WO2024113032A1 - Système de libération et d'administration de médicaments dirigés vers un tissu cible spécifique par utilisation d'une matrice multifonctionnelle de nanoparticules magnétiques et application destinée à des plateformes et des dispositifs endovasculaires et intraorganiques constitués de graphène - Google Patents
Système de libération et d'administration de médicaments dirigés vers un tissu cible spécifique par utilisation d'une matrice multifonctionnelle de nanoparticules magnétiques et application destinée à des plateformes et des dispositifs endovasculaires et intraorganiques constitués de graphène Download PDFInfo
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- WO2024113032A1 WO2024113032A1 PCT/BR2023/050425 BR2023050425W WO2024113032A1 WO 2024113032 A1 WO2024113032 A1 WO 2024113032A1 BR 2023050425 W BR2023050425 W BR 2023050425W WO 2024113032 A1 WO2024113032 A1 WO 2024113032A1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
Definitions
- cenamene “er e seu asssene,uns, e moeo exerremceannaazaarnamm”aumeanauranroareaaczaavoacua areroraa aomna.ase uma caa am uma,nreasruenz reazou armera as, em coronraransumnaercunea noasa v,ncano umarane revorao emacene oena coronr ouo noraamenoa o caazerraa.
- Aosesrameorromsa neserevenconosaesoecmumsanoeraauua eue crrcaeron ourane a reazaoema rocemenos. aonusa enuaonmases and meromaoveneoxoanroeaomarazue srua-eneoeromaoseaonasanue, aua e remoeameno vascuar n sases enomnao rerao esca araea evo aro, monma.seanoumna nca nsucerasa reesenoserouzam umaeraua ene e a cnco naaxae a osse beginning success months ago.
- encae conserve ora raa, axa raoacae uoroscoa, eom nravzeo e ocoma ae,ara cer carue occur ve axase erasa neonma eromosen axas urane o seumeno cnco e onor ra-senana, chromo-coao or or azo.
- maosvsanenasemarmsaocore have sewn conventions concerning the sens raations ranomz andsoa reesenosis.
- ros sueros and resrosavamemonsrao a armacoraceos a seuna era os sens reesenosis c sonrceaoesasnenosrconcvae, nccoomnaasxansomueane nova revascuarzaes e ev enorese sen, mas maneno enos e romose nracncoseme comarves axas e resuaos mocro esonrmnoesoencese o enaroo mu cnrcos.
- amenzn u cau a mea- aaaouano in a rsco increase aus ae m an se, emonsrano romose a ores enaro auo aene anro eravo e a romose aus ae à revesmenoomrco. Reconnect with each other, even though it feels like a coma when used in a rare cosermeraeration, an event that doesn't add up to your life's work and the occurrence.
- aaormao mo caaar ensarmaco cos the mother case, coao-croa cons unes in the uas rocavam the rocavam or ano-chrome, the aces and maor and uo with less thickness and the new ox ae.memorized conuations as if mocuas with maor ocoma ae, armaco zcoaaromumsus,,ervoerocamnusouemanovmoasmurs aaeamu ao enacsounseeruecneemeonseeunma.masseurreacnocaecoeruraenoea eraoe sensarmaco cos e eccaa seuna numeros cncos rm so consaaas in sn cavas reue anomzaos, emonsrano rocemeno, as only in the events cncos s
- um ma vezue oomero no ae only como concarroreaaaoreso e cromnacon,uammaesnea,mommeoseunaanoa erao sem armaco com noomrco vvovmenoe um nova enooa ara man eo a reuerer um era o aene anerro humeraaeuao nve e neermnao, no voivo un razo recen son ae e seumero como vecuo .
- Ens me co en convencona visse omeros oerav s coneno um no camaae oem vr a rere es aumnasouorossoas enseanrar um aernava mas suara.
- enomnaas and ro amene oasorvves eses vos sevneema armacoeracoo maermacococearmanoecnaeenoossuroreo twelve months and the reasoro begins mere rocano the restoration in months, a vasomooraur roumna norm e a uauer res ane anos, aravsa removale arosesavourovees, ma eeraa coaeanzcaemecnaue sarreeuvzenos necessaee manuenoaeraaua an ra oronorazo ,erm not to ncurses auera if necessary.
- rmros com ao esao a are eve seu esare anurco,vu reaereoncaaaenonareaseenreecur.so.raeo a.nos.ma,seare.,,or cmuenoorazaeroenaoamenaoeneu-sers ..
- the reesenosis as the coocaoo sen ana seazaresene in enseroves levels, in the ose a, osraava the vos with mecncasues comroreaes mecncasue revearscaumarzaroocar flow begins meao s-roc, and with the success anor with mnu or the sucesmeno, orm aonorazo ,ava vascuar, in so cnco, evo reesenose sos vos sommencese - naueeeroo.as face and hands were raised like an ascersca esca,os noneraam, mo cano serraorosesaveescoamaareoeovcaascuaeraroeaas,a,ao ouesomene esaas no conroe the process emomeno,
- mmamm resuaosesavorveorreor aonorazoe esuo os conssomeoremreoesarese arovaoo Usoesareao o reerencaara a orm o sine rec sectiono nore-amercano, os only aus enemene rerao commercialcamene cosamm esavacavaeaxo nvee venas.
- the roreaes the marcesos sensorialenoasases oam to be omecraas with the dog and coherence the rro osoroco carries the susanca as the cone, in the en ovso, with caroneo and the ecuae carono-amane and the gold.
- ceou a ser mo caaara uma ares cao sen oros e – micromeros, senenoaoorosa anro eravo reamene eosao neso aene urane arouo e coreo sen.oe es oros caso esec co, a eraoo rma nano, nese e ser conroaa e aunsouc co era muo c conroaç ⁇ es noemo os esuos ranomzaos none om nsraramnerorae, masamm comarao za ⁇ o nos resuaos uano armacoscos.
- nvesecrescenes no sen oaase man cas semas e erao or nanoarcuas eroerama.n,camenoesn anrouzos na caae na ma aner, ,orm, ormuaes mcaana,coasncerreesscseeuaermaasaeroaaevavoo aeo measesnvaovamseonosceamaoeermasrmmuaansmacos masoenes in asunes, so, maerasnecasoaase maerasrocam to comna ranscos.
- suerara a caes only be craas ar comeene oeraves, ue, so vsuazaaavse esec coesn. me ca, what s in maens and maem ressonnca, r roca eecar, sensorameno, eses ueczaonnaomenaomeasomaecnanoo-aarvocuea.rasamaenouea craeaecomeoaeerranrsamcoas.
- rosruoseesusaores daughters-in-law and no nxaneoraorrcuvaesmuncesoennavozvaenasouemmoeoasmaaarear er roenase succeeds in its structure, not in connection with human asthma, uano meem o reconameno ormano coronas ue neresse, ame reuesasarcuass cuase ssema.
- sa auosa soeneaas emares ormae ves es are esruuras ocomaves em encasuar aecnueasseeramuenscoosnsaonomversceam, usuaaaseareao avroos seoveossseomveusa.soencoorrmoaraouse, emnumraeceanmaesa auoossasovees soossonmcaosromraanossecmosumaecrmacos avos osomas lame.eramen amaa cae maneoossomas: uma e, uas escese auosa, e conenoxose mea na camaa en nuano oura conssno emxose mea avuereooaoessem cama
- escaorereme rsucsosoesroo,rasmesremanaososancoems,ouoeeo roaernaoenoumserosesemsecooerreso, coancrueoreasva-sexsenes.nes is a maera mensonaeonoe in case a maeraosse sees cancer, or sea, be “escao”, if aeramene mensona ao orenaosea uosrmaomos fell dwarves and exsnca.ssm,arnue no seraossve sua raeno orae “escaoo” ,it is the sca, the emo as a micro unconouor muo ormaoorversas camasco eernco.
- rae ormaoe come ase carono, oranzaas in oranzaaesa oraeno, uma camaa smes e rorea ses caronos.ssm, oraenoossu car es muoarcuares: comosooromose resosnoe,nesu,eaesmaeeecseemrermeaonsesconuumocrasexremamene eercae.
- orcerxomoavos muame cor ao ser emeraura,uz,ermesso,o eacu.maoeeeemrmnaasaovaurazoae em seores como o dog, enre ou os ro ⁇ raeeareassnamarneeseonrraeoecoso u:s. m cmao cam sua uamene, so u zaos,or e mo lame.
- Raa is a unique aaorma, with reinforcement and space and marz o cae era ⁇ o and ococmos burdensome.
- se rvo em um marz e ave cons uno um “coan” coerura e srao emoa a suerce exerorasaseso asos voro co em s,uer sea, emornoas oeso sen, eu e aresena auno e eu e ncmoorocruaaso e em snuansoanrcacsuasummacans, caasravs e su era, com roreaes an-aeero um moo anro eravas, anrocas, anu ncas, reesruuraorasaaree va moxcas ee storagemen scuar,rocano aunormacos,
- naonoerarsecruaaseaconra uer number men and mecaes, ae eno essaanoue acros ones to diamonds.
- caa camaaammncae erao eseccae um dog oe ser conroaa ruaramaaor aareamoo cemaunar, cocueaxevranro, a aocoeaoneonu no em um eermnao comrmenoe ona r sae oue eraoe nanoarcuas.
- a caeer ao esa ora aeauaao cea nsuao o cao ao, oro va aeerue envove oua
- a aase na eaosrom cos aree vascuar, nonuoe c regeneration and continuous recovery on onerr aoraemoa nsuccess cnoco and conroeos evenose vascuar,an ae anorco as omaneo without cocuerroureaonaormarcazos.
- aroreae erm no su manuuas que son cas cas, man co exerno.e ao aravs e um camo oeecnooaesaorma, a usa a caoese na aua monstrase comoenca sru vo mosas, caomoraosesm muge enorrmaeameexnaonsoearvaruas versaeereasa mecna.
- venr oaaesrcrooc onnaos sua maa, ano na, como narmacona e emonsrano o aro reerenca rnca am, eomrcao oeoesee o, um se reveaa esruura em coresnnerruose a um e osano, coneno caa unaes emorma nernas caa, sosas unae uas su vses os aos croaxes in the same sen oe reoe sos oaera.
- ss corese oremar are anoas in os en oe reo in reaction to the same unations coanunuasaresaxraesresernnacvaass oeurenmceanrees ao cores amm, aso o esaca,orm s, as well as hunting squeezing the skin and mensoas to the vertices strains and resnernas, and coaao colors and shallow unaeserencenes to the waters to pray, they will all have the same ring in their anerores.
- rersa xe aaorma in nve aroxmao and aroxm aa in nve mas s ao e a emonsravs a.
- a ma a eem maannomasaersecvas enovascuar au escra, , aaorma hollow aroxmaoo semen a aorma em , e or m,o meermanoa aaorma em s, ersecvar mensona a n ⁇ o a vsuazao enovascuar,, a uznernaaaaorma mas sa arra sua seuna meae aora ersecvass .
- ersec ovamene in a vas esacas seuencas, in a hollow but coroexrmuarao, aarmacaoaorcmaaeneovansacnuoaaracomanaaa and its unconazaas, in ersec rcuas man houses ases, as in , evma meas aroxmaa as esaca the camaase nanoar ae, alone the ses areenam and cuasunconazaas.
- caa oe mecamm sos o orenaa in reaction to his era in the aeno u zao comoransore a camaas se ree ceuar avo, aruaos em e uencas, some sore ouras.
- n ncameneo,r umm, as e emonsram, sore aersecvaanenca e oservao mmaan cas,coerura,ar emaucmo execmaareenannaonoararcucuasa en mocuaamuo uenccoanraa,eenxcaosuarmrencoo,aescasases nseroe rmacos eon rse,reesec oerura, unconazao, conorme nonauoanao e an.es aresenaaes maosoemas esec co , waxes reerncas are uas usram uumar,mem reactions and, as aaorma enova oa ae reerença and a rae scuar, cons uaunamenamenee nranou, ou sos vo ro
- s es reresenavas the reo in reaction as or anoas inorma, otherwise they reresenavaserencen meessmaasosuncoraeesscounoassanuaxaraess esarcnac, to the srmoauomearesm, enasssomacsomoacmam, aa alone or the sanuares nernas, these structures coerate the unity and coercion to the verices oreemroraers, serenenes to the cores and an.
- aao eunaaoe comreaaenoa, rr section vsoer amene, na , reresenano uma , emesrsececva oa a aorma , e no sen. go but aroxmaa nooraroxma as camaas eraz o mooe sos o esaca unconazaas s nanoarcuas man cas .
- camaas and nanoarcuas ma. only avo vrosruamenose nano ra,uer sea, varao em arcuas coneno a number these ecaes, aeros one to the other.
- aaorma enov nm a aresenao beginsa rnca mo ascuar au reresenaaea sua e roas ae, sen armaco co com erao uncona aravs e nanoarcuas man cas, marzzaaos, mcoasraoncoomsaeuve “coeamnue”soeucoennsvouro ssreecmaonaoes aeecrao-oavoe esenecreaco,earamvescameno os esa mar z mu uncona and nanoarc the use .
- soso emoa suerce exe uas man cas sos vora co em s,uer serorasaseso aseso sen, comooe ser a, emornoas ue aresena aunoe eu nooaeo nao, e susncasumcas, aravse s, mocuase roreaes a-aeroncas, aueas com anrocas e an umoxca an ro eravas, reesruuraorasaaree s, como amm and store vascuar, rocano auno rmacos, armeanzeon, asousoereareusaacosaneessmaus nanoeraoe man cas unconazaas,ara a arcuas aree arera, and comone vo em camaasa rmra
- moecuaromen ao nanoecnooa e ooa romssorareaoue oes suppliesnav:oavnmaennooonuemcanoeomera.ene e se o, as nanoarcuas man cas son ese enamene esves que ar nanoeras conroaa, ossuem e senam em less eons exe aacaeara sorerem manuao e aenese cronnasr,aseersoouzuesmo meeroersasmoennnoccomouno ormaem.omo resuao, these a man ca aresenar vras a cae nanoarcuasoem mecna, ncunour sano na ooa como na ermacos, e maen caoeroen
- the nanoarches are unconstant and oerecer vanaens ruaens,sc asa sernee amsconomuacaass.com dwarfs, anchors, exem an acoamennoo aaramceunaessmea envocas nooecunco-oanavos.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne le développement d'un système de libération pharmacologique pour des tissus organiques spécifiques de cibles, par utilisation de nanoparticules magnétiques multifonctionnelles, une matrice biocompatible couplée sous forme de couche à une plateforme endovasculaire, moulée essentiellement dans du graphène étant constituée. Les nanoparticules magnétiques sont utiles dans des applications industrielles et biomédicales en raison de leur degré élevé de biocompatibilité, de leur facilité de modification de la surface et de leurs propriétés magnétiques. Le ciblage des médicaments sur des tissus cibles par le biais de nanoparticules magnétiques se produit fréquemment par reconnaissance chimique. Les nanoparticules d'oxyde de fer présentent une utilisation de référence, elles peuvent être visualisées sur des images de résonance magnétique, permettant de détecter, mesurer, évaluer par image, cibler et traiter la région affectée avec une seule nanoparticule.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR102022024677-7A BR102022024677A2 (pt) | 2022-12-01 | Sistema de liberação e entrega de medicamentos direcionados a tecido-alvo específico através do uso de matriz multifuncional de nanopartículas magnéticas e aplicação destinada a plataformas e dispositivos endovasculares e intraorgânicos constituídos por grafeno | |
| BR1020220246777 | 2022-12-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2024113032A1 true WO2024113032A1 (fr) | 2024-06-06 |
Family
ID=91322547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/BR2023/050425 WO2024113032A1 (fr) | 2022-12-01 | 2023-12-01 | Système de libération et d'administration de médicaments dirigés vers un tissu cible spécifique par utilisation d'une matrice multifonctionnelle de nanoparticules magnétiques et application destinée à des plateformes et des dispositifs endovasculaires et intraorganiques constitués de graphène |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2024113032A1 (fr) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004069169A2 (fr) * | 2003-01-31 | 2004-08-19 | Scimed Life Systems, Inc. | Distribution localisee d'un medicament au moyen de nanocapsules chargees de medicament |
| EP2974699A1 (fr) * | 2003-04-16 | 2016-01-20 | The Children's Hospital of Philadelphia | Stents contrôlables magnétiquement d'administration de médicaments et de gènes |
| BR102016012105A2 (pt) * | 2016-05-27 | 2017-12-12 | Dias Maués Christiane | Cylindrical tubular protective device; and protetic device with biological support matrix for drug release; with or without polymers |
| BR102020019674A2 (pt) * | 2020-09-27 | 2022-04-12 | Christiane Dias Maués | Dispositivo protético tubular cilíndrico; e dispositivo protético com matriz biológica não-polimérica de suporte para liberação de fármacos, induzida por microchip e nanossensores de operabilidade e monitoramento remotos |
-
2023
- 2023-12-01 WO PCT/BR2023/050425 patent/WO2024113032A1/fr unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004069169A2 (fr) * | 2003-01-31 | 2004-08-19 | Scimed Life Systems, Inc. | Distribution localisee d'un medicament au moyen de nanocapsules chargees de medicament |
| EP2974699A1 (fr) * | 2003-04-16 | 2016-01-20 | The Children's Hospital of Philadelphia | Stents contrôlables magnétiquement d'administration de médicaments et de gènes |
| BR102016012105A2 (pt) * | 2016-05-27 | 2017-12-12 | Dias Maués Christiane | Cylindrical tubular protective device; and protetic device with biological support matrix for drug release; with or without polymers |
| BR102020019674A2 (pt) * | 2020-09-27 | 2022-04-12 | Christiane Dias Maués | Dispositivo protético tubular cilíndrico; e dispositivo protético com matriz biológica não-polimérica de suporte para liberação de fármacos, induzida por microchip e nanossensores de operabilidade e monitoramento remotos |
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