NADALJNJI NOVI ALKANOFENONI, P-substituirani alkanofenoni s splošno formulo I v kateri R1 pomeni v danem primeru fluoriran nižji alkil, R2 vodik, v danem primeru fluoriran nižji alkil ali nižji alkenil, X pomeni nižji alkilen, oksi, tio ali direktno vez, alk predstavlja nižji alkilen, n stoji za 1 ali 2, R3 pomeni nesubstituiran ali z v danem primeru fluoriranim nižjim alkilom, zaetrenim ali zaestrenim hidroksi, halogenom v danem primeru nižje alkiliranim amino in/ali v danem primeru zaestrenim ali amidiranim karboksi substituiran, 5-členski heteroarilni ostanek, ki ima kot hetero atom 1 atom dušika, kisika ali žvepla, R4 predstavlja v danem primeru zaestren ali amidiran karboksi ali 5-tetrazolil in R5 stoji za vodik ali nižji alkil, imajo levkotrien-antagonistične lastnosti in se jih da uporabiti kot antialergične lastnosti in se jih da uporabiti kot antialergične učinkovine v zdravilih. Postopek za njihovo pripravo poteka tako, da epoksid s formulo II kjer imajo R1, R2, X, alk, n in R3 zgornje pomene, pretvorimo s tiolom s formulo III kjer imata R4 in R5 zgornje pomene, ali njegovo soljo, ter po želji v smislu postopka dostopno spojino pretvorimo v neko drugo spojino s formulo I, v smislu postopka dostopno stereoizomerno zmes ločimo na komponente in/ali v smislu postopka dobljeno prosto spojino prevedemo v sol, ali v smislu postopka dostopno sol prevedemo v prosto spojino ali v neko drugo sol.FURTHER NEW ALKANOPHENONS, P-substituted alkanophenones of general formula I in which R1 represents optionally fluorinated lower alkyl, R2 hydrogen, optionally fluorinated lower alkyl or lower alkenyl, X represents lower alkylene, oxy, thio or a direct bond, alk lower alkylene, n stands for 1 or 2, R3 represents unsubstituted or optionally fluorinated lower alkyl, esterified or esterified hydroxy, halogen optionally lower alkylated amino and / or optionally esterified or amidated carboxy substituted, 5-membered heteroaryl residue , having as hetero atom 1 nitrogen, oxygen or sulfur atom, R4 represents optionally esterified or amidated carboxy or 5-tetrazolyl and R5 stands for hydrogen or lower alkyl, have leukotriene-antagonistic properties and can be used as antiallergic properties and they can be used as antiallergic agents in medicines. The process for their preparation is carried out by converting the epoxide of formula II wherein R1, R2, X, alk, n and R3 have the above meanings with a thiol of formula III wherein R4 and R5 have the above meanings, or a salt thereof, and optionally in in the context of the process the accessible compound is converted into another compound of formula I, in the sense of the process the stereoisomeric mixture is separated into components and / or in the sense of the process the obtained free compound is converted into a salt, or in the sense of the process the available salt is converted into a free .