YU34400A - Conjugates useful in the treatment of prostate cancer - Google Patents

Conjugates useful in the treatment of prostate cancer

Info

Publication number
YU34400A
YU34400A YU34400A YU34400A YU34400A YU 34400 A YU34400 A YU 34400A YU 34400 A YU34400 A YU 34400A YU 34400 A YU34400 A YU 34400A YU 34400 A YU34400 A YU 34400A
Authority
YU
Yugoslavia
Prior art keywords
conjugates
treatment
prostate cancer
conjugates useful
useful
Prior art date
Application number
YU34400A
Other languages
Serbo-Croatian (sh)
Inventor
Stephen Brady
Dong-Mei Feng
M. Victor Garsky
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Publication of YU34400A publication Critical patent/YU34400A/en

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Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be desacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
YU34400A 1997-12-02 1998-11-25 Conjugates useful in the treatment of prostate cancer YU34400A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6711097P 1997-12-02 1997-12-02
GBGB9804399.5A GB9804399D0 (en) 1998-03-02 1998-03-02 Conjugates useful in the treatment of prostate cancer

Publications (1)

Publication Number Publication Date
YU34400A true YU34400A (en) 2002-08-12

Family

ID=10827842

Family Applications (1)

Application Number Title Priority Date Filing Date
YU34400A YU34400A (en) 1997-12-02 1998-11-25 Conjugates useful in the treatment of prostate cancer

Country Status (2)

Country Link
GB (1) GB9804399D0 (en)
YU (1) YU34400A (en)

Also Published As

Publication number Publication date
GB9804399D0 (en) 1998-04-29

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