of YU36987A publication Critical patent/YU36987A/en
Publication of YU46420B publication Critical patent/YU46420B/en

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  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

POSTUPAK ZA DOBIJANJE CIKLODEKSTRIN KLATRATA DERIVATA KARBACIKLINA, opšte formule gde R1 predstavlja atom vodonika ili ravnočlanski ili račvasti alkil ostatak sa čak 10 C atoma, A -CH2CH2-, trans -CH=CH- ili -C ≡ C- grupu, W slobodnu ili funkcionalno izmenjenu hidroksimetilen grupu ili slobodnu ili funcionalno izmenjenu pri čemu OH grupa može da bude u položaju alfa- ili beta, D ravnolančastu, zasićenu alkilen grupu sa 1-5 C atoma, račvastu ili ravnolančastu ili račvastu nezasićenu alkilen grupu sa 2-5 C atoma, koja u datom slučaju može da bude supstituisana fluor atomima m može da znači broj 1, 2 ili 3, E direktnu vezu, -C ≡ C- grupu ili predstavlja -Cr4=CR5- grupu pri čemu znači R4 vodonik ili alkil grupa sa 1-5 C atoma R5 vodonik, halogen, ili alkil grupu sa 1-5 C atoma, R2 alkil grupu sa 1-10 C atoma, cikloalkil grupu sa 3-10 C atoma ili supstituisanu aril grupu sa 6-10 C atoma ili heterocikličnu grupu i R3 slobodnu ili funkcionalno izmenjenu hidroksi grupu, n broj 1, 2, 3, 4, ili 5 i X-CH2- grupu ili atom kiseonika, naznačen time, što se derivatu karbaciklina opšte formule I rastvorenom u farmaceutski prihvatljivom alkoholu, kao što je etanol, dodaje beta-ciklodekstrin opšte formule II: rastvoren u vodi na reakcionoj temperaturi od 25В° C-60В° C i meša u vremenskom periodu od maksimalno 50 časova. Prijava sadrži još 3 zavisna zahteva.A PROCESS FOR THE PREPARATION OF CYCLODEXTRIN CLATRATE OF CARBACYCLINE DERIVATIVES OF GENERAL FORMULA wherein R1 represents a hydrogen atom or a straight or branched alkyl residue with as many as 10 C atoms, an A -CH2CH2-, trans -CH = CH- or -C ≡ C- group, W free or functional an altered hydroxymethylene group or a free or functionally altered wherein the OH group may be in the alpha- or beta position, a D-chain, saturated alkylene group with 1-5 C atoms, a branched or straight-chain or branched unsaturated alkylene group with 2-5 C atoms, which may optionally be substituted by fluorine atoms m may represent the number 1, 2 or 3, E a direct bond, a -C ≡ C- group or represent a -Cr4 = CR5- group wherein R4 is hydrogen or an alkyl group having 1- 5 C atoms R5 is hydrogen, halogen, or an alkyl group having 1-5 C atoms, an R2 alkyl group having 1-10 C atoms, a cycloalkyl group having 3-10 C atoms or a substituted aryl group having 6-10 C atoms or a heterocyclic group and R3 is a free or functionally modified hydroxy group, n is the number 1, 2, 3, 4, or 5 and X-CH2- group or oxygen atom, wherein a beta-cyclodextrin of the general formula II is added to the carbacicline derivative of general formula I dissolved in a pharmaceutically acceptable alcohol, such as ethanol. : dissolved in water at a reaction temperature of 25V ° C-60V ° C and stirred for a maximum period of 50 hours. The application contains 3 more dependent requests.

YU36987A 1986-03-07 1987-03-06 PROCESS FOR PREPARATION OF CYCLODEXTRIN CLATRATE OF CARBACYCLINE DERIVATIVES YU46420B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863608086 DE3608086A1 (en) 1983-11-04 1986-03-07 TEST DEVICE AND METHOD FOR DETECTING SURFACE INFORMATION

Publications (2)

Publication Number Publication Date
YU36987A YU36987A (en) 1988-08-31
YU46420B true YU46420B (en) 1993-10-20

Family

ID=6296072

Family Applications (1)

Application Number Title Priority Date Filing Date
YU36987A YU46420B (en) 1986-03-07 1987-03-06 PROCESS FOR PREPARATION OF CYCLODEXTRIN CLATRATE OF CARBACYCLINE DERIVATIVES

Country Status (1)

Country Link
YU (1) YU46420B (en)

Also Published As

Publication number Publication date
YU36987A (en) 1988-08-31

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