WO2024076951A3 - Antiviral prodrugs and formulations thereof - Google Patents

Antiviral prodrugs and formulations thereof Download PDF

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Publication number
WO2024076951A3
WO2024076951A3 PCT/US2023/075779 US2023075779W WO2024076951A3 WO 2024076951 A3 WO2024076951 A3 WO 2024076951A3 US 2023075779 W US2023075779 W US 2023075779W WO 2024076951 A3 WO2024076951 A3 WO 2024076951A3
Authority
WO
WIPO (PCT)
Prior art keywords
formulations
compounds
antiviral prodrugs
prodrugs
antiviral
Prior art date
Application number
PCT/US2023/075779
Other languages
French (fr)
Other versions
WO2024076951A2 (en
Inventor
Anil Kumar Gupta
Arnab Kumar CHATTERJEE
Jian Jeffrey Chen
Original Assignee
The Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Scripps Research Institute filed Critical The Scripps Research Institute
Publication of WO2024076951A2 publication Critical patent/WO2024076951A2/en
Publication of WO2024076951A3 publication Critical patent/WO2024076951A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The application provides compounds of Formula (I) as further defined herein, pharmaceutical compositions comprising said compounds, and methods of using said compounds and compositions for the treatment and/or prevention of various viral infections, including SARS-CoV-2 infections.
PCT/US2023/075779 2022-10-04 2023-10-03 Antiviral prodrugs and formulations thereof WO2024076951A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263412961P 2022-10-04 2022-10-04
US63/412,961 2022-10-04

Publications (2)

Publication Number Publication Date
WO2024076951A2 WO2024076951A2 (en) 2024-04-11
WO2024076951A3 true WO2024076951A3 (en) 2024-05-30

Family

ID=90609010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/075779 WO2024076951A2 (en) 2022-10-04 2023-10-03 Antiviral prodrugs and formulations thereof

Country Status (1)

Country Link
WO (1) WO2024076951A2 (en)

Also Published As

Publication number Publication date
WO2024076951A2 (en) 2024-04-11

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