WO2024094837A1 - Medical infusion device system having a dosing range extension - Google Patents

Medical infusion device system having a dosing range extension Download PDF

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Publication number
WO2024094837A1
WO2024094837A1 PCT/EP2023/080642 EP2023080642W WO2024094837A1 WO 2024094837 A1 WO2024094837 A1 WO 2024094837A1 EP 2023080642 W EP2023080642 W EP 2023080642W WO 2024094837 A1 WO2024094837 A1 WO 2024094837A1
Authority
WO
WIPO (PCT)
Prior art keywords
dosing
dosing chamber
amount
liquid medicament
minimum
Prior art date
Application number
PCT/EP2023/080642
Other languages
French (fr)
Inventor
Harald VON CAMPENHAUSEN
Original Assignee
F. Hoffmann-La Roche Ag
Roche Diabetes Care Gmbh
Roche Diabetes Care, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag, Roche Diabetes Care Gmbh, Roche Diabetes Care, Inc. filed Critical F. Hoffmann-La Roche Ag
Publication of WO2024094837A1 publication Critical patent/WO2024094837A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16827—Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407—Infusion of two or more substances
    • A61M5/1408—Infusion of two or more substances in parallel, e.g. manifolds, sequencing valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing

Definitions

  • the present invention relates to a medical infusion device system comprising a first dosing chamber that is configured for delivering one or more times of a first minimum dosing amount of a liquid medicament, a second dosing chamber that is configured for delivering one or more times of a second minimum dosing amount of the liquid medicament, a fluid line that is operatively coupled to the first dosing chamber and the second dosing chamber for conveying a total amount of liquid medicament for delivering by the first and second dosing chamber to an outlet of the fluid line, and a controller that is configured to control the total amount of liquid medicament for delivering via the fluid line by operating the first dosing chamber and the second dosing chamber.
  • Hitherto known medical infusion device systems are used for administering a liquid medicament to a user.
  • the liquid medicament is intended to improve the patient’s health condition.
  • liquid medicament is dispensed by the first dosing chamber and the second dosing chamber.
  • the at least first minimum dosing amount provided by the first dosing chamber and the at least second minimum dosing amount provided by the second dosing chamber together form the total amount of liquid medicament.
  • Operation of the first dosing chamber and operation of the second dosing chamber is controlled by the controller.
  • the first dosing chamber and the second dosing chamber are operated with the same type of liquid medicament.
  • the overall dosing accuracy of a hitherto known medical infusion system is based on the dosing accuracy of the first dosing chamber and the dosing accuracy of the second dosing chamber. Care has to be taken that the total dosing amount does not result in an overdosing or an underdosing of the liquid medicament.
  • a deviation in the delivered amount of liquid medicament is significant for the overall dosing amount. For example, due to individual needs and metabolism characteristics, different user’s of the known medical infusion device systems may have different needs with respect to dosages.
  • a medical infusion device system comprises a first dosing chamber that is configured for delivering one or more of a first minimum dosing amount of a liquid medicament, a second dosing chamber that is configured for delivering one or more of a second minimum dosing amount of the liquid medicament, a fluid line that is operatively coupled to the first dosing chamber and the second dosing chamber for conveying a total amount of liquid medicament for delivering by the first dosing chamber and second dosing chamber to an outlet of the fluid line, and a controller that is configured to control operation of the first dosing chamber and the second dosing chamber for providing the total amount of liquid medicament via the fluid line, wherein the second minimum dosing amount of the liquid medicament provided by the second dosing chamber is larger than the first minimum dosing amount of the liquid medicament provided by the first dosing chamber.
  • the first minimum dosing amount and the second minimum dosing amount are inherent parameters of the first dosing chamber and the second dosing chamber, respectively.
  • the first minimum dosing amount and the second minimum dosing amount are determined by the underlying constructions, mechanisms and electronics of the first dosing chamber and the second dosing chamber, respectively, as well as any further component of the medical infusion device system needed for delivering a dosage of liquid medicament by operating the first dosing chamber and the second dosing chamber, respectively.
  • the respective minimum dosing amount of the first dosing chamber and the second dosing chamber equals the minimal volume that is conveyed by the first dosing chamber or the second chamber, respectively, into ambient air, i.e.
  • the first minimum dosing amount and the second minimum dosing amount cannot be further reduced by separately operating the first dosing chamber and the second dosing chamber, i.e., the first minimum dosing amount and the second minimum dosing amount is the respective minimal amount that can be repeatedly delivered by operating the first dosing chamber and the second dosing chamber, respectively, with a standard deviation of ⁇ 5% in the setting of the medical infusion device.
  • the first minimum dosing amount is the smallest possible volume that can be delivered by operating the first dosing chamber.
  • the second minimum dosing amount is the smallest possible volume that can be delivered by operating the second dosing chamber.
  • the first minimum dosing amount and the second minimum dosing amount together are used to form the total amount of liquid medicament that is conveyed through the outlet of the fluid line of the medical infusion device system, the first minimum dosing amount and the second minimum dosing amount can be used to alter the total amount of liquid medicament which can then be delivered via the fluid line.
  • the first minimum dosing amount can be added to the second minimum dosing amount, and vice versa. I.e. the second minimum dosing amount can also be added to the first minimum dosing amount.
  • a large amount of more than just one or more of the second minimum dosing amount or just one or more of the first minimum dosing amount, respectively, can be administered so that the total dosing amount can be extended by using both, the first dosing chamber and the second dosing chamber.
  • the total amount of the liquid medicament to be administered into multiple amounts of the first minimum dosing amount and the second minimum dosing amount, it is possible to take advantage of the respective accuracies of the first dosing chamber and the second dosing chamber so to provide a total amount of liquid medicament with a high accuracy.
  • the first minimum dosing amount and the second minimum dosing amount are of different volume, wherein the second minimum dosing amount is larger than the first minimum dosing amount, i.e., the first dosing amount is smaller than the second minimum dosing amount.
  • a relatively large volume can be delivered to a user of the medical infusion device system by delivering one or multiple times of the second minimum dosing amount.
  • Providing the relatively large volume by delivering one or multiple times of the second minimum dosing amount is faster than providing said relatively large volume by a respectively higher times of delivery by the first dosing amount.
  • a total volume can be delivered by providing a relatively large volume by actuating the second dosing chamber, and a relatively small volume by actuating the first dosing chamber.
  • the total volume delivered can advantageously be expanded beyond the maximum volume that can be delivered by the second dosing chamber by simultaneously delivering volume from the first dosing chamber and from the second dosing chamber.
  • a controller is an electro-technical component that is configured for controlling actuation of the first dosing chamber and the second dosing chamber.
  • the controller can be a microprocessor.
  • “Operatively coupled” refers to a configuration of the medical device system in which the fluid line is in fluid communication with the first dosing chamber and the second dosing chamber, so that liquid medicament from the first dosing chamber and/or the second dosing chamber can flow out of the respective dosing chamber through the outlet.
  • the outlet of the fluid line can be formed by or operatively coupled to a cannula or an infusion set.
  • the coupling can be irreversible or reversible, preferably reversible.
  • the cannula can be a steel cannula or a soft cannula, preferably a soft cannula.
  • the medical infusion device system can comprise an infusion pump having the first dosing chamber, the second dosing chamber, the fluid line, and the controller.
  • the controller can be located inside the infusion pump or it can be a separate device such as a remote controller communicatively connected to the infusion pump.
  • the remote controller can be a mobile device or a personal computer.
  • the infusion pump can be a patch pump, i.e. a bodywearable pump comprising an adhesive layer for temporarily adhering the body-wearable pump to a patient’s body.
  • the liquid medicament can be any kind of infusible medicament.
  • the liquid medicament can be insulin or glucagon.
  • the controller is configured to simultaneously operate the first dosing chamber and the second dosing chamber for transferring liquid medicament in the amount equal to one or more of the first minimum dosing amount to the second dosing chamber and/or for transferring liquid medicament in the amount equal to one or more of the second minimum dosing amount to the first dosing chamber.
  • the controller cannot only control operation of the first dosing chamber and the second dosing chamber to deliver liquid medicament through the outlet of the fluid line, but can also control simultaneous operation of the first dosing chamber and the second dosing chamber in order to transfer liquid medicament from one of the first dosing chamber or the second dosing chamber into the respective other one of the first dosing chamber or the second dosing chamber.
  • the one or more times of the minimum first dosing amount can be transferred from the first dosing chamber into the second dosing chamber, and vice versa.
  • one or more times of the minimum second dosing amount can be transferred from the second dosing chamber into the first dosing chamber, and vice versa.
  • the controller can advantageously be used to balance the filling level within the first dosing chamber and the second dosing chamber.
  • This transfer of liquid to the first dosing chamber can be of advantage if for certain patients, such as a patient with a low body weight such as a child, usually a very small amount of the liquid medicament is to be delivered and which small amount is below the minimum dosing amount that can be delivered by the second dosing chamber.
  • the replenishing of the first dosing chamber thus expands the total volume of the liquid medicament that can be delivered by the first dosing chamber at a dosing amount below the minimum dosing amount of the second dosing chamber but beyond the total volume of the first dosing chamber.
  • liquid medicament can be first transferred from the first dosing chamber into the second dosing chamber.
  • a relatively large amount can be delivered through the outlet of the fluid line by controlling operation of the second dosing chamber, only.
  • the delivering speed of the first dosing chamber and the second dosing chamber can be used more beneficially than providing a relatively larger amount of liquid medicament by controlling operation of the first dosing chamber, which may took longerthan when using the second dosing chamber.
  • the controller is configured to control simultaneous operation of the first dosing chamber and the second dosing chamber for delivering the total amount of liquid medicament via the fluid line and through the outlet, wherein the total amount of liquid medicament is equal to the sum or difference of one or more multiple times of the first minimum dosing amount of liquid medicament and one or more multiple times of the second minimum dosing amount of liquid medicament, wherein the total amount of liquid medicament conveyed to the outlet is equal to or larger zero.
  • the first dosing amount or a multiple thereof can be transferred into the second dosing chamber, or at least the second dosing amount or a multiple thereof can be transferred into the first dosing chamber.
  • the first minimum dosing amount or a multiple thereof can be deducted from the second minimum dosing amount, or vice versa. I.e. the second minimum dosing amount or a multiple thereof can be deducted from the first minimum dosing amount.
  • the total amount of liquid medicament provided by controlling the first dosing chamber and the second dosing chamber can be a sum of the first minimum dosing amount or multiple thereof and the second minimum dosing amount or a multiple thereof; or the total amount of liquid medicament provided by simultaneously operating the first dosing chamber and the second dosing chamber can be a difference of one or more times of the first minimum dosing amount and one or more times of the second minimum dosing amount.
  • the total amount of liquid medicament should not be a negative amount, which could result in liquid medicament and/or bodily fluids to be withdrawn from a patient into the outlet.
  • the dosing accuracy has no effect on the dosing as provided by the medical infusion device system.
  • the transfer of liquid medicament from one dosing chamber to another dosing chamber helps a user to adapt the configuration of the medical infusion device system to its personal needs. For instance, a user who often administered small amounts of liquid medicament will likely have a higher need for replenish the first dosing chamber.
  • the controller is configured to control operation of the first dosing chamber and the second dosing chamber for providing the total amount of liquid medicament via the fluid line, wherein the total amount of liquid medicament is equal to or larger than zero.
  • This safety mechanism is associated with the advantage to avoid that a liquid enters the outlet or the fluid line.
  • the medical infusion device system comprises a sensor that is configured for detecting a negative pressure in the outlet, wherein the sensor is operatively connected to the controller to prevent liquid medicament from flowing through the outlet into the first dosing chamber and/or the second dosing chamber.
  • the medical infusion device system can comprise a check valve that prevents liquid medicament from flowing through the outlet into the first dosing chamber and/or the second dosing chamber.
  • the first dosing chamber is operatively coupled to a first drive mechanism for actuating the first dosing chamber, and in that the second dosing chamber is operatively coupled to a second drive mechanism for actuating the second dosing chamber, wherein the controller is configured to control operation of the first drive mechanism and the second drive mechanism.
  • Operation of the first drive mechanism can be controlled by the controller to dispense liquid medicament out of the first dosing chamber or to admit liquid medicament to the first dosing chamber.
  • operation of the second drive mechanism can be controlled by the controller to dispense liquid medicament out of the second dosing chamber or to admit liquid medicament to the second dosing chamber.
  • first drive mechanism is operatively coupled to the first dosing chamber and the second drive mechanism is operatively coupled to the second dosing chamber
  • controlling operation of the first drive mechanism and the second drive mechanism also controls operation of the first dosing chamber and second dosing chamber, and thus, the total amount of liquid medicament flowing through the fluid line.
  • “Operatively coupled” in this context means that the drive mechanism is configured to effect discharging or charging of liquid medicament out or into, respectively, in the respective dosing chamber.
  • the first dosing chamber is a first reservoir that is configured for containing the liquid medicament
  • the first dosing chamber comprises a first plunger that is moveably arranged within the first reservoir for delivering the one or more times of the first minimum dosing amount of liquid medicament when being actuated by the first drive mechanism
  • the second dosing chamber is a second reservoir that is configured for containing the liquid medicament
  • the second dosing chamber comprises a second plunger that is moveably arranged within the second reservoir for delivering the one or more times of the second minimum dosing amount of liquid medicament when being actuated by the second drive mechanism.
  • the first drive mechanism moves the first plunger within the first reservoir.
  • the first reservoir forms the first dosing chamber.
  • liquid medicament is dispensed out of the first reservoir.
  • the second drive mechanism moves the second plunger within the second reservoir.
  • the second reservoir forms the second dosing chamber.
  • liquid medicament is dispensed out of the second reservoir.
  • the second plunger is moved within the second reservoir in a fourth direction, opposite to the third direction, liquid medicament is drawn into the second reservoir.
  • the first plunger is configured to move one or more times of the first minimum dosing amount
  • the second plunger is configured to move one or more times of the second minimum dosing amount.
  • the first reservoir has a first cross-section and the second reservoir has a second cross-section different to the first cross-section.
  • the second cross-section of the second reservoir can be larger than the first cross-section of the first reservoir.
  • the second minimum dosing amount equals integer-times of the first minimum dosing amount. Since the second minimum dosing amount is larger than the first minimum dosing amount, the first minimum dosing amount equals half or less of the second minimum dosing amount. For instance, the second minimum dosing amount can equal x times of first minimum dosing amount, wherein x is an integer equal to 2, 3, 4, 5, 6, 7, 8, 9, or 10. Thus, the total amount of liquid medicament can be one or more times of the second minimum dosing amount plus or minus one or more times of the first minimum dosing amount.
  • the first minimum dosing amount can be 0.01 ml, 0.001 ml, 0.0001 ml, 0.0001 ml, or 0.00001 ml.
  • At least one of the above objects is also solved by a method for operating a medical infusion device system according to one or more of the aforementioned embodiments, wherein the method comprises the step of controlling operation of the first dosing chamber and the second dosing chamber by the controller for providing the total amount of liquid medicament via the fluid line, wherein the total amount of liquid medicament is equal to or larger than zero, and the total amount of liquid medicament is equal to one or more times of the first minimum dosing amount plus or minus of one or more times of the second minimum dosing amount.
  • Figure 1 shows a schematic view of a medical infusion device system according to an embodiment of the present invention.
  • Figure 2a shows a first operation mode of the medical infusion device system according to figure 1
  • Figure 2b shows a second operation mode of the medical infusion device system according to figure 1
  • Figure 2c shows a third operation mode of the medical infusion device system according to figure 1 .
  • Figure 2d shows a fourth operation mode of the medical infusion device system according to figure 1.
  • FIG. 1 shows a schematic view of a medical infusion device system 1 according to an embodiment of the present invention.
  • the medical infusion device system 1 comprises a first dosing chamber 1 and a second dosing chamber 2.
  • the first dosing chamber 2 forms a first reservoir that is configured for holding liquid medicament.
  • a first plunger 2b is moveable within the reservoir, wherein the movement of the first plunger 2b is caused by a first drive mechanism 2a.
  • a fluid line 4 is operatively coupled to the first dosing chamber 2.
  • liquid medicament is dispensed out of the first reservoir into the fluid line 4.
  • liquid medicament is drawn into the first dosing chamber 2.
  • the fluid line 4 is further operatively coupled to a second dosing chamber 3.
  • the second dosing chamber 3 forms a second reservoir that is also configured for holding an amount of the same liquid medicament as contained in the first dosing chamber 2.
  • a second plunger 3b is moveably arranged within the second dosing chamber 3, wherein the movement of the second plunger 3b is induced by a second drive mechanism 3a.
  • a movement of the first plunger 2b by moving the second plunger 3b in a second direction, liquid medicament contained in the second dosing chamber 3 is pushed into the fluid line 4, while when moving the second plunger 3b in a direction, opposite to the second direction, liquid medicament is admitted to the second dosing chamber s.
  • Operation of the first drive mechanism 2a and operation of the second drive mechanism 3a is controlled by a controller 6.
  • the controller 6 is configured to control operation of the first dosing chamber 2 and the second dosing chamber 3 so to provide a total amount of liquid medicament via the fluid line 4.
  • the fluid line 4 comprises an outlet 5.
  • the outlet 5 is coupled to a cannula.
  • the first dosing chamber 2 is configured for delivering one or more times of a first minimum dosing amount of a liquid medicament.
  • the second dosing chamber 3 is configured for delivering one or more of a second minimum dosing amount of a liquid medicament, wherein the second minimum dosing amount of the liquid medicament provided by the second dosing chamber s is larger than the first minimum dosing amount of liquid medicament provided by the first dosing chamber 2.
  • the total amount of liquid medicament is formed by summing up or subtracting the one or more times of the first minimum dosing amount and the one or more times of the second dosing amount.
  • the cross-section of the first dosing chamber 2 is smaller than the cross-section of the second dosing chamber 3.
  • the liquid amount provided by the first dosing chamber 2 when moving the first plunger 2b about a specific distance is smaller than the liquid amount provided by the second dosing chamber 3 when moving the second plunger 3b about the same distance.
  • Figures 2a to 2d show four exemplarily operation modes of a medical infusion device system 1 according to the embodiment of figure 1.
  • the controller s is configured to control operation of the first dosing chamber 2 and the second dosing chamber 3 and is thereby configured to control the total amount of liquid medicament delivered via the fluid line 4 and the outlet 5 of the fluid line 4.
  • a first operation mode is schematically shown in figure 2a.
  • operation of the first drive mechanism 2a and operation of the second drive mechanism 3a are controlled by the controller 6 so that the first plunger 2b and the second plunger 3b are further advanced within the first dosing chamber 2 and the second dosing chamber 3, respectively.
  • liquid medicament is dispensed out of the first dosing chamber 2 and the second dosing chamber 3 into fluid line 4.
  • a second operation mode is schematically shown in figure 2b.
  • operation of the first drive mechanism 2a and operation of the second drive mechanism 3a are controlled by the controller s so that the first plunger 2b is retracted within the first reservoir formed by the first dosing chamber 2, while the second plunger 3b is simultaneously further advanced within the second reservoir formed by the second dosing chamber 3.
  • the one or more multiple times of the first minimum dosing amount that is drawn into the first dosing chamber 2 by retracting the first plunger 2b within the first dosing chamber 2 is smaller than the one or more times of the second minimum dosing amount that is provided by further advancing the second plunger 3b within the second dosing chamber 3.
  • Figure 2c schematically shows a third operation mode of the medical infusion device system 1 according to figure 1 .
  • operation of the first drive mechanism 2a and operation of the second drive mechanism 3a are controlled by the controller 6.
  • the first drive mechanism 2a and the second drive mechanism 3a are operated so to simultaneously move the first plunger 2b within the first dosing chamber 2 and the second plunger 3b within the second dosing chamber 3.
  • the first plunger 2b is retracted within the first dosing chamber 3 by the first drive mechanism 2a, while the second plunger 3b is further advanced within the second dosing chamber 3.
  • the amount of liquid medicament drawn into the first dosing chamber 2 by retracting the first plunger 2b within the first dosing chamber 2 equals one or more time of the first minimum dosing amount.
  • the amount of liquid medicament dispensed from the second dosing chamber 3 by further advancing the second plunger 3b within the second dosing chamber 3 equals the amount of liquid medicament drawn into the first dosing chamber 2.
  • the total amount of liquid medicament dispensed through the outlet 5 of the fluid line 4 is zero. Therefore, by this operation mode liquid medicament is totally transferred from the second dosing chamber 3 into the first dosing chamber 2.
  • liquid medicament can be transferred from the first dosing chamber 2 into the second dosing chamber 3 by the fourth operation mode as schematically visualized in figure 2d.
  • Operation of the first drive mechanism 2a and operation of the second drive mechanism 3a are controlled by the controller 6.
  • the first drive mechanism 2a is operated so to further advance the first plunger 2b within the first dosing chamber 2 while the second drive mechanism 3a is operated so to simultaneously retract the second plunger 3b within the second dosing chamber 3.
  • the amount of liquid medicament dispensed out of the first dosing chamber 2 equals one or more time of the first minimum dosing amount.
  • the amount of liquid medicament drawn into the second dosing chamber 3 by retracting the second plunger 3b within the second dosing chamber 3 equals the amount of liquid medicament provided by the first dosing chamber 2 and also equals one or more times of the second minimum dosing amount.

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Abstract

The present invention relates to a medical infusion device system comprising a first dosing chamber for delivering at least a first minimum dosing amount of a liquid medicament, a second dosing chamber for delivering at least a second minimum dosing amount of the liquid medicament, a fluid line operatively coupled to the first dosing chamber and the second dosing chamber for conveying a total amount of liquid medicament for delivering by the first and second dosing chamber to an outlet of the fluid line, and a controller to control the total amount of liquid medicament. In order to provide relatively small and large dosing amounts both fast and accurate the second minimum dosing amount of the liquid medicament provided by the second dosing chamber larger than the first minimum dosing amount of the liquid medicament provided by the first dosing chamber.

Description

Medical infusion device system having a dosing range extension
The present invention relates to a medical infusion device system comprising a first dosing chamber that is configured for delivering one or more times of a first minimum dosing amount of a liquid medicament, a second dosing chamber that is configured for delivering one or more times of a second minimum dosing amount of the liquid medicament, a fluid line that is operatively coupled to the first dosing chamber and the second dosing chamber for conveying a total amount of liquid medicament for delivering by the first and second dosing chamber to an outlet of the fluid line, and a controller that is configured to control the total amount of liquid medicament for delivering via the fluid line by operating the first dosing chamber and the second dosing chamber.
Hitherto known medical infusion device systems are used for administering a liquid medicament to a user. The liquid medicament is intended to improve the patient’s health condition. During use, liquid medicament is dispensed by the first dosing chamber and the second dosing chamber. Thus, both, the at least first minimum dosing amount provided by the first dosing chamber and the at least second minimum dosing amount provided by the second dosing chamber together form the total amount of liquid medicament. Operation of the first dosing chamber and operation of the second dosing chamber is controlled by the controller. The first dosing chamber and the second dosing chamber are operated with the same type of liquid medicament.
However, when having two dosing chambers contributing to the total amount of liquid medicament to be delivered to a patient, the overall dosing accuracy of a hitherto known medical infusion system is based on the dosing accuracy of the first dosing chamber and the dosing accuracy of the second dosing chamber. Care has to be taken that the total dosing amount does not result in an overdosing or an underdosing of the liquid medicament. In particular, when delivering a small amount of liquid medicament, a deviation in the delivered amount of liquid medicament is significant for the overall dosing amount. For example, due to individual needs and metabolism characteristics, different user’s of the known medical infusion device systems may have different needs with respect to dosages. Infant often needs a lower dosage of liquid medicament than adults, and infants often bears a higher risk of overdosing when using a medical infusion system that is used by infants and adults alike. Such known medical infusion systems will exhibit an overall dosing accuracy which is a compromise between low body weight patients requiring a smaller dose administered with higher dosing accuracy and large body weight patients requiring a larger dose administered with lower dosing accuracy. In medical infusion systems with two chambers the overall dosing accuracy is based on the dosing accuracy of the first dosing chamber and the dosing accuracy of the second dosing chamber. Accordingly, it is an object of the present invention to provide a medical infusion device system that avoids at least one of the problems associated with medical infusion device systems known from the prior art. In particular, it is an object of the present invention to provide a medical infusion device system that allows a more variable dosing of liquid medicament.
At least one of the above objects is solved by the provision of the subject-matter disclosed in the claims and throughout the specification.
According to a first aspect, a medical infusion device system is provided. The medical infusion device system comprises a first dosing chamber that is configured for delivering one or more of a first minimum dosing amount of a liquid medicament, a second dosing chamber that is configured for delivering one or more of a second minimum dosing amount of the liquid medicament, a fluid line that is operatively coupled to the first dosing chamber and the second dosing chamber for conveying a total amount of liquid medicament for delivering by the first dosing chamber and second dosing chamber to an outlet of the fluid line, and a controller that is configured to control operation of the first dosing chamber and the second dosing chamber for providing the total amount of liquid medicament via the fluid line, wherein the second minimum dosing amount of the liquid medicament provided by the second dosing chamber is larger than the first minimum dosing amount of the liquid medicament provided by the first dosing chamber.
The first minimum dosing amount and the second minimum dosing amount are inherent parameters of the first dosing chamber and the second dosing chamber, respectively. The first minimum dosing amount and the second minimum dosing amount are determined by the underlying constructions, mechanisms and electronics of the first dosing chamber and the second dosing chamber, respectively, as well as any further component of the medical infusion device system needed for delivering a dosage of liquid medicament by operating the first dosing chamber and the second dosing chamber, respectively. For instance, the respective minimum dosing amount of the first dosing chamber and the second dosing chamber equals the minimal volume that is conveyed by the first dosing chamber or the second chamber, respectively, into ambient air, i.e. without any other pressure hindering a flow out of the outlet of the first dosing chamber or the second dosing chamber, respectively, than the pressure of ambient air. The first minimum dosing amount and the second minimum dosing amount cannot be further reduced by separately operating the first dosing chamber and the second dosing chamber, i.e., the first minimum dosing amount and the second minimum dosing amount is the respective minimal amount that can be repeatedly delivered by operating the first dosing chamber and the second dosing chamber, respectively, with a standard deviation of ± 5% in the setting of the medical infusion device. The first minimum dosing amount is the smallest possible volume that can be delivered by operating the first dosing chamber. Likewise, the second minimum dosing amount is the smallest possible volume that can be delivered by operating the second dosing chamber. However, since the first minimum dosing amount and the second minimum dosing amount together are used to form the total amount of liquid medicament that is conveyed through the outlet of the fluid line of the medical infusion device system, the first minimum dosing amount and the second minimum dosing amount can be used to alter the total amount of liquid medicament which can then be delivered via the fluid line. The first minimum dosing amount can be added to the second minimum dosing amount, and vice versa. I.e. the second minimum dosing amount can also be added to the first minimum dosing amount. Thereby, a large amount of more than just one or more of the second minimum dosing amount or just one or more of the first minimum dosing amount, respectively, can be administered so that the total dosing amount can be extended by using both, the first dosing chamber and the second dosing chamber. In particular, by dividing the total amount of the liquid medicament to be administered into multiple amounts of the first minimum dosing amount and the second minimum dosing amount, it is possible to take advantage of the respective accuracies of the first dosing chamber and the second dosing chamber so to provide a total amount of liquid medicament with a high accuracy.
The first minimum dosing amount and the second minimum dosing amount are of different volume, wherein the second minimum dosing amount is larger than the first minimum dosing amount, i.e., the first dosing amount is smaller than the second minimum dosing amount. Thus, a relatively large volume can be delivered to a user of the medical infusion device system by delivering one or multiple times of the second minimum dosing amount. Providing the relatively large volume by delivering one or multiple times of the second minimum dosing amount is faster than providing said relatively large volume by a respectively higher times of delivery by the first dosing amount.
Controlling the operation of the first dosing chamber and the second dosing chamber, a total volume can be delivered by providing a relatively large volume by actuating the second dosing chamber, and a relatively small volume by actuating the first dosing chamber. Thus, the total volume delivered can advantageously be expanded beyond the maximum volume that can be delivered by the second dosing chamber by simultaneously delivering volume from the first dosing chamber and from the second dosing chamber. In the meaning of the present invention, a controller is an electro-technical component that is configured for controlling actuation of the first dosing chamber and the second dosing chamber. For instance the controller can be a microprocessor. “Operatively coupled” refers to a configuration of the medical device system in which the fluid line is in fluid communication with the first dosing chamber and the second dosing chamber, so that liquid medicament from the first dosing chamber and/or the second dosing chamber can flow out of the respective dosing chamber through the outlet.
According to an embodiment of the present invention, the outlet of the fluid line can be formed by or operatively coupled to a cannula or an infusion set. The coupling can be irreversible or reversible, preferably reversible. The cannula can be a steel cannula or a soft cannula, preferably a soft cannula. According to an embodiment of the present invention, the medical infusion device system can comprise an infusion pump having the first dosing chamber, the second dosing chamber, the fluid line, and the controller. The controller can be located inside the infusion pump or it can be a separate device such as a remote controller communicatively connected to the infusion pump. The remote controller can be a mobile device or a personal computer. The infusion pump can be a patch pump, i.e. a bodywearable pump comprising an adhesive layer for temporarily adhering the body-wearable pump to a patient’s body.
The liquid medicament can be any kind of infusible medicament. In particular, the liquid medicament can be insulin or glucagon.
According to an embodiment, the controller is configured to simultaneously operate the first dosing chamber and the second dosing chamber for transferring liquid medicament in the amount equal to one or more of the first minimum dosing amount to the second dosing chamber and/or for transferring liquid medicament in the amount equal to one or more of the second minimum dosing amount to the first dosing chamber.
The controller cannot only control operation of the first dosing chamber and the second dosing chamber to deliver liquid medicament through the outlet of the fluid line, but can also control simultaneous operation of the first dosing chamber and the second dosing chamber in order to transfer liquid medicament from one of the first dosing chamber or the second dosing chamber into the respective other one of the first dosing chamber or the second dosing chamber. For instance the one or more times of the minimum first dosing amount can be transferred from the first dosing chamber into the second dosing chamber, and vice versa. Furthermore, one or more times of the minimum second dosing amount can be transferred from the second dosing chamber into the first dosing chamber, and vice versa. Thereby, the controller can advantageously be used to balance the filling level within the first dosing chamber and the second dosing chamber. This transfer of liquid to the first dosing chamber can be of advantage if for certain patients, such as a patient with a low body weight such as a child, usually a very small amount of the liquid medicament is to be delivered and which small amount is below the minimum dosing amount that can be delivered by the second dosing chamber. The replenishing of the first dosing chamber thus expands the total volume of the liquid medicament that can be delivered by the first dosing chamber at a dosing amount below the minimum dosing amount of the second dosing chamber but beyond the total volume of the first dosing chamber. For instance, in case relatively larger amounts of liquid medicament are to be delivered through the outlet of the fluid line, during an idle phase liquid medicament can be first transferred from the first dosing chamber into the second dosing chamber. Once the liquid medicament has been transferred from the first dosing chamber into the second dosing chamber, secondly, a relatively large amount can be delivered through the outlet of the fluid line by controlling operation of the second dosing chamber, only. Thereby the delivering speed of the first dosing chamber and the second dosing chamber can be used more beneficially than providing a relatively larger amount of liquid medicament by controlling operation of the first dosing chamber, which may took longerthan when using the second dosing chamber.
According to an embodiment of the present invention, the controller is configured to control simultaneous operation of the first dosing chamber and the second dosing chamber for delivering the total amount of liquid medicament via the fluid line and through the outlet, wherein the total amount of liquid medicament is equal to the sum or difference of one or more multiple times of the first minimum dosing amount of liquid medicament and one or more multiple times of the second minimum dosing amount of liquid medicament, wherein the total amount of liquid medicament conveyed to the outlet is equal to or larger zero.
By simultaneously operating the first dosing chamber and the second dosing chamber, at least the first dosing amount or a multiple thereof can be transferred into the second dosing chamber, or at least the second dosing amount or a multiple thereof can be transferred into the first dosing chamber. Thereby, the first minimum dosing amount or a multiple thereof can be deducted from the second minimum dosing amount, or vice versa. I.e. the second minimum dosing amount or a multiple thereof can be deducted from the first minimum dosing amount. The total amount of liquid medicament provided by controlling the first dosing chamber and the second dosing chamber, can be a sum of the first minimum dosing amount or multiple thereof and the second minimum dosing amount or a multiple thereof; or the total amount of liquid medicament provided by simultaneously operating the first dosing chamber and the second dosing chamber can be a difference of one or more times of the first minimum dosing amount and one or more times of the second minimum dosing amount. However, in case of a deduction, the total amount of liquid medicament should not be a negative amount, which could result in liquid medicament and/or bodily fluids to be withdrawn from a patient into the outlet. For the transfer of liquid medicament from the first dosing chamber into the second dosing chamber, or vice versa, the dosing accuracy has no effect on the dosing as provided by the medical infusion device system. However, the transfer of liquid medicament from one dosing chamber to another dosing chamber helps a user to adapt the configuration of the medical infusion device system to its personal needs. For instance, a user who often administered small amounts of liquid medicament will likely have a higher need for replenish the first dosing chamber.
Therefore, in an embodiment the controller is configured to control operation of the first dosing chamber and the second dosing chamber for providing the total amount of liquid medicament via the fluid line, wherein the total amount of liquid medicament is equal to or larger than zero. This safety mechanism is associated with the advantage to avoid that a liquid enters the outlet or the fluid line. In an embodiment, the medical infusion device system comprises a sensor that is configured for detecting a negative pressure in the outlet, wherein the sensor is operatively connected to the controller to prevent liquid medicament from flowing through the outlet into the first dosing chamber and/or the second dosing chamber. Additionally or alternatively, the medical infusion device system can comprise a check valve that prevents liquid medicament from flowing through the outlet into the first dosing chamber and/or the second dosing chamber.
According to an embodiment of the present invention, the first dosing chamber is operatively coupled to a first drive mechanism for actuating the first dosing chamber, and in that the second dosing chamber is operatively coupled to a second drive mechanism for actuating the second dosing chamber, wherein the controller is configured to control operation of the first drive mechanism and the second drive mechanism. Operation of the first drive mechanism can be controlled by the controller to dispense liquid medicament out of the first dosing chamber or to admit liquid medicament to the first dosing chamber. Likewise, operation of the second drive mechanism can be controlled by the controller to dispense liquid medicament out of the second dosing chamber or to admit liquid medicament to the second dosing chamber. Thus, since the first drive mechanism is operatively coupled to the first dosing chamber and the second drive mechanism is operatively coupled to the second dosing chamber, controlling operation of the first drive mechanism and the second drive mechanism also controls operation of the first dosing chamber and second dosing chamber, and thus, the total amount of liquid medicament flowing through the fluid line. “Operatively coupled” in this context means that the drive mechanism is configured to effect discharging or charging of liquid medicament out or into, respectively, in the respective dosing chamber.
According to an embodiment of the present invention, the first dosing chamber is a first reservoir that is configured for containing the liquid medicament, wherein the first dosing chamber comprises a first plunger that is moveably arranged within the first reservoir for delivering the one or more times of the first minimum dosing amount of liquid medicament when being actuated by the first drive mechanism, and in that the second dosing chamber is a second reservoir that is configured for containing the liquid medicament, wherein the second dosing chamber comprises a second plunger that is moveably arranged within the second reservoir for delivering the one or more times of the second minimum dosing amount of liquid medicament when being actuated by the second drive mechanism.
The first drive mechanism moves the first plunger within the first reservoir. The first reservoir forms the first dosing chamber. By advancing the first plunger within the first reservoir in a first direction, liquid medicament is dispensed out of the first reservoir. When the first plunger is moved by the first drive mechanism into a second direction, opposite to the first direction, liquid medicament is drawn into the first reservoir. Likewise, the second drive mechanism moves the second plunger within the second reservoir. The second reservoir forms the second dosing chamber. When being advanced in a third direction within the second reservoir, liquid medicament is dispensed out of the second reservoir. When the second plunger is moved within the second reservoir in a fourth direction, opposite to the third direction, liquid medicament is drawn into the second reservoir. Thus, the first plunger is configured to move one or more times of the first minimum dosing amount, and the second plunger is configured to move one or more times of the second minimum dosing amount.
According to an embodiment of the present invention, the first reservoir has a first cross-section and the second reservoir has a second cross-section different to the first cross-section. For instance, the second cross-section of the second reservoir can be larger than the first cross-section of the first reservoir. By having cross-sections of different size, the delivery volume provided when moving the first plunger within the first reservoir per distance is smaller than the delivery volume provided by moving second plunger within the second reservoir about the same distance within the second reservoir. “Cross-section” refers to the area of the plunger that during use of the medical infusion device system is in contact with the liquid medicament.
According to an embodiment of the present invention, the second minimum dosing amount equals integer-times of the first minimum dosing amount. Since the second minimum dosing amount is larger than the first minimum dosing amount, the first minimum dosing amount equals half or less of the second minimum dosing amount. For instance, the second minimum dosing amount can equal x times of first minimum dosing amount, wherein x is an integer equal to 2, 3, 4, 5, 6, 7, 8, 9, or 10. Thus, the total amount of liquid medicament can be one or more times of the second minimum dosing amount plus or minus one or more times of the first minimum dosing amount. Thereby, both large amounts and small amounts of the liquid medicament can be delivered by the medical infusion device system relatively fast and with a high accuracy when compared to a medical infusion device system having only one dosing chamber or two dosing chambers capable of delivering the same minimum dosing amount. For example, the first minimum dosing amount can be 0.01 ml, 0.001 ml, 0.0001 ml, 0.0001 ml, or 0.00001 ml.
At least one of the above objects is also solved by a method for operating a medical infusion device system according to one or more of the aforementioned embodiments, wherein the method comprises the step of controlling operation of the first dosing chamber and the second dosing chamber by the controller for providing the total amount of liquid medicament via the fluid line, wherein the total amount of liquid medicament is equal to or larger than zero, and the total amount of liquid medicament is equal to one or more times of the first minimum dosing amount plus or minus of one or more times of the second minimum dosing amount.
Further advantages, features and technical effects of the present invention are apparent from the following description of embodiments and the accompanying figures.
Figure 1 shows a schematic view of a medical infusion device system according to an embodiment of the present invention; and
Figure 2a shows a first operation mode of the medical infusion device system according to figure 1 , Figure 2b shows a second operation mode of the medical infusion device system according to figure 1 ,
Figure 2c shows a third operation mode of the medical infusion device system according to figure 1 , and
Figure 2d shows a fourth operation mode of the medical infusion device system according to figure 1.
Figure 1 shows a schematic view of a medical infusion device system 1 according to an embodiment of the present invention. The medical infusion device system 1 comprises a first dosing chamber 1 and a second dosing chamber 2. The first dosing chamber 2 forms a first reservoir that is configured for holding liquid medicament. A first plunger 2b is moveable within the reservoir, wherein the movement of the first plunger 2b is caused by a first drive mechanism 2a. A fluid line 4 is operatively coupled to the first dosing chamber 2. Thus, when being moved forward in a first direction, liquid medicament is dispensed out of the first reservoir into the fluid line 4. When being moved in a direction, opposite to the first direction, liquid medicament is drawn into the first dosing chamber 2.
The fluid line 4 is further operatively coupled to a second dosing chamber 3. The second dosing chamber 3 forms a second reservoir that is also configured for holding an amount of the same liquid medicament as contained in the first dosing chamber 2. A second plunger 3b is moveably arranged within the second dosing chamber 3, wherein the movement of the second plunger 3b is induced by a second drive mechanism 3a. Like, a movement of the first plunger 2b, by moving the second plunger 3b in a second direction, liquid medicament contained in the second dosing chamber 3 is pushed into the fluid line 4, while when moving the second plunger 3b in a direction, opposite to the second direction, liquid medicament is admitted to the second dosing chamber s.
Operation of the first drive mechanism 2a and operation of the second drive mechanism 3a is controlled by a controller 6. The controller 6 is configured to control operation of the first dosing chamber 2 and the second dosing chamber 3 so to provide a total amount of liquid medicament via the fluid line 4. The fluid line 4 comprises an outlet 5. Here the outlet 5 is coupled to a cannula.
The first dosing chamber 2 is configured for delivering one or more times of a first minimum dosing amount of a liquid medicament. Likewise, the second dosing chamber 3 is configured for delivering one or more of a second minimum dosing amount of a liquid medicament, wherein the second minimum dosing amount of the liquid medicament provided by the second dosing chamber s is larger than the first minimum dosing amount of liquid medicament provided by the first dosing chamber 2. The total amount of liquid medicament is formed by summing up or subtracting the one or more times of the first minimum dosing amount and the one or more times of the second dosing amount. Here, the cross-section of the first dosing chamber 2 is smaller than the cross-section of the second dosing chamber 3. Thus, the liquid amount provided by the first dosing chamber 2 when moving the first plunger 2b about a specific distance is smaller than the liquid amount provided by the second dosing chamber 3 when moving the second plunger 3b about the same distance. In figure 1 , c
Figures 2a to 2d show four exemplarily operation modes of a medical infusion device system 1 according to the embodiment of figure 1. The controller s is configured to control operation of the first dosing chamber 2 and the second dosing chamber 3 and is thereby configured to control the total amount of liquid medicament delivered via the fluid line 4 and the outlet 5 of the fluid line 4.
A first operation mode is schematically shown in figure 2a. According to the first operation mode, operation of the first drive mechanism 2a and operation of the second drive mechanism 3a are controlled by the controller 6 so that the first plunger 2b and the second plunger 3b are further advanced within the first dosing chamber 2 and the second dosing chamber 3, respectively. Accordingly, liquid medicament is dispensed out of the first dosing chamber 2 and the second dosing chamber 3 into fluid line 4. Thus, at least the first minimum dosing amount provided by the first dosing chamber 2 and at least the second minimum dosing amount provided by the second dosing chamber
3 add up to the total amount of liquid amount. In figure, 2a the flow of liquid medicament and the movement of the respective first and second plungers 2b, 3b are indicated by arrows.
A second operation mode is schematically shown in figure 2b. According to the second operation mode, operation of the first drive mechanism 2a and operation of the second drive mechanism 3a are controlled by the controller s so that the first plunger 2b is retracted within the first reservoir formed by the first dosing chamber 2, while the second plunger 3b is simultaneously further advanced within the second reservoir formed by the second dosing chamber 3. However, the one or more multiple times of the first minimum dosing amount that is drawn into the first dosing chamber 2 by retracting the first plunger 2b within the first dosing chamber 2 is smaller than the one or more times of the second minimum dosing amount that is provided by further advancing the second plunger 3b within the second dosing chamber 3. Thus, there is a resulting total liquid amount that is dispensed through the fluid line
4 and the outlet 5. Again, in figure 2b the flow of liquid medicament and the corresponding movement of the first plunger 2b and second plunger 3b are indicate by arrows. Part of the liquid amount dispensed out of the second dosing chamber 3 is transferred into the first dosing chamber 2, while the remainder of the liquid amount dispensed out of the second dosing chamber 3 is delivered through the outlet 5 of the fluid line 4. The total amount provided through the outlet 5 equals the amount of liquid medicament provided by the second dosing chamber 3 minus the amount of liquid medicament that is drawn into the first dosing chamber 2.
Figure 2c schematically shows a third operation mode of the medical infusion device system 1 according to figure 1 . According to the third operation mode, operation of the first drive mechanism 2a and operation of the second drive mechanism 3a are controlled by the controller 6. The first drive mechanism 2a and the second drive mechanism 3a are operated so to simultaneously move the first plunger 2b within the first dosing chamber 2 and the second plunger 3b within the second dosing chamber 3. Under control of the controller 6, the first plunger 2b is retracted within the first dosing chamber 3 by the first drive mechanism 2a, while the second plunger 3b is further advanced within the second dosing chamber 3. The amount of liquid medicament drawn into the first dosing chamber 2 by retracting the first plunger 2b within the first dosing chamber 2 equals one or more time of the first minimum dosing amount. At the same time, the amount of liquid medicament dispensed from the second dosing chamber 3 by further advancing the second plunger 3b within the second dosing chamber 3 equals the amount of liquid medicament drawn into the first dosing chamber 2. Thus, the total amount of liquid medicament dispensed through the outlet 5 of the fluid line 4 is zero. Therefore, by this operation mode liquid medicament is totally transferred from the second dosing chamber 3 into the first dosing chamber 2.
Likewise, liquid medicament can be transferred from the first dosing chamber 2 into the second dosing chamber 3 by the fourth operation mode as schematically visualized in figure 2d. Operation of the first drive mechanism 2a and operation of the second drive mechanism 3a are controlled by the controller 6. Under the control of the controller, the first drive mechanism 2a is operated so to further advance the first plunger 2b within the first dosing chamber 2 while the second drive mechanism 3a is operated so to simultaneously retract the second plunger 3b within the second dosing chamber 3. The amount of liquid medicament dispensed out of the first dosing chamber 2 equals one or more time of the first minimum dosing amount. The amount of liquid medicament drawn into the second dosing chamber 3 by retracting the second plunger 3b within the second dosing chamber 3 equals the amount of liquid medicament provided by the first dosing chamber 2 and also equals one or more times of the second minimum dosing amount.
List of reference numbers
1 medical infusion device system
2 first dosing chamber 2a first drive mechanism
2b first plunger
3 second dosing chamber
3a second drive mechanism
3b second plunger 4 fluid line
5 outlet of fluid line
6 controller

Claims

Claims
1 . A medical infusion device system (1) comprising
• a first dosing chamber (2) that is configured for delivering one or more times of a first minimum dosing amount of a liquid medicament,
• a second dosing chamber (3) that is configured for delivering one or more times of a second minimum dosing amount of the liquid medicament,
• a fluid line (4) that is operatively coupled to the first dosing chamber (2) and the second dosing chamber (3) for delivering a total amount of liquid medicament through an outlet (5) of the fluid line (4), the total amount of liquid medicament provided by the first dosing chamber (2) and second dosing chamber (3), and
• a controller (6) that is configured to control operation of the first dosing chamber (2) and of the second dosing chamber (3) for providing the total amount of liquid medicament via the fluid line (4), characterized in that the second minimum dosing amount of the liquid medicament provided by the second dosing chamber (3) is larger than the first minimum dosing amount of the liquid medicament provided by the first dosing chamber (2).
2. Medical infusion device system (1) according to claim 1 , characterized in that the controller (6) is configured to control simultaneous operation of the first dosing chamber (2) and of the second dosing chamber (3) for transferring liquid medicament in the amount equal to one or more times of the first minimum dosing amount to the second dosing chamber (3) and/or for transferring liquid medicament in the amount equal to one or more times of the second minimum dosing amount to the first dosing chamber (2).
3. Medical infusion device system (1) according to claim 1 or 2, characterized in that the controller (6) is configured to control simultaneous operation of the first dosing chamber (2) and the second dosing chamber (3) for delivering the total amount of liquid medicament via the fluid line (4) and through the outlet (5), wherein the total amount of liquid medicament is equal to the sum or difference of one or more multiple times of the first minimum dosing amount of liquid medicament and one or more multiple times of the second minimum dosing amount of liquid medicament, wherein the total amount of liquid medicament delivered through the outlet (5) is equal to or larger than zero.
4. Medical infusion device system (1) according to any one of claims 1 to 3, characterized in that the first dosing chamber (2) is operatively coupled to a first drive mechanism (2a) that is configured for actuating the first dosing chamber (2), and in that the second dosing chamber (3) is operatively coupled to a second drive mechanism (3a) that is configured for actuating the second dosing chamber (3), wherein the controller (6) is configured to control operation of the first drive mechanism (2a) and the second drive mechanism (3a). Medical infusion device system (1) according to claim 4, characterized in that the first dosing chamber (2) is a first reservoir that is configured for containing the liquid medicament, wherein the first dosing chamber comprises a first plunger (2b) that is moveably arranged within the first reservoir for delivering the one or more times of the first minimum dosing amount of liquid medicament when being actuated by the first drive mechanism (2a), and in that the second dosing chamber (3) is a second reservoir that is configured for containing the liquid medicament, wherein the second dosing chamber (3) comprises a second plunger (3b) that is moveably arranged within the second reservoir for delivering the one or more of the second minimum dosing amount of liquid medicament when being actuated by the second drive mechanism (3a). Medical infusion device system (1), according to claim 5, characterized in that the first reservoir has a first cross-section and the second reservoir has a second cross-section different to the first cross-section. Medical infusion device system (1) according to any one of claims 1 to 6, characterized in that the second minimum dosing amount equals integer-times of the first minimum dosing amount. Method for operating a medical infusion device system (1) according to any one of claims 1 to 7, characterized in that the controller (6) contrails operation of the first dosing chamber (2) and of the second dosing chamber (3) for providing the total amount of liquid medicament via the fluid line (4), wherein the total amount of liquid medicament is equal to or larger than zero, and the total amount of liquid medicament is equal to one or more times of the first minimum dosing amount plus or minus of one or more times of the second minimum dosing amount.
PCT/EP2023/080642 2022-11-05 2023-11-03 Medical infusion device system having a dosing range extension WO2024094837A1 (en)

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EP22205674.9 2022-11-05

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020046889A1 (en) * 2018-08-28 2020-03-05 Bayer Healthcare Llc Fluid injector system with improved ratio performance
US20200147301A1 (en) * 2018-11-13 2020-05-14 Contraline, Inc. Systems and methods for delivering biomaterials

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020046889A1 (en) * 2018-08-28 2020-03-05 Bayer Healthcare Llc Fluid injector system with improved ratio performance
US20200147301A1 (en) * 2018-11-13 2020-05-14 Contraline, Inc. Systems and methods for delivering biomaterials

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