WO2024239160A1 - 经颅超声应用装置 - Google Patents

经颅超声应用装置 Download PDF

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Publication number
WO2024239160A1
WO2024239160A1 PCT/CN2023/095361 CN2023095361W WO2024239160A1 WO 2024239160 A1 WO2024239160 A1 WO 2024239160A1 CN 2023095361 W CN2023095361 W CN 2023095361W WO 2024239160 A1 WO2024239160 A1 WO 2024239160A1
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WO
WIPO (PCT)
Prior art keywords
guide rail
application device
bracket
annular guide
head
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2023/095361
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English (en)
French (fr)
Inventor
李帅
佘仲君
郑永平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hong Kong Polytechnic University HKPU
Original Assignee
Hong Kong Polytechnic University HKPU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hong Kong Polytechnic University HKPU filed Critical Hong Kong Polytechnic University HKPU
Priority to PCT/CN2023/095361 priority Critical patent/WO2024239160A1/zh
Publication of WO2024239160A1 publication Critical patent/WO2024239160A1/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves

Definitions

  • the present application relates to the technical field of medical devices, and in particular to a transcranial ultrasound application device.
  • Transcranial sonography uses ultrasound grayscale images to display the internal structure of the brain; transcranial Doppler (TCD) and transcranial color Doppler (TCCD) are non-invasive cerebrovascular disease detection methods that use the ultrasound Doppler effect to detect the hemodynamics and blood flow physiological parameters of the main intracranial arteries.
  • TCS Transcranial sonography
  • TCD transcranial Doppler
  • TCCD transcranial color Doppler
  • These technologies all rely on lower frequency transmission frequencies (1-3.5MHz) to allow the ultrasound beam to penetrate thinner parts of the skull.
  • pulsed Doppler technology is used to obtain the Doppler frequency shift of intracranial arterial blood flow to obtain intracranial hemodynamic parameters to reflect the functional state of cerebrovascular vessels.
  • Ultrasound applications related to imaging usually use naturally weak parts of the skull as detection windows, such as the temporal window, the eye window, and the occipital window.
  • the location of the skull acoustic window is mostly determined by the operator's subjective experience, and after the determination is completed, the ultrasound equipment is operated for ultrasound diagnosis or even stimulation. This process has high requirements for the operator and is prone to problems such as low diagnostic accuracy and low reproducibility due to inaccurate skull acoustic window positioning.
  • One of the purposes of the embodiments of the present application is to provide a transcranial ultrasound application device for solving the technical problems of high difficulty and inaccurate positioning of the skull acoustic window in the related art.
  • the present application provides a transcranial ultrasound application device, comprising:
  • the head frame body comprises a fixing assembly and an annular guide rail, wherein the fixing assembly is connected to the annular guide rail and is used to mount the annular guide rail on the user's head;
  • a first mounting assembly comprising a first mounting frame and a first loading platform, wherein the first mounting frame is slidably connected to the annular guide rail and is used to mount the first loading platform, and the first mounting frame can slide along the annular guide rail to drive the first loading platform to rotate around the circumference of the user's head;
  • the first detection component includes a depth camera and a first ultrasonic probe arranged on the first stage, wherein the depth camera is used to scan the outer contour of the user's head and determine the position of the skull acoustic window.
  • the first mounting bracket includes a first bracket and a second bracket rotatably connected, wherein the first bracket The angle between the first bracket and the second bracket is adjustable, the first bracket is connected to the annular guide rail, and the second bracket is connected to the first loading platform.
  • the second bracket is a telescopic rod with adjustable length.
  • the first ultrasonic probe is a single-element probe or a multi-element probe, and the first ultrasonic probe emits ultrasonic waves at a frequency of 0.5 MHz to 20 MHz and an intensity of 1 mW/cm2 to 3 W/cm2.
  • the first detection component further includes a pressure sensor, which is disposed on the first stage and is used to detect the contact pressure between the first ultrasonic probe and the user's head.
  • a coupling pad is disposed at the front end of the first ultrasonic probe, and the ultrasonic waves emitted by the first ultrasonic probe can penetrate the coupling pad.
  • the head frame body also includes a connecting rod, which is mounted on the annular guide rail, and both ends of the connecting rod are fixedly connected to the annular guide rail;
  • the transcranial ultrasound application device also includes a second mounting component and a second detection component, the second mounting component includes a second mounting frame and a second stage, the second mounting frame is mounted on the connecting rod and is used to mount the second stage, and the second detection component is arranged on the second stage and is used to ultrasonically stimulate the target area of the cerebral cortex on the user's head and obtain electroencephalogram signals.
  • the second mounting bracket includes a fixing seat and a third bracket, the fixing seat is arranged on the connecting rod, the third bracket is installed on the fixing seat, and the third bracket is a telescopic rod with adjustable length.
  • the second detection component includes an electrode sheet and a second ultrasonic probe.
  • the fixing assembly includes a fixing bracket, which is connected to any position of the connecting rod and is used to suspend the connecting rod and the annular guide rail.
  • the fixing assembly includes an annular headband and a plurality of support rods, wherein the plurality of support rods are arranged at intervals along the circumference of the annular headband, and one end of the support rods is connected to the annular headband, and the other end is connected to the annular guide rail.
  • the annular headband is used to be worn on the user's head and to support the annular guide rail.
  • the annular headband is an open structure and has a first end and a second end, the first end is configured with a first adjustment hole, the second end is configured with a second adjustment hole, the first adjustment hole and the second adjustment hole are arranged opposite to each other, and the first adjustment hole and the second adjustment hole are both configured with a rack structure;
  • the fixing assembly also includes an adjusting knob, which is inserted into the first adjusting hole and the second adjusting hole.
  • the adjusting knob is meshed with the rack structure, and the rotation of the adjusting knob can drive the first end and the second end to move relative to each other.
  • the inner side wall of the annular guide rail is provided with a plurality of slots, one end of the support rod is fixedly connected to the annular headband, and the other end is clamped in the slot, the number of the slots is greater than the number of the support rods, and the installation position of the support rod is adjustable.
  • the beneficial effect of the transcranial ultrasound application device includes a head frame body, a first mounting assembly and a first detection assembly, wherein the head frame body includes a fixing assembly and an annular guide rail, the first mounting assembly includes a first mounting frame and a first stage, and the detection assembly includes a depth camera and a first ultrasound probe.
  • the annular guide rail can be set on the user's head by using the fixing assembly, and the first mounting frame and the first stage are used to drive the depth camera and the first ultrasound probe to slide along the annular guide rail.
  • the depth camera and the first ultrasound probe rotate around the circumference of the user's head, which can complete the three-dimensional reconstruction of the user's head and determine the position of the skull acoustic window, and after determining the position of the skull acoustic window, the first ultrasound probe can be fixed at the position of the skull acoustic window for ultrasound diagnosis.
  • the difficulty of positioning the skull acoustic window in brain ultrasound surgery can be reduced and the positioning accuracy of the skull acoustic window can be improved.
  • FIG1 is a schematic diagram of a user's skull acoustic window
  • FIG2 is a schematic structural diagram of a transcranial ultrasound application device provided in Example 1 of the present application.
  • FIG3 is a schematic structural diagram of the transcranial ultrasound application device shown in FIG2 in another state
  • FIG4 is a schematic structural diagram of the transcranial ultrasound application device shown in FIG2 from another perspective;
  • FIG5 is a schematic diagram of the structure of another transcranial ultrasound application device provided in Example 1 of the present application.
  • FIG6 is a schematic structural diagram of another transcranial ultrasound application device provided in Example 1 of the present application.
  • FIG7 is a schematic structural diagram of a first mounting assembly in the transcranial ultrasound application device shown in FIG2 ;
  • FIG8 is a schematic structural diagram of a first carrier plate and a first detection assembly in the transcranial ultrasound application device shown in FIG2 ;
  • FIG9 is a schematic structural diagram of the first object carrier and the first detection assembly in the transcranial ultrasound application device shown in FIG2 from another perspective;
  • FIG10 is a schematic diagram of the structure of a transcranial ultrasound application device provided in Example 2 of the present application.
  • FIG11 is a schematic structural diagram of the transcranial ultrasound application device shown in FIG10 from another viewing angle
  • FIG12 is a schematic diagram of the structure of another transcranial ultrasound application device provided in Example 2 of the present application.
  • Head frame body 11. Fixing assembly; 111. Annular headband; 112. Support rod; 113. Adjustment knob; 114. Fixing bracket; 12. Annular guide rail; 13. Connecting rod;
  • First mounting assembly 21. First mounting frame; 211. First bracket; 212. Second bracket; 22. First loading device 23. Universal shaft;
  • First detection component 31. Depth camera; 32. First ultrasonic probe; 33. Pressure sensor;
  • Second mounting assembly 51. Second mounting frame; 511. Fixed seat; 512. Third bracket; 52. Second loading platform;
  • Embodiment 1 is a diagrammatic representation of Embodiment 1:
  • the present application provides a transcranial ultrasound application device, which is applied in the field of brain ultrasound and is mainly used for ultrasound diagnosis.
  • the transcranial ultrasound application device 100 includes a head frame body 1, a first mounting assembly 2 and a first detection assembly 3.
  • the head frame body 1 includes a fixing assembly 11 and an annular guide rail 12, wherein the fixing assembly 11 is connected to the annular guide rail 12 and is used to set the annular guide rail 12 on the user's head.
  • the first mounting assembly 2 includes a first mounting frame 21 and a first stage 22, wherein the first mounting frame 21 is slidably connected to the annular guide rail 12 and is used to install the first stage 22, wherein the first mounting frame 21 can slide along the annular guide rail 12 to drive the first stage 22 to rotate circumferentially around the user's head.
  • the first detection assembly 3 includes a depth camera 31 and a first ultrasound probe 32 disposed on the first stage 22, wherein the depth camera 31 is used to scan the outer contour of the user's head and determine the position of the skull acoustic window.
  • the fixing component 11 is worn on the user's head, and the annular guide rail 12 connected to the fixing component 11 can be mounted on the user's head.
  • the annular guide rail 12 may be in the shape of a circular ring, but is not limited thereto.
  • the annular guide rail 12 may also be in the shape of an elliptical ring, a square ring, or the like.
  • the inner diameter of the annular guide rail 12 is larger than the head circumference of the user, so that the annular guide rail 12 can be mounted on the user's head and maintain a distance from the user's head.
  • the first mounting frame 21 is used to mount the first loading platform 22 and the first detection assembly 3 .
  • the first mounting frame 21 can slide along the annular guide rail 12 , thereby driving the first detection assembly 3 on the first loading platform 22 to move around the user's head.
  • the depth camera 31 is used to perform a 360° scan and detection of the user's head to obtain three-dimensional information of the user's head contour and determine the position of the skull acoustic window.
  • the depth camera 31 includes a light source transmitter and a receiver, the light source transmitter is used to emit light into space, the receiver is used to receive the reflected light from the user's head and obtain image information of the user's head based on the reflected light, and the depth camera 31 can obtain the surface details of the user's head and complete the three-dimensional reconstruction of the user's head through the captured image information of the user's head, and determine the position of the skull acoustic window after the three-dimensional reconstruction is completed.
  • the skull acoustic window includes at least one of the temporal window (as shown in a in Figure 1), the eye window (as shown in b in Figure 1) and the occipital window (as shown in c in Figure 1).
  • the first ultrasonic probe 32 is used to transmit ultrasonic waves to the skull acoustic window for ultrasonic stimulation or to collect ultrasonic brain images. Specifically, the first ultrasonic probe 32 can be used to implement ultrasonic nerve regulation, two-dimensional imaging or three-dimensional imaging, etc.
  • the first ultrasonic probe 32 also has a positioning function. Specifically, the first ultrasonic probe 32 transmits ultrasonic waves toward the user's head, and by comparing the attenuation of the transmitted and received signals, it can automatically analyze and determine the position of the acoustic window. In some cases, in order to improve the accuracy of the positioning of the skull acoustic window, the depth camera 31 can be used to preliminarily determine the position of the acoustic window, and then the first ultrasonic probe 32 can be used to further locate the position of the acoustic window.
  • the solution provided in the present application includes a head frame body 1, a first mounting assembly 2 and a first detection assembly 3, wherein the head frame body 1 includes a fixing assembly 11 and an annular guide rail 12, the first mounting assembly 2 includes a first mounting frame 21 and a first stage 22, and the first detection assembly 3 includes a depth camera 31 and a first ultrasonic probe 32.
  • the annular guide rail 12 can be set on the user's head by using the fixing assembly 11, and the first mounting frame 21 and the first stage 22 can be used to drive the depth camera 31 and the first ultrasonic probe 32 to slide along the annular guide rail 12.
  • the depth camera 31 and the first ultrasonic probe 32 rotate around the circumference of the user's head, and the three-dimensional reconstruction of the user's head can be completed and the skull acoustic window position can be determined.
  • the first ultrasonic probe 32 can be fixed at the skull acoustic window position for ultrasonic diagnosis. In this way, by providing a transcranial ultrasound application device 100 with a skull acoustic window positioning function, the positioning difficulty of the skull acoustic window in brain ultrasound surgery can be reduced and the positioning accuracy of the skull acoustic window can be improved.
  • the first mounting frame 21 includes a first bracket 211 and a second bracket 212 that are rotatably connected, the angle between the first bracket 211 and the second bracket 212 is adjustable, the first bracket 211 is connected to the annular guide rail 12, and the second bracket 212 is connected to the first loading platform 22.
  • first bracket 211 and the second bracket 212 are rotatably connected via a fixed-axis rotating shaft, and the second bracket 212 can rotate relative to the first bracket 211 and drive the first loading platform 22 disposed at the end thereof to move.
  • the flexibility of the first stage 22 can be improved and its range of motion can be widened, so that the position of the first detection component 3 can be easily adjusted during use, which is beneficial to improving the detection accuracy of the first detection component 3.
  • the first mounting frame 21 only includes a first bracket 211, and the first bracket 211 is rotatably connected to the annular guide rail 12.
  • the first bracket 211 can slide circumferentially along the annular guide rail 12 and can also rotate in a vertical plane relative to the annular guide rail 12 to achieve position adjustment of the first detection component 3.
  • the specific design can be based on actual conditions and is not limited here.
  • the second bracket 212 is a telescopic rod and the length of the second bracket 212 is adjustable.
  • the activity range of the first stage 22 is further widened by improving the structure of the second bracket 212.
  • the first detection component 3 can be moved closer to or away from the user's head, thereby further improving the detection accuracy of the first detection component 3 and helping to improve the applicability of the transcranial ultrasound application device 100.
  • the telescopic structure of the second bracket 212 is not unique.
  • the second bracket 212 includes a set of upper rods and lower rods, the upper rod is rotatably connected to the first bracket 211, and the lower rod is slidably connected to the upper rod and one end is connected to the first loading platform 22; or, in some embodiments, the second bracket 212 can also be designed as a scissor-type telescopic bracket, which can be specifically designed according to actual conditions and is not limited here.
  • the first loading platform 22 is connected to the second bracket 212 via a universal shaft 23 , and the first loading platform 22 can rotate relative to the second bracket 212 .
  • the angle adjustment of the first stage 22 can be achieved, thereby facilitating the adjustment of the positional relationship between the first detection component 3 and the user's head.
  • a slider is provided on the annular guide rail 12, one end of the first bracket 211 is connected to the slider, and the other end is hinged to the second bracket 212.
  • the first bracket 211 and the slider can be fixedly connected or rotatably connected, which can be specifically designed according to actual conditions.
  • the first ultrasonic probe 32 is a single-element probe or a multi-element probe, and the frequency of the ultrasonic wave emitted by the first ultrasonic probe 32 is 0.5 MHz-20 MHz, and the intensity is 1 mW/cm2-3 W/cm2.
  • the first ultrasonic probe 32 can be a single-element probe of Olympus, model A303S-SU.
  • single-element probes can be used for ultrasonic nerve regulation (stimulation) and transcranial Doppler; multi-element probes can be used for ultrasonic brain imaging, including grayscale transcranial B-ultrasound and color ultrasound.
  • the first detection component 3 further includes a pressure sensor 33 , which is disposed on the first stage 22 and is used to detect the contact pressure between the first ultrasonic probe 32 and the user's head.
  • the pressure sensor 33 is disposed at the front end of the first ultrasonic probe 32 or between the first ultrasonic probe 32 and the first stage. 22, which can be specifically designed according to the installation method of the first ultrasonic probe 32, and is not limited here.
  • the first ultrasonic probe 32 When the first ultrasonic probe 32 is used, it needs to contact the skin of the user at the measured part, and the contact pressure between the first ultrasonic probe 32 and the user's skin can reflect the contact effect.
  • the pressure sensor 33 By arranging the pressure sensor 33 on the first stage 22, the pressure data can be obtained in real time, and the position of the first ultrasonic probe 32 can be adjusted according to the pressure data information obtained to improve the acoustic window positioning accuracy and ultrasonic diagnosis effect.
  • a coupling pad 41 is provided at the front end of the first ultrasonic probe 32 , and the ultrasonic waves emitted by the first ultrasonic probe 32 can penetrate the coupling pad 41 .
  • the coupling pad 41 has a "transition" effect. Designing the coupling pad 41 between the first ultrasonic probe 32 and the user's skin is beneficial to reducing the acoustic impedance difference between the first ultrasonic probe 32 and the user's skin, making the ultrasonic incident path and reflection path smoother, thereby obtaining clearer ultrasonic images and improving the acoustic window positioning accuracy and ultrasonic diagnostic effect.
  • the depth camera 31 and the first ultrasonic probe 32 are both disposed on the first stage 22 , and the coupling pad 41 covers the front end of the first ultrasonic probe 32 without blocking the depth camera 31 .
  • the first ultrasonic probe 32 is rotatably disposed on the first stage 22 through a rotating shaft.
  • a motor 42 is also provided on the first stage 22. The motor 42 is connected to the first ultrasonic probe 32 and is used to drive the first ultrasonic probe 32 to rotate.
  • the motor 42 can rotate clockwise or counterclockwise and drive the first ultrasonic probe 32 to rotate in different directions in a plane parallel to the first stage 22 to adjust the first ultrasonic probe 32 to an optimal incident angle or scanning plane to achieve high-precision three-dimensional ultrasonic imaging.
  • the above design can improve the flexibility of the first ultrasonic probe 32, thereby facilitating further improving the acoustic window positioning accuracy and ultrasonic diagnostic effect.
  • an infrared imaging sensor may also be provided at the front end of the first ultrasonic probe 32.
  • the infrared imaging sensor can be used to detect the user's brain activity and to determine whether the coupling pad 41 or the coupling agent meets the requirements.
  • At least one of an accelerometer, a gyroscope, and a magnetic sensor may be further disposed on the first stage 22 , and the specific design may be based on the use requirements of the transcranial ultrasound application device 100 .
  • one or more groups of first mounting components 2 and first detection components 3 may be provided.
  • two groups of first mounting components 2 and two groups of first detection components 3 are provided on the head frame body 1, and the two groups of first detection components 3 are used in coordination to jointly locate the skull acoustic window.
  • the transcranial ultrasound application device 100 provided in the present application is also equipped with a control module, which can be used to control the position and movement of the first mounting frame 21 and the first stage 22, and control the operation of the first detection component 3, but is not limited thereto.
  • angle and length adjustment of the first mounting bracket 21 can be automatically adjusted by the control module, or can also be manually adjusted.
  • the control module can be arranged on the annular guide rail 12 .
  • the specific arrangement method and position can be designed according to actual conditions and are not limited here.
  • the head frame body 1 also includes a connecting rod 13, the connecting rod 13 is mounted on the annular guide rail 12, and both ends of the connecting rod 13 are fixedly connected to the annular guide rail 12.
  • the transcranial ultrasound application device 100 also includes a second mounting assembly 5 and a second detection assembly 6, the second mounting assembly 5 includes a second mounting frame 51 and a second stage 52, the second mounting frame 51 is arranged on the connecting rod 13 and is used to install the second stage 52, and the second detection assembly 6 is arranged on the second stage 52 and is used to ultrasonically stimulate the target area of the cerebral cortex on the user's head and obtain electroencephalographic signals.
  • the connecting rod 13 is an arc-shaped rod.
  • the connecting rod 13 and the second detection component 6 are installed on the top of the user's head, and the second detection component 6 faces the user's head.
  • the second installation assembly 5 and the second detection assembly 6 can be installed above or below the connecting rod 13, which is not limited here.
  • ultrasound neuromodulation has been proven to have significant therapeutic effects on diseases such as epilepsy, depression, Parkinson's disease, drug addiction, and sleep dysfunction.
  • accurate positioning of the stimulation area has become a problem.
  • the target stimulation area of the cerebral cortex on the user's head can be positioned, and EEG signals can be obtained and ultrasound diagnosis can be performed, which improves the practicality of the transcranial ultrasound application device 100 and solves the problems of inaccurate positioning of the target stimulation area of the cerebral cortex and difficulty in ultrasound diagnosis in related products.
  • connecting rod 13 is also used to improve the strength of the head frame body 1 to further reduce the deformation risk of the annular guide rail 12.
  • first detection component 3 and the second detection component 6 are independent of each other and can be used simultaneously or individually.
  • the second mounting frame 51 includes a fixing seat 511 and a third bracket 512.
  • the fixing seat 511 is arranged on the connecting rod 13, and the third bracket 512 is installed on the fixing seat 511.
  • the third bracket 512 is a telescopic rod with adjustable length.
  • the fixing seat 511 can be clamped on the connecting rod 13, or can be installed on the connecting rod 13 by fasteners such as bolts, or can be clamped on the connecting rod 13 by a clamping structure such as a snap.
  • the specific design can be based on actual conditions and is not limited here.
  • the third bracket 512 is rotatably mounted on the fixing seat 511 via a rotating shaft or other structures. During use, the positional relationship between the second detection component 6 and the user's head can be adjusted by adjusting the angle and length of the third bracket 512.
  • the second installation assembly 5 has a reasonable structure and high flexibility.
  • angle and length adjustment of the second mounting bracket 51 can be automatically adjusted by the control module, or can also be manually adjusted.
  • the second mounting frame 51 may further include a plurality of hingedly connected third brackets 512 , and the specific structure of the second mounting frame 51 may be adjusted according to actual needs.
  • the second detection component 6 includes an electrode sheet and a second ultrasonic probe.
  • the electrode sheet is attached to the user's head to obtain the EEG signal from the user's head.
  • the second ultrasonic probe is used to transmit ultrasonic waves to the user's head for ultrasonic stimulation or to collect ultrasonic brain images.
  • the second ultrasonic probe is a single-element probe or a multi-element probe.
  • the frequency of the ultrasonic waves emitted by the second ultrasonic probe is 0.5MHz-20MHz, and the intensity is 1mW/cm2-3W/cm2.
  • the second ultrasonic probe can be a single-element probe of Olympus, model A303S-SU.
  • the number and shape of the connecting rods 13, as well as the number and setting positions of the second detection components 6 can be designed according to actual conditions and are not limited here.
  • At least one of a pressure sensor, a coupling pad, an accelerometer, a gyroscope, a magnetic sensor, and an infrared sensor is also disposed on the second stage 52 .
  • the fixing assembly 11 includes an annular headband 111 and a plurality of support rods 112.
  • the plurality of support rods 112 are arranged at intervals along the circumference of the annular headband 111, and one end of the support rod 112 is connected to the annular headband 111, and the other end is connected to the annular guide rail 12.
  • the annular headband 111 is used to be worn on the user's head and to support the annular guide rail 12.
  • the annular headband 111 is clamped on the forehead of the user, and the annular guide rail 12 is set at a position at a certain distance from the user's head through the support rod 112.
  • the fixing component 11 has a reasonable structure, good fixing and supporting effects, and is easy to wear.
  • the annular headband 111 and the support rod 112 need to be made of a non-deformable rigid material.
  • the annular headband 111 and the support rod 112 are both made of plastic material, and the annular headband 111 and the support rod 112 are integrally injection molded by an injection molding process.
  • the annular headband 111 is an open structure and has a first end and a second end.
  • the first end is provided with a first adjustment hole
  • the second end is provided with a second adjustment hole.
  • the first adjustment hole and the second adjustment hole are arranged opposite to each other, and the first adjustment hole and the second adjustment hole are both provided with a rack structure.
  • the fixing assembly 11 also includes an adjustment knob 113, which is inserted into the first adjustment hole and the second adjustment hole, and the adjustment knob 113 is meshed with the rack structure. The rotation of the adjustment knob 113 can drive the first end and the second end to move relative to each other.
  • the upper wall of the first adjustment hole has a rack structure
  • the lower wall of the second adjustment hole has a rack structure.
  • the adjustment knob 113 includes a connecting portion and a rotating portion connected to each other, and the connecting portion also has a rack structure.
  • the connecting portion extends into the first adjustment hole. and the second adjustment hole, and the rack structure on the connecting part is engaged with the rack structure in the first adjustment hole and the second adjustment hole.
  • the rotating part is arranged outside the first adjustment hole and the second adjustment hole. Twisting the rotating part can drive the first end and the second end to move in different directions, thereby realizing the tightness adjustment of the annular headband 111.
  • the annular headband 111 By adopting the above design, by designing the annular headband 111 as a structure with adjustable tightness, the applicability of the annular headband 111 can be improved, and its fixing effect can be improved; and the above tightness adjustment structure is simple and easy to adjust, and it is also beneficial to reduce the difficulty of wearing a fixed head frame.
  • annular headband 111 is not unique.
  • a resisting tension adjustment structure can be provided on the annular headband 111, or a plurality of adjustable buckle structures can be provided on the annular headband 111.
  • the specific design can be made according to the actual situation and is not limited here.
  • the first mounting bracket 21 is connected to the outer wall of the annular guide rail 12
  • the support rod 112 is connected to the inner wall of the annular guide rail 12 .
  • the inner wall of the annular guide rail 12 is provided with multiple slots, one end of the support rod 112 is fixedly connected to the annular head hoop 111, and the other end is clamped in the slot.
  • the number of slots is greater than the number of support rods 112, and the installation position of the support rod 112 is adjustable.
  • the tightness of the annular headband 111 is adjustable, and the alignment relationship between the support rod 112 and the annular guide rail 12 changes under different tightness, that is, under different sizes.
  • the support rod 112 has multiple installation positions on the annular guide rail 12, which is conducive to improving the alignment and connection effect between the support rod 112 and the annular guide rail 12, and can reduce the risk of deformation of the annular guide rail 12.
  • one end of the support rod 112 connected to the annular guide rail 12 can be designed as a snap-fit structure that cooperates with the slot, or an interference fit structure.
  • the specific design can be based on actual conditions and is not limited here.
  • the support rod 112 can also be connected to the bottom wall of the annular guide rail 12; and the support frame can also be designed as a telescopic rod structure, which can be specifically designed according to actual conditions and is not limited here.
  • the cross-sectional shape of the annular guide rail 12 can be T-shaped or L-shaped, but is not limited thereto.
  • the annular guide rail 12 can be made of aluminum alloy, stainless steel or titanium alloy, but is not limited thereto.
  • the transcranial ultrasound application device 100 can reduce the difficulty of positioning the skull acoustic window in brain ultrasound surgery and improve the positioning accuracy of the skull acoustic window by providing an annular guide rail 12 that can be erected on the user's head and arranging a first detection component 3 on the annular guide rail 12; and, by arranging a connecting rod 13 on the annular guide rail 12 and arranging a second detection component 6 on the connecting rod 13, it can reduce the difficulty of positioning the target stimulation area in ultrasonic nerve regulation and improve the positioning accuracy of the target stimulation area, thereby effectively improving the ease of use of the transcranial ultrasound application device 100 and the ultrasonic diagnostic results. The accuracy of the results.
  • Embodiment 2 is a diagrammatic representation of Embodiment 1:
  • the transcranial ultrasound application device 100 includes a head frame body 1, a first mounting assembly 2 and a first detection assembly 3.
  • the head frame body 1 includes a fixing assembly 11 and an annular guide rail 12, and the fixing assembly 11 is connected to the annular guide rail 12 and is used to set the annular guide rail 12 on the user's head.
  • the first mounting assembly 2 includes a first mounting frame 21 and a first stage 22, and the first mounting frame 21 is slidably connected to the annular guide rail 12 and is used to install the first stage 22, and the first mounting frame 21 can slide along the annular guide rail 12 to drive the first stage 22 to rotate circumferentially around the user's head.
  • the first detection assembly 3 includes a depth camera 31 and a first ultrasound probe 32 arranged on the first stage 22, and the depth camera 31 is used to scan the outer contour of the user's head and determine the position of the skull acoustic window.
  • the head frame body 1 also includes a connecting rod 13, the connecting rod 13 is mounted on the annular guide rail 12, and both ends of the connecting rod 13 are fixedly connected to the annular guide rail 12.
  • the transcranial ultrasound application device 100 also includes a second mounting assembly 5 and a second detection assembly 6, the second mounting assembly 5 includes a second mounting frame 51 and a second stage 52, the second mounting frame 51 is arranged on the connecting rod 13 and is used to install the second stage 52, and the second detection assembly 6 is arranged on the second stage 52 and is used to obtain EEG signals and perform ultrasonic stimulation on the target area of the cerebral cortex on the user's head.
  • the fixing assembly 11 includes a fixing bracket 114 , which is connected to any position of the connecting rod 13 and is used to suspend the connecting rod 13 and the annular guide rail 12 .
  • the fixing bracket 114 includes a fixing structure, and can be fixedly arranged on a bed frame, a table, a chair, a wall, etc., so as to fix the position of the transcranial ultrasound application device 100 .
  • the solution provided in this embodiment improves the structure of the fixing component 11 so that the fixing head frame can be fixed in external facilities, and can also effectively improve the convenience of using the fixing head frame.
  • the present application provides a method for using a transcranial ultrasound application device.
  • Example 1 The specific structure of the transcranial ultrasound application device 100 is shown in Example 1 and Example 2, which will not be described in detail here.
  • the method of use includes:
  • the annular guide rail 12 of the head frame body 1 should be placed on the user's head.
  • the first detection component 3 should be aligned with the user's head to ensure the positioning accuracy of the skull acoustic window.
  • the first ultrasonic probe 32 When adjusting the first mounting bracket 21, the first ultrasonic probe 32 should be closely attached to the user's skin, and the contact pressure should not be too great. It can be too high to ensure that ultrasound diagnosis can be performed normally.
  • the first ultrasonic probe 32 can transmit ultrasonic waves to the skull acoustic window for ultrasonic stimulation or acquisition of ultrasonic brain images. By improving the emission intensity of the first ultrasonic probe 32, different ultrasonic stimulation or ultrasonic imaging requirements can be met.
  • a pressure sensor 33 and a motor 42 are provided on the transcranial ultrasound application device 100.
  • the position of the first ultrasound probe 32 can also be adjusted according to the real-time monitoring results of structures such as the pressure sensor 33, so that the first ultrasound probe 32 is configured to the optimal incident angle or scanning plane, thereby achieving high-precision three-dimensional ultrasound imaging.

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Abstract

一种经颅超声应用装置(100)，包括环形导轨(12)、第一安装架(21)、第一载物台(22)和第一检测组件(3)。环形导轨(12)架设于用户头部，第一安装架(21)滑动连接于环形导轨(12)并用于带动第一载物台(22)绕用户头部的周向转动，第一检测组件(3)设于第一载物台(22)上且用于扫描用户头部的外轮廓并确定颅骨声窗位置。该经颅超声应用装置(100)，能够解决相关技术中颅骨声窗定位难度高及定位不准的技术问题。

Description

经颅超声应用装置 技术领域
本申请涉及医疗器械技术领域，具体涉及一种经颅超声应用装置。
背景技术
随着超声技术的发展，经颅的超声应用成为临床诊断和治疗中不可或缺的一部分。经颅超声(Transcranial sonography，TCS)，使用超声灰阶图像显示脑部内部结构；经颅多普勒(Transcranial Doppler，TCD)和经颅彩色多普勒(Transcranial color Doppler，TCCD)是用超声多普勒效应来检测颅内主要动脉的血流动力学及血流生理参数的一项无创性的脑血管疾病检测方法。这些技术都借助较低频段的发射频率(1-3.5MHz)，使超声声束得以穿透颅骨较薄的部位。不同的是，脉冲多普勒技术是用来获取颅内动脉血流多普勒频移，以获取颅内的血流动力学参数，来反应脑血管功能状态。
成像相关的超声应用通常利用颅骨自然薄弱的部位作为检测声窗，例如颞窗、眼窗和枕窗等。现有技术中，颅骨声窗位置多以操作者的主观经验进行判断，并在判断完成后操作超声设备进行超声诊断甚至刺激，此过程对操作者要求较高，容易出现颅骨声窗定位不准所导致的诊断准确度低和复现率低的问题。
技术问题
本申请实施例的目的之一在于：提供一种经颅超声应用装置，用于解决相关技术中颅骨声窗定位难度高及定位不准的技术问题。
技术解决方案
为解决上述技术问题，本申请实施例采用的技术方案是：
本申请提供了一种经颅超声应用装置，包括：
头架本体，包括固定组件和环形导轨，所述固定组件连接于所述环形导轨且用于将所述环形导轨架设于用户头部；
第一安装组件，包括第一安装架和第一载物台，所述第一安装架滑动连接于所述环形导轨且用于安装所述第一载物台，所述第一安装架能够沿所述环形导轨滑动，以带动所述第一载物台绕用户头部的周向转动；
第一检测组件，包括设于所述第一载物台上的深度向相机和第一超声探头，所述深度相机用于扫描用户头部的外轮廓并确定颅骨声窗位置。
在一个实施例中，所述第一安装架包括转动连接的第一支架和第二支架，所述第一支 架与所述第二支架间的夹角可调，所述第一支架连接于所述环形导轨，所述第二支架连接于所述第一载物台。
在一个实施例中，所述第二支架为伸缩杆且长度可调。
在一个实施例中，所述第一超声探头为单振元探头或多振元探头，所述第一超声探头发射超声波的频率为0.5MHz-20MHz，强度为1mW/cm2-3W/cm2。
在一个实施例中，所述第一检测组件还包括压力传感器，所述压力传感器设于所述第一载物台上且用于检测所述第一超声探头与用户头部间的接触压力。
在一个实施例中，所述第一超声探头的前端设有耦合垫，所述第一超声探头发射的超声波可穿透所述耦合垫。
在一个实施例中，所述头架本体还包括连接杆，所述连接杆架设于所述环形导轨上，并且所述连接杆的两端均固定连接于所述环形导轨；所述经颅超声应用装置还包括第二安装组件和第二检测组件，所述第二安装组件包括第二安装架和第二载物台，所述第二安装架设于所述连接杆上且用于安装所述第二载物台，所述第二检测组件设于所述第二载物台上且用于对用户头部上大脑皮层的目标区域进行超声刺激并获取脑电信号。
在一个实施例中，所述第二安装架包括固定座和第三支架，所述固定座设于所述连接杆上，所述第三支架安装于所述固定座上，所述第三支架为伸缩杆且长度可调。
在一个实施例中，所述第二检测组件包括电极片和第二超声探头。
在一个实施例中，所述固定组件包括固定支架，所述固定支架连接于所述连接杆的任意位置且用于悬挂所述连接杆和所述环形导轨。
在一个实施例中，所述固定组件包括环形头箍和多个支撑杆，多个所述支撑杆沿所述环形头箍的周向间隔设置，并且所述支撑杆的一端连接于所述环形头箍，另一端连接于所述环形导轨，所述环形头箍用于佩戴于用户头部并用于支撑所述环形导轨。
在一个实施例中，所述环形头箍为开口式结构并且具有第一端和第二端，所述第一端上配置有第一调节孔，所述第二端上配置有第二调节孔，所述第一调节孔和所述第二调节孔相对设置，并且所述第一调节孔和所述第二调节孔均配置有齿条结构；
所述固定组件还包括调节旋钮，所述调节旋钮插入至所述第一调节孔和所述第二调节孔内，所述调节旋钮与所述齿条结构啮合，所述调节旋钮转动可带动所述第一端和所述第二端相对移动。
在一个实施例中，所述环形导轨的内侧壁设有多个卡槽，所述支撑杆的一端与所述环形头箍固定连接，另一端卡持于所述卡槽内，所述卡槽的数量大于所述支撑杆的数量，所述支撑杆的安装位置可调。
有益效果
本申请实施例提供的经颅超声应用装置的有益效果在于：本申请提供的方案中，包括头架本体、第一安装组件和第一检测组件，其中，头架本体包括固定组件和环形导轨，第一安装组件包括第一安装架和第一载物台，检测组件包括深度相机和第一超声探头，在使用时，可利用固定组件将环形导轨架设于用户头部，并利用第一安装架和第一载物台带动深度相机和第一超声探头沿环形导轨滑动，在此过程中，深度相机和第一超声探头绕用户头部的周向转动，能够完成用户头部的三维重建并确定颅骨声窗位置，以及在确定颅骨声窗位置后可将第一超声探头固定于颅骨声窗位置处以进行超声诊断。如此，通过提供一种具有颅骨声窗定位功能的经颅超声应用装置，能够降低脑部超声手术中颅骨声窗的定位难度并提高颅骨声窗的定位精度。
附图说明
为了更清楚地说明本申请实施例中的技术方案，下面将对实施例或示范性技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本申请的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其它的附图。
图1为用户头部颅骨声窗的示意图；
图2为本申请实施例一提供的一种经颅超声应用装置的结构示意图；
图3为图2所示经颅超声应用装置在另一状态的结构示意图；
图4为图2所示经颅超声应用装置在另一视角的结构示意图；
图5为本申请实施例一提供的另一种经颅超声应用装置的结构示意图；
图6为本申请实施例一提供的又一种经颅超声应用装置的结构示意图；
图7为图2所示经颅超声应用装置中第一安装组件的结构示意图；
图8为图2所示经颅超声应用装置中第一载物板及第一检测组件的结构示意图；
图9为图2所示经颅超声应用装置中第一载物板及第一检测组件在另一视角的结构示意图；
图10为本申请实施例二提供的一种经颅超声应用装置的结构示意图；
图11为图10所示经颅超声应用装置在另一视角的结构示意图；
图12为本申请实施例二提供的另一种经颅超声应用装置的结构示意图。
100、经颅超声应用装置；
1、头架本体；11、固定组件；111、环形头箍；112、支撑杆；113、调节旋钮；114、固定支架；12、环形导轨；13、连接杆；
2、第一安装组件；21、第一安装架；211、第一支架；212、第二支架；22、第一载物 台；23、万向轴；
3、第一检测组件；31、深度相机；32、第一超声探头；33、压力传感器；
41、耦合垫；42、马达；
5、第二安装组件；51、第二安装架；511、固定座；512、第三支架；52、第二载物台；
6、第二检测组件。
本发明的实施方式
为了使本申请的目的、技术方案及优点更加清楚明白，以下结合附图及实施例，对本申请进行进一步详细说明。应当理解，此处所描述的具体实施例仅用以解释本发明，并不用于限定本申请。
需说明的是，当部件被称为“固定于”或“设置于”另一个部件，它可以直接在另一个部件上或者间接设置在该另一个部件上。当一个部件被称为是“连接于”另一个部件，它可以是直接或者间接连接至该另一个部件上。术语“上”、“下”、“左”、“右”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本申请的限制，对于本领域的普通技术人员而言，可以根据具体情况理解上述术语的具体含义。术语“第一”、“第二”仅用于便于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明技术特征的数量。“多个”的含义是两个或两个以上，除非另有明确具体的限定。
为了说明本申请所提供的技术方案，以下结合具体附图及实施例进行详细说明。
实施例一：
本申请提供了一种经颅超声应用装置，应用于脑部超声领域，主要用于进行超声诊断。
参照图2、图3和图4，经颅超声应用装置100包括头架本体1、第一安装组件2和第一检测组件3。头架本体1包括固定组件11和环形导轨12，固定组件11连接于环形导轨12且用于将环形导轨12架设于用户头部。第一安装组件2包括第一安装架21和第一载物台22，第一安装架21滑动连接于环形导轨12且用于安装第一载物台22，第一安装架21能够沿环形导轨12滑动以带动第一载物台22环绕用户头部的周向转动。如图2、图8和图9所示，第一检测组件3包括设于第一载物台22上的深度相机31和第一超声探头32，深度相机31用于扫描用户头部的外轮廓并确定颅骨声窗位置。
固定组件11佩戴于用户头部，连接于固定组件11的环形导轨12可架设于用户头部。
环形导轨12可为圆环形，但不限于此，例如，环形导轨12也可呈椭圆形环、方环等。 环形导轨12的内径大于用户的头围，使得环形导轨12能够架设于用户头部，并且与用户头部间保持间隔。
第一安装架21用于安装第一载物台22和第一检测组件3，第一安装架21能够沿环形导轨12滑动，进而能够带动第一载物台22上的第一检测组件3绕用户头部移动。
深度相机31用于对用户头部进行360°的扫描检测，以获取用户头部轮廓的三维信息，并确定颅骨声窗位置。具体地，深度相机31包括光源发射件和接收件，光源发射件用于向空间中发射光线，接收件用于接收用户头部的反射光线并根据反射光线获取用户头部的图像信息，深度相机31通过捕捉到的用户头部的图像信息，能够获取用户头部的表面细节并完成用户头部的三维重建，并且在三维重建完成后确定颅骨声窗的位置。其中，颅骨声窗包括颞窗(如图1中a所示)、眼窗(如图1中b所示)和枕窗(如图1中c所示)中的至少一种。
第一超声探头32用于向颅骨声窗处发射超声波以进行超声刺激或采集超声脑部图像。具体地，第一超声探头32能够用于实现超声神经调控、二维成像或三维成像等。
第一超声探头32还具有定位作用。具体地，第一超声探头32朝向用户头部发射超声波，通过对比发射和接收额度信号衰减，能够自动分析并判断声窗位置。在一些情形中，为提高颅骨声窗定位精度，可以利用深度相机31初步确定声窗位置，而后利用第一超声探头32进一步定位声窗位置。
本申请提供的方案中，包括头架本体1、第一安装组件2和第一检测组件3，其中，头架本体1包括固定组件11和环形导轨12，第一安装组件2包括第一安装架21和第一载物台22，第一检测组件3包括深度相机31和第一超声探头32，在使用时，可利用固定组件11将环形导轨12架设于用户头部，并利用第一安装架21和第一载物台22带动深度相机31和第一超声探头32沿环形导轨12滑动，在此过程中，深度相机31和第一超声探头32绕用户头部的周向转动，能够完成用户头部的三维重建并确定颅骨声窗位置，以及在确定颅骨声窗位置后可将第一超声探头32固定于颅骨声窗位置处以进行超声诊断。如此，通过提供一种具有颅骨声窗定位功能的经颅超声应用装置100，能够降低脑部超声手术中颅骨声窗的定位难度并提高颅骨声窗的定位精度。
本实施例所提供的方案中，如图2、图3和图7所示，第一安装架21包括转动连接的第一支架211和第二支架212，第一支架211与第二支架212间的夹角可调，第一支架211连接于环形导轨12，第二支架212连接于第一载物台22。
例如，第一支架211与第二支架212通过定轴转轴转动连接，第二支架212可相对第一支架211转动，并带动设置于其端部的第一载物台22移动。
采用上述设计，通过改进第一安装架21的结构，能够提高第一载物台22的灵活性并拓宽其活动范围，从而使用过程中方便调整第一检测组件3的位置，有利于提高第一检测组件3的检测精度。
可以理解，在一些实施例中，第一安装架21仅包括第一支架211，第一支架211转动连接于环形导轨12，第一支架211既可沿环形导轨12周向滑动，还可相对环形导轨12在竖直面内转动，以实现第一检测组件3的位置调节，具体可根据实际情况进行设计，在此不作限定。
本实施例所提供的方案中，第二支架212为伸缩杆且长度可调。
采用上述设计，通过改进第二支架212的结构，进一步拓宽了第一载物台22的活动范围，使用过程中通过调整第二支架212的伸缩长度，能够使第一检测组件3靠近或远离用户头部，从而能够进一步提高第一检测组件3的检测精度，以及有利于提高经颅超声应用装置100的适用性。
进一步地，第二支架212的伸缩结构不唯一。可选的，在一些实施例中，第二支架212包括套装的上杆和下杆，上杆与第一支架211转动连接，下杆与上杆滑动连接并且一端连接第一载物台22；或者，在一些实施例中，第二支架212还可设计为剪叉式伸缩架，具体可根据实际情况进行设计，在此不作唯一限定。
本实施例所提供的方案中，如图7所示，第一载物台22通过万向轴23连接于第二支架212，第一载物台22可相对于第二支架212转动。
通过改进第一载物台22与第二支架212的连接结构，能够实现第一载物台22的角度调节，进而方便调整第一检测组件3与用户头部的位置关系。
本申请提供的实施例中，环形导轨12上设有滑块，第一支架211的一端连接于滑块，另一端与第二支架212铰接。其中，第一支架211与滑块可固定连接或转动连接，具体可根据实际情况进行设计。
本实施例所提供的方案中，第一超声探头32为单振元探头或多振元探头，第一超声探头32发射的超声波的频率为0.5MHz-20MHz，强度为1mW/cm2-3W/cm2。例如，第一超声探头32可选用奥林巴斯，型号为A303S-SU的单振元探头。
其中，单振元探头可以应用于超声神经调控(刺激)和经颅多普勒；多振元探头可以应用于超声脑部成像，包括灰阶图的经颅B超和彩超。
本实施例所提供的方案中，如图7所示，第一检测组件3还包括压力传感器33，压力传感器33设于第一载物台22上且用于检测第一超声探头32与用户头部间的接触压力。
压力传感器33设置于第一超声探头32的前端或设置于第一超声探头32与第一载物台 22之间，具体可根据第一超声探头32的安装方式进行设计，在此不作唯一限定。
第一超声探头32使用时，需要与用户被测部位处的皮肤接触，并且第一超声探头32与用户皮肤间接触压力能够反应接触效果。通过在第一载物台22上设置压力传感器33，能够实时获取压力数据，根据所获取的压力数据信息可以调节第一超声探头32的位置，以提高声窗定位精度和超声诊断效果。
本实施例所提供的方案中，如图8所示，第一超声探头32的前端设有耦合垫41，第一超声探头32发射的超声波可穿透耦合垫41。
耦合垫41具有“过渡”作用，在第一超声探头32与用户皮肤之间设计耦合垫41，有利于减小第一超声探头32与用户皮肤之间的声阻抗差，使得超声波入射途径和反射途径更加通畅，从而能够获取更加清晰的超声图形，提高声窗定位精度和超声诊断效果。
需要说明的是，深度相机31与第一超声探头32均设置于第一载物台22上，耦合垫41覆盖于第一超声探头32的前端且不遮挡深度相机31。
本实施例所提供的方案中，如图7和图8所示，第一超声探头32通过转轴转动设置于第一载物台22上，第一载物台22上还设有马达42，马达42连接于第一超声探头32且用于驱动第一超声探头32转动。
马达42可以顺时针或逆时针转动，并驱动第一超声探头32在平行于第一载物台22的平面内朝向不同方向转动，以将第一超声探头32调整至最佳的入射角度或扫描平面，实现高精度的三维超声成像。
采用上述设计，能够提高第一超声探头32的灵活性，从而有利于进一步提高声窗定位精度和超声诊断效果。
本实施例所提供的方案中，第一超声探头32的前端还可设置红外成像传感器。红外成像传感器能够用于检测用户的大脑活动情况，以及用于判断耦合垫41或耦合剂是否符合要求。
此外，第一载物台22上还可上还设置加速度计、陀螺计、磁传感器中的至少一种，具体可根据经颅超声应用装置100的使用需求进行设计。
本实施例所提供的方案中，可以设置一组或多组第一安装组件2和第一检测组件3。可选的，在一实施例中，如图2所示，为提升经颅超声应用装置100的使用便捷性及可靠性，头架本体1上设置两组第一安装组件2及两组第一检测组件3，两组第一检测组件3协同使用，共同定位颅骨声窗位置。
本申请提供的经颅超声应用装置100还搭载控制模块，控制模块能够用于控制第一安装架21和第一载物台22的位置及移动，以及控制第一检测组件3的运行，但不限于此。
可以理解，第一安装架21的角度及长度调节可以依靠控制模块自动调节，或者还可手动调节。
控制模块可以设置于环形导轨12上，具体设置方式及位置可根据实际情况进行设计，在此不作限定。
本实施例所提供的方案中，如图5所示，头架本体1还包括连接杆13，连接杆13架设于环形导轨12上，并且连接杆13的两端均固定连接于环形导轨12。经颅超声应用装置100还包括第二安装组件5和第二检测组件6，第二安装组件5包括第二安装架51和第二载物台52，第二安装架51设于连接杆13上且用于安装第二载物台52，第二检测组件6设于第二载物台52上且用于对用户头部上大脑皮层的目标区域进行超声刺激并获取脑电信号。
具体地，连接杆13为弧形杆，经颅超声应用装置100使用时，连接杆13及第二检测组件6被架设于用户头顶区域，第二检测组件6朝向用户头部。
第二安装组件5和第二检测组件6可以安装于连接杆13的上方或下方，在此不作唯一限定。
在超声应用方面，超声神经调控(Ultrasound Neuromodulation)已经被证实在癫痫、抑郁症、帕金森病、药物成瘾以及睡眠功能障碍等疾病有着显著治疗效果，然而也是由于颅骨的影响，刺激区域的精准定位成了难题。本方案中，通过在环形导轨12上架设连接杆13结构，并在连接杆13上设置第二检测组件6，能够对用户头部上大脑皮层的目标刺激区域进行定位，以及获取脑电信号、进行超声诊断等，提升了经颅超声应用装置100的实用性，还解决了相关产品中大脑皮层目标刺激区域定位不准、超声诊断困难的问题。
此外，连接杆13还用于提升头架本体1的强度，以进一步降低环形导轨12的变形风险。
需要说明的是，第一检测组件3和第二检测组件6相互独立，能够同时使用或单独使用。
本实施例所提供的方案中，第二安装架51包括固定座511和第三支架512，固定座511设于连接杆13上，第三支架512安装于固定座511上，第三支架512为伸缩杆且长度可调。
根据固定座511的结构不同，固定座511可以夹设于连接杆13上，或者可通过螺栓等紧固件安装于连接杆13上，或者可通过卡扣等卡接结构卡持于连接杆13上，具体可根据实际情况进行设计，在此不作唯一限定。
第三支架512通过转轴等结构转动设于固定座511上。使用过程中，通过调整第三支架512的角度和长度，可以调节第二检测组件6与用户头部的位置关系。
采用上述设计，第二安装组件5结构合理，灵活性高。
可以理解，第二安装架51的角度及长度调节可以依靠控制模块自动调节，或者还可手动调节。
在其他实施例中，如图6所示，第二安装架51还可包括多个铰接连接的第三支架512，第二安装架51的具体结构可根据实际需求进行调整。
本实施例所提供的方案中，第二检测组件6包括电极片和第二超声探头。
电极片贴合于用户头部，用于获取用户头部的脑电信号。
第二超声探头用于向用户头部发射超声波以进行超声刺激或采集超声脑部图像。第二超声探头为单振元探头或多振元探头，第二超声探头发射的超声波的频率为0.5MHz-20MHz，强度为1mW/cm2-3W/cm2。例如，第二超声探头可选用奥林巴斯，型号为A303S-SU的单振元探头。
需要说明的是，连接杆13的数量及形状，以及第二检测组件6的数量及设置位置可根据实际情况进行设计，在此不作唯一限定。
此外，在一些实施例中，第二载物台52上还设置压力传感器、耦合垫、加速度计、陀螺计、磁传感器、红外传感器中的至少一种。
本实施例所提供的方案中，如图2和图3所示，固定组件11包括环形头箍111和多个支撑杆112，多个支撑杆112沿环形头箍111的周向间隔设置，并且支撑杆112的一端连接于环形头箍111，另一端连接于环形导轨12，环形头箍111用于佩戴于用户头部并用于支撑环形导轨12。
具体地，环形头箍111卡紧于用户的额头，并且通过支撑杆112将环形导轨12架设于距用户头部一定间隔的位置处。
采用上述设计，固定组件11结构合理，固定及支撑效果好，并且易于佩戴。
本实施例所提供的方案中，为确保支撑效果，环形头箍111和支撑杆112需要采用不可变形的刚性材质制成。可选的，在一实施例中，环形头箍111和支撑杆112均为塑胶材质，并且环形头箍111与支撑杆112通过注塑工艺一体注塑成型。
本实施例所提供的方案中，环形头箍111为开口式结构并且具有第一端和第二端，第一端上配置有第一调节孔，第二端上配置有第二调节孔，第一调节孔和第二调节孔相对设置，并且第一调节孔和第二调节孔均配置有齿条结构。固定组件11还包括调节旋钮113，调节旋钮113插入至第一调节孔和第二调节孔内，调节旋钮113与齿条结构啮合，调节旋钮113转动可带动第一端和第二端相对移动。
具体地，第一调节孔的上壁具有齿条结构，第二调节孔的下壁具有齿条结构。调节旋钮113包括相连接的连接部和转动部，连接部也具有齿条结构，连接部伸入至第一调节孔 和第二调节孔内，并且连接部上的齿条结构与第一调节孔和第二调节孔内的齿条结构啮合，转动部设置于第一调节孔和第二调节孔外，扭动转动部，可带动第一端和第二端朝向不同的方向移动，进而实现环形头箍111的松紧度调节。
采用上述设计，通过将环形头箍111设计为松紧度可调结构，能够提高环形头箍111的适用性，并且能够提高其固定效果；以及，上述松紧调节结构简单，调节方便，还有利于降低固定头架佩戴难度。
可以理解，环形头箍111的结构不唯一，在一些实施例中，还可在环形头箍111上设置抵持式的松紧调节结构，或是在环形头箍111上设置多个可调式卡扣结构，具体可根据实际情况进行设计，在此不作限定。
本实施例所提供的方案中，为避免第一安装架21与固定组件11发生干涉，第一安装架21连接于环形导轨12的外侧壁，支撑杆112连接于环形导轨12的内侧壁。
本实施例所提供的方案中，环形导轨12的内侧壁设有多个卡槽，支撑杆112的一端与环形头箍111固定连接，另一端卡持于卡槽内，卡槽的数量大于支撑杆112的数量，支撑杆112的安装位置可调。
环形头箍111松紧度可调，并且在不同松紧度下，也就是不同尺寸下，支撑杆112与环形导轨12的对位关系发生改变。通过在环形导轨12上设置多个卡槽，使得支撑杆112在环形导轨12上具有多个安装位，有利于提高支撑杆112与环形导轨12的对位及连接效果，以及能够降低环形导轨12变形风险。
进一步地，支撑杆112连接于环形导轨12的一端可设计为与卡槽配合的卡扣结构，或者过盈插接结构，具体可根据实际情况进行设计，在此不作唯一限定。
可以理解，在一些实施例中，在环形导轨12设计符合要求，并且第一安装架21与支撑杆112间不发生干涉的前提下，还可将支撑杆112连接于环形导轨12的底壁；以及，支撑架还可设计为伸缩杆结构，具体可根据实际情况进行设计，在此不作限定。
本实施例所提供的方案中，环形导轨12的横截面形状可以为T形或L形，但不限于此。
本实施例所提供的方案中，环形导轨12可以为铝合金材质、不锈钢材质或钛合金材质，但不限于此。
综上，本申请提供的经颅超声应用装置100，通过提供一可架设于用户头部的环形导轨12，并在环形导轨12上设置第一检测组件3，能够降低脑部超声手术中颅骨声窗的定位难度并提高颅骨声窗的定位精度；以及，通过在环形导轨12上设置连接杆13，并在连接杆13上设置第二检测组件6，能够降低超声神经调控中目标刺激区域的定位难度并提高目标刺激区域的定位精度，从而有效提升了经颅超声应用装置100的使用便捷性及超声诊断结 果的准确性。
实施例二：
如图10和图11所示，本实施例提供的经颅超声应用装置100包括头架本体1、第一安装组件2和第一检测组件3。头架本体1包括固定组件11和环形导轨12，固定组件11连接于环形导轨12且用于将环形导轨12架设于用户头部。第一安装组件2包括第一安装架21和第一载物台22，第一安装架21滑动连接于环形导轨12且用于安装第一载物台22，第一安装架21能够沿环形导轨12滑动以带动第一载物台22环绕用户头部的周向转动。如图2、图6和图7所示，第一检测组件3包括设于第一载物台22上的深度相机31和第一超声探头32，深度相机31用于扫描用户头部的外轮廓并确定颅骨声窗位置。
本实施例所提供的方案中，如图12所示，头架本体1还包括连接杆13，连接杆13架设于环形导轨12上，并且连接杆13的两端均固定连接于环形导轨12。经颅超声应用装置100还包括第二安装组件5和第二检测组件6，第二安装组件5包括第二安装架51和第二载物台52，第二安装架51设于连接杆13上且用于安装第二载物台52，第二检测组件6设于第二载物台52上且用于获取脑电信号并对用户头部上大脑皮层的目标区域进行超声刺激。
本实施例所提供的方案中，如图10和图12所示，固定组件11包括固定支架114，固定支架114连接于连接杆13的任意位置且用于悬挂连接杆13和环形导轨12。
固定支架114包括固定结构，能够固定设置于床架、桌椅或墙壁等位置出，以实现经颅超声应用装置100的位置固定。
本实施例所提供的方案，通过改进固定组件11的结构，使得该固定头架能够固定于外部设施中，还能够有效提高该固定头架的使用便捷性。
实施例三：
本申请提供了一种经颅超声应用装置的使用方法。
经颅超声应用装置100的具体结构参见实施例一和实施例二，在此不再赘述。使用方法包括：
S1、将经颅超声应用装置100佩戴于用户头部。
佩戴该诊断装置时，应使头架本体1的环形导轨12架设于用户头部。
S2、利用第一检测组件3扫描用户头部的外轮廓并确定颅骨声窗位置。
检测过程中，应使使第一检测组件3对准用户头部，以确保颅骨声窗的定位精度。
S3、调节第一安装架21，使第一超声探头32贴合用户头部并与预定颅骨声窗相对。
调节第一安装架21时，应使第一超声探头32与用户皮肤紧密贴合，并且接触压力不 能过高，以确保超声诊断能够正常进行。
S4、控制第一超声探头32发射超声信号，以进行超声诊断。
第一超声探头32能够向颅骨声窗处发射超声波以进行超声刺激或采集超声脑部图像，通过改进第一超声探头32的发射强度，能够满足不同超声刺激或超声成像的需求。
在一些实施例中，经颅超声应用装置100上设置压力传感器33和马达42，脑部超声手术中，还可根据压力传感器33等结构的实时监测结果，调整第一超声探头32的位置，以使第一超声探头32配置为最佳的入射角度或扫描平面，实现高精度的三维超声成像。
以上仅为本申请的可选实施例而已，并不用于限制本申请。对于本领域的技术人员来说，本申请可以有各种更改和变化。凡在本申请的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本申请的权利要求范围之内。

Claims (13)

  1. 一种经颅超声应用装置(100)，其特征在于，包括：
    头架本体(1)，包括固定组件(11)和环形导轨(12)，所述固定组件(11)连接于所述环形导轨(12)且用于将所述环形导轨(12)架设于用户头部；
    第一安装组件(2)，包括第一安装架(21)和第一载物台(22)，所述第一安装架(21)滑动连接于所述环形导轨(12)且用于安装所述第一载物台(22)，所述第一安装架(21)能够沿所述环形导轨(12)滑动，以带动所述第一载物台(22)绕用户头部的周向转动；
    第一检测组件(3)，包括设于所述第一载物台(22)上的深度相机(31)和第一超声探头(32)，所述深度相机(31)用于扫描用户头部的外轮廓并确定颅骨声窗位置。
  2. 根据权利要求1所述的经颅超声应用装置(100)，其特征在于，所述第一安装架(21)包括转动连接的第一支架(211)和第二支架(212)，所述第一支架(211)与所述第二支架(212)间的夹角可调，所述第一支架(211)连接于所述环形导轨(12)，所述第二支架(212)连接于所述第一载物台(22)。
  3. 根据权利要求2所述的经颅超声应用装置(100)，其特征在于，所述第二支架(212)为伸缩杆且长度可调。
  4. 根据权利要求1所述的经颅超声应用装置(100)，其特征在于，所述第一超声探头(32)为单振元探头或多振元探头，所述第一超声探头(32)发射超声波的频率为0.5MHz-20MHz，强度为1mW/cm2-3W/cm2。
  5. 根据权利要求1所述的经颅超声应用装置(100)，其特征在于，所述第一检测组件(3)还包括压力传感器(33)，所述压力传感器(33)设于所述第一载物台(22)上且用于检测所述第一超声探头(32)与用户头部间的接触压力。
  6. 根据权利要求1所述的经颅超声应用装置(100)，其特征在于，所述第一超声探头(32)的前端设有耦合垫(41)，所述第一超声探头(32)发射的超声波可穿透所述耦合垫(41)。
  7. 根据权利要求1-6中任一项所述的经颅超声应用装置(100)，其特征在于，所述头架本体(1)还包括连接杆(13)，所述连接杆(13)架设于所述环形导轨(12)上，并且所述连接杆(13)的两端均固定连接于所述环形导轨(12)；
    所述经颅超声应用装置(100)还包括第二安装组件(5)和第二检测组件(6)，所述第二安装组件(5)包括第二安装架(51)和第二载物台(52)，所述第二安装架(51)设于所述连接杆(13)上且用于安装所述第二载物台(52)，所述第二检测组件(6)设于所 述第二载物台(52)上且用于对用户头部上大脑皮层的目标区域进行超声刺激并获取脑电信号。
  8. 根据权利要求7所述的经颅超声应用装置(100)，其特征在于，所述第二安装架(51)包括固定座(511)和第三支架(512)，所述固定座(511)设于所述连接杆(13)上，所述第三支架(512)安装于所述固定座(511)上，所述第三支架(512)为伸缩杆且长度可调。
  9. 根据权利要求7所述的经颅超声应用装置(100)，其特征在于，所述第二检测组件(6)包括电极片和第二超声探头。
  10. 根据权利要求7所述的经颅超声应用装置(100)，其特征在于，所述固定组件(11)包括固定支架(114)，所述固定支架(114)连接于所述连接杆(13)的任意位置且用于悬挂所述连接杆(13)和所述环形导轨(12)。
  11. 根据权利要求1-6中任一项所述的经颅超声应用装置(100)，其特征在于，所述固定组件(11)包括环形头箍(111)和多个支撑杆(112)，多个所述支撑杆(112)沿所述环形头箍(111)的周向间隔设置，并且所述支撑杆(112)的一端连接于所述环形头箍(111)，另一端连接于所述环形导轨(12)，所述环形头箍(111)用于佩戴于用户头部并用于支撑所述环形导轨(12)。
  12. 根据权利要求11所述的经颅超声应用装置(100)，其特征在于，所述环形头箍(111)为开口式结构并且具有第一端和第二端，所述第一端上配置有第一调节孔，所述第二端上配置有第二调节孔，所述第一调节孔和所述第二调节孔相对设置，并且所述第一调节孔和所述第二调节孔均配置有齿条结构；
    所述固定组件(11)还包括调节旋钮(113)，所述调节旋钮(113)插入至所述第一调节孔和所述第二调节孔内，所述调节旋钮(113)与所述齿条结构啮合，所述调节旋钮(113)转动可带动所述第一端和所述第二端相对移动。
  13. 根据权利要求11所述的经颅超声应用装置(100)，其特征在于，所述环形导轨(12)的内侧壁设有多个卡槽，所述支撑杆(112)的一端与所述环形头箍(111)固定连接，另一端卡持于所述卡槽内，所述卡槽的数量大于所述支撑杆(112)的数量，所述支撑杆(112)的安装位置可调。
PCT/CN2023/095361 2023-05-19 2023-05-19 经颅超声应用装置 Ceased WO2024239160A1 (zh)

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