YU153991A - PROCESS FOR PREPARATION OF 1 - [(2S) -3-MERCAPTO-METHYL-1-OXOPROPYL] -L-PROLINE - Google Patents
PROCESS FOR PREPARATION OF 1 - [(2S) -3-MERCAPTO-METHYL-1-OXOPROPYL] -L-PROLINEInfo
- Publication number
- YU153991A YU153991A YU153991A YU153991A YU153991A YU 153991 A YU153991 A YU 153991A YU 153991 A YU153991 A YU 153991A YU 153991 A YU153991 A YU 153991A YU 153991 A YU153991 A YU 153991A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- formula
- proline
- methyl
- preparation
- oxopropyl
- Prior art date
Links
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- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Izum se nanaša na nov postopek za pripravo 1-((2S)-3-merkapto-2-metil-1-oksopropil)-L-prolina (kaptoprila) s formulo (I) ki obsega hidrogeniranje 1-((2S)-2-metil-1-okso-3-rodanidopropil)-L-prolina s formulo (II) v inertnem topilu v prisotnosti katalizatorja pri temperaturi od 50 do 120В°C pod tlakom 105 do 107 Pa. Gornja spojina s formulo (II) je nova in jo lahko pripravimo z aciliranjem L-prolina z reaktivnim acilirnim derivatom (2S)-2-metil-3-rodanidopropionske kisline s formulo (III) Postopek v smislu izuma omogoča pripravo spojine s formulo (I) na preprost način z veliko čistoto in dobrimi celokupnimi dobitki. The invention relates to a new process for the preparation of 1 - ((2S) -3-mercapto-2-methyl-1-oxopropyl) -L-proline (captopril) of formula (I) comprising the hydrogenation of 1 - ((2S) -2 -methyl-1-oxo-3-rhodanidopropyl) -L-proline of formula (II) in an inert solvent in the presence of a catalyst at a temperature of from 50 to 120 ° C under a pressure of 105 to 107 Pa. The above compound of formula (II) is novel and can be prepared by acylating L-proline with a reactive acylating derivative of (2S) -2-methyl-3-rhodanidopropionic acid of formula (III). The process according to the invention allows the preparation of a compound of formula (I) ) in a simple way with great purity and good overall gains.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
YU153991A YU153991A (en) | 1991-09-17 | 1991-09-17 | PROCESS FOR PREPARATION OF 1 - [(2S) -3-MERCAPTO-METHYL-1-OXOPROPYL] -L-PROLINE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
YU153991A YU153991A (en) | 1991-09-17 | 1991-09-17 | PROCESS FOR PREPARATION OF 1 - [(2S) -3-MERCAPTO-METHYL-1-OXOPROPYL] -L-PROLINE |
Publications (1)
Publication Number | Publication Date |
---|---|
YU153991A true YU153991A (en) | 1994-06-10 |
Family
ID=47352334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU153991A YU153991A (en) | 1991-09-17 | 1991-09-17 | PROCESS FOR PREPARATION OF 1 - [(2S) -3-MERCAPTO-METHYL-1-OXOPROPYL] -L-PROLINE |
Country Status (1)
Country | Link |
---|---|
YU (1) | YU153991A (en) |
-
1991
- 1991-09-17 YU YU153991A patent/YU153991A/en unknown
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