YU19300A - Process for preparing 8-cyclopentyl-6-ethyl-3(substituted)-5,8-dihydro-4h-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein - Google Patents
Process for preparing 8-cyclopentyl-6-ethyl-3(substituted)-5,8-dihydro-4h-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful thereinInfo
- Publication number
- YU19300A YU19300A YU19300A YUP19300A YU19300A YU 19300 A YU19300 A YU 19300A YU 19300 A YU19300 A YU 19300A YU P19300 A YUP19300 A YU P19300A YU 19300 A YU19300 A YU 19300A
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- formula
- compound
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- protected
- ethyl
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Abstract
Procedure for obtaining -8-cyclopentyl-6- ethyl -3-(subsitituted) -5,8-dihydro - 4H- 1,2,3a, 7,8 -penthasa-as-indacene compounds of formula (1.0.0): and its pharmaceutically acceptable forms of salts, R1 is hydrogen; alkyl, alcoxy; alcoxyalkyl; alkenyl; cycloalkyl; cycloalkylkyl; protected or unprotected heterociclyc - (CH2)n - group or group of formula (1.1.0), where all the mentioned substituents are defined in more detail in this specification that encompasses: (a) subjecting reaction compound without disolvent from gama-caprolactone and --metoxybenzilamine to heating whereas producing the compounds of amide N-protected with p-metoxy benzole of formula (2.0.0); (b) reducing mentioned compound of amides of formula (2.0.0) whereas it is possible to produce amino alcohol compound N-protected with p-metoxy benzile of formula (3.0.0) (c) acylating the mentioned amino alcohol compounds of formula (3.0.0) with ethyl axalile chloride whereas compounds produced of oxalminic acid of ethyl esther N-protected with p-metoxybenzile of the formula (4.0.0) (d) oxidation of mentioned compound of oxalamine acid of ethyl ester of formula (4.0.0) whereas there we find produced oxalamide keton compound N-protected with p-metoxybenzile of formula (5.0.0); (e) closing a ring of the mentioned oxalamide keton compound of formula (5.0.0) where we produce piridinone compound N-protected with p-metoxy benzile, of formula (6.0.0) (f) 0-methylating the mentioned piridinone compound of formula (6.0.0) where we produce 3-metoxy-piridinone compound N-protected with p-metoxybenzile of formula (7.0.0) (g) treatment of the mentioned 3-metoxy piridinone compounds of formula (7.0.0) with the cyclopentil hydrazine, whereas pirozolopiridinone compound N-protected with p-metoxybenzile, of formula (8.0.0) (h) taking away protexction of mentioned pirazolopiridinone compound of formula (8.0.0) with taking away of the mentioned p-metoxybenzile group, where producing compound of lactane of formula (9.0.0) (i) estherification of mentioned compound of lactane formula (9.0.0) where we produce the suitable imino-esther (imidat) compound of the formula (10.0.0) (j) treatment of mentioned imino estar (imidat) compound of formula (10.0.0) with the compound of carboxile hydrazide of formula (11.0.0) where R1 has the same meaning as given above, where the mentioned compound is produced of 8-cyclopenthyl-6-ethyl-3-(substituted)- 5,8 dihydro-4H-1,2,3A, 7,8 - penthoza-es-indacene of formula (1.0.0).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19194999P | 1999-04-30 | 1999-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU19300A true YU19300A (en) | 2003-01-31 |
Family
ID=47682117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU19300A YU19300A (en) | 1999-04-30 | 2000-03-31 | Process for preparing 8-cyclopentyl-6-ethyl-3(substituted)-5,8-dihydro-4h-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein |
Country Status (1)
| Country | Link |
|---|---|
| YU (1) | YU19300A (en) |
-
2000
- 2000-03-31 YU YU19300A patent/YU19300A/en unknown
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