WO2024093863A1

WO2024093863A1 - High-efficiency tool for measuring and transferring specified trace amount of solid powder

Info

Publication number: WO2024093863A1
Application number: PCT/CN2023/127527
Authority: WO
Inventors: 胥波; 齐义舟; 朱建民; 齐培州; 张强
Original assignee: 上海组波智能仪器科技有限公司
Priority date: 2022-11-01
Filing date: 2023-10-30
Publication date: 2024-05-10
Also published as: CN115646564A

Abstract

A high-efficiency tool for measuring and transferring a specified trace amount of solid powder, the tool comprising a disposable sampling head, wherein the disposable sampling head comprises an outer tube (1) and a piston block (2), the piston block (2) being slidably fitted into the outer tube (1); one end of the piston block (2) is connected to a driving module, which is used for driving the piston block (2) to slide in the outer tube (1); and the other end of the piston block (2) away from the driving module defines, together with the outer tube (1), a cavity therebetween that is used for accommodating powder.

Description

High-efficiency quantitative measurement and transfer tool for trace solid powder

Technical Field

The invention relates to the field of laboratory chemical research, in particular to a high-efficiency quantitative measuring and transferring tool for trace solid powder.

Background technique

Chemical synthesis is widely used in various fields such as medicine, pesticides, fine chemicals, materials, sensors, aerospace, etc., but chemical synthesis is still a very dangerous and labor-intensive industry. Due to the wide variety of chemicals involved in chemical synthesis, in order to achieve automatic synthesis, it is first necessary to realize the automated quantitative transfer of a large number of chemical reagents. The automated transfer of liquid reagents is relatively easy, but the automated quantitative transfer of solid and semi-solid reagents faces great challenges. In addition, chemical synthesis often encounters highly toxic or water- and air-sensitive chemical reagents, and their automated processing will be more difficult. There is currently no good solution at home and abroad.

At present, the main methods for automated weighing and transfer of powdered solid reagents at home and abroad are It is based on the use of powder transmission device and electronic balance. Among the mainstream solutions on the market, Mettler's automatic weighing device is the most successful (other companies also have systems with similar principles). The principle is to pre-load the solid powder reagent into the feeding bottle, then invert the feeding bottle, and the powder is transferred to the weighing target container through a metal screw device. The transferred amount is fed back by the balance and controls the operation of the metal screw transmission device to achieve quantitative powder transfer.

Although electronic analytical balances have high accuracy under ideal conditions, high-precision weighing usually requires a very stable working environment and sufficient stabilization time. Different solid powder reagents usually have different physical properties such as particle size, bulk density, and flow properties, which makes the transfer process extremely complicated. It is difficult to turn back once the target weight is exceeded, so the accuracy is difficult to control. In addition, the laboratory environment needs to be ventilated, and the airflow has a great influence on the accuracy of the balance, so it is almost impossible to handle highly toxic or water- and air-sensitive chemical reagents. In addition, solid samples must be added to special sample bottles in advance, and because the metal screw drive device is of high value, it is difficult to clean, and the tolerance to corrosive chemical reagents is difficult to guarantee. Therefore, the system is difficult to handle samples with a large number and type, especially corrosive samples.

Usually, using a liquid workstation or manual pipette, the quantitative transfer and transfer of liquid reagents is achieved by volumetric method, so we also think that the weighing and transfer of solid reagents can also be achieved by volumetric method in theory. The volumetric method is relatively rare in the market. The representative product is the automatic powder dispensing and processing system of Zinsser Analytic. The principle is to suck the powder with vacuum in a volumetric manner and then blow the powder out with compressed air. However, since the system uses vacuum, the corresponding filter needs to be replaced or cleaned every time the sample is changed, and the special structure and control method of vacuum quantitative adsorption of powder are extremely complex and difficult to operate, which makes the actual use very complicated and the practicality is low.

Existing gravimetric method: Although electronic analytical balances have high accuracy under ideal conditions, weighing requires a certain amount of stabilization time, the powder transfer process is complicated, it is difficult to turn back once the target weight is exceeded, and the accuracy is difficult to control. In addition, the laboratory environment needs ventilation, and the airflow has a great influence on the accuracy of the balance, so it is almost impossible to automatically handle highly toxic or water and air sensitive chemical reagents. In addition, solid samples must be added to special sample bottles in advance, making it difficult to handle a large number of samples. Moreover, since the metal screw drive device is difficult to clean and has a high value, it is difficult to guarantee tolerance to corrosive chemical reagents.

Existing volumetric method: Each time the sample is changed, the corresponding sampling head, filter sheet, etc. need to be replaced or cleaned, which makes the use very complicated and has low practicality.

Summary of the invention

The purpose of the present invention is to provide a method based on volumetric method with simple structure and high performance. Reliable and easy-to-use automated or semi-automated quantitative measurement and transfer tools for trace solid powders. They can also be used in combination with mass measurement tools such as analytical balances to improve accuracy. The use of low-cost disposable sampling heads completely solves the problem of cross-contamination in the transfer of multiple samples. And the design is highly lightweight and can be used in relatively small closed environments such as glove boxes, solving the problem of handling toxic and highly water/oxygen sensitive reagents.

The embodiment of the present invention is achieved as follows:

According to one aspect of an embodiment of the present invention, there is provided a high-efficiency quantitative measuring and transferring tool for trace solid powders, comprising: a disposable sampling head, wherein the disposable sampling head comprises an outer tube and a piston block, wherein the piston block is slidably sleeved within the outer tube; one end of the piston block is connected to a driving module, wherein the driving module is used to drive the piston block to slide within the outer tube, and a cavity for accommodating powder is formed between the other end of the piston block away from the driving module and the outer tube.

In some embodiments, the disposable sampling head is made by plastic injection molding.

In some embodiments, the volume of the cavity is adjustable.

In some embodiments, the driving module includes a push rod, the push rod has an inner A vacuum channel is formed; and the bottom of the piston block is made of porous material.

In some embodiments, the porous material comprises a porous plastic sheet.

In some embodiments, the bottom of the piston block is sealed, and the piston block is made of a conductive material; the driving module includes a push rod, and the push rod is a metal push rod, and the push rod is connected to an electrostatic generator.

In some embodiments, the conductive material includes conductive plastic.

In some embodiments, the bottom of the piston block is sealed and the piston block is made of ordinary non-conductive plastic.

Another aspect of an embodiment of the present invention provides a high-efficiency quantitative measuring and transferring tool for trace solid powders, comprising: a disposable sampling head, the disposable sampling head comprising an outer tube and a push rod, the push rod being slidably sleeved within the outer tube; one end of the push rod being connected to a driving module, the driving module being used to drive the push rod to slide within the outer tube, and a cavity for accommodating powder is formed between the other end of the push rod facing away from the driving module and the outer tube.

In some embodiments, the driving module includes two forms: electric drive or manual drive.

BRIEF DESCRIPTION OF THE DRAWINGS

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without creative work.

FIG1 is a schematic structural diagram of a first embodiment of a disposable sampling head of the present invention;

FIG2 is a schematic structural diagram of a second embodiment of a disposable sampling head of the present invention;

FIG3 is a schematic structural diagram of a third embodiment of a disposable sampling head of the present invention;

FIG4 is a schematic structural diagram of a fourth embodiment of a disposable sampling head of the present invention;

FIG5 is a schematic diagram of the structure of an electric powder capacity control system provided by an embodiment of the present invention;

FIG6 is a schematic diagram of the structure of a manual mechanical capacity control system provided in an embodiment of the present invention.

Detailed ways

In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings here can be arranged and designed in various different configurations.

Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, it does not require further definition and explanation in the subsequent drawings.

In the description of the present invention, it should be noted that the directions or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the accompanying drawings, or are the directions or positional relationships in which the inventive product is usually placed when used, and are only for the convenience of describing the present invention and The description is simplified, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", "third", etc. are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.

In addition, the terms "horizontal", "vertical" and the like do not mean that the components are required to be absolutely horizontal or suspended, but can be slightly tilted. For example, "horizontal" only means that its direction is more horizontal than "vertical", and does not mean that the structure must be completely horizontal, but can be slightly tilted.

In the description of the present invention, it is also necessary to explain that, unless otherwise clearly specified and limited, the terms "set", "install", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

Example 1

1. Sampling head design

As shown in Figure 1, the present invention uses a disposable sampling head, which can be produced by plastic injection molding and has a low production cost. The design of the sampling head is similar to that of a disposable syringe, and is divided into two parts: an outer tube 1 and a piston block, wherein the piston block 2 and the outer tube 1 are in close contact. The method of use is to first insert the mechanical push rod 3 into the piston block 2, and then insert the mechanical push rod 3 with the piston block 2 installed into the outer tube 1. In this way, a structure similar to a syringe is formed, and the mechanical push rod 3 with the piston block 2 installed can be regarded as a piston, and the capacity of the powder sampling device can be set by adjusting the position of the piston. Our piston block 2 and push rod 3 can have a variety of designs for different powders.

A porous plastic sheet 21 can be installed at the front end of the piston block 2, and in this case, it is used in conjunction with a push rod 3 with a vacuum channel 31. The vacuum is used to assist the powder transfer into the sampling head. This situation is suitable for inorganic powders with a large solid density.

Example 2

As shown in FIG2 , the difference between this embodiment and the first embodiment of FIG1 is that the front end of the piston block 2 is solid, but the piston block 2 is made of conductive plastic. The corresponding metal push rod 3 is connected to an electrostatic generator, and the electrostatic auxiliary powder is transferred into the sampling head. This design is suitable for organic powders with low solid density.

Example 3

As shown in FIG3 , the difference between this embodiment and the first embodiment of FIG1 is that the front end of the piston block 2 is solid, but the piston block 2 is made of ordinary non-conductive plastic, and the push rod 3 does not need to be connected to an electrostatic generator. The aggregation formed by the van der Waals force between the powder particles is used to transfer the powder into the sampling head. This design is suitable for powders with higher viscosity and finer powders.

Example 4

As shown in FIG4 , the difference between this embodiment and the first embodiment of FIG1 is that there is no piston block design, and only the outer tube 1 is retained. At this time, the push rod 3 directly replaces the function of the piston block. This simplifies the system design and reduces the system cost. The outer tube 1 is discarded after use, but the push rod 3 must be cleaned after each use.

Furthermore, a powder volume control system can be further provided. In this embodiment, the sampling head is designed as a structure similar to a syringe, and the mechanical push rod with the piston block installed can be regarded as a piston. The capacity of the cavity of the powder sampling device can be set by adjusting the position of the piston. The position or capacity control of the piston can be controlled by electric control or by a manual mechanical structure.

As shown in Figure 5, Figure 5 is a schematic diagram of the powder capacity control system. The push rod is connected to the push rod motor for linear motion through a coupling, and the outer tube is inserted into the outer tube fixing seat to achieve fixation. The push rod is inserted into the sampling head, so that a cavity of a certain volume can be generated through the movement of the motor for powder transfer. The push rod is a hollow structure made of metal, so it can be connected to a vacuum system or an electrostatic generator to assist in the transfer of powder.

As shown in Figure 6, Figure 6 is a schematic diagram of manual mechanical control of powder capacity. The push rod is connected to a screw structure with a mechanical counter (gear carry count) that can move linearly, the outer tube is inserted into the outer tube fixing seat to fix it, and the push rod is inserted into the above-mentioned sampling head, so that the push rod can be moved by adjusting the screw knob of the mechanical counter to generate a cavity of a certain volume for powder transfer. The manual structure does not use a vacuum or electrostatic generator, the cost is low, and the transfer is achieved only by using the viscosity of the powder itself.

The following is a method of using the high-efficiency quantitative measuring and transfer tool for trace solid powders provided in this embodiment.

1. First insert the push rod into the piston block, then insert the mechanical push rod with the piston block into the outer tube.

2. Use the above-mentioned electric or mechanical method to pull the piston block with a push rod to create a cavity of a certain volume.

3. Insert the sampling head into the solid powder and repeat the insertion operation until the powder Fill the cavity and reach a relatively constant powder density. If the powder has poor viscosity or high fluidity, a vacuum or electrostatic sampling head can be used to strengthen the interaction between the powder and the sampling head.

4. Take out the sampling head and push the push rod to push the powder out

5. Pop out the sampling head and complete the operation

The technical solution of this embodiment has the following technical effects: it can realize automated (high throughput) or semi-automated (high flexibility) operation at the same time; it can be used in combination with mass measurement tools such as analytical balances to improve accuracy; it uses low-cost disposable sampling heads to completely solve the problem of cross-contamination in the transfer of multiple samples; and it is highly lightweight in design and can be used in a small closed environment such as a glove box, solving the problem of handling toxic and highly water/oxygen sensitive reagents.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

A high-efficiency quantitative measuring and transfer tool for trace solid powder, characterized in that it includes: a disposable sampling head, the disposable sampling head includes an outer tube and a piston block, the piston block is slidably sleeved in the outer tube; one end of the piston block is connected to a driving module, the driving module is used to drive the piston block to slide in the outer tube, and a cavity for accommodating powder is formed between the other end of the piston block away from the driving module and the outer tube.
The high-efficiency quantitative measuring and transfer tool for trace solid powders according to claim 1 is characterized in that the disposable sampling head is made by plastic injection molding.
The high-efficiency quantitative measuring and transferring tool for trace solid powders according to claim 1 is characterized in that the volume of the cavity is adjustable.
The high-efficiency quantitative measuring and transfer tool for trace solid powders according to claim 1 is characterized in that the driving module includes a push rod, a vacuum channel is formed inside the push rod; and the bottom of the piston block is made of a porous material.
The high-efficiency quantitative measuring and transferring tool for trace solid powders according to claim 4 is characterized in that the porous material comprises a porous plastic sheet or other porous materials.
The high-efficiency quantitative measuring and transfer tool for trace solid powders according to claim 1 is characterized in that the bottom of the piston block is sealed and the piston block is made of a conductive material; the driving module includes a push rod, which is a metal push rod and is connected to an electrostatic generator.
The high-efficiency quantitative measuring and transfer tool for trace solid powders according to claim 6 is characterized in that the conductive material comprises conductive plastic.
The high-efficiency quantitative measuring and transferring tool for trace solid powders according to claim 1 is characterized in that the bottom of the piston block is sealed and the piston block is made of ordinary non-conductive plastic.
A high-efficiency quantitative measuring and transfer tool for trace solid powder, characterized in that it comprises: a disposable sampling head, the disposable sampling head comprises an outer tube and a push rod, the push rod is slidably sleeved in the outer tube; one end of the push rod is connected to a driving module, the driving module is used to drive the push rod to slide in the outer tube, A cavity for accommodating powder is formed between the other end of the push rod away from the driving module and the outer tube.
The high-efficiency quantitative measuring and transfer tool for trace solid powders according to claim 9 is characterized in that the driving module includes two forms: electric drive or manual drive.