YU203390A - IMPROVED PROCESS FOR PREPARATION OF USEFUL DIAZINYLPIPERIDINE DERIVATIVES - Google Patents

IMPROVED PROCESS FOR PREPARATION OF USEFUL DIAZINYLPIPERIDINE DERIVATIVES

Info

Publication number
YU203390A
YU203390A YU203390A YU203390A YU203390A YU 203390 A YU203390 A YU 203390A YU 203390 A YU203390 A YU 203390A YU 203390 A YU203390 A YU 203390A YU 203390 A YU203390 A YU 203390A
Authority
YU
Yugoslavia
Prior art keywords
formula
give
useful
diazine
improved process
Prior art date
Application number
YU203390A
Other languages
Serbo-Croatian (sh)
Inventor
G.D. Madding
J.L. Minielli
R.J. Mattson
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of YU203390A publication Critical patent/YU203390A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

POBOLJŠANI POSTUPAK ZA DOBIJANJE KORISNIH DERIVATA DIAZINILPIPERIDINA, pronalazak se odnosi na poboljšani postupak, pogodan za proizvodnju u širokim razmerama, kojim se dobijaju korisni derivati diazinilpiperidina formule: gde je Z R1, R2 -disupstituisani diazin koji je vezan preko C-atoma u svom prstenu, pri čemu su R1 i R2 nezavisno H, alkil, alkoksi, alkiltio, CN, CF3, C2F5 ili halogeni, vezani za C-atome diazinskog prstena. Postupak obuhvata reakciju 2-pirolidinona i halogenometilpiridina, u prisustvu NaH, d bi se dobio intermedijer formule: koji se, u obliku vodenog rastvora svoje halogenohidratne soli, podvrgava katalitičkoj hidrogenaciji da bi se dobilo jedinjenje formule: gde je Y halogen, nakon čega se dobijeni rastvor alkalizuje i tretira sa diazinskim reagensom Z-Q, gde je Q odlazeća grupa, čime se dobija jedinjenje formule (I) kao korisno sredstvo za poboljšanje cerebralne funkcije.The invention relates to an improved process suitable for large-scale production to give useful diazinylpiperidine derivatives of the formula: wherein Z is R1, R2 is a -disubstituted diazine attached via C wherein R 1 and R 2 are independently H, alkyl, alkoxy, alkylthio, CN, CF 3, C 2 F 5 or halogen, attached to the C-atoms of the diazine ring. The process comprises reacting 2-pyrrolidinone and halogenomethylpyridine, in the presence of NaH, d to give an intermediate of formula: which, in the form of an aqueous solution of its halide salt, is subjected to catalytic hydrogenation to give a compound of formula: wherein Y is halogen, followed by the solution is alkalized and treated with the diazine reagent ZQ, wherein Q is a leaving group, to give a compound of formula (I) as a useful agent for improving cerebral function.

YU203390A 1989-10-27 1990-10-26 IMPROVED PROCESS FOR PREPARATION OF USEFUL DIAZINYLPIPERIDINE DERIVATIVES YU203390A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42838289A 1989-10-27 1989-10-27
US58558990A 1990-09-20 1990-09-20

Publications (1)

Publication Number Publication Date
YU203390A true YU203390A (en) 1993-10-20

Family

ID=27027734

Family Applications (1)

Application Number Title Priority Date Filing Date
YU203390A YU203390A (en) 1989-10-27 1990-10-26 IMPROVED PROCESS FOR PREPARATION OF USEFUL DIAZINYLPIPERIDINE DERIVATIVES

Country Status (9)

Country Link
KR (1) KR910007913A (en)
CN (1) CN1035112C (en)
AT (1) AT398972B (en)
ES (1) ES2026060A6 (en)
FI (1) FI95468C (en)
GR (1) GR1001134B (en)
NO (1) NO176715C (en)
PT (1) PT95712B (en)
YU (1) YU203390A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100432283B1 (en) * 2001-10-27 2004-05-22 한국과학기술연구원 Tetrahydropyridine Derivatives Acting on Muscarinic Acetylcholine Receptor
KR20200047989A (en) 2018-10-29 2020-05-08 이수완 The violin with easy tuning construction

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826843A (en) * 1985-07-08 1989-05-02 Bristol-Myers Cerebral function enhancing diazinylpiperidine derivatives
US4963678A (en) * 1989-10-27 1990-10-16 Bristol-Myers Squibb Co. Process for large-scale production of BMY 21502

Also Published As

Publication number Publication date
NO904588D0 (en) 1990-10-24
PT95712A (en) 1991-09-13
AT398972B (en) 1995-02-27
NO904588L (en) 1991-04-29
GR1001134B (en) 1993-04-28
CN1035112C (en) 1997-06-11
NO176715B (en) 1995-02-06
GR900100777A (en) 1992-03-20
FI95468B (en) 1995-10-31
NO176715C (en) 1995-05-16
FI95468C (en) 1996-02-12
PT95712B (en) 1998-01-30
ATA214890A (en) 1994-07-15
FI905226A0 (en) 1990-10-24
CN1051357A (en) 1991-05-15
KR910007913A (en) 1991-05-30
ES2026060A6 (en) 1992-04-01

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