YU103391A - HETEROCYCLIC ANTHRACYCLINONS AND ANTHRACYCLINAL ANALYSIS - Google Patents

HETEROCYCLIC ANTHRACYCLINONS AND ANTHRACYCLINAL ANALYSIS

Info

Publication number
YU103391A
YU103391A YU103391A YU103391A YU103391A YU 103391 A YU103391 A YU 103391A YU 103391 A YU103391 A YU 103391A YU 103391 A YU103391 A YU 103391A YU 103391 A YU103391 A YU 103391A
Authority
YU
Yugoslavia
Prior art keywords
heterocyclic
hydrogen
anthracyclinons
anthracyclinal
analysis
Prior art date
Application number
YU103391A
Other languages
Serbo-Croatian (sh)
Inventor
G. Attardo
B. Belleau
Y.Ch. XU
J.F. Lavallee
R.N. Rej
Original Assignee
Jaf Biochem International Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jaf Biochem International Inc. filed Critical Jaf Biochem International Inc.
Publication of YU103391A publication Critical patent/YU103391A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Forms Removed On Construction Sites Or Auxiliary Members Thereof (AREA)

Abstract

HETEROCIKLIČNI ANTRACIKLINONI I ANTRACIKLINSKI ANALOZI, pronalazak opisuje heterociklične antraciklinone i antraciklinske analoge koji imaju sledeću opštu formulu u kojoj su X1 i X2 nezavisno odabrani iz grupe koja se sastoji od O, S i C=N(R), X3 je O,S,SO,SO2, NO, R1,R2,R3,R4,R5 i R8 su vodonik, hidroksil, C1-16 alkil, tosil, triflat, halogen, nitro, cijano, C1-16 acil, R6 je vodonik, C1-16 alkil, R'6 je vodonik, halogen, amino, hidroksi, Y i R7 su vodonik, halogen, hidroksil, cijano. Pomenuta jedinjenja su korisna pri lečenju kancerogenih oboljenja ili tumora.HETEROCYCLIC ANTHRACYCLINONS AND ANTHRACYCLINAL ANALYSIS, the invention describes heterocyclic anthracyclines and anthracycline analogs having the following general formula wherein X1 and X2 are independently selected from the group consisting of O, S and C = N (R), X3 is O, S , SO2, NO, R1, R2, R3, R4, R5 and R8 are hydrogen, hydroxyl, C1-16 alkyl, tosyl, triflate, halogen, nitro, cyano, C1-16 acyl, R6 is hydrogen, C1-16 alkyl, R 16 is hydrogen, halogen, amino, hydroxy, Y and R 7 are hydrogen, halogen, hydroxyl, cyano. Said compounds are useful in the treatment of cancerous diseases or tumors.

YU103391A 1990-06-11 1991-06-11 HETEROCYCLIC ANTHRACYCLINONS AND ANTHRACYCLINAL ANALYSIS YU103391A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53610790A 1990-06-11 1990-06-11

Publications (1)

Publication Number Publication Date
YU103391A true YU103391A (en) 1994-04-05

Family

ID=24137175

Family Applications (1)

Application Number Title Priority Date Filing Date
YU103391A YU103391A (en) 1990-06-11 1991-06-11 HETEROCYCLIC ANTHRACYCLINONS AND ANTHRACYCLINAL ANALYSIS

Country Status (18)

Country Link
EP (1) EP0533744A1 (en)
JP (1) JPH06504034A (en)
CN (1) CN1058781A (en)
AP (1) AP340A (en)
AU (1) AU653348B2 (en)
CA (1) CA2085120A1 (en)
CS (1) CS178691A3 (en)
FI (1) FI925611A0 (en)
HU (1) HU9203720D0 (en)
IE (1) IE911965A1 (en)
IL (1) IL98460A0 (en)
MA (1) MA22178A1 (en)
NZ (1) NZ238490A (en)
PL (1) PL297164A1 (en)
PT (1) PT97931A (en)
WO (1) WO1991019725A2 (en)
YU (1) YU103391A (en)
ZA (1) ZA914452B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0659190A1 (en) * 1992-11-09 1995-06-28 Biochem Pharma Inc Antineoplastic heteronaphthoquinones
US5736523A (en) * 1992-11-09 1998-04-07 Biochem Pharma Inc. Antineoplastic heteronapthoquinones
US5606037A (en) * 1992-11-09 1997-02-25 Biochem Pharma Inc. Processes antineoplastic heteronaphthoquinones
AU6672794A (en) * 1993-11-05 1995-05-23 Biochem Pharma Inc. Antineoplastic heteronaphthoquinones
IT1271689B (en) * 1994-08-04 1997-06-04 Menarini Farma Ind 8-FLUORO-ANTRACICLINE, THEIR PREPARATION PROCESSES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MA53434A (en) 2018-08-23 2021-12-01 Seagen Inc ANTI-TIGIT ANTIBODIES
CN111087377B (en) * 2020-03-19 2020-06-26 广东省微生物研究所（广东省微生物分析检测中心） Benzo isochroman quinone compound and preparation method and application thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52148088A (en) * 1976-06-01 1977-12-08 Richardson Merrell Inc 111aminoalkylmorphansridinee 111ols
JPS6030315B2 (en) * 1976-06-01 1985-07-16 三井東圧化学株式会社 Method for producing 4-halogenomethylisocoumarin derivative
GB2067552B (en) * 1980-01-16 1984-02-29 Erba Farmitalia Anthracyline derivatives
JPS60142976A (en) * 1983-12-28 1985-07-29 Yoshinori Asakawa Isocoumarin derivative
CA1330560C (en) * 1986-05-21 1994-07-05 Maurits E. A. Vandewalle Di- and tetrahydroisoquinoline derivatives
JPH01238579A (en) * 1988-03-18 1989-09-22 Yamanouchi Pharmaceut Co Ltd Substance y-05460m-a and production thereof
JPH08112310A (en) * 1994-10-18 1996-05-07 New Oji Paper Co Ltd Disposable diaper

Also Published As

Publication number Publication date
CA2085120A1 (en) 1991-12-12
FI925611A (en) 1992-12-10
ZA914452B (en) 1992-06-24
FI925611A0 (en) 1992-12-10
CS178691A3 (en) 1992-01-15
WO1991019725A3 (en) 1992-04-30
AP340A (en) 1994-05-13
AP9100278A0 (en) 1991-07-31
AU8097391A (en) 1992-01-07
IL98460A0 (en) 1992-07-15
NZ238490A (en) 1994-03-25
JPH06504034A (en) 1994-05-12
CN1058781A (en) 1992-02-19
PT97931A (en) 1992-03-31
AU653348B2 (en) 1994-09-29
PL297164A1 (en) 1992-10-05
IE911965A1 (en) 1991-12-18
HU9203720D0 (en) 1993-03-29
EP0533744A1 (en) 1993-03-31
WO1991019725A2 (en) 1991-12-26
MA22178A1 (en) 1991-12-31

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