WO2024114508A1 - Appareil pour stimuler électriquement un animal de type rongeur pour le traitement de la cystite interstitielle et dispositif porté par l'utilisateur - Google Patents

Appareil pour stimuler électriquement un animal de type rongeur pour le traitement de la cystite interstitielle et dispositif porté par l'utilisateur Download PDF

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Publication number
WO2024114508A1
WO2024114508A1 PCT/CN2023/133781 CN2023133781W WO2024114508A1 WO 2024114508 A1 WO2024114508 A1 WO 2024114508A1 CN 2023133781 W CN2023133781 W CN 2023133781W WO 2024114508 A1 WO2024114508 A1 WO 2024114508A1
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WO
WIPO (PCT)
Prior art keywords
animal
electrical
stimulation
controller
interstitial cystitis
Prior art date
Application number
PCT/CN2023/133781
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English (en)
Chinese (zh)
Inventor
李蕾
单筱淳
林子逸
纪树钦
Original Assignee
中国科学院深圳先进技术研究院
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Application filed by 中国科学院深圳先进技术研究院 filed Critical 中国科学院深圳先进技术研究院
Publication of WO2024114508A1 publication Critical patent/WO2024114508A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation

Definitions

  • the present invention belongs to the field of biomedical electronics technology and relates to a device and a wearable device for electrically stimulating rodents to treat interstitial cystitis.
  • Interstitial cystitis is a syndrome of unknown cause with clinical manifestations of frequent urination, urgency, nocturia, suprapubic and pelvic pain after bladder filling, and relief after urination. This disease brings great pain to patients and seriously reduces their quality of life. Since its etiology and pathogenesis are not clear at present, the diagnosis of interstitial cystitis mainly relies on clinical manifestations and exclusion method. At present, clinical treatment is mostly aimed at controlling symptoms. Although there are many treatment methods, there is no definite cure for drugs and methods. The epidemiological data on interstitial cystitis are extremely limited. However, from the analysis of existing data, interstitial cystitis may be one of the most often ignored and most confusing difficult diseases in urology. At present, oral medications may not be completely effective and carry a high risk of adverse side effects, leading to intolerance and frequent discontinuation of medication. Effective therapies that reduce side effects are needed.
  • systems and methods may include a wearable device having a conductive skin interface that excites underlying nerves via a transperitoneal stimulator.
  • the device may be sized for a range of user sizes, with stimulation electrodes positioned to target appropriate nerves, such as the saphenous nerve and/or the tibial nerve.
  • Stimulation may include short bursts of rapid pulse stimulation and involve receiving input regarding autonomic nervous system activity of a rodent and, based on the input, modifying a brain or spinal cord autonomic feedback loop related to bladder function to balance the parasympathetic and sympathetic nervous system activity of the rodent.
  • the existing technology has a large range of electrical stimulation and will affect surrounding non-target tissues; some experiments require animals to be anesthetized during electrical stimulation, which will have a certain impact on the animals and is not conducive to the conduct of subsequent experiments.
  • the purpose of the present invention is to overcome the shortcomings of the above-mentioned prior art and provide a device and a wearable device for electrically stimulating rodents to treat interstitial cystitis.
  • the device and the wearable device can avoid affecting surrounding non-target tissues, and at the same time, the animal does not need to be anesthetized during electrical stimulation.
  • the present invention adopts the following technical scheme:
  • the present invention provides an apparatus for electrically stimulating rodents to treat interstitial cystitis, comprising a controller, a first peripheral nerve effector for applying a first electrical nerve stimulation signal to the saphenous nerve of the animal, a second peripheral nerve effector for applying a second electrical nerve stimulation signal to the tibial nerve of the animal, and a power supply for providing electrical energy, wherein the controller is connected to the power supply, the first peripheral nerve effector, and the second peripheral nerve effector.
  • the device for treating interstitial cystitis in rodents with electrical stimulation according to the present invention is further improved in that:
  • It also includes a biomedical sensor for collecting feedback information of the animal, wherein the biomedical sensor is connected to the controller.
  • the first electrical nerve stimulation signal and the second electrical nerve stimulation signal are both short burst rapid pulse stimulation signals.
  • the frequency adjustment range of the first electrical nerve stimulation signal is 5Hz-30Hz;
  • the frequency adjustment range of the second electrical nerve stimulation signal is 10 Hz-20 Hz.
  • the first peripheral nerve effector comprises a first stimulating electrode sheet and a first patch, wherein the first stimulating electrode sheet is adhered to the electrical stimulation position of the animal via the first patch, and the first stimulating electrode sheet is connected to a controller.
  • the second peripheral nerve effector comprises a second stimulating electrode sheet and a second patch, wherein the second stimulating electrode sheet is adhered to the electrical stimulation position of the animal via the second patch, and the second stimulating electrode sheet is connected to the controller.
  • the first stimulation electrode sheet and the second stimulation electrode sheet are both hydrogel patches.
  • the present invention provides a wearable device, comprising a wearable component and the apparatus for electrically stimulating rodents to treat interstitial cystitis as described in the claim, wherein the wearable component is worn on the animal's body, the controller and the power supply are installed on the wearable component, and the first peripheral nerve effector and the second peripheral nerve effector are installed at the electrical stimulation position of the animal.
  • the wearable device of the present invention is further improved in that:
  • It also includes a display screen and a biomedical sensor for collecting feedback information from the animal, wherein the biomedical sensor is installed on the animal's body, the display screen is installed on the wearable component, and the display screen and the biomedical sensor are connected to the controller.
  • the device and wearable device for electrically stimulating rodents to treat interstitial cystitis described in the present invention when in specific operation, controls the first peripheral nerve effector and the second peripheral nerve effector through a controller to generate a first electrical nerve stimulation signal and a second electrical nerve stimulation signal, respectively, to apply electrical stimulation to the saphenous nerve and tibial nerve of the animal, avoiding effects on surrounding non-target tissues.
  • the present invention adopts a wearable method, and when in use, the wearable component is worn on the animal's body, and then electrical stimulation is applied to the animal. During the entire electrical stimulation process, the animal does not need to be anesthetized, avoiding adverse effects on subsequent experiments.
  • feedback information of electrical stimulation of the animal is collected through biomedical sensors, and the controller adjusts the parameters of the first electrical nerve stimulation signal and the second electrical nerve stimulation signal according to the feedback information to modify the brain or spinal cord autonomic feedback loop related to bladder function and balance the sympathetic and parasympathetic nerve activities to reduce the symptoms of interstitial cystitis.
  • FIG1 is a non-limiting structural diagram related to bladder function
  • Fig. 2 is a schematic diagram of the structure of the present invention.
  • FIG3 is a structural diagram of Embodiment 3.
  • FIG4 is a diagram showing the locations of Zusanli and Sanyinjiao in mice
  • FIG. 5 is a diagram showing the installation positions of the first peripheral nerve effector 1 and the second peripheral nerve effector 2 in the third embodiment.
  • 1 is the first peripheral nerve effector
  • 2 is the second peripheral nerve effector
  • 3 is the controller
  • 4 is the biomedical sensor
  • 5 is the display screen
  • 6 is the power supply.
  • the device for treating interstitial cystitis in rodents by electrical stimulation of the present invention comprises:
  • a second peripheral nerve effector 2 for applying a second electrical nerve stimulation signal to the tibial nerve of the animal
  • Biomedical sensor 4 used to collect feedback information from animals
  • a controller 3 is used to adjust and control the first peripheral nerve effector 1 and the second peripheral nerve effector 2 according to the feedback information of the animal to adjust the parameters of the first electrical nerve stimulation signal and the second electrical nerve stimulation signal to reduce the symptoms of interstitial cystitis by modifying the brain or spinal cord autonomic feedback loop related to bladder function and balancing the sympathetic and parasympathetic nerve activities, wherein the present invention is not configured for implantation in the animal, and the first electrical nerve stimulation signal and the second electrical nerve stimulation signal may both include short burst rapid pulse stimulation, wherein the short burst rapid pulse stimulation is ⁇ short burst rapid pulse stimulation, ⁇ short burst rapid pulse stimulation or ⁇ short burst rapid pulse stimulation.
  • the first peripheral nerve effector 1 delivers a first electrical nerve stimulation signal percutaneously to the saphenous nerve
  • the second peripheral nerve effector 2 delivers a second electrical nerve stimulation signal percutaneously to the tibial nerve
  • the first peripheral nerve effector 1 and the second peripheral nerve effector 2 are controlled by a controller 3 to adjust the frequencies of the first electrical nerve stimulation signal and the second electrical nerve stimulation signal, wherein the frequency adjustment range of the first electrical nerve stimulation signal is 5Hz-30Hz, and the frequency adjustment range of the second electrical nerve stimulation signal is 10Hz-20Hz
  • the feedback signal includes the autonomic nervous system activity of the rodent
  • the stimulation can be a short burst of rapid pulses (burst), offset, or alternation (alternating) between multiple nerves.
  • the first peripheral nerve effector 1 described in the present invention comprises a first stimulating electrode sheet and a first patch, wherein the first stimulating electrode sheet is bonded to the electrical stimulation position of the animal via the first patch, the first stimulating electrode sheet is connected to the controller 3, the first stimulating electrode sheet is bonded to the electrical stimulation position of the animal via the first patch, and the parameters of the first electrical nerve stimulation signal emitted by the first stimulating electrode sheet are controlled by the controller 3 to achieve stimulation of the saphenous nerve.
  • the controller 3 is connected to the first stimulating electrode sheet and the second stimulating electrode sheet via a wire.
  • the second peripheral nerve effector 2 includes a second stimulation electrode sheet and a second patch, wherein the second stimulation electrode sheet is bonded to the electrical stimulation position of the animal through the second patch, the second stimulation electrode sheet is connected to the controller 3, the second stimulation electrode sheet is bonded to the electrical stimulation position of the animal through the second patch, and the parameters of the second electrical nerve stimulation signal emitted by the second stimulation electrode sheet are controlled by the controller 3 to achieve stimulation of the tibial nerve, in addition, the present invention does not need to be implanted in the body of the animal, when not in use, the first patch and the second patch are directly removed, and the harm to the animal is small.
  • the first patch and the second patch can be hydrogel patches.
  • the present invention uses the first stimulation electrode sheet and the second stimulation electrode sheet to stimulate the animal, thereby reducing the stimulation of the surrounding non-target tissues by electrical stimulation, protecting the animal from injury, eliminating experimental interference, and reducing experimental operation errors.
  • the specific working process of the device for electrically stimulating rodents to treat interstitial cystitis of the present invention is as follows:
  • the controller 3 sends a first electrical nerve stimulation signal and a second electrical nerve stimulation signal to the saphenous nerve and the tibial nerve of the animal respectively through the first peripheral nerve effector 1 and the second peripheral nerve effector 2, stimulates the animal through the first electrical nerve stimulation signal and the second electrical nerve stimulation signal, and collects the feedback signal of the animal through the biomedical sensor 4, and then adjusts the parameters of the first electrical nerve stimulation signal and the second electrical nerve stimulation signal, such as the frequency, according to the feedback signal of the animal to balance the activities of the parasympathetic and sympathetic nervous systems of the animal, so as to better treat bladder-related symptoms in a targeted manner.
  • the wearable device described in the present invention includes a wearable component, the controller 3 and the power supply 6 are installed on the wearable component, and when working, the wearable component is worn on the animal body, and then the biomedical sensor 4, the first peripheral nerve effector 1 and the second peripheral nerve effector 2 are installed on the animal body.
  • the display screen 5 displays the frequencies of the first electrical nerve stimulation signal and the second electrical nerve stimulation signal, and displays the feedback information collected by the biomedical sensor 4.
  • the power source 6 is a battery
  • the display screen 5 is a flexible LED screen to meet the wearable requirements.
  • the present invention is applied to mice, and the first peripheral nerve effector 1 and the second peripheral nerve effector 2 are placed below the knee and/or above the ankle of the mouse to stimulate the saphenous nerve and/or tibial nerve of the mouse.
  • the acupuncture points (acupuncture points) stimulated are Zusanli and Sanyinjiao, as shown in Figures 3, 4 and 5.
  • the present invention can safely separate the acupuncture points and surrounding non-acupuncture point tissues, has little effect on non-acupuncture point tissues, and can perform electrical acupuncture point stimulation while the mouse is active. After a period of electrical stimulation treatment (about 20 minutes), the mouse did not show any shedding of the wearing parts or other adverse damage symptoms, and the quality of the final experimental data was not lower than that of the data obtained using the prior art.

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Rehabilitation Therapy (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Electrotherapy Devices (AREA)

Abstract

Sont ici divulgué un appareil de stimulation électrique destiné à un animal de type rongeur pour le traitement de la cystite interstitielle et un dispositif porté par l'utilisateur. L'appareil comprend un dispositif de commande, un premier effecteur des nerfs périphériques pour appliquer un premier signal électrique de stimulation nerveuse à un nerf saphène interne de l'animal, un second effecteur des nerfs périphériques pour appliquer un second signal électrique de stimulation nerveuse à un nerf tibial de l'animal, et une alimentation électrique pour fournir de l'énergie électrique. Le dispositif de commande est connecté à l'alimentation électrique, au premier effecteur des nerfs périphériques et au second effecteur des nerfs périphériques. Le dispositif porté par l'utilisateur comprend une partie de protection et l'appareil de stimulation électriquement d'un animal de type rongeur pour le traitement de la cystite interstitielle selon les revendications. La partie de protection est portée sur le corps de l'animal. Le dispositif de commande et l'alimentation électrique sont montés sur la partie de protection. Le premier effecteur des nerfs périphériques et le second effecteur des nerfs périphériques sont montés au niveau de positions de stimulation électrique de l'animal. Selon la présente invention, des influences sur des tissus non-cibles environnants peuvent être évitées, et il n'est pas nécessaire d'anesthésier l'animal pendant une stimulation électrique.
PCT/CN2023/133781 2022-11-28 2023-11-23 Appareil pour stimuler électriquement un animal de type rongeur pour le traitement de la cystite interstitielle et dispositif porté par l'utilisateur WO2024114508A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202211505265.8 2022-11-28
CN202211505265.8A CN115779269A (zh) 2022-11-28 2022-11-28 电刺激啮齿类动物治疗间质性膀胱炎的装置及可穿戴设备

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WO2024114508A1 true WO2024114508A1 (fr) 2024-06-06

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WO (1) WO2024114508A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115779269A (zh) * 2022-11-28 2023-03-14 中国科学院深圳先进技术研究院 电刺激啮齿类动物治疗间质性膀胱炎的装置及可穿戴设备

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170056653A1 (en) * 2013-10-09 2017-03-02 GiMer Medical Co., Ltd. Method for reducing overactive bladder syndrome and computer-readable medium thereof
US20170281938A1 (en) * 2015-02-21 2017-10-05 Neurostim Solutions LLC Topical Nerve Stimulator and Sensor for Bladder Control
CN108778411A (zh) * 2016-01-21 2018-11-09 卡拉健康公司 用来治疗与膀胱过动症相关的疾病的用于外周神经调制的系统、方法和装置
US10363414B1 (en) * 2018-04-12 2019-07-30 Feinstein Patents, Llc Combined bladder scanner and (functional) interferential electrical stimulation device
CN110809486A (zh) * 2017-04-03 2020-02-18 卡拉健康公司 用于治疗与膀胱过度活动症相关的疾病的周围神经调节系统、方法和装置
US20210252278A1 (en) * 2018-01-17 2021-08-19 Cala Health, Inc. Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation
CN113784748A (zh) * 2019-03-08 2021-12-10 卡拉健康公司 利用节律生物过程治疗疾病的可穿戴周围神经刺激
CN115779269A (zh) * 2022-11-28 2023-03-14 中国科学院深圳先进技术研究院 电刺激啮齿类动物治疗间质性膀胱炎的装置及可穿戴设备

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170056653A1 (en) * 2013-10-09 2017-03-02 GiMer Medical Co., Ltd. Method for reducing overactive bladder syndrome and computer-readable medium thereof
US20170281938A1 (en) * 2015-02-21 2017-10-05 Neurostim Solutions LLC Topical Nerve Stimulator and Sensor for Bladder Control
CN108778411A (zh) * 2016-01-21 2018-11-09 卡拉健康公司 用来治疗与膀胱过动症相关的疾病的用于外周神经调制的系统、方法和装置
CN110809486A (zh) * 2017-04-03 2020-02-18 卡拉健康公司 用于治疗与膀胱过度活动症相关的疾病的周围神经调节系统、方法和装置
US20210252278A1 (en) * 2018-01-17 2021-08-19 Cala Health, Inc. Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation
US10363414B1 (en) * 2018-04-12 2019-07-30 Feinstein Patents, Llc Combined bladder scanner and (functional) interferential electrical stimulation device
CN113784748A (zh) * 2019-03-08 2021-12-10 卡拉健康公司 利用节律生物过程治疗疾病的可穿戴周围神经刺激
CN115779269A (zh) * 2022-11-28 2023-03-14 中国科学院深圳先进技术研究院 电刺激啮齿类动物治疗间质性膀胱炎的装置及可穿戴设备

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