WO2024130548A1 - Simple 3d printing batch mouse fixator - Google Patents

Simple 3d printing batch mouse fixator Download PDF

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Publication number
WO2024130548A1
WO2024130548A1 PCT/CN2022/140376 CN2022140376W WO2024130548A1 WO 2024130548 A1 WO2024130548 A1 WO 2024130548A1 CN 2022140376 W CN2022140376 W CN 2022140376W WO 2024130548 A1 WO2024130548 A1 WO 2024130548A1
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WO
WIPO (PCT)
Prior art keywords
fixing
head
neck
trunk
ring
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PCT/CN2022/140376
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French (fr)
Chinese (zh)
Inventor
吴至凤
王霞
何丽
明黎
范琼丽
魏鋆
李文藻
沈开凤
杨小林
张雨平
Original Assignee
中国人民解放军陆军军医大学第二附属医院
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Application filed by 中国人民解放军陆军军医大学第二附属医院 filed Critical 中国人民解放军陆军军医大学第二附属医院
Priority to PCT/CN2022/140376 priority Critical patent/WO2024130548A1/en
Publication of WO2024130548A1 publication Critical patent/WO2024130548A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes

Definitions

  • the invention relates to the technical field of experimental animal fixing devices, and in particular to a simple 3D printed batch mouse fixing device.
  • mice are the most important experimental animals and are widely used as experimental subjects in medical, biological, pharmaceutical, and hygiene experiments and research. Mice need to be fixed during the process of dissection, acupuncture, drug injection, blood sampling, etc. If they are not fixed well, the mice will struggle and be difficult to control, which will not only increase the difficulty of the experiment, but also affect the progress and accuracy of the experiment, and may even cause the experimenters to be scratched or bitten by the mice.
  • Some animal surgical devices in the prior art are relatively expensive. For general animal dissection, animal trauma surgery, animal injection, etc., a relatively low-cost fixator can achieve the purpose of fixation.
  • Some other animal surgical devices in the prior art such as the Chinese patent with publication number CN110179564A, discloses a laboratory mouse fixation board, including a main board, a rubber fixing ring and a rubber fixing belt.
  • the main board includes an outer plastic shell, an iron plate is embedded inside the plastic shell, and the four corners of the rear side of the plastic shell are integrally formed with support feet.
  • the front of the main board is adsorbed with a rubber fixing ring and a rubber fixing belt.
  • the fixation is not firm enough by adsorbing the rubber ring and rubber belt on the iron plate, and the mouse may break free from the restraint, affecting the experiment.
  • the fixation is relatively troublesome and not conducive to operation; the mouse has only one fixed posture, which is difficult to match multiple experimental requirements; in addition, this laboratory mouse fixation board is for a single mouse. When there are many experimental subjects, batch operation is often required to achieve the purpose of saving time and effort.
  • a 3D printed batch fixation device for mice is proposed.
  • the device is printed with plastic material and can be used for MRI and CT examinations after fixing mice. It can also be used in any scenario where batch fixation is required.
  • the object of the present invention is to provide a batch fixation device for rats, which can solve or improve at least one of the above-mentioned technical problems under anesthesia or non-anesthesia conditions.
  • the present invention provides a simple 3D printed batch mouse holder, comprising a fixing plate, wherein the fixing plate is divided into a plurality of fixing areas;
  • the fixed area includes:
  • Fixed columns which are arranged at four corners of the fixed area and are fixedly connected to the fixed plate;
  • a head fixing ring the head fixing ring is arranged between the two fixing columns at the top, and the head fixing ring is fixedly connected to the top surface of the fixing plate;
  • Neck fixing holes which are arranged in pairs and are symmetrical about the axis of the head fixing ring;
  • Trunk fixing holes which are arranged in pairs and are symmetrical about the axis of the head fixing ring, and are located on a side of the neck fixing hole away from the head fixing ring;
  • the neck fixing hole, the trunk fixing hole and the fixing column are all provided with binding structures.
  • the head fixing ring is tubular; the bottom end of the inner wall of the head fixing ring is flush with the top surface of the fixing plate.
  • a U-shaped notch is provided above one end of the head fixing ring close to the neck fixing hole.
  • the neck fixing hole is an elongated hole.
  • the trunk fixing hole is an elongated hole, and the distance between the two paired trunk fixing holes gradually decreases from the direction away from the head fixing ring to the direction close to the head fixing ring.
  • a plurality of support columns are fixedly connected to the lower bottom surface of the fixing plate, and the support columns are arranged corresponding to the fixing columns.
  • the fixing plate is a detachable structure, and a clamping structure is provided between two adjacent fixing areas for clamping.
  • a fixing plate of the present invention can be provided with multiple fixing areas, each of which can fix an experimental mouse, and the mouse body fixing device can fix the experimental mice in batches, which is convenient for batch operation of the experimental mice when there are many experimental objects, saving time and labor;
  • the head fixing ring is used to fix the head of the experimental mouse, reducing the possibility of the mouse biting the experimenter during the experiment;
  • the fixing column is used to fix the mouse limbs when the mouse needs to expose its abdomen, such as anatomical experiments, etc.;
  • the tying structure passes through the neck fixing hole and the neck fixing hole to fix the neck and trunk of the experimental mouse respectively
  • the fixing device is integrally formed by 3D printing, and is printed as a plastic material, and the fixing device includes a tying structure without any magnetic or metal material, which can be applied to MRI and CT examinations after fixing the mouse, and has a simple structure and is easy to produce.
  • the present invention can perform various fixations such as positive and negative fixation and exposed abdomen fixation on the experimental mouse according to needs, is applicable to various experimental needs, and is firmly fixed, the fixing operation process is convenient, and it is not easy to be scratched or bitten, and is safer to use.
  • FIG1 is a schematic structural diagram of a simple 3D printed batch mouse holder according to the present invention.
  • FIG2 is a schematic diagram of a simple 3D printed batch mouse fixer for fixing the mouse with exposed abdomen
  • FIG3 is a schematic diagram of the Velcro fixation of the simple 3D printed batch mouse fixer of the present invention.
  • FIG4 is a schematic diagram of a simple 3D printed batch mouse fixer fixing rope of the present invention.
  • fixing plate 1. fixing plate; 2. fixing area; 3. fixing column; 4. head fixing ring; 5. neck fixing hole; 6. torso fixing hole; 7. binding structure; 8. supporting column; 9. U-shaped notch; 10. snap-on structure; 71. fixing rope; 72. Velcro; 73. rubber band.
  • the present invention provides a simple 3D printed batch mouse holder, comprising a fixing plate 1 , the fixing plate 1 being divided into a plurality of fixing areas 2 ;
  • Fixed area 2 includes:
  • Fixed columns 3 which are arranged at the four corners of the fixed area 2 and are fixedly connected to the fixed plate 1;
  • a head fixing ring 4 which is arranged between the two top fixing columns 3 and is fixed to the top surface of the fixing plate 1;
  • Neck fixing holes 5, which are arranged in pairs and are symmetrical about the axis of the head fixing ring 4;
  • the trunk fixing holes 6 are arranged in pairs and are symmetrical about the axis of the head fixing ring 4.
  • the trunk fixing holes 6 are located on the side of the neck fixing holes 5 away from the head fixing ring 4;
  • the neck fixing hole 5 , the trunk fixing hole 6 and the fixing column 3 are all provided with a binding structure 7 .
  • a plurality of fixing areas 2 can be arranged on a fixing plate 1, and one experimental mouse can be fixed in each fixing area 2.
  • the mouse body fixing device can fix experimental mice in batches, which is convenient for batch operation of experimental mice when there are many experimental objects, saving time and labor; the head fixing ring 4 is used to fix the head of the experimental mouse, reducing the possibility of the mouse biting the experimenter during the experiment; the tying structure 7 ties and fixes the limbs of the experimental mouse on the fixing column 3.
  • the present invention can perform various fixations on the experimental mouse such as positive and negative fixation and belly-exposing fixation according to needs, is suitable for various experimental needs, and is firmly fixed, the fixing operation process is convenient, and it is not easy to be scratched or bitten, and is safer to use.
  • the binding structure 7 is preferably a rubber band 73 or a fixing rope 71 .
  • the fixing device is integrally formed by 3D printing and is printed as a plastic material.
  • the fixing device includes a tying structure without any magnetic or metal material, and can be used for fixing mice for MRI and CT examinations.
  • the head fixing ring 4 is tubular; the bottom end of the inner wall of the head fixing ring 4 is flush with the top surface of the fixing plate 1 .
  • the mouse head When in use, the mouse head is fixed inside the head fixing ring 4, and the head fixing ring 4 encircles the mouse head to prevent the mouse head from turning and biting the experimenter; the bottom end of the inner wall of the head fixing ring 4 is flush with the top surface of the fixing plate 1, so that the mouse body and head are located in the same plane, which is convenient for the staff to push the mouse head into and out of the head fixing ring 4 and reduce the bumps of the mouse head.
  • a U-shaped notch 9 is provided above one end of the head fixing ring 4 close to the neck fixing hole 5 .
  • the U-shaped notch 9 can clamp the mouse head when the head fixing ring 4 fixes the mouse head, making the fixation more firm and not easy to loosen.
  • the neck fixing hole 5 is a long hole.
  • the design of the long hole facilitates the adjustment of the position of the binding structure 7 passing through the neck fixing hole 5 to adapt to different neck fixing positions of mice of different sizes, making the fixation more secure.
  • the trunk fixing hole 6 is a long hole, and the distance between the two pairs of trunk fixing holes 6 gradually decreases from away from the head fixing ring 4 to close to the head fixing ring 4.
  • the trunk fixing hole 6 is designed as a long hole, which is convenient for adjusting the position of the binding structure 7 passing through the trunk fixing hole 6 to adapt to different trunk fixing positions of mice of different sizes, making the fixation more firm and flexible.
  • the design of the gradually decreasing distance between the two trunk fixing holes 6 from bottom to top is also more tolerant to the size of the mouse, and has a firm fixing effect on mice of different sizes.
  • a plurality of support columns 8 are fixedly connected to the bottom surface of the fixed plate 1 , and the support columns 8 are arranged corresponding to the fixed columns 3 .
  • the support column 8 lifts the fixing plate away from the operating table, leaving a certain space for the binding structure 7 passing through the neck fixing hole 5 and the torso fixing hole 6, so as to avoid the instability caused by the binding structure 7 at the bottom of the fixing plate 1 when the fixing plate 1 is placed directly on the table.
  • the fixing plate 1 is a detachable structure, and a clamping structure 10 is provided between two adjacent fixing areas 2 for clamping.
  • the fixing plates 1 can be conveniently inserted and spliced from the side through the clamping structure 10 to form a plurality of fixing areas 2 for batch experiments on mice.
  • the mouse head is pushed into the head fixing ring 4 with the head facing upward, and the mouse limbs are fixed to the fixing column 3 respectively with rubber bands 73 or fixing ropes 71, as shown in Figure 2. It is used for experiments such as anatomical experiments that require the abdomen to be exposed.
  • the binding structure 7 of this embodiment is preferably a fixing rope 71 and a Velcro 72; the mouse head is pushed upward into the head fixing ring 4, and the protruding part of the mouse head is stuck in the U-shaped notch 9; when the front side is fixed, the protruding part is the mouth, and when the back side is fixed, the protruding part is the ear on the top of the head; the mouse neck is fixed with the fixing rope 71, and the mouse trunk is fixed with the Velcro 72, and the Velcro 72 passes through the trunk fixing hole 6 and quickly binds the abdomen of the experimental mouse. It can be used for experiments such as gavage experiments that do not require large-area exposure of the abdomen.
  • the tying structure 7 of the embodiment is preferably a fixing rope 71 with adjustable length, and the fixing rope 71 passes through the neck fixing hole 5 and the trunk fixing hole 6 and then ties the neck and abdomen of the experimental mouse; the mouse head is pushed into the head fixing ring 4 with the head facing upward, and the protruding part of the mouse head is stuck in the U-shaped notch 9; when fixed from the front, the protruding part is the mouth, and when fixed from the back, the protruding part is the ear on the top of the head; the neck of the mouse is fixed with the fixing rope 71, and the trunk of the mouse is fixed with the fixing rope 71. It can be used for experiments that require skin exposure, such as acupuncture experiments.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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Abstract

A simple 3D printing batch mouse fixator, comprising a fixing plate (1). The fixing plate (1) is divided into several fixing areas (2). The fixing areas (2) each comprise fixing columns (3) respectively arranged at four corners of the fixing area (2) and fixedly connected to the fixing plate (1); a head fixing ring (4) arranged between the two fixing columns (3) at the top and fixedly connected to the top surface of the fixing plate (1); neck fixing holes (5) arranged in pairs and symmetrical about the axis of the head fixing ring (4); and trunk fixing holes (6) arranged in pairs and symmetrical about the axis of the head fixing ring (4). The trunk fixing holes (6) are located on the side of the neck fixing holes (5) away from the head fixing ring (4). The neck fixing holes (5), the trunk fixing holes (6), and the fixing columns (3) are each provided with a binding structure (7). The fixator allows for batch operations on laboratory mice, saving time and effort; the fixator can fix the laboratory mice in multiple manners, such as front fixing, back fixing and abdomen-exposed fixing, according to needs, thus being suitable for various experimental requirements.

Description

一种简易的3D打印批量鼠固定器A simple 3D printed batch mouse holder 技术领域Technical Field
本发明涉及实验动物固定装置技术领域，特别是涉及一种简易的3D打印批量鼠固定器。The invention relates to the technical field of experimental animal fixing devices, and in particular to a simple 3D printed batch mouse fixing device.
背景技术Background technique
鼠是最重要的实验性动物，作为实验对象被广泛的应用于医学、生物学、药学、卫生学实验及研究中。在实验人员进行解剖、针灸、药物注射、抽取血样等实验过程中，都需要对鼠实施固定。若固定不好，鼠挣扎，难以控制，不仅增加了实验的难度，影响了实验的进度和准确度，甚至可能会出现实验人员被鼠抓伤或咬伤的情况。Mice are the most important experimental animals and are widely used as experimental subjects in medical, biological, pharmaceutical, and hygiene experiments and research. Mice need to be fixed during the process of dissection, acupuncture, drug injection, blood sampling, etc. If they are not fixed well, the mice will struggle and be difficult to control, which will not only increase the difficulty of the experiment, but also affect the progress and accuracy of the experiment, and may even cause the experimenters to be scratched or bitten by the mice.
现有技术中的一些动物手术装置成本较高，对于一般性的动物解剖、动物创伤手术、动物注射等，成本较低的固定器便可达到固定的目的。现有技术中的另一些动物手术装置，如公开号为CN110179564A的中国专利公开了一种实验鼠固定板，包括主板、橡胶固定环和橡胶固定带，主板包括外侧的塑料外壳，塑料外壳内部嵌入有铁板，塑料外壳后侧四角一体成形的设有支撑脚，主板正面吸附有橡胶固定环和橡胶固定带。通过橡胶环、橡胶带吸附在铁板上固定，固定不够牢固，老鼠有可能挣脱束缚，影响实验，并且固定较为麻烦，不利于操作；鼠仅有一种固定姿态，难以匹配多种实验要求；此外此实验鼠固定板针对单只鼠，在实验对象较多时，往往需要批量操作才能达到省时省力的目的。Some animal surgical devices in the prior art are relatively expensive. For general animal dissection, animal trauma surgery, animal injection, etc., a relatively low-cost fixator can achieve the purpose of fixation. Some other animal surgical devices in the prior art, such as the Chinese patent with publication number CN110179564A, discloses a laboratory mouse fixation board, including a main board, a rubber fixing ring and a rubber fixing belt. The main board includes an outer plastic shell, an iron plate is embedded inside the plastic shell, and the four corners of the rear side of the plastic shell are integrally formed with support feet. The front of the main board is adsorbed with a rubber fixing ring and a rubber fixing belt. The fixation is not firm enough by adsorbing the rubber ring and rubber belt on the iron plate, and the mouse may break free from the restraint, affecting the experiment. In addition, the fixation is relatively troublesome and not conducive to operation; the mouse has only one fixed posture, which is difficult to match multiple experimental requirements; in addition, this laboratory mouse fixation board is for a single mouse. When there are many experimental subjects, batch operation is often required to achieve the purpose of saving time and effort.
为此，提出一种鼠体的3D打印的批量固定装置，打印为塑料材 料，可适用于固定鼠后MRI、CT检查，也可适用于任何需要批量固定的场景。To this end, a 3D printed batch fixation device for mice is proposed. The device is printed with plastic material and can be used for MRI and CT examinations after fixing mice. It can also be used in any scenario where batch fixation is required.
发明内容Summary of the invention
本发明的目的是提供一种鼠体的批量固定装置，配合麻醉或非麻醉的情况下能解决或改善上述技术问题中的至少之一。The object of the present invention is to provide a batch fixation device for rats, which can solve or improve at least one of the above-mentioned technical problems under anesthesia or non-anesthesia conditions.
为实现上述目的，本发明提供了如下方案：本发明提供一种简易的3D打印批量鼠固定器，包括固定板，所述固定板划分为若干固定区域；To achieve the above-mentioned object, the present invention provides the following solution: The present invention provides a simple 3D printed batch mouse holder, comprising a fixing plate, wherein the fixing plate is divided into a plurality of fixing areas;
所述固定区域包括：The fixed area includes:
固定柱，所述固定柱设置于所述固定区域的四角处，并与所述固定板固接；Fixed columns, which are arranged at four corners of the fixed area and are fixedly connected to the fixed plate;
头部固定环，所述头部固定环设置于顶部两所述固定柱之间，所述头部固定环固接于所述固定板顶面；A head fixing ring, the head fixing ring is arranged between the two fixing columns at the top, and the head fixing ring is fixedly connected to the top surface of the fixing plate;
颈部固定孔，所述颈部固定孔成对设置，且关于所述头部固定环轴线对称；Neck fixing holes, which are arranged in pairs and are symmetrical about the axis of the head fixing ring;
躯干固定孔，所述躯干固定孔成对设置，且关于所述头部固定环轴线对称，所述躯干固定孔位于所述颈部固定孔远离头部固定环的一侧；Trunk fixing holes, which are arranged in pairs and are symmetrical about the axis of the head fixing ring, and are located on a side of the neck fixing hole away from the head fixing ring;
所述颈部固定孔、所述躯干固定孔和所述固定柱上均设有绑扎结构。The neck fixing hole, the trunk fixing hole and the fixing column are all provided with binding structures.
优选的，所述头部固定环为管状；所述头部固定环内壁底端与所述固定板顶面平齐。Preferably, the head fixing ring is tubular; the bottom end of the inner wall of the head fixing ring is flush with the top surface of the fixing plate.
优选的，所述头部固定环靠近所述颈部固定孔的一端上方开设有U形缺口。Preferably, a U-shaped notch is provided above one end of the head fixing ring close to the neck fixing hole.
优选的，所述颈部固定孔为长条孔。Preferably, the neck fixing hole is an elongated hole.
优选的，所述躯干固定孔为长条孔，成对的两所述躯干固定孔之间从远离头部固定环向靠近头部固定环的方向距离逐渐减小。Preferably, the trunk fixing hole is an elongated hole, and the distance between the two paired trunk fixing holes gradually decreases from the direction away from the head fixing ring to the direction close to the head fixing ring.
优选的，所述固定板下底面固接有若干支撑柱，所述支撑柱与所述固定柱对应设置。Preferably, a plurality of support columns are fixedly connected to the lower bottom surface of the fixing plate, and the support columns are arranged corresponding to the fixing columns.
优选的，所述固定板为可拆卸结构，相邻两个固定区域之间设置有卡接结构进行卡接。Preferably, the fixing plate is a detachable structure, and a clamping structure is provided between two adjacent fixing areas for clamping.
本发明公开了以下技术效果：本发明的一个固定板上可设置有多个固定区域，每个固定区域内可固定一只实验鼠，本鼠体固定装置可对实验鼠进行批量固定，便于在实验对象较多时，对实验鼠进行批量操作，省时省力；头部固定环用于固定实验鼠头部，减少在实验过程中，鼠咬伤实验人员；固定柱用于在需要鼠露出腹部的情况下，固定鼠四肢，例如解剖实验等；绑扎结构穿过颈部固定孔和颈部固定孔分别对实验鼠的颈部和躯干进行固定，固定装置由3D打印一体成型，打印为塑料材料，固定装置包括绑扎结构无任何磁性或金属材料，可适用于固定鼠后进行MRI、CT检查，且结构简单，易生产。本发明可根据需要对实验鼠进行正反固定、露腹固定等多种固定，适用于多种实验需求，且固定牢固，固定操作过程方便，不易被抓伤咬伤，使用更加安全。The present invention discloses the following technical effects: a fixing plate of the present invention can be provided with multiple fixing areas, each of which can fix an experimental mouse, and the mouse body fixing device can fix the experimental mice in batches, which is convenient for batch operation of the experimental mice when there are many experimental objects, saving time and labor; the head fixing ring is used to fix the head of the experimental mouse, reducing the possibility of the mouse biting the experimenter during the experiment; the fixing column is used to fix the mouse limbs when the mouse needs to expose its abdomen, such as anatomical experiments, etc.; the tying structure passes through the neck fixing hole and the neck fixing hole to fix the neck and trunk of the experimental mouse respectively, the fixing device is integrally formed by 3D printing, and is printed as a plastic material, and the fixing device includes a tying structure without any magnetic or metal material, which can be applied to MRI and CT examinations after fixing the mouse, and has a simple structure and is easy to produce. The present invention can perform various fixations such as positive and negative fixation and exposed abdomen fixation on the experimental mouse according to needs, is applicable to various experimental needs, and is firmly fixed, the fixing operation process is convenient, and it is not easy to be scratched or bitten, and is safer to use.
附图说明BRIEF DESCRIPTION OF THE DRAWINGS
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.
图1为本发明简易的3D打印批量鼠固定器的结构示意图；FIG1 is a schematic structural diagram of a simple 3D printed batch mouse holder according to the present invention;
图2为本发明简易的3D打印批量鼠固定器露腹固定示意图；FIG2 is a schematic diagram of a simple 3D printed batch mouse fixer for fixing the mouse with exposed abdomen;
图3为本发明简易的3D打印批量鼠固定器魔术贴固定示意图；FIG3 is a schematic diagram of the Velcro fixation of the simple 3D printed batch mouse fixer of the present invention;
图4为本发明简易的3D打印批量鼠固定器固定绳固定示意图；FIG4 is a schematic diagram of a simple 3D printed batch mouse fixer fixing rope of the present invention;
其中，1、固定板；2、固定区域；3、固定柱；4、头部固定环；5、颈部固定孔；6、躯干固定孔；7、绑扎结构；8、支撑柱；9、U形缺口；10、卡接结构；71、固定绳；72、魔术贴；73、橡皮筋。Among them, 1. fixing plate; 2. fixing area; 3. fixing column; 4. head fixing ring; 5. neck fixing hole; 6. torso fixing hole; 7. binding structure; 8. supporting column; 9. U-shaped notch; 10. snap-on structure; 71. fixing rope; 72. Velcro; 73. rubber band.
具体实施方式Detailed ways
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
为使本发明的上述目的、特征和优点能够更加明显易懂，下面结合附图和具体实施方式对本发明作进一步详细的说明。In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.
实施例1Example 1
参照图1-2，本发明提供一种简易的3D打印批量鼠固定器，包括固定板1，固定板1划分为若干固定区域2；1-2 , the present invention provides a simple 3D printed batch mouse holder, comprising a fixing plate 1 , the fixing plate 1 being divided into a plurality of fixing areas 2 ;
固定区域2包括： Fixed area 2 includes:
固定柱3，固定柱3设置于固定区域2的四角处，并与固定板1固接；Fixed columns 3, which are arranged at the four corners of the fixed area 2 and are fixedly connected to the fixed plate 1;
头部固定环4，头部固定环4设置于顶部两固定柱3之间，头部固定环4固接于固定板1顶面；A head fixing ring 4, which is arranged between the two top fixing columns 3 and is fixed to the top surface of the fixing plate 1;
颈部固定孔5，颈部固定孔5成对设置，且关于头部固定环4轴线对称； Neck fixing holes 5, which are arranged in pairs and are symmetrical about the axis of the head fixing ring 4;
躯干固定孔6，躯干固定孔6成对设置，且关于头部固定环4轴线对称，躯干固定孔6位于颈部固定孔5远离头部固定环4的一侧；The trunk fixing holes 6 are arranged in pairs and are symmetrical about the axis of the head fixing ring 4. The trunk fixing holes 6 are located on the side of the neck fixing holes 5 away from the head fixing ring 4;
颈部固定孔5、躯干固定孔6和固定柱3上均设有绑扎结构7。The neck fixing hole 5 , the trunk fixing hole 6 and the fixing column 3 are all provided with a binding structure 7 .
一个固定板1上可设置有多个固定区域2，每个固定区域2内可固定一只实验鼠，本鼠体固定装置可对实验鼠进行批量固定，便于在实验对象较多时，对实验鼠进行批量操作，省时省力；头部固定环4用于固定实验鼠头部，减少在实验过程中，鼠咬伤实验人员；绑扎结构7将实验鼠四肢绑扎固定于固定柱3上。本发明可根据需要对实验鼠进行正反固定、露腹固定等多种固定，适用于多种实验需求，且固定牢固，固定操作过程方便，不易被抓伤咬伤，使用更加安全。A plurality of fixing areas 2 can be arranged on a fixing plate 1, and one experimental mouse can be fixed in each fixing area 2. The mouse body fixing device can fix experimental mice in batches, which is convenient for batch operation of experimental mice when there are many experimental objects, saving time and labor; the head fixing ring 4 is used to fix the head of the experimental mouse, reducing the possibility of the mouse biting the experimenter during the experiment; the tying structure 7 ties and fixes the limbs of the experimental mouse on the fixing column 3. The present invention can perform various fixations on the experimental mouse such as positive and negative fixation and belly-exposing fixation according to needs, is suitable for various experimental needs, and is firmly fixed, the fixing operation process is convenient, and it is not easy to be scratched or bitten, and is safer to use.
进一步的，根据附图2所示，绑扎结构7优选为橡皮筋73或固定绳71。Further, as shown in FIG. 2 , the binding structure 7 is preferably a rubber band 73 or a fixing rope 71 .
进一步的，固定装置由3D打印一体成型，打印为塑料材料。固 定装置包括绑扎结构无任何磁性或金属材料，可适用于固定鼠后MRI、CT检查。Furthermore, the fixing device is integrally formed by 3D printing and is printed as a plastic material. The fixing device includes a tying structure without any magnetic or metal material, and can be used for fixing mice for MRI and CT examinations.
进一步优化方案，头部固定环4为管状；头部固定环4内壁底端与固定板1顶面平齐。According to a further optimized solution, the head fixing ring 4 is tubular; the bottom end of the inner wall of the head fixing ring 4 is flush with the top surface of the fixing plate 1 .
使用时，鼠头部固定于头部固定环4内部，头部固定环4将鼠头部环住，避免鼠头部转动咬伤实验人员；头部固定环4内壁底端与固定板1顶面平齐，可使鼠身体与头部位于同一平面，便于工作人员将鼠头部头部推入和拉出头部固定环4，且减少鼠头部磕碰。When in use, the mouse head is fixed inside the head fixing ring 4, and the head fixing ring 4 encircles the mouse head to prevent the mouse head from turning and biting the experimenter; the bottom end of the inner wall of the head fixing ring 4 is flush with the top surface of the fixing plate 1, so that the mouse body and head are located in the same plane, which is convenient for the staff to push the mouse head into and out of the head fixing ring 4 and reduce the bumps of the mouse head.
进一步优化方案，头部固定环4靠近颈部固定孔5的一端上方开设有U形缺口9。According to a further optimized solution, a U-shaped notch 9 is provided above one end of the head fixing ring 4 close to the neck fixing hole 5 .
U形缺口9可在头部固定环4固定鼠头部时，对头部进行卡固，使固定更加牢固，不易松动。The U-shaped notch 9 can clamp the mouse head when the head fixing ring 4 fixes the mouse head, making the fixation more firm and not easy to loosen.
进一步优化方案，颈部固定孔5为长条孔。According to a further optimized solution, the neck fixing hole 5 is a long hole.
长条孔的设计方便调节穿过颈部固定孔5的绑扎结构7的位置，以适应不同尺寸的鼠不同的颈部固定位置，使固定更加牢固。The design of the long hole facilitates the adjustment of the position of the binding structure 7 passing through the neck fixing hole 5 to adapt to different neck fixing positions of mice of different sizes, making the fixation more secure.
进一步优化方案，躯干固定孔6为长条孔，成对的两躯干固定孔6之间从远离头部固定环4向靠近头部固定环4的方向距离逐渐减小。According to a further optimized solution, the trunk fixing hole 6 is a long hole, and the distance between the two pairs of trunk fixing holes 6 gradually decreases from away from the head fixing ring 4 to close to the head fixing ring 4.
躯干固定孔6为长条孔的设计方便调节穿过躯干固定孔6的绑扎结构7的位置，以适应不同尺寸的鼠不同的躯干固定位置，使固定更加牢固和灵活，两躯干固定孔6之间由下到上距离逐渐减小的设计对鼠的身材也有更大的包容性，对不同尺寸的鼠均具有牢固的固定作用。The trunk fixing hole 6 is designed as a long hole, which is convenient for adjusting the position of the binding structure 7 passing through the trunk fixing hole 6 to adapt to different trunk fixing positions of mice of different sizes, making the fixation more firm and flexible. The design of the gradually decreasing distance between the two trunk fixing holes 6 from bottom to top is also more tolerant to the size of the mouse, and has a firm fixing effect on mice of different sizes.
进一步优化方案，固定板1下底面固接有若干支撑柱8，支撑柱8与固定柱3对应设置。According to a further optimized solution, a plurality of support columns 8 are fixedly connected to the bottom surface of the fixed plate 1 , and the support columns 8 are arranged corresponding to the fixed columns 3 .
支撑柱8将固定板抬高，离开操作台面，给穿过颈部固定孔5、躯干固定孔6的绑扎结构7预留一定空间，避免固定板1直接放置在台面上由于绑扎结构7在固定板1底部而导致的不平稳现象发生。The support column 8 lifts the fixing plate away from the operating table, leaving a certain space for the binding structure 7 passing through the neck fixing hole 5 and the torso fixing hole 6, so as to avoid the instability caused by the binding structure 7 at the bottom of the fixing plate 1 when the fixing plate 1 is placed directly on the table.
进一步优化方案，固定板1为可拆卸结构，相邻两个固定区域2之间设置有卡接结构10进行卡接。According to a further optimized solution, the fixing plate 1 is a detachable structure, and a clamping structure 10 is provided between two adjacent fixing areas 2 for clamping.
通过卡接结构10可方便地从侧方进行穿插拼接固定板1，形成多个固定区域2，用于鼠批量进行实验。The fixing plates 1 can be conveniently inserted and spliced from the side through the clamping structure 10 to form a plurality of fixing areas 2 for batch experiments on mice.
使用方法：Instructions:
将鼠麻醉后，将鼠头部头朝上推入头部固定环4中，再用橡皮筋73或固定绳71分别将鼠四肢固定于固定柱3上，如图2所示。用于解剖实验等需要露出腹部的实验。After the mouse is anesthetized, the mouse head is pushed into the head fixing ring 4 with the head facing upward, and the mouse limbs are fixed to the fixing column 3 respectively with rubber bands 73 or fixing ropes 71, as shown in Figure 2. It is used for experiments such as anatomical experiments that require the abdomen to be exposed.
实施例2Example 2
如图3所示，与实施例1不同的是，本实施例绑扎结构7优选为固定绳71和魔术贴72；将鼠头部头朝上推入头部固定环4中，鼠头部突出部位卡于U形缺口9处；正面固定时，突出部位为嘴部，反面固定时，突出部位为头顶耳部；用固定绳71固定鼠颈部，用魔术贴72固定鼠躯干，魔术贴72穿过躯干固定孔6后快速绑扎实验鼠的腹部。可用于灌胃实验等不用大面积露腹的实验。As shown in FIG3 , different from the embodiment 1, the binding structure 7 of this embodiment is preferably a fixing rope 71 and a Velcro 72; the mouse head is pushed upward into the head fixing ring 4, and the protruding part of the mouse head is stuck in the U-shaped notch 9; when the front side is fixed, the protruding part is the mouth, and when the back side is fixed, the protruding part is the ear on the top of the head; the mouse neck is fixed with the fixing rope 71, and the mouse trunk is fixed with the Velcro 72, and the Velcro 72 passes through the trunk fixing hole 6 and quickly binds the abdomen of the experimental mouse. It can be used for experiments such as gavage experiments that do not require large-area exposure of the abdomen.
实施例3Example 3
如附图4所示，与实施例1不同的是，本实施例绑扎结构7优选为长度可调节的固定绳71，固定绳71穿过颈部固定孔5和躯干固定孔6后绑扎实验鼠的颈部和腹部；将鼠头部头朝上推入头部固定环4中，鼠头部突出部位卡于U形缺口9处；正面固定时，突出部位为嘴部，反面固定时，突出部位为头顶耳部；用固定绳71固定鼠颈部，用固定绳71固定鼠躯干。可用于针灸实验等需要露肤的实验。As shown in FIG. 4 , different from the embodiment 1, the tying structure 7 of the embodiment is preferably a fixing rope 71 with adjustable length, and the fixing rope 71 passes through the neck fixing hole 5 and the trunk fixing hole 6 and then ties the neck and abdomen of the experimental mouse; the mouse head is pushed into the head fixing ring 4 with the head facing upward, and the protruding part of the mouse head is stuck in the U-shaped notch 9; when fixed from the front, the protruding part is the mouth, and when fixed from the back, the protruding part is the ear on the top of the head; the neck of the mouse is fixed with the fixing rope 71, and the trunk of the mouse is fixed with the fixing rope 71. It can be used for experiments that require skin exposure, such as acupuncture experiments.
在本发明的描述中，需要理解的是，术语“纵向”、“横向”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”、“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。In the description of the present invention, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.
以上所述的实施例仅是对本发明的优选方式进行描述，并非对本发明的范围进行限定，在不脱离本发明设计精神的前提下，本领域普通技术人员对本发明的技术方案做出的各种变形和改进，均应落入本发明权利要求书确定的保护范围内。The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims (7)

  1. 一种简易的3D打印批量鼠固定器，其特征在于：包括固定板(1)，所述固定板(1)划分为若干固定区域(2)；A simple 3D printed batch mouse holder, characterized in that it comprises a fixing plate (1), wherein the fixing plate (1) is divided into a plurality of fixing areas (2);
    所述固定区域(2)包括：The fixed area (2) comprises:
    固定柱(3)，所述固定柱(3)设置于所述固定区域(2)的四角处，并与所述固定板(1)固接；Fixed columns (3), the fixed columns (3) being arranged at the four corners of the fixed area (2) and fixedly connected to the fixed plate (1);
    头部固定环(4)，所述头部固定环(4)设置于顶部两所述固定柱(3)之间，所述头部固定环(4)固接于所述固定板(1)顶面；A head fixing ring (4), the head fixing ring (4) is arranged between the two fixing columns (3) at the top, and the head fixing ring (4) is fixedly connected to the top surface of the fixing plate (1);
    颈部固定孔(5)，所述颈部固定孔(5)成对设置，且关于所述头部固定环(4)轴线对称；Neck fixing holes (5), the neck fixing holes (5) are arranged in pairs and are symmetrical about the axis of the head fixing ring (4);
    躯干固定孔(6)，所述躯干固定孔(6)成对设置，且关于所述头部固定环(4)轴线对称，所述躯干固定孔(6)位于所述颈部固定孔(5)远离头部固定环(4)的一侧；Trunk fixing holes (6), the trunk fixing holes (6) are arranged in pairs and are symmetrical about the axis of the head fixing ring (4), and the trunk fixing holes (6) are located on a side of the neck fixing hole (5) away from the head fixing ring (4);
    所述颈部固定孔(5)、所述躯干固定孔(6)和所述固定柱(3)上均设有绑扎结构(7)。The neck fixing hole (5), the trunk fixing hole (6) and the fixing column (3) are all provided with a binding structure (7).
  2. 根据权利要求1所述的简易的3D打印批量鼠固定器，其特征在于：所述头部固定环(4)为管状；所述头部固定环(4)内壁底端与所述固定板(1)顶面平齐。The simple 3D printed batch mouse holder according to claim 1 is characterized in that: the head fixing ring (4) is tubular; and the bottom end of the inner wall of the head fixing ring (4) is flush with the top surface of the fixing plate (1).
  3. 根据权利要求1所述的简易的3D打印批量鼠固定器，其特征在于：所述头部固定环(4)靠近所述颈部固定孔(5)的一端上方开设有U形缺口(9)。The simple 3D printed batch mouse holder according to claim 1 is characterized in that a U-shaped notch (9) is provided above one end of the head fixing ring (4) close to the neck fixing hole (5).
  4. 根据权利要求1所述的简易的3D打印批量鼠固定器，其特征在于：所述颈部固定孔(5)为长条孔。The simple 3D printed batch mouse holder according to claim 1 is characterized in that the neck fixing hole (5) is a long hole.
  5. 根据权利要求1所述的简易的3D打印批量鼠固定器，其特征在于：所述躯干固定孔(6)为长条孔，成对的两所述躯干固定孔(6)之间从远离头部固定环(4)向靠近头部固定环(4)的方向距离逐渐减小。According to the simple 3D printed batch mouse holder according to claim 1, it is characterized in that: the trunk fixing hole (6) is a long hole, and the distance between the two pairs of trunk fixing holes (6) gradually decreases from away from the head fixing ring (4) to close to the head fixing ring (4).
  6. 根据权利要求1所述的简易的3D打印批量鼠固定器，其特征在于：所述固定板(1)下底面固接有若干支撑柱(8)，所述支撑柱(8)与所述固定柱(3)对应设置。According to the simple 3D printed batch mouse holder according to claim 1, it is characterized in that: a plurality of support columns (8) are fixedly connected to the bottom surface of the fixing plate (1), and the support columns (8) are arranged corresponding to the fixing columns (3).
  7. 根据权利要求1所述的简易的3D打印批量鼠固定器，其特征在于：所述固定板(1)为可拆卸结构，相邻两个固定区域(2)之间设置有卡接结构(10)进行卡接。The simple 3D printed batch mouse holder according to claim 1 is characterized in that: the fixing plate (1) is a detachable structure, and a clamping structure (10) is provided between two adjacent fixing areas (2) for clamping.
PCT/CN2022/140376 2022-12-20 2022-12-20 Simple 3d printing batch mouse fixator WO2024130548A1 (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107951586A (en) * 2017-11-21 2018-04-24 南宁市生润科技有限公司 A kind of semi-automatic hog auxiliary device
KR20190020081A (en) * 2016-07-21 2019-02-27 토쿠노리 타니우라 Animal fasteners
CN209864610U (en) * 2019-02-15 2019-12-31 苏州大学 Pathology are experimental with live body white mouse moxa-moxibustion mount
CN217611560U (en) * 2022-04-05 2022-10-21 周凤 Poultry animal doctor is with livestock fixing device
CN217853472U (en) * 2022-05-16 2022-11-22 中国人民解放军陆军军医大学第二附属医院 Adjustable fixing plate for mouse surgery

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190020081A (en) * 2016-07-21 2019-02-27 토쿠노리 타니우라 Animal fasteners
CN107951586A (en) * 2017-11-21 2018-04-24 南宁市生润科技有限公司 A kind of semi-automatic hog auxiliary device
CN209864610U (en) * 2019-02-15 2019-12-31 苏州大学 Pathology are experimental with live body white mouse moxa-moxibustion mount
CN217611560U (en) * 2022-04-05 2022-10-21 周凤 Poultry animal doctor is with livestock fixing device
CN217853472U (en) * 2022-05-16 2022-11-22 中国人民解放军陆军军医大学第二附属医院 Adjustable fixing plate for mouse surgery

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