YU195291A - NEW 15-NITRO-2BETA, 3BETA-DIHYDRO AND 15-NITRO-2-BETA, 3BETA, 6,7-TETRAHYDROTABERSONINE DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THE PROCEDURE FOR OBTAINING THEM - Google Patents
NEW 15-NITRO-2BETA, 3BETA-DIHYDRO AND 15-NITRO-2-BETA, 3BETA, 6,7-TETRAHYDROTABERSONINE DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THE PROCEDURE FOR OBTAINING THEMInfo
- Publication number
- YU195291A YU195291A YU195291A YU195291A YU195291A YU 195291 A YU195291 A YU 195291A YU 195291 A YU195291 A YU 195291A YU 195291 A YU195291 A YU 195291A YU 195291 A YU195291 A YU 195291A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- 3beta
- nitro
- 2beta
- dihydro
- obtaining
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
NOVI 15-NITRO-2BETA, 3BETA-DIHIDRO I 15-NITRO-2-BETA, 3BETA, 6,7-TETRAHIDROTABERSONIN DERIVATI, FARMACEUTSKI PREPARATI KOJI NJIH SADRŽE I POSTUPAK ZA NJIHOVO DOBIJANJE, pronalazak se odnosi na nove 15-nitro-2beta,3beta-dihidro- 15-nitro-2beta,3beta,6,7-tetrahidrotabersonin derivata formule (I), gde je R1 je vodonik; R2 je vodonik ili C1-6 alkil grupa; i simbol --- je jednostruka ili dvostruka veza, kao i na njihove soli; kao i na postupak za dobijanje istih. Jedinjenje formule (I) pokazuju redukcioni ili inhibitorski efekt na cerebralni edem i pokazuju antihipoksične osobine. Tako ona su korisna za prevenciju ili tretman povreda mozga raznog porekla indukovanih sa hipoksijom mozga.NEW 15-NITRO-2BETA, 3BETA-DIHYDRO AND 15-NITRO-2-BETA, 3BETA, 6,7-TETRAHYDROTABERSONINE DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR OBTAINING-new, invention relates to 3beta-dihydro-15-nitro-2beta, 3beta, 6,7-tetrahydrotabersonin derivative of formula (I), wherein R 1 is hydrogen; R 2 is hydrogen or a C 1-6 alkyl group; and the symbol --- is a single or double bond, as well as to their salts; as well as the procedure for obtaining them. The compounds of formula (I) show a reducing or inhibitory effect on cerebral edema and show antihypoxic properties. Thus, they are useful for the prevention or treatment of brain injuries of various origins induced by brain hypoxia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU908313A HU206883B (en) | 1990-12-18 | 1990-12-18 | Process for producing new 15-nitro-2-beta-, 3-beta-dihydro- and 15-nitro-2-beta, 3-beta-, 6,7-tetrahydro-tabersonin derivatives and pharmaceutical compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
YU195291A true YU195291A (en) | 1994-04-05 |
Family
ID=10972531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU195291A YU195291A (en) | 1990-12-18 | 1991-12-18 | NEW 15-NITRO-2BETA, 3BETA-DIHYDRO AND 15-NITRO-2-BETA, 3BETA, 6,7-TETRAHYDROTABERSONINE DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THE PROCEDURE FOR OBTAINING THEM |
Country Status (16)
Country | Link |
---|---|
US (1) | US5204355A (en) |
EP (1) | EP0491549B1 (en) |
JP (1) | JPH04334380A (en) |
KR (1) | KR920012079A (en) |
CN (1) | CN1063690A (en) |
AU (1) | AU8972591A (en) |
CA (1) | CA2057829A1 (en) |
DE (1) | DE69118340T2 (en) |
FI (1) | FI915930A (en) |
HU (1) | HU206883B (en) |
IE (1) | IE914198A1 (en) |
IL (1) | IL100393A0 (en) |
NO (1) | NO914985L (en) |
PL (1) | PL292813A1 (en) |
YU (1) | YU195291A (en) |
ZA (1) | ZA919912B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7205404B1 (en) * | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
CN102558178B (en) * | 2012-01-09 | 2015-06-03 | 中国科学院昆明植物研究所 | Tabersonine derivative, pharmaceutical compositions, preparing method and medical application thereof |
WO2015123352A1 (en) | 2014-02-13 | 2015-08-20 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
CN106687118A (en) | 2014-07-02 | 2017-05-17 | 配体药物公司 | Prodrug compounds and uses thereof |
CN111788196A (en) | 2018-01-09 | 2020-10-16 | 配体药物公司 | Acetal compounds and their therapeutic use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2358147A1 (en) * | 1976-07-13 | 1978-02-10 | Parcor | ASPIDOSPERMIDINS |
JPS62234054A (en) * | 1985-12-16 | 1987-10-14 | Ono Pharmaceut Co Ltd | 3-phenoxy(or phenylthio)cyclopentanecarbonylamino acid derivative and remedy for cerebral edema containing said derivative as active ingredient |
-
1990
- 1990-12-18 HU HU908313A patent/HU206883B/en not_active IP Right Cessation
-
1991
- 1991-12-03 IE IE419891A patent/IE914198A1/en not_active Application Discontinuation
- 1991-12-12 US US07/806,975 patent/US5204355A/en not_active Expired - Fee Related
- 1991-12-17 PL PL29281391A patent/PL292813A1/en unknown
- 1991-12-17 FI FI915930A patent/FI915930A/en not_active Application Discontinuation
- 1991-12-17 CA CA002057829A patent/CA2057829A1/en not_active Abandoned
- 1991-12-17 IL IL100393A patent/IL100393A0/en unknown
- 1991-12-17 NO NO91914985A patent/NO914985L/en unknown
- 1991-12-17 DE DE69118340T patent/DE69118340T2/en not_active Expired - Fee Related
- 1991-12-17 EP EP91311694A patent/EP0491549B1/en not_active Expired - Lifetime
- 1991-12-17 KR KR1019910023172A patent/KR920012079A/en not_active Application Discontinuation
- 1991-12-17 ZA ZA919912A patent/ZA919912B/en unknown
- 1991-12-17 AU AU89725/91A patent/AU8972591A/en not_active Abandoned
- 1991-12-18 CN CN91107991A patent/CN1063690A/en active Pending
- 1991-12-18 YU YU195291A patent/YU195291A/en unknown
- 1991-12-18 JP JP3334992A patent/JPH04334380A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2057829A1 (en) | 1992-06-19 |
NO914985D0 (en) | 1991-12-17 |
FI915930A (en) | 1992-06-19 |
EP0491549B1 (en) | 1996-03-27 |
JPH04334380A (en) | 1992-11-20 |
US5204355A (en) | 1993-04-20 |
ZA919912B (en) | 1992-10-28 |
CN1063690A (en) | 1992-08-19 |
IE914198A1 (en) | 1992-07-01 |
HU206883B (en) | 1993-01-28 |
AU8972591A (en) | 1992-06-25 |
HU908313D0 (en) | 1991-07-29 |
NO914985L (en) | 1992-06-19 |
KR920012079A (en) | 1992-07-25 |
DE69118340T2 (en) | 1996-08-29 |
DE69118340D1 (en) | 1996-05-02 |
PL292813A1 (en) | 1992-12-14 |
IL100393A0 (en) | 1992-09-06 |
HUT59681A (en) | 1992-06-29 |
EP0491549A1 (en) | 1992-06-24 |
FI915930A0 (en) | 1991-12-17 |
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