WO2025213451A1 - 基于负压的吸附系统和方法、生化物质分析方法和装置 - Google Patents

基于负压的吸附系统和方法、生化物质分析方法和装置

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Publication number
WO2025213451A1
WO2025213451A1 PCT/CN2024/087487 CN2024087487W WO2025213451A1 WO 2025213451 A1 WO2025213451 A1 WO 2025213451A1 CN 2024087487 W CN2024087487 W CN 2024087487W WO 2025213451 A1 WO2025213451 A1 WO 2025213451A1
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WO
WIPO (PCT)
Prior art keywords
module
adsorption
negative pressure
gas storage
storage module
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/CN2024/087487
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English (en)
French (fr)
Inventor
卢剑
牛子华
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MGI Tech Co Ltd
Original Assignee
MGI Tech Co Ltd
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Filing date
Publication date
Application filed by MGI Tech Co Ltd filed Critical MGI Tech Co Ltd
Priority to PCT/CN2024/087487 priority Critical patent/WO2025213451A1/zh
Publication of WO2025213451A1 publication Critical patent/WO2025213451A1/zh
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G47/00—Article or material-handling devices associated with conveyors; Methods employing such devices
    • B65G47/74—Feeding, transfer, or discharging devices of particular kinds or types
    • B65G47/90—Devices for picking-up and depositing articles or materials
    • B65G47/91—Devices for picking-up and depositing articles or materials incorporating pneumatic, e.g. suction, grippers

Definitions

  • the present application relates to negative pressure control, and in particular to a negative pressure-based adsorption system, a negative pressure-based adsorption method, a biochemical substance analysis system, and a biochemical substance analysis device.
  • a target object can be placed on a support platform, then adsorbed to the support platform under negative pressure, and then the desired operation can be performed on the target object.
  • a microfluidic chip can be placed on a chip platform, adsorbed to the chip platform under negative pressure, and then fluid can be introduced into the microfluidic chip to perform a biochemical reaction, and then the post-reaction fluid can be tested.
  • the vacuum pump needs to be started all the time, and long-term continuous operation will reduce the service life of the vacuum pump.
  • the present application provides a negative pressure-based adsorption system, comprising a gas storage module, a first power module, and a first adsorption module.
  • the first power module is in communication with the gas storage module and configured to generate a negative pressure within the gas storage module.
  • the first adsorption module is configured to communicate with the gas storage module and transmit negative pressure to the first adsorption module, causing the first adsorption module to use the negative pressure to adsorb a target object.
  • the second aspect of the present application provides an adsorption method based on negative pressure, including: establishing a connection between a first power module and a gas storage module; starting the first power module and generating negative pressure in the gas storage module; shutting down the first power module and establishing a connection between the gas storage module and the first adsorption module; the gas storage module transmits negative pressure to the first adsorption module, so that the first adsorption module uses the negative pressure to adsorb the target object.
  • a third aspect of the present application provides a method for analyzing biochemical substances, including: establishing a connection between a first power module and a gas storage module; starting the first power module and generating negative pressure in the gas storage module; shutting down the first power module and establishing a connection between the gas storage module and a first adsorption module; the gas storage module transmits negative pressure to the first adsorption module, so that the first adsorption module uses the negative pressure to adsorb a carrier; performing a first operation or a second operation on the carrier, the first operation being to cause a biochemical reaction of the fluid in the carrier, and the second operation being to detect the fluid in the carrier.
  • the present application provides a biochemical substance analysis device, comprising the negative pressure-based adsorption system described above, wherein the adsorption system is configured to adsorb the target object, which is a slide.
  • the adsorption system of the present application introduces a gas storage module. Even after the first power module is shut down, the negative pressure of the adsorption system changes slowly, so that the first adsorption module can continuously and stably adsorb the target object to facilitate subsequent corresponding operations on the target object, and it is also beneficial to increase the life of the first power module.
  • FIG1 is a module architecture diagram of an adsorption system provided in one embodiment of the present application.
  • FIG2 is a module architecture diagram of the adsorption system shown in FIG1 when performing the first adsorption method.
  • FIG3 is a module architecture diagram of the adsorption system shown in FIG1 when operating the second adsorption method.
  • FIG4 is a module architecture diagram of the adsorption system shown in FIG1 when operating the third adsorption method.
  • FIG5 is a schematic structural diagram of the adsorption system shown in FIG1 in some embodiments.
  • FIG6 is a diagram showing the relationship between negative pressure and time when the adsorption system shown in FIG5 executes different pressure building methods.
  • FIG. 7 is a schematic structural diagram of the adsorption system shown in FIG. 5 after a shielding component is installed on the wafer carrier platform.
  • FIG8 is a schematic structural diagram of the adsorption system shown in FIG1 in other embodiments.
  • FIG9 is a module architecture diagram of a biochemical substance analysis device provided in one embodiment of the present application.
  • a component when referred to as being “fixed to” or “mounted on” another component, it may be directly on the other component or there may be a central component. When a component is referred to as being “disposed on” another component, it may be directly on the other component or there may be a central component.
  • the term “and/or” includes all and any combinations of one or more of the relevant listed items.
  • one embodiment of the present application provides a negative pressure adsorption system 100 for adsorbing a target object (not shown) to facilitate subsequent operations on the target object.
  • the adsorption system 100 includes a gas storage module 10 , a power module 20 , and an adsorption module 30 .
  • the power module 20 is a functional module for generating negative pressure in the adsorption system 100.
  • the power module 20 may include M power modules, M ⁇ 1, that is, the power module 20 includes a first power module 21 to an Mth power module 2M.
  • each power module can work independently.
  • the structures of each power module may be the same or different.
  • the power module 20 includes a first power module 21 and a second power module 22. When one of the first power module 21 and the second power module 22 is working, the other may not be working.
  • the first power module 21 and the second power module 22 may also work successively or in parallel. "Working in parallel" means that the working time of the first power module 21 and the second power module 22 completely overlaps or at least partially overlaps on the time axis, thereby optimizing the total time required to generate the target negative pressure.
  • the gas storage module 10 is a functional module in the adsorption system 100 for storing negative pressure. Both the first power module 21 and the second power module 22 can be connected to the gas storage module 10. As used herein, “connected” or “connected” means that the modules are connected or connected to each other via pipes or other suitable components.
  • the gas storage module 10 can be a container suitable for storing gas, such as a gas tank.
  • the adsorption module 30 is a functional module in the adsorption system 100 for adsorbing and securing a target object.
  • the adsorption module 30 may include N adsorption modules, where N ⁇ M, meaning the adsorption module 30 includes a first adsorption module 31 through an Nth adsorption module 3N.
  • Each adsorption module can be independent of one another and adsorb different target objects.
  • the structures of the modules can be identical or different.
  • the adsorption module 30 includes a first adsorption module 31 and a second adsorption module 32. At least one of the first adsorption module 31 and the second adsorption module 32 is selectively connected to the gas storage module 10.
  • the first adsorption module 31 and the second adsorption module 32 can adsorb the target object sequentially or in parallel.
  • the first adsorption module 31 and the second adsorption module 32 can be components having an opening H (shown in FIG. 7 ) suitable for providing support for the target object.
  • the negative pressure acts on the target object through the opening H, allowing the first adsorption module 31 or the second adsorption module 32 to utilize the negative pressure to adsorb the target object.
  • the first power module 21 can be connected to the gas storage module 10 and generate negative pressure within the gas storage module 10.
  • the gas storage module 10 can deliver negative pressure to the first adsorption module 31, allowing the first adsorption module 31 to use the negative pressure to adsorb the target object.
  • the first power module 21 can drive gas movement in the reverse direction, which refers to the direction in which gas is extracted and flows from the gas storage module 10 to the first power module 21.
  • the first power module 21 can be any type of pump capable of driving gas movement, such as a syringe pump, plunger pump, diaphragm pump, gear pump, peristaltic pump, or vacuum pump.
  • the second power module 22 can be connected to the gas storage module 10 and generate negative pressure in the gas storage module 10.
  • the gas storage module 10 can transmit negative pressure to the second adsorption module 32, so that the second adsorption module 32 can use the negative pressure to adsorb another target object.
  • the second power module 22 can drive the gas to move in the reverse direction, which refers to the direction in which the gas is extracted and flows from the gas storage module 10 to the second power module 22.
  • At least one of the first power module 21 and the second power module 22 is selectively started.
  • the first power module 21 and the second power module 22 can operate in parallel to generate negative pressure within the gas storage module 10.
  • the second power module 22 can also serve as a backup power module, connected to the gas storage module 10 only when needed (e.g., when the pressure building speed of the first power module 21 is insufficient).
  • the two power modules simultaneously build pressure, thereby improving the reliability of the adsorption system 100.
  • the second power module 22 can be any type of pump capable of driving gas movement, such as a syringe pump, a plunger pump, a diaphragm pump, a gear pump, a peristaltic pump, or a vacuum pump.
  • the adsorption system 100 may further include a selection module 40.
  • the selection module 40 may include N selection modules, that is, the selection module 40 includes a first selection module 41 to an Nth selection module 4N. Each selection module can work independently. The structure of each selection module may be the same or different. Each selection module can connect the gas storage module 10 with different adsorption modules to achieve the selection of the negative pressure flow direction in the gas storage module 10.
  • the selection module 40 includes a first selection module 41 and a second selection module 42.
  • the first selection module 41 can connect or disconnect the gas storage module 10 with the first adsorption module 31, and the second selection module 42 can connect or disconnect the gas storage module 10 with the second adsorption module 32.
  • the first selection module 41 or the second selection module 42 can be various types of solenoid valves, selection valves (such as rotary valves) and other valves or a combination thereof.
  • the first power module 21 and the gas storage module 10 can be connected via a first pipe L1, the gas storage module 10 and the first selection module 41 can be connected via a second pipe L2, and the first selection module 41 and the first adsorption module 31 can be connected via a third pipe L3.
  • the second power module 22 and the gas storage module 10 can be connected via a fourth pipe L4, the gas storage module 10 and the second selection module 42 can be connected via a fifth pipe L5, and the second selection module 42 and the second adsorption module 32 can be connected via a sixth pipe L6.
  • the internal volume of all components connected to the first power module 21 is related to the volume of the gas storage module 10, the first pipe L1, the second pipe L2, and the third pipe L3.
  • the internal volume of the adsorption system 100 is defined as V
  • the leakage rate between the adsorption system 100 and the atmosphere is defined as leak rate (sccm)
  • the atmospheric pressure is defined as P atm
  • the negative pressure change of the adsorption system 100 within a time ⁇ t is defined as ⁇ P.
  • the calculation formula for ⁇ P is as follows:
  • the present application introduces a larger gas storage module 10. Even after the first power module 21 is shut down, the negative pressure in the adsorption system 100 changes more slowly, allowing the first adsorption module 31 to continuously and stably adsorb the target object, facilitating subsequent operations on the target object. Furthermore, the first power module 21 does not need to operate continuously, which also helps to improve the lifespan of the first power module 21.
  • the volume of the gas storage module 10 is defined as V1
  • V2 the sum of the volumes of the first pipeline L1, the second pipeline L2, and the third pipeline L3 is defined as V2 .
  • the volume of the gas storage module 10 can be set in the liter range, while the pipeline volume is typically in the milliliter range. That is, V1 is much larger than V2 . Therefore, even after the first power module 21 is shut down, the negative pressure in the adsorption system 100 changes more slowly.
  • the sum of the volumes of the fourth pipe L4 , the fifth pipe L5 and the sixth pipe L6 is V 3
  • V 1 is much larger than V 3 . Therefore, even after the second power module 22 is turned off, the negative pressure of the adsorption system 100 changes slowly.
  • N can be set to > M, that is, the number of power modules is less than the number of adsorption modules.
  • the present application can appropriately reduce the number of power modules by introducing the gas storage module 10, thereby reducing costs.
  • the adsorption system 100 may also include an air pressure sensing device 11 in communication with the gas storage module 10.
  • the air pressure sensing device 11 may be used to sense the negative pressure within the gas storage module 10.
  • the first power module 21 may generate negative pressure within the gas storage module 10 again, thereby reducing the negative pressure within the gas storage module 10 so that the first adsorption module 31 can continuously and stably adsorb the target object.
  • the adsorption system 100 may further include N sensing devices and an alarm device (not shown), i.e., the number of sensing devices corresponds to the number of adsorption modules.
  • the adsorption system 100 may include a first sensing device 51 connected between the first adsorption module 31 and the first selection module 41, a second sensing device 52 connected between the second adsorption module 32 and the second selection module 42, and an Nth sensing device 5N connected between the Nth adsorption module 3N and the Nth selection module 4N.
  • the first sensing device 51 is an air pressure sensor connected to the third pipeline L3, which can sense the negative pressure value within the third pipeline L3.
  • the position and function of the second sensing device 52 are similar.
  • the adsorption system 100 If the adsorption system 100 is leak-free, the sum of the negative pressure values measured by the N sensing devices is the negative pressure change ⁇ P. Conversely, if the adsorption system 100 is leaking, the sum of the negative pressure values measured by the N sensing devices will exceed the negative pressure change ⁇ P.
  • the alarm device is electrically connected to the air pressure sensing device 11 and each sensing device. The alarm device can calculate the negative pressure change from the negative pressure value sensed by the air pressure sensing device 11, and then compare this negative pressure change with the sum of the negative pressure values measured by each sensing device. When it is determined that a leak has occurred in the adsorption system 100, an alarm signal is generated (such as a flashing alarm indicator or an audible alarm).
  • the alarm device can also compare the negative pressure values measured by each sensing device. When the negative pressure value measured by one sensing device is significantly lower than the negative pressure values measured by the other sensing devices, it indicates that the negative pressure value of the corresponding pipeline has not reached the predetermined value within the specified time, and an alarm signal is generated.
  • the first sensing device 51 may also be a flow sensor connected to the third pipe L3, which can sense the gas flow rate within the third pipe L3.
  • the location and function of the second sensing device 52 are similar.
  • the alarm device can also determine when the gas flow rate exceeds a threshold value. If this threshold value is exceeded, it indicates that the corresponding adsorption module has failed to adsorb the target object, thereby generating an alarm signal.
  • the adsorption system 100 may also include N gas-liquid separation devices, i.e., the number of gas-liquid separation devices corresponds to the number of adsorption modules.
  • the adsorption system 100 may include a first gas-liquid separation device 61 connected between the first adsorption module 31 and the first selection module 41, a second gas-liquid separation device 62 connected between the second adsorption module 32 and the second selection module 42, and an Nth gas-liquid separation device 6N connected between the Nth adsorption module 3N and the Nth selection module 4N.
  • the first gas-liquid separation device 61 is connected to the third pipeline L3 and can prevent liquid from flowing from the first adsorption module 31 to the first selection module 41 and the gas storage module 10.
  • the position and function of the second gas-liquid separation device 62 are similar.
  • the first gas-liquid separation device 61 and the second gas-liquid separation device 62 can be gas-liquid separators that block the passage of liquid.
  • the adsorption system 100 may also include N filter devices, that is, the number of filter devices corresponds to the number of adsorption modules.
  • the adsorption system 100 may include a first filter device 71 connected to the first selection module 41, a second filter device 72 connected to the second selection module 42, and an Nth filter device 7N connected to the Nth selection module 4N.
  • the first filter device 71 can prevent impurities in the air from entering the third pipe L3.
  • the position and function of the second filter device 72 The first filter device 71 and the second filter device 72 can be filters that prevent impurities from entering, such as filter screens.
  • the first power module 21 can also generate positive pressure within the gas storage module 10, thereby allowing the gas storage module 10 to deliver positive pressure to the first adsorption module 31.
  • the first power module 21 is reversible and can therefore drive gas movement in a positive direction, which refers to the direction in which gas is drawn from the first power module 21 to the gas storage module 10. Under the action of positive pressure, residue (such as impurities and dust) in the first adsorption module 31 can be removed under positive pressure.
  • the adsorption system 100 may further include a positive pump to generate positive pressure within the gas storage module 10.
  • the first adsorption method is used to adsorb a target object through the first adsorption module 31. Assume that in the initial state, the target object is not placed on the first adsorption module 31 and the first adsorption module 31 is connected to the atmosphere.
  • the first adsorption method can be specifically decomposed into four steps, namely steps 1 to 4. According to different needs, the order of the steps of the above method can be changed, and some steps can be omitted or combined.
  • Step 1 Establish a connection between the first power module 21 and the gas storage module 10 .
  • the first power module 21 starts up and generates negative pressure in the gas storage module 10 .
  • this step may also generate negative pressure in the first pipeline L1 and the second pipeline L2.
  • step 2 the first power module 21 is turned off, and the target object is placed on the first adsorption module 31 .
  • Step three establish a connection between the gas storage module 10 and the first adsorption module 31 so that the gas storage module 10 delivers negative pressure to the first adsorption module 31 , thereby enabling the first adsorption module 31 to adsorb the target object using the negative pressure.
  • the gas storage module 10 can be connected to the first adsorption module 31 through the first selection module 41.
  • the first adsorption module 31 uses negative pressure to adsorb the target object
  • the target object is fixed to the first adsorption module 31, and corresponding operations can be performed on the target object.
  • a pressure sensing device 11 can be installed within the gas storage module 10.
  • the pressure sensing device 11 can be fully activated or activated in step 3 to sense the negative pressure within the gas storage module 10.
  • the first power module 21 generates negative pressure within the gas storage module 10 again.
  • Step 4 disconnect the gas storage module 10 from the first adsorption module 31 , so that the negative pressure at the first adsorption module 31 is released.
  • the gas storage module 10 can be disconnected from the first adsorption module 31 through the first selection module 41 .
  • the second adsorption method only the first power module 21 works, and other power modules such as the second power module 22 do not work or can even be omitted from the adsorption system 100.
  • This adsorption method is used to adsorb different target objects respectively through the first adsorption module 31 and the second adsorption module 32. Assume that the target object is not placed in the initial state.
  • the first adsorption module 31 and the second adsorption module 32 are both connected to the atmosphere.
  • the second adsorption method can be specifically broken down into six steps, namely, steps 1 to 6. Depending on different needs, the order of the steps in the above method can be changed, and some steps can be omitted or combined.
  • Step 1 Establish a connection between the first power module 21 and the gas storage module 10 .
  • the first power module 21 starts up and generates negative pressure in the gas storage module 10 .
  • this step may also generate negative pressure in the first pipeline L1 and the second pipeline L2.
  • step 2 the first power module 21 is turned off, and the target object is placed on the first adsorption module 31 .
  • Step three establish a connection between the gas storage module 10 and the first adsorption module 31 so that the gas storage module 10 delivers negative pressure to the first adsorption module 31 , thereby enabling the first adsorption module 31 to adsorb the target object using the negative pressure.
  • the gas storage module 10 can be connected to the first adsorption module 31 through the first selection module 41.
  • the first adsorption module 31 uses negative pressure to adsorb the target object
  • the target object is fixed to the first adsorption module 31, and corresponding operations can be performed on the target object.
  • Step 4 Place another target object on the second adsorption module 32 .
  • Step five establish a connection between the gas storage module 10 and the second adsorption module 32 so that the gas storage module 10 delivers negative pressure to the second adsorption module 32 , thereby enabling the second adsorption module 32 to adsorb the target object using the negative pressure.
  • the gas storage module 10 can be connected to the second adsorption module 32 via the second selection module 42.
  • the second adsorption module 32 uses negative pressure to adsorb the target object, the target object is fixed to the second adsorption module 32, and corresponding operations can now be performed on the target object.
  • Step six disconnect the gas storage module 10 from the first adsorption module 31 and the second adsorption module 32 , so that the negative pressures at the first adsorption module 31 and the second adsorption module 32 are released respectively.
  • the gas storage module 10 can be disconnected from the first adsorption module 31 through the first selection module 41, and the gas storage module 10 can be disconnected from the second adsorption module 32 through the second selection module 42.
  • the above embodiment performs concurrent adsorption of different target objects (i.e., the adsorption times of different target objects at least partially overlap on the time axis) for illustrative purposes.
  • the order of steps 4 through 6 can be adjusted as needed to achieve sequential adsorption of different target objects.
  • the gas storage module 10 can be disconnected from the first adsorption module 31 before placing another target object on the second adsorption module 32.
  • a pressure sensing device 11 can be installed within the gas storage module 10.
  • the pressure sensing device 11 can be fully activated or activated during steps 3/5 to sense the negative pressure within the gas storage module 10.
  • the first power module 21 generates negative pressure within the gas storage module 10 again.
  • both the first power module 21 and the second power module 22 need to work.
  • This adsorption method is used to successively adsorb different target objects through the first adsorption module 31. Assuming that the target is The object is not placed on the first adsorption module 31, and the first adsorption module 31 is connected to the atmosphere.
  • the third adsorption method can be specifically broken down into eight steps, namely, steps 1 to 8. Depending on different needs, the order of the steps in the above method can be changed, and some steps can be omitted or combined.
  • Step 1 Establish a connection between the first power module 21 and the gas storage module 10 .
  • the first power module 21 starts up and generates negative pressure in the gas storage module 10 .
  • this step may also generate negative pressure in the first pipeline L1 and the second pipeline L2.
  • step 2 the first power module 21 is turned off, and the target object is placed on the first adsorption module 31 .
  • Step three establish a connection between the gas storage module 10 and the first adsorption module 31 so that the gas storage module 10 delivers negative pressure to the first adsorption module 31 , thereby enabling the first adsorption module 31 to adsorb the target object using the negative pressure.
  • the gas storage module 10 can be connected to the first adsorption module 31 through the first selection module 41.
  • the first adsorption module 31 uses negative pressure to adsorb the target object
  • the target object is fixed to the first adsorption module 31, and corresponding operations can be performed on the target object.
  • a pressure sensing device 11 can be installed within the gas storage module 10.
  • the pressure sensing device 11 can be fully activated or activated in step 3 to sense the negative pressure within the gas storage module 10.
  • the first power module 21 generates negative pressure within the gas storage module 10 again.
  • Step 4 disconnect the gas storage module 10 from the first adsorption module 31 , so that the negative pressure at the first adsorption module 31 is released.
  • the gas storage module 10 can be disconnected from the first adsorption module 31 through the first selection module 41 .
  • Step five establishing a connection between the second power module 22 and the gas storage module 10 , the second power module 22 is started and generates negative pressure in the gas storage module 10 .
  • this step may also generate negative pressure in the fourth pipe L4 and the fifth pipe L5.
  • Step six the second power module 22 is turned off, and another target object is placed on the first adsorption module 31 .
  • Step 7 Establish a connection between the gas storage module 10 and the first adsorption module 31, so that the gas storage module 10 transmits negative pressure to the first adsorption module 31, so that the first adsorption module 31 uses the negative pressure to adsorb the target object.
  • the target object can be operated accordingly.
  • Step eight disconnect the gas storage module 10 from the first adsorption module 31 , so that the negative pressure at the first adsorption module 31 is released.
  • This embodiment employs alternating operation of the first and second power modules 21, 22, which helps extend the lifespan of the first and second power modules 21, 22. Furthermore, even if one of the first and second power modules 21, 22 is damaged, the other can be used to replace it, allowing maintenance personnel to use the remaining time to repair the damaged power module. Furthermore, by calculating the pressure buildup time and the negative pressure drop time corresponding to the simultaneous application of negative pressure to all adsorption modules, the operating time of each power module can be designed, allowing them to operate alternately to extend their service life.
  • adsorption system 100 and the adsorption method of the present application will be further described below in conjunction with specific embodiments based on the specific structure of the adsorption system 100.
  • Those skilled in the art should understand that the structures described in this application are merely examples, and any other suitable structures are within the scope of this application.
  • the first power module 21 and the second power module 22 utilize plunger pumps 20a and 20b, respectively.
  • the gas storage module 10 utilizes a gas tank 10a (which is airtight and virtually leak-proof).
  • the air pressure sensing device 11 utilizes an air pressure sensor 11a.
  • the first adsorption module 31, the second adsorption module 32, the third adsorption module (not shown), and the fourth adsorption module (not shown) utilize wafer carriers 30a, 30b, 30c, and 30d, respectively.
  • the first selection module 41, the second selection module 42, the third selection module (not shown), and the fourth selection module (not shown) utilize three-way solenoid valves 40a, 40b, 40c, and 40d, respectively.
  • the gas tank 10a is connected to the three-way solenoid valves 40a, 40b, 40c, and 40d simultaneously via a five-way connector 90.
  • the first sensing device 51, the second sensing device 52, the third sensing device (not shown), and the fourth sensing device (not shown) respectively use air pressure sensors 50a, 50b, 50c, and 50d.
  • the first gas-liquid separation device 61, the second gas-liquid separation device 62, the third gas-liquid separation device (not shown), and the fourth gas-liquid separation device (not shown) respectively use gas-liquid separators 60a, 60b, 60c, and 60d.
  • the first filtering device 71, the second filtering device 72, the third filtering device (not shown), and the fourth filtering device (not shown) respectively use filters 70a, 70b, 70c, and 70d.
  • the target object is a slide.
  • This embodiment can use the second adsorption method to successively adsorb different carriers, specifically including: (1) all three-way solenoid valves 40a, 40b, 40c, and 40d are closed, and the plunger pump 20a is opened, thereby establishing negative pressure in the first pipeline L1, the gas tank 10a, and the second pipeline L2.
  • the plunger pump 20a After the negative pressure is established, the plunger pump 20a is closed, and the air pressure sensor 11a measures the negative pressure value as P1 ; (2) the carrier is placed on the carrier platform 30a, and the three-way solenoid valve 40a is opened to connect the carrier platform 30a and the gas tank 10a, so that the carrier is adsorbed and fixed to the carrier platform 30a under the action of negative pressure, and then the fluid can undergo biochemical reaction in the carrier; (3) after the biochemical reaction is completed, the three-way solenoid valve 40a is closed, so that the carrier platform 30a is connected to the atmosphere and the negative pressure is released.
  • plunger pump 20a When plunger pump 20a is turned on again and negative pressure is generated in gas tank 10a, the flow rate of plunger pump 20a is usually greater than the drop in negative pressure. Therefore, even if the slide is still adsorbed at this time, plunger pump 20a can still complete the pressure buildup in gas tank 10a. While plunger pump 20a is building pressure, another plunger pump 20b serves as a backup.
  • the negative pressure conditions of the four slides (named slide a, slide b, slide c, and slide d for ease of distinction) during their successive adsorption are recorded in Table 1.
  • the plunger pump 20a and the plunger pump 20b can be started at the same time to increase the pressure building speed.
  • the flow rate of the plunger pump 20b can also be set to be greater than the flow rate of the plunger pump 20a, and the plunger pump 20b can maintain a lower negative pressure, while the plunger pump 20a can maintain a higher negative pressure.
  • the plunger pump 20b and the plunger pump 20a can also be started successively, and the plunger pump 20b first quickly builds pressure in the fourth pipeline L4, the gas tank 10a and the fifth pipeline L5, and then the plunger pump 20a further reduces the negative pressure in the first pipeline L1, the gas tank 10a and the second pipeline L2 to the target value, thereby increasing the pressure building speed.
  • the dotted line portion in Figure 6 represents the degree of decrease in the negative pressure in the gas tank 10a when the pressure is built up by the plunger pump 20a
  • the solid line portion represents the degree of decrease in the negative pressure in the gas tank 10a when the pressure is built up by the plunger pump 20b and the plunger pump 20a successively.
  • This embodiment can also use a second adsorption method to adsorb different carriers in parallel, specifically including: (1) all three-way solenoid valves 40a, 40b, 40c, and 40d are closed, and the plunger pump 20a is turned on, thereby establishing a negative pressure in the first pipeline L1, the gas tank 10a, and the second pipeline L2. After the negative pressure is established, the plunger pump 20a is turned off, and the air pressure sensor 11a measures a negative pressure value of P1 .
  • this embodiment can also purge the slide platform 30a, 30b, 30c, 30d, specifically including: (1) all three-way solenoid valves 40a, 40b, 40c, 40d are closed, and the plunger pump 20a is switched on, thereby establishing positive pressure in the first pipeline L1, the gas tank 10a, and the second pipeline L2.
  • step (2) After the positive pressure is established, the plunger pump 20a is closed; (2) the three-way solenoid valve 40a is opened to connect the slide platform 30a and the gas tank 10a, and the gas flows from the gas tank 10a to the slide platform 30a and removes impurities on the slide platform 30a; (3) repeating steps similar to (2) to purge the other slide platforms 30a, 30b, 30c, 30d.
  • step (3) all three-way solenoid valves 40a, 40b, 40c, and 40d may be opened simultaneously to purge all wafer carrier platforms 30a, 30b, 30c, and 30d. In this case, step (3) may be omitted.
  • a shielding member 80 e.g., a cover
  • the shielding member 80 and the wafer platform 30a, 30b, 30c, or 30d may together form an air passage 81 for positive pressure gas to pass through.
  • the air passage 81 communicates with an opening H provided on the wafer platform 30a.
  • Example 8 the difference from Example 1 is that the gas tank 10a between the first and second pipes L1 and L2 is omitted, and only the wafer carrier platform 30a is in operation. To simplify the diagram, inoperative components are deleted from FIG8 .
  • This embodiment uses two plunger pumps 20a and 20b to alternately build pressure, specifically including: (1) the three-way solenoid valve 40a is closed, and the plunger pump 20a is opened, thereby establishing negative pressure in the first pipe L1 and the second pipe L2. After the negative pressure is established, the plunger pump 20a is closed; (2) the slide is placed on the slide platform 30a, and the three-way solenoid valve 40a is opened to connect the slide platform 30a and the first pipe L1 and the second pipe L2, so that the slide is adsorbed and fixed to the slide under the action of the negative pressure.
  • the fluid can then undergo a biochemical reaction within the slide; (3) After the biochemical reaction is completed, the three-way solenoid valve 40a is closed, allowing the slide platform 30a to be connected to the atmosphere, releasing the negative pressure, and the slide is removed from the slide platform 30a; (4) After the second cycle, another plunger pump 20b is turned on, thereby establishing a negative pressure in the fourth pipeline L4 and the second pipeline L2. After the negative pressure is established, the plunger pump 20b is turned off; (5) Steps (2)-(3) are repeated to perform a second cycle. In this case, the switch to step (5) can be long-term (such as after half a year or a year), at which time the plunger pump 20b serves as a backup air pump.
  • One embodiment of the present application also provides a biochemical substance analysis method.
  • the biochemical substance analysis method first adsorbs the target object (such as a slide) onto the adsorption module according to the above adsorption method, and then performs a first operation or a second operation on the slide.
  • the first operation is to cause the fluid to undergo a biochemical reaction within the slide
  • the second operation is to detect the fluid within the slide.
  • the slide can be a flow cell slide.
  • an embodiment of the present application further provides a biochemical substance analysis device 1, which includes the above-mentioned adsorption system 100. More specifically, the biochemical substance analysis device 1 can be a gene sequencer.

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Abstract

一种基于负压的吸附系统和方法、生化物质分析方法和装置。所述吸附系统包括气体存储模块、第一动力模块以及第一吸附模块。所述第一动力模块与所述气体存储模块连通，并被配置为在所述气体存储模块内产生负压。所述第一吸附模块被配置为与所述气体存储模块连通。所述气体存储模块被配置为向所述第一吸附模块输送负压，使所述第一吸附模块利用所述负压吸附目标对象。

Description

基于负压的吸附系统和方法、生化物质分析方法和装置 技术领域
本申请涉及负压控制，尤其涉及一种基于负压的吸附系统、基于负压的吸附方法、生化物质分析系统以及生化物质分析装置。
背景技术
在相关领域，目标对象可先放置于支撑平台上，在负压状态下将目标对象吸附于支撑平台，然后再对目标对象执行所需操作。例如在生化或医疗等领域，可先将微流控芯片先放置于芯片平台上，在负压状态下将微流控芯片吸附于芯片平台，然后将流体引入微流控芯片内进行生化反应，再对反应后的流体进行检测。
然而，为了使芯片平台保持吸附状态，真空泵需要一直启动，长时间的持续工作会降低真空泵的使用寿命。
发明内容
有鉴于此，有必要提供一种基于负压的吸附系统、基于负压的吸附方法、生化物质分析系统以及生化物质分析装置。
本申请第一方面提供一种基于负压的吸附系统，包括气体存储模块、第一动力模块以及第一吸附模块。所述第一动力模块与所述气体存储模块连通，并被配置为在所述气体存储模块内产生负压。所述第一吸附模块被配置为与所述气体存储模块连通，所述气体存储模块被配置为向所述第一吸附模块输送负压，使所述第一吸附模块利用所述负压吸附目标对象。
本申请第二方面提供一种基于负压的吸附方法，包括：建立第一动力模块与气体存储模块的连接；所述第一动力模块启动并在所述气体存储模块内产生负压；所述第一动力模块关闭且建立所述气体存储模块与第一吸附模块的连接；所述气体存储模块向所述第一吸附模块输送负压，从而使所述第一吸附模块利用所述负压吸附目标对象。
本申请第三方面提供一种生化物质分析方法，包括：建立第一动力模块与气体存储模块的连接；所述第一动力模块启动并在所述气体存储模块内产生负压；所述第一动力模块关闭且建立所述气体存储模块与第一吸附模块的连接；所述气体存储模块向所述第一吸附模块输送负压，从而使所述第一吸附模块利用所述负压吸附载片；对所述载片执行第一操作或第二操作，所述第一操作为使流体在所述载片内发生生化反应，所述第二操作为对所述载片内的流体进行检测。
本申请第四方面提供一种生化物质分析装置，包括如上所述的基于负压的吸附系统。所述吸附系统被配置为吸附所述目标对象，所述目标对象为载片。
本申请的吸附系统通过引入气体存储模块，即便第一动力模块关闭后，吸附系统的负压变化较慢，使得第一吸附模块可持续、稳定地吸附目标对象以便于后续对目标对象执行相应的操作，也利于提高第一动力模块的寿命。
附图说明
图1为本申请一实施方式提供的吸附系统的模块架构图。
图2为图1所示的吸附系统执行第一种吸附方法时的模块架构图。
图3为图1所示的吸附系统运行第二种吸附方法时的模块架构图。
图4为图1所示的吸附系统运行第三种吸附方法时的模块架构图。
图5为图1所示的吸附系统于一些实施例中的结构示意图。
图6为图5所示的吸附系统执行不同的建压方法时负压与时间的关系图。
图7为在图5所示的吸附系统的载片平台上盖设遮挡部件后的结构示意图。
图8为图1所示的吸附系统于另一些实施例中的结构示意图。
图9为本申请一实施方式提供的生化物质分析装置的模块架构图。
主要元件符号说明
生化物质分析装置   1
气体存储模块       10
气罐               10a
气压感测装置       11
气压传感器         11a
动力模组           20
柱塞泵             20a、20b
第一动力模块       21
第二动力模块       22
第M动力模块        2M
吸附模组           30
载片平台           30a、30b、30c、30d
第一吸附模块       31
第二吸附模块       32
第N吸附模块        3N
选择模组           40
三通电磁阀         40a、40b、40c、40d
第一选择模块       41
第二选择模块       42
第N选择模块        4N
气压传感器         50a、50b、50c、50d
第一传感装置       51
第二传感装置       52
第N传感装置        5N
气液分离器         60a、60b、60c、60d
第一气液分离装置   61
第二气液分离装置   62
第N气液分离装置    6N
过滤器             70a、70b、70c、70d
第一过滤装置       71
第二过滤装置       72
第N过滤装置        7N
遮挡部件           80
气道               81
五通接头           90
吸附系统           100
第一管道           L1
第二管道           L2
第三管道           L3
第四管道           L4
第五管道           L5
第六管道           L6
开孔               H
如下具体实施方式将结合上述附图进一步说明本申请。
具体实施方式
以下将结合本申请实施例中的附图，对本申请实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本申请一部分实施例，而不是全部的实施例。
需要说明的是，当组件被称为“固定于”、“安装于”另一个组件，它可以直接在另一个组件上或者也可以存在居中的组件。当一个组件被认为是“设置于”另一个组件，它可以是直接设置在另一个组件上或者可能同时存在居中组件。本文所使用的术语“及/或”包括一个或多个相关的所列项目的所有的和任意的组合。
需要说明的是，虽然在流程图中示出了逻辑顺序，但是在某些情况下，可以以不同于流程图中的顺序执行所示出或描述的步骤。本申请实施例中公开的方法包括用于 实现方法的一个或多个步骤或动作。方法步骤和/或动作可以在不脱离权利要求的范围的情况下彼此互换。除非指定步骤或动作的特定顺序，否则特定步骤和/或动作的顺序和/或使用可以在不脱离权利要求范围的情况下被修改。
请参阅图1，本申请一实施方式提供一种基于负压的吸附系统100，用于吸附目标对象(图未示)以便于后续对目标对象进行相应操作。吸附系统100包括气体存储模块10、动力模组20和吸附模组30。
动力模组20是吸附系统100中用于产生负压的功能模块。动力模组20可包括M个动力模块，M≥1，即动力模组20包括第一动力模块21至第M动力模块2M。当动力模组20包括多个动力模块时，各个动力模块可独立工作。各个动力模块的结构可以相同，也可以不同。在一些实施例中，动力模组20包括第一动力模块21和第二动力模块22。当第一动力模块21和第二动力模块22的其中一者工作时，另一者可以不工作。第一动力模块21和第二动力模块22也可以先后工作或者并行工作。“并行工作”意味着第一动力模块21和第二动力模块22的工作时间在时间轴上完全重叠或至少部分重叠，从而对产生目标负压所需的总时间进行优化。
气体存储模块10是吸附系统100中用于存储负压的功能模块。第一动力模块21和第二动力模块22可均与气体存储模块10连通。其中，本申请所称的“连接”或“连通”，指的是模块之间通过管道或其它合适的部件相互连接或连通。气体存储模块10可以为适于存储气体的容器，如气体罐。
吸附模组30是吸附系统100中用于吸附并固定目标对象的功能模块。吸附模组30可包括N个吸附模块，N≥M，即吸附模组30包括第一吸附模块31至第N吸附模块3N。各个吸附模块可相互独立并吸附不同的目标对象。各个吸附模块的结构可以相同，也可以不同。在一些实施例中，吸附模组30包括第一吸附模块31和第二吸附模块32。第一吸附模块31和第二吸附模块32中的至少一者选择性地连通至气体存储模块10。如，第一吸附模块31和第二吸附模块32可以先后吸附目标对象，也可以对目标对象进行并行吸附。第一吸附模块31和第二吸附模块32可以是具有与开孔H(在图7中示出)且适于为目标对象提供支撑的部件，当外界向第一吸附模块31或第二吸附模块32输送负压后，负压通过开孔H作用于目标对象，从而使第一吸附模块31或第二吸附模块32可利用负压吸附目标对象。
第一动力模块21可与气体存储模块10连通并在气体存储模块10内产生负压。当第一吸附模块31与气体存储模块10连通后，气体存储模块10可向第一吸附模块31输送负压，使第一吸附模块31利用负压吸附目标对象。如，第一动力模块21可沿反方向驱动气体运动，反方向是指抽取气体使其从气体存储模块10向第一动力模块21流动的方向。第一动力模块21可以是各种类型的可驱动气体运动的泵，例如，注射泵、柱塞泵、隔膜泵、齿轮泵、蠕动泵或真空泵等。
第二动力模块22可与气体存储模块10连通并在气体存储模块10内产生负压。当第二吸附模块32与气体存储模块10连通后，气体存储模块10可向第二吸附模块32输送负压，使第二吸附模块32利用负压吸附另一目标对象。如，第二动力模块22可沿反方向驱动气体运动，反方向是指抽取气体使其从气体存储模块10向第二动力模块22流动的方向。第一动力模块21和第二动力模块22中的至少一者选择性地启动。如， 第一动力模块21和第二动力模块22可以并行工作以在气体存储模块10内产生负压，第二动力模块22也可以作为备用的动力模块，当需要使用时才连通至气体存储模块10(如当第一动力模块21的建压速度不足时才连通至气体存储模块10)，二者同时建压，从而提高吸附系统100的可靠性。第二动力模块22可以是各种类型的可驱动气体运动的泵，例如，注射泵、柱塞泵、隔膜泵、齿轮泵、蠕动泵或真空泵等。
在一些实施例中，吸附系统100还可包括选择模组40。选择模组40可包括N个选择模块，即选择模块40包括第一选择模块41至第N选择模块4N。各个选择模块可独立工作。各个选择模块的结构可以相同，也可以不同。每一选择模块可将气体存储模块10与不同的吸附模块相互连通，从而实现对气体存储模块10内负压流向的选择。在一些实施例中，选择模组40包括第一选择模块41和第二选择模块42。第一选择模块41可将气体存储模块10与第一吸附模块31连通或断开连接，第二选择模块42可将气体存储模块10与第二吸附模块32连通或断开连接。其中，第一选择模块41或第二选择模块42可以是各种类型的电磁阀、选择阀(如旋转阀)等阀门或其组合。
其中，可设置第一动力模块21和气体存储模块10通过第一管道L1连接，气体存储模块10和第一选择模块41通过第二管道L2连接，第一选择模块41和第一吸附模块31通过第三管道L3连接。同理，可设置第二动力模块22和气体存储模块10通过第四管道L4连接，气体存储模块10和第二选择模块42通过第五管道L5连接，第二选择模块42和第二吸附模块32通过第六管道L6连接。吸附系统100中，连接于第一动力模块21的所有部件的内体积气体存储模块10、第一管道L1、第二管道L2以及第三管道L3四者的体积有关。定义吸附系统100的内体积为V，吸附系统100与大气之间的泄漏率为leak rate(sccm)，大气压力为Patm，时间Δt内吸附系统100的负压变化为ΔP，ΔP的计算公式如下：
从上述计算公式可知，在吸附系统100的泄漏率一定的情况下，在相同的时间Δt内，若吸附系统100的内体积V越大，则负压变化ΔP越慢，即吸附系统100中负压下降的速度越慢。
相较于直接通过管路连接动力模块、选择模块和吸附模块的方案(管路的内体积一般仅为毫升级别，当动力模块关闭后吸附系统的负压变化较快，使得动力模块需要一直工作以持续吸附目标对象)，本申请通过引入体积较大的气体存储模块10，即便第一动力模块21关闭后，吸附系统100的负压变化较慢，使得第一吸附模块31可持续、稳定地吸附目标对象以便于后续对目标对象执行相应的操作。而且第一动力模块21不需一直工作，也利于提高第一动力模块21的寿命。定义气体存储模块10的体积为V1，第一管道L1、第二管道L2以及第三管道L3的体积之和为V2，可设置气体存储模块10的体积为升的级别，而管道体积一般为毫升级别，即V1远大于V2，因此即便第一动力模块21关闭后，吸附系统100的负压变化较慢。同理，第四管道L4、第五管道L5以及第六管道L6的体积之和为V3，V1远大于V3，因此即便第二动力模块22关闭后，吸附系统100的负压变化较慢。
在一些实施例中，可设置N>M，即动力模块的数量少于吸附模块的数量。相较于直接通过管路连接动力模块、选择模块和吸附模块的方案(动力模块、选择模块和吸附模块需要一一对应连接，即每个吸附模块需要搭配一个动力模块)，本申请通过引入气体存储模块10，可以适当减少动力模块的数量，从而降低成本。
进一步地，吸附系统100还可包括与气体存储模块10连通的气压感测装置11。气压感测装置11可用于感测气体存储模块10内的负压值。第一动力模块21还可当气压感测装置11感测到的负压值高于预设值时，再次在气体存储模块10内产生负压，从而降低气体存储模块10内的负压值以使第一吸附模块31可持续、稳定地吸附目标对象。
在一些实施例中，吸附系统100还可包括N个传感装置和报警装置(图未示)，即传感装置的数量与吸附模块的数量对应。例如，吸附系统100可包括连接于第一吸附模块31和第一选择模块41之间的第一传感装置51、连接于第二吸附模块32和第二选择模块42之间的第二传感装置52、以及连接于第N吸附模块3N和第N选择模块4N之间的第N传感装置5N。第一传感装置51为连接第三管道L3的气压传感器，其可感测第三管道L3内的负压值。第二传感装置52的位置和作用同理。若吸附系统100未发生泄漏，N个传感装置所测得的负压值之和为负压变化ΔP。反之，若吸附系统100发生泄漏，N个传感装置所测得的负压值之和会超过负压变化ΔP。报警装置与气压感测装置11以及各个传感装置均电性连接。报警装置可通过气压感测装置11所感测的负压值计算负压变化，然后将该负压变化与各个传感装置所测得的负压值之和比较，当判断吸附系统100发生泄漏产生报警信号(如报警指示灯闪烁或发出报警音)。报警装置还可比较各个传感装置所测得的负压值，当其中一传感装置所测得的负压值明显未达到其它传感装置所测得的负压值时，表明对应的一管道在规定时间内负压值未达到预定值，从而产生报警信号。
在另一实施例中，第一传感装置51还可以为连接第三管道L3的流量传感器，其可感测第三管道L3内的气体流量值。第二传感装置52的位置和作用同理。报警装置还可判断该气体流量超出阈值时，当超出阈值时表明对应的吸附模块未成功吸附目标对象，从而产生报警信号。
吸附系统100还可包括N个气液分离装置，即气液分离装置的数量与吸附模块的数量对应。例如，吸附系统100可包括连接于第一吸附模块31和第一选择模块41之间的第一气液分离装置61、连接于第二吸附模块32和第二选择模块42之间的第二气液分离装置62、以及连接于第N吸附模块3N和第N选择模块4N之间的第N气液分离装置6N。例如，第一气液分离装置61连接于第三管道L3，第一气液分离装置61可防止液体由第一吸附模块31流向第一选择模块41和气体存储模块10。第二气液分离装置62的位置和作用同理。其中，第一气液分离装置61和第二气液分离装置62可为阻挡液体通过的气液分离器。
吸附系统100还可包括N个过滤装置，即过滤装置的数量与吸附模块的数量对应。例如，吸附系统100可包括连接于第一选择模块41的第一过滤装置71、连接于第二选择模块42的第二过滤装置72、以及连接于第N选择模块4N的第N过滤装置7N。第一过滤装置71可防止空气中的杂质进入第三管道L3。第二过滤装置72的位置和作 用同理。其中，第一过滤装置71和第二过滤装置72可为阻挡杂质进入的过滤器，如滤网。
在一些实施例中，第一动力模块21还可在气体存储模块10内产生正压，因此气体存储模块10可向第一吸附模块31输送正压。如，第一动力模块21可换向，因此还可沿正方向驱动气体运动，正方向是指抽取气体使其从第一动力模块21向气体存储模块10流动的方向。在正压的作用下，第一吸附模块31的残留物(如杂质、灰尘)可在正压下被移除。在另一些实施例中，吸附系统100还可另外包括一正向泵以在气体存储模块10内产生正压。
以下将结合吸附系统100的各个功能模块对吸附系统100的三种吸附方法进行说明。
第一种吸附方法
如图2所示，第一种吸附方法下仅有第一动力模块21工作，其它动力模块如第二动力模块22不工作甚至可以从吸附系统100中省略。该吸附方法用于通过第一吸附模块31吸附一个目标对象。假设初始状态下目标对象未放置于第一吸附模块31上，第一吸附模块31连通大气。第一种吸附方法具体可被分解为四个步骤，即步骤一至步骤四。根据不同需求，上述方法的步骤顺序可以改变，某些步骤可以省略或合并。
步骤一，建立第一动力模块21与气体存储模块10的连接，第一动力模块21启动并在气体存储模块10内产生负压。
在一些实施例中，当第一动力模块21和气体存储模块10通过第一管道L1连接且气体存储模块10和第一选择模块41通过第二管道L2连接时，该步骤还可在第一管道L1和第二管道L2内产生负压。
步骤二，第一动力模块21关闭，将目标对象放置于第一吸附模块31上。
步骤三，建立气体存储模块10与第一吸附模块31的连接，使气体存储模块10向第一吸附模块31输送负压，从而使第一吸附模块31利用负压吸附目标对象。
在一些实施例中，当吸附系统100包括第一选择模块41时，可通过第一选择模块41将气体存储模块10与第一吸附模块31连通。当第一吸附模块31利用负压吸附目标对象后，目标对象已固定于第一吸附模块31上，此时可对目标对象进行相应的操作。
可以理解，当气体存储模块10向第一吸附模块31输送负压后，气体存储模块10本身的负压会下降。因此可在气体存储模块10内设置气压感测装置11，气压感测装置11可全程开启或在步骤三中开启，从而感测气体存储模块10内的负压值，当负压值高于预设值时，第一动力模块21再次在气体存储模块10内产生负压。
步骤四，断开气体存储模块10与第一吸附模块31的连接，使得第一吸附模块31处的负压被释放。
在一些实施例中，当完成对目标对象进行相应的操作之后，可通过第一选择模块41将气体存储模块10与第一吸附模块31断开连接。
第二种吸附方法
如图3所示，第二种吸附方法下仅有第一动力模块21工作，其它动力模块如第二动力模块22不工作甚至可以从吸附系统100中省略。该吸附方法用于通过第一吸附模块31和第二吸附模块32分别吸附不同的目标对象。假设初始状态下目标对象未放置 于第一吸附模块31和第二吸附模块32上，第一吸附模块31和第二吸附模块32均连通大气。第二种吸附方法具体可被分解为六个步骤，即步骤一至步骤六。根据不同需求，上述方法的步骤顺序可以改变，某些步骤可以省略或合并。
步骤一，建立第一动力模块21与气体存储模块10的连接，第一动力模块21启动并在气体存储模块10内产生负压。
在一些实施例中，当第一动力模块21和气体存储模块10通过第一管道L1连接且气体存储模块10和第一选择模块41通过第二管道L2连接时，该步骤还可在第一管道L1和第二管道L2内产生负压。
步骤二，第一动力模块21关闭，将目标对象放置于第一吸附模块31上。
步骤三，并建立气体存储模块10与第一吸附模块31的连接，使气体存储模块10向第一吸附模块31输送负压，从而使第一吸附模块31利用负压吸附目标对象。
在一些实施例中，当吸附系统100包括第一选择模块41时，可通过第一选择模块41将气体存储模块10与第一吸附模块31连通。当第一吸附模块31利用负压吸附目标对象后，目标对象已固定于第一吸附模块31上，此时可对目标对象进行相应的操作。
步骤四，将另一目标对象放置于第二吸附模块32上。
步骤五，并建立气体存储模块10与第二吸附模块32的连接，使气体存储模块10向第二吸附模块32输送负压，从而使第二吸附模块32利用负压吸附目标对象。
在一些实施例中，当吸附系统100还包括第二选择模块42时，可通过第二选择模块42将气体存储模块10与第二吸附模块32连通。当第二吸附模块32利用负压吸附目标对象后，目标对象已固定于第二吸附模块32上，此时可对目标对象进行相应的操作。
步骤六，断开气体存储模块10与第一吸附模块31以及第二吸附模块32的连接，使得第一吸附模块31和第二吸附模块32处的负压分别被释放。
在一些实施例中，当完成对目标对象进行相应的操作之后，可通过第一选择模块41将气体存储模块10与第一吸附模块31断开连接，通过第二选择模块42将气体存储模块10与第二吸附模块32断开连接。
以上实施例对不同目标对象进行并行吸附(即对不同目标对象的吸附时间在时间轴上至少部分重叠)为了进行说明。在另一些实施例中，还可步骤四至步骤六的先后顺序还可以根据需求进行调整，实现对不同目标对象的先后吸附。例如可先断开气体存储模块10与第一吸附模块31的连接，然后再将另一目标对象放置于第二吸附模块32上。
可以理解，当气体存储模块10向第一吸附模块31或者第二吸附模块32输送负压后，气体存储模块10本身的负压会下降。因此可在气体存储模块10内设置气压感测装置11，气压感测装置11可全程开启或在步骤三/步骤五中开启，从而感测气体存储模块10内的负压值，当负压值高于预设值时，第一动力模块21再次在气体存储模块10内产生负压。
第三种吸附方法
如图4所示，第三种吸附方法下第一动力模块21和第二动力模块22均需要工作。该吸附方法用于通过第一吸附模块31先后吸附不同的目标对象。假设初始状态下目标 对象未放置于第一吸附模块31上，第一吸附模块31连通大气。第三种吸附方法具体可被分解为八个步骤，即步骤一至步骤八。根据不同需求，上述方法的步骤顺序可以改变，某些步骤可以省略或合并。
步骤一，建立第一动力模块21与气体存储模块10的连接，第一动力模块21启动并在气体存储模块10内产生负压。
在一些实施例中，当第一动力模块21和气体存储模块10通过第一管道L1连接且气体存储模块10和第一选择模块41通过第二管道L2连接时，该步骤还可在第一管道L1和第二管道L2内产生负压。
步骤二，第一动力模块21关闭，将目标对象放置于第一吸附模块31上。
步骤三，建立气体存储模块10与第一吸附模块31的连接，使气体存储模块10向第一吸附模块31输送负压，从而使第一吸附模块31利用负压吸附目标对象。
在一些实施例中，当吸附系统100包括第一选择模块41时，可通过第一选择模块41将气体存储模块10与第一吸附模块31连通。当第一吸附模块31利用负压吸附目标对象后，目标对象已固定于第一吸附模块31上，此时可对目标对象进行相应的操作。
可以理解，当气体存储模块10向第一吸附模块31输送负压后，气体存储模块10本身的负压会下降。因此可在气体存储模块10内设置气压感测装置11，气压感测装置11可全程开启或在步骤三中开启，从而感测气体存储模块10内的负压值，当负压值高于预设值时，第一动力模块21再次在气体存储模块10内产生负压。
步骤四，断开气体存储模块10与第一吸附模块31的连接，使得第一吸附模块31处的负压被释放。
在一些实施例中，当完成对目标对象进行相应的操作之后，可通过第一选择模块41将气体存储模块10与第一吸附模块31断开连接。
步骤五，建立第二动力模块22与气体存储模块10的连接，第二动力模块22启动并在气体存储模块10内产生负压。
在一些实施例中，当第二动力模块22和气体存储模块10通过第四管道L4连接且气体存储模块10和第二选择模块42通过第五管道L5连接时，该步骤还可在第四管道L4和第五管道L5内产生负压。
步骤六，第二动力模块22关闭，将另一目标对象放置于第一吸附模块31上。
步骤七，建立气体存储模块10与第一吸附模块31的连接，使气体存储模块10向第一吸附模块31输送负压，从而使第一吸附模块31利用负压吸附目标对象。此时可对目标对象进行相应的操作。
步骤八，断开气体存储模块10与第一吸附模块31的连接，使得第一吸附模块31处的负压被释放。
本实施例采用第一动力模块21和第二动力模块22交替工作，利于提高第一动力模块21和第二动力模块22的寿命。而且即便第一动力模块21和第二动力模块22中的一个意外损坏，可以由第一动力模块21和第二动力模块22中的另一个进行补位工作，利于维修人员利用该补位时间维护损坏的动力模块。另外，通过计算建压时间和同时供给所有吸附模块负压对应的负压下降时间，可设计各个动力模块的工作时间，使各个动力模块交替工作以延长动力模块的使用寿命。
以下将根据吸附系统100的具体结构，结合具体实施例进一步说明本申请的吸附系统100和吸附方法。本领域技术人员应理解，本申请中描述的结构仅是实施例，其他任何合适的结构均在本申请的范围内。
实施例1
请参阅图5，第一动力模块21和第二动力模块22分别采用柱塞泵20a、20b，气体存储模块10采用气罐10a(气密性较好，几乎不发生泄漏)，气压感测装置11采用气压传感器11a。第一吸附模块31、第二吸附模块32、第三吸附模块(图未标示)和第四吸附模块(图未标示)分别采用载片平台30a、30b、30c、30d。第一选择模块41、第二选择模块42、第三选择模块(图未标示)和第四选择模块(图未标示)分别为三通电磁阀40a、40b、40c和40d。气罐10a通过五通接头90同时连接三通电磁阀40a、40b、40c和40d。第一传感装置51、第二传感装置52、第三传感装置(图未标示)和第四传感装置(图未标示)分别采用气压传感器50a、50b、50c和50d。第一气液分离装置61、第二气液分离装置62、第三气液分离装置(图未标示)和第四气液分离装置(图未标示)分别采用气液分离器60a、60b、60c和60d。第一过滤装置71、第二过滤装置72、第三过滤装置(图未标示)和第四过滤装置(图未标示)分别采用过滤器70a、70b、70c和70d。目标对象为载片。
本实施例可采用第二种吸附方法对不同载片进行先后吸附，具体包括：(1)所有三通电磁阀40a、40b、40c、40d关闭，柱塞泵20a开启，从而在第一管道L1、气罐10a和第二管道L2内建立负压，负压建立完毕后柱塞泵20a关闭，气压传感器11a测得负压值为P1；(2)将载片放置于载片平台30a上，三通电磁阀40a开启以连通载片平台30a和气罐10a，使载片在负压作用下被吸附并固定至载片平台30a上，而后流体可在载片内进行生化反应；(3)生化反应完成后，三通电磁阀40a关闭，使载片平台30a连通大气，释放负压，此时将载片从载片平台30a上移除，气压传感器11a测得负压变化为ΔP，即气罐10a内的负压为P2＝P1+ΔP；(4)重复与(3)至(5)相似的步骤以使其它载片在载片平台30b、30c、30d上进行生化反应，若P2>预设值P0(预设值)则重新打开柱塞泵20a以使气罐10a内的负压重新达到P1。
其中，当柱塞泵20a再次开启并在气罐10a内产生负压时，柱塞泵20a的流量通常大于负压下降，因此即便此时对载片保持吸附，柱塞泵20a仍可完成对气罐10a的建压。在柱塞泵20a建压的过程中，另一柱塞泵20b作为备选。其中，四个载片(为便于区分，命名为载片a、载片b、载片c和载片d)先后吸附时的负压情况记录于表1中。
表1
其中，在上述步骤(1)中，若柱塞泵20a的建压速度不足，可同时启动柱塞泵20a和柱塞泵20b，提高建压速度。在另一实施例中，也可设置柱塞泵20b的流量大于柱塞泵20a的流量，同时柱塞泵20b可保持的负压较低，而柱塞泵20a可保持的负压较高。此时也可先后启动柱塞泵20b和柱塞泵20a，先由柱塞泵20b快速地在第四管道L4、气罐10a和第五管道L5内建压，再由柱塞泵20a将第一管道L1、气罐10a和第二管道L2内的负压进一步降低至目标值，从而提高建压速度。如图6所示，图6中的点划线部分表示由柱塞泵20a建压时气罐10a内负压的下降程度，实线部分表示先后由柱塞泵20b和柱塞泵20a建压时气罐10a内负压的下降程度，由此可知，先后由柱塞泵20b和柱塞泵20a建压时负压降低至目标值(用虚线表示)所需时间较少，即建压速度较高。
请参阅图5，本实施例还可采用第二种吸附方法对不同载片进行并行吸附，具体包括：(1)所有三通电磁阀40a、40b、40c、40d关闭，柱塞泵20a开启，从而在第一管道L1、气罐10a和第二管道L2内建立负压，负压建立完毕后柱塞泵20a关闭，气压传感器11a测得负压值为P1；(2)将载片分别放置于载片平台30a、30b、30c、30d上，所有三通电磁阀40a、40b、40c、40d开启以分别连通不同的载片平台30a、30b、30c、30d和气罐10a，使载片在负压作用下被吸附并固定至对应的载片平台30a、30b、30c、30d上，而后流体可在载片内进行生化反应；(3)生化反应完成后，所有三通电磁阀40a、40b、40c、40d关闭，使载片平台30a、30b、30c、30d连通大气，释放负压，此时可将载片分别从载片平台30a、30b、30c、30d上移除，气压传感器11a测得负压变化为4ΔP，即气罐10a内的负压为P2＝P1+4ΔP；(4)若P2大于预设值P0则重新打开柱塞泵20a以使气罐10a内的负压重新达到P1。
其中，四个载片并行吸附时的负压情况记录于表2中。
表2
当完成生化反应并将载片从载片平台30a、30b、30c、30d上移除之后，本实施例还可对载片平台30a、30b、30c、30d进行吹扫，具体包括：(1)所有三通电磁阀40a、40b、40c、40d关闭，柱塞泵20a换向开启，从而在第一管道L1、气罐10a和第二管道L2内建立正压，正压建立完毕后柱塞泵20a关闭；(2)三通电磁阀40a开启以连通载片平台30a和气罐10a，气体从气罐10a中流向载片平台30a并清除载片平台30a上的杂质；(3)重复与(2)相似的步骤以对其它载片平台30a、30b、30c、30d进行吹扫。另一实施例中，步骤(2)中也可以同时开启所有三通电磁阀40a、40b、40c、40d以对所有载片平台30a、30b、30c、30d进行吹扫，此时步骤(3)可省略。
请参阅图7，在本实施例中，在对某一载片平台30a、30b、30c或30d进行吹扫时，可预先在该载片平台30a、30b、30c或30d上设置遮挡部件80(如盖板)。遮挡部件80与该载片平台30a、30b、30c或30d可共同形成一供正压气体吹过的气道81，该气道81与载片平台30a本身设置的开孔H连通。
实施例2
请参阅图8，与实施例1不同之处在于省略第一管道L1和第二管道L2之间的气罐10a，且只有载片平台30a工作。为简化图示，未工作的部件从图8中删除。
本实施例采用两个柱塞泵20a、20b交替地建压，具体包括：(1)三通电磁阀40a关闭，柱塞泵20a开启，从而在第一管道L1和第二管道L2内建立负压，负压建立完毕后柱塞泵20a关闭；(2)将载片放置于载片平台30a上，三通电磁阀40a开启以连通载片平台30a和第一管道L1、第二管道L2，使载片在负压作用下被吸附并固定至载片平台30a上，而后流体可在载片内进行生化反应；(3)生化反应完成后，三通电磁阀40a关闭，使载片平台30a连通大气，释放负压，此时将载片从载片平台30a上移除；(4)在第二个循环后另一柱塞泵20b开启，从而在第四管道L4和第二管道L2内建立负压，负压建立完毕后柱塞泵20b关闭；(5)重复步骤(2)-(3)以进行第二个循环。其中，可以是长期(如半年或一年后)切换至步骤(5)，此时柱塞泵20b作为备用的气泵。
本申请一实施方式还提供一种生化物质分析方法。该生化物质分析方法先根据上述吸附方法将目标对象(如载片)吸附于吸附模块上，然后对载片执行第一操作或第 二操作。第一操作为使流体在载片内发生生化反应，第二操作为对载片内的流体进行检测。更具体地，载片可以为流动池载片。
请参阅图9，本申请一实施方式还提供一种生化物质分析装置1，其包括上述吸附系统100。更具体地，该生化物质分析装置1可以为基因测序仪。
最后应说明的是，以上实施例仅用以说明本申请的技术方案而非限制，尽管参照较佳实施例对本申请进行了详细说明，本领域的普通技术人员应当理解，可以对本申请的技术方案进行修改或等同替换，而不脱离本申请技术方案的精神和范围。

Claims (31)

  1. 一种基于负压的吸附系统，其特征在于，包括：
    气体存储模块；
    第一动力模块，与所述气体存储模块连通并被配置为在所述气体存储模块内产生负压；以及
    第一吸附模块，被配置为与所述气体存储模块连通，所述气体存储模块被配置为向所述第一吸附模块输送负压，使所述第一吸附模块利用所述负压吸附目标对象。
  2. 如权利要求1所述的基于负压的吸附系统，其特征在于，还包括：
    第二动力模块，与所述气体存储模块连通并被配置为在所述气体存储模块内产生负压，所述第一动力模块和所述第二动力模块的至少一个选择性地启动以产生所述负压。
  3. 如权利要求2所述的基于负压的吸附系统，其特征在于，所述第一动力模块和所述第二动力模块被配置为交替地启动以产生所述负压。
  4. 如权利要求2所述的基于负压的吸附系统，其特征在于，所述第一动力模块和所述第二动力模块被配置为并行地启动以产生所述负压。
  5. 如权利要求1至4中任一项所述的基于负压的吸附系统，其特征在于，还包括：
    第二吸附模块，与所述气体存储模块连通，所述气体存储模块还被配置为向所述第二吸附模块输送负压，使所述第二吸附模块利用所述负压吸附另一目标对象。
  6. 如权利要求1至5中任一项所述的基于负压的吸附系统，其特征在于，还包括：
    第一选择模块，与所述气体存储模块和所述第一吸附模块分别连接，所述第一选择模块被配置为将所述气体存储模块与所述第一吸附模块连通或断开连接。
  7. 如权利要求6所述的基于负压的吸附系统，其特征在于，还包括：
    第一管道，连接所述第一动力模块和所述气体存储模块；
    第二管道，连接所述气体存储模块和所述第一选择模块；
    第三管道，连接所述第一选择模块和所述第一吸附模块。
  8. 如权利要求7所述的基于负压的吸附系统，其特征在于，还包括：
    气压感测装置，与所述气体存储模块连通且被配置为感测所述气体存储模块内的负压值；
    所述第一动力模块还被配置为当所述气压感测装置感测到的负压值高于预设值时，再次在所述气体存储模块内产生负压。
  9. 如权利要求8所述的基于负压的吸附系统，其特征在于，还包括：
    第一传感装置，与所述第三管道连通且被配置为感测所述第三管道内的负压值，所述第一动力模块感测到的负压值和所述第一传感装置感测到的负压值能够指示所述吸附系统是否发生泄漏。
  10. 如权利要求8所述的基于负压的吸附系统，其特征在于，还包括：
    第一传感装置，与所述第三管道连通且被配置为感测所述第三管道内的气体流量值，所述气体流量值能够指示所述第一吸附模块是否成功吸附所述目标对象。
  11. 如权利要求7至10中任一项所述的基于负压的吸附系统，其特征在于，还包括：
    气液分离装置，连接于所述第三管道且被配置为阻挡液体由所述第一吸附模块流向所述气体存储模块。
  12. 如权利要求1至11中任一项所述的基于负压的吸附系统，其特征在于，所述吸附系统包括动力模组和吸附模组，所述动力模组包括所述第一动力模块和至少一其它动力模块，所述吸附模组包括所述第一吸附模块和至少一其它吸附模块，所述动力模组所包括的动力模块的数量少于所述吸附模组所包括的吸附模块的数量。
  13. 如权利要求1至12中任一项所述的基于负压的吸附系统，其特征在于，所述第一动力模块还被配置为在所述气体存储模块内产生正压，所述气体存储模块还被配置为向所述第一吸附模块输送所述正压。
  14. 一种基于负压的吸附方法，其特征在于，包括：
    建立第一动力模块与气体存储模块的连接；
    所述第一动力模块启动并在所述气体存储模块内产生负压；
    所述第一动力模块关闭且建立所述气体存储模块与第一吸附模块的连接；
    所述气体存储模块向所述第一吸附模块输送负压，从而使所述第一吸附模块利用所述负压吸附目标对象。
  15. 如权利要求14所述的基于负压的吸附方法，其特征在于，还包括：
    建立第二动力模块与所述气体存储模块的连接；
    所述第二动力模块启动并在所述气体存储模块内产生负压；
    所述第二动力模块关闭且建立所述气体存储模块与第二吸附模块的连接；
    所述气体存储模块向所述第二吸附模块输送负压，从而使所述第二吸附模块利用所述负压吸附另一目标对象。
  16. 如权利要求15所述的基于负压的吸附方法，其特征在于，所述第一动力模块和所述第二动力模块交替地启动以产生所述负压。
  17. 如权利要求15所述的基于负压的吸附方法，其特征在于，所述第一动力模块和所述第二动力模块并行地启动以产生所述负压。
  18. 如权利要求14至17中任一项所述的基于负压的吸附方法，其特征在于，还包括：
    建立所述气体存储模块与第二吸附模块的连接；
    所述气体存储模块向所述第二吸附模块输送负压，从而使所述第二吸附模块利用所述负压吸附另一目标对象。
  19. 如权利要求14至18中任一项所述的基于负压的吸附方法，其特征在于，“建立第一动力模块与气体存储模块的连接”具体包括：
    将第一选择模块与所述气体存储模块和所述第一吸附模块分别连接，控制所述第一选择模块将所述气体存储模块与所述第一吸附模块连通。
  20. 如权利要求14至19中任一项所述的基于负压的吸附方法，其特征在于，还包括：
    通过气压感测装置感测所述气体存储模块内的负压值；
    当所述负压值高于预设值时，所述第一动力模块再次在所述气体存储模块内产生负压。
  21. 如权利要求14至20中任一项所述的基于负压的吸附方法，其特征在于，还包括：
    所述第一动力模块在所述气体存储模块内产生正压；
    所述气体存储模块向所述第一吸附模块输送所述正压。
  22. 一种生化物质分析方法，其特征在于，包括：
    建立第一动力模块与气体存储模块的连接；
    所述第一动力模块启动并在所述气体存储模块内产生负压；
    所述第一动力模块关闭且建立所述气体存储模块与第一吸附模块的连接；
    所述气体存储模块向所述第一吸附模块输送负压，从而使所述第一吸附模块利用所述负压吸附载片；
    对所述载片执行第一操作或第二操作，所述第一操作为使流体在所述载片内发生生化反应，所述第二操作为对所述载片内的流体进行检测。
  23. 如权利要求22所述的生化物质分析方法，其特征在于，还包括：
    建立第二动力模块与所述气体存储模块的连接；
    所述第二动力模块启动并在所述气体存储模块内产生负压；
    所述第二动力模块关闭且建立所述气体存储模块与第二吸附模块的连接；
    所述气体存储模块向所述第二吸附模块输送负压，从而使所述第二吸附模块利用所述负压吸附另一载片；
    对所述另一载片执行第三操作或第四操作，所述第三操作为使流体在所述另一载片内发生生化反应，所述第四操作为对所述另一载片内的流体进行检测。
  24. 如权利要求23所述的生化物质分析方法，其特征在于，所述第一动力模块和所述第二动力模块交替地启动以产生所述负压。
  25. 如权利要求23所述的生化物质分析方法，其特征在于，所述第一动力模块和所述第二动力模块并行地启动以产生所述负压。
  26. 如权利要求22至25中任一项所述的生化物质分析方法，其特征在于，还包括：
    建立所述气体存储模块与第二吸附模块的连接；
    所述气体存储模块向所述第二吸附模块输送负压，从而使所述第二吸附模块利用所述负压吸附另一载片；
    对所述另一载片执行第三操作或第四操作，所述第三操作为使流体在所述另一载片内发生生化反应，所述第四操作为对所述另一载片内的流体进行检测。
  27. 如权利要求22至26中任一项所述的生化物质分析方法，其特征在于，“建立第一动力模块与气体存储模块的连接”具体包括：
    将第一选择模块与所述气体存储模块和所述第一吸附模块分别连接，控制所述第一选择模块将所述气体存储模块与所述第一吸附模块连通。
  28. 如权利要求22至27中任一项所述的生化物质分析方法，其特征在于，还包括：
    通过气压感测装置感测所述气体存储模块内的负压值；
    当所述负压值高于预设值时，所述第一动力模块再次在所述气体存储模块内产生 负压。
  29. 如权利要求22至28中任一项所述的生化物质分析方法，其特征在于，还包括：
    所述第一动力模块在所述气体存储模块内产生正压；
    所述气体存储模块向所述第一吸附模块输送所述正压，从而使所述第一吸附模块的残留物在所述正压下被移除。
  30. 一种基于负压的吸附系统，其特征在于，包括：
    第一吸附模块；
    第一动力模块；以及
    第二动力模块，所述第一动力模块和所述第二动力模块的至少一个选择性地与所述第一吸附模块连通，所述第一动力模块和所述第二动力模块被配置为在所述第一吸附模块内产生负压，使所述第一吸附模块利用所述负压吸附目标对象。
  31. 一种生化物质分析装置，其特征在于，包括如权利要求1至13、30中任一项所述的基于负压的吸附系统，所述吸附系统被配置为吸附所述目标对象，所述目标对象为载片。
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