WO2024052089A1 - Procédé et dispositif de détermination de signaux de cardiogramme d'une ou de plusieurs personnes - Google Patents

Procédé et dispositif de détermination de signaux de cardiogramme d'une ou de plusieurs personnes Download PDF

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Publication number
WO2024052089A1
WO2024052089A1 PCT/EP2023/072845 EP2023072845W WO2024052089A1 WO 2024052089 A1 WO2024052089 A1 WO 2024052089A1 EP 2023072845 W EP2023072845 W EP 2023072845W WO 2024052089 A1 WO2024052089 A1 WO 2024052089A1
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WO
WIPO (PCT)
Prior art keywords
magnetic field
sensor
signals
magnetic
field sensors
Prior art date
Application number
PCT/EP2023/072845
Other languages
German (de)
English (en)
Inventor
Florian DOLDE
Frederik SCHAAL
Timo Weggler
Florian KRIST
Riccardo Cipolletti
Simon David BINDER
Eckhard Wehrse
Original Assignee
Robert Bosch Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert Bosch Gmbh filed Critical Robert Bosch Gmbh
Publication of WO2024052089A1 publication Critical patent/WO2024052089A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/242—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
    • A61B5/243—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetocardiographic [MCG] signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
    • A61B5/6892—Mats

Definitions

  • the present invention relates to a method and a device for determining magnetic cardiogram signals of one or more people, wherein cardiogram signals of one or more people lying on the same support are determined in a non-contact manner by a sensor device integrated into a support.
  • the present invention further relates to a device for a support, in particular a mattress, comprising a sensor device.
  • Medical emergency detection such as a heart attack
  • a heart attack is currently only possible through direct derivation of heart muscle signals. This is usually done via electrodes with direct skin contact and is therefore unsuitable for comfortable integration into a surface on which a person can sit or lie comfortably for a longer period of time.
  • the system includes a variety of different types of heart rate sensors mounted on a seat cushion or a Seat backrest are arranged.
  • the heart rate sensors are designed as electrocardiogram sensors.
  • a sensor device which is integrated into a vehicle seat and comprises magnetic field sensors in a gradiometer arrangement, whereby measurement signals of a person sitting on the vehicle seat are determined in a non-contact manner and cardiogram signals are determined from the measurement signals. Vital functions of the person can be determined from the cardiogram signals, it being further provided that the sensor device is a magnetic field sensor device and that the cardiogram signals are magnetic cardiogram signals (MCG).
  • MCG magnetic cardiogram signals
  • Such M KG systems as well as pulse monitoring systems based on other technologies are designed to monitor only a single person or to record their heart signal. Especially when arranging such a sensor device in a mattress, it can happen that the mattress is used by several people at the same time or, for example, that there is a pet on the mattress in addition to the person.
  • the present invention is based on the object of providing a method for determining a person's cardiogram signals by means of a sensor device integrated into a support, for example a mattress, which enables precise measurements, even if several people are present on the support.
  • a method for determining magnetic cardiogram signals from one or more people is proposed, with measurement signals from at least one person being determined in a non-contact manner by at least one sensor device integrated into a support, for example a mattress, the measurement signals being transmitted to an evaluation unit , wherein the sensor device is a magnetic field sensor device, and wherein the measurement signals Magnetic cardiogram signals are and wherein the magnetic field sensor device has a plurality of magnetic field sensors, which are arranged as a sensor array in or on the support.
  • sensor groups of, in particular spatially adjacent, magnetic field sensors are formed by evaluating the sensor signals of the individual magnetic field sensors of the sensor array, with a sensor group being assigned to a signal source, i.e. in particular the heart of a person.
  • a signal source i.e. in particular the heart of a person.
  • those spatially adjacent magnetic field sensors through which a heart signal is maximally measured can be assigned to a specific sensor group. These are typically the magnetic field sensors that are closest to the person's heart. In this way, the individual signal sources (hearts) can be localized and the individual magnetic cardiogram signals can be derived.
  • the invention thus makes it possible to separate their different heart signals when several people are present so that separate monitoring of the respective cardiac activity of all relevant people can be ensured.
  • the assignment of the magnetic cardiogram signals to different signal sources, in particular different people, can preferably be done by means of a signal analysis, for example the distance of the detecting magnetic field sensor from the sensor plane and/or characteristic patterns such as amplitude, frequency, etc. of the magnetic cardiogram signals can be taken into account. Artificial intelligence methods can be used particularly advantageously here.
  • a pattern of the magnetic cardiogram signal that is characteristic of a specific person is previously recorded once during a calibration operation. For example, when the edition is put into operation, the A specific person is placed on the support once for a specific period of time to record the pattern and magnetic cardiogram signals are recorded. In this way, a characteristic pattern of the magnetic cardiogram signal can be determined and stored, which can be assigned to a person in the future.
  • Such pattern recognition can also differentiate between interference signals (e.g. from pets lying on the bed).
  • the evaluation unit can draw conclusions about the fitness and health status of the people on the support.
  • the evaluation of the magnetic cardiogram signals makes it possible to detect medically relevant cardiac emergencies at an early stage.
  • Vector information of the magnetic cardiogram signal is preferably determined by means of the magnetic field sensor device.
  • vector magnetometry it is advantageous to record the direction of the signal sources to one another and thus the precise localization (3D image).
  • 3D image With a scalar measurement (in which the direction of the measured magnetic field is not taken into account), two hearts at the same distance from a magnetic field sensor in different directions cannot be distinguished. This distinction is made possible by using a sensor array through which the spatial components of the magnetic field vector can be determined.
  • the magnetic field sensor device is a gradiometer with at least two magnetic field sensors arranged at positions spaced apart from one another, the at least two magnetic field sensors measuring a magnetic field at the spaced positions and generating the measurement signal, the magnetic cardiogram signal more preferably as a difference signal of the measurement signals of the at least two Magnetic field sensors are determined.
  • certain magnetic field sensors on the edge preferably three, one in each spatial direction
  • each magnetic field sensor it is also possible for each magnetic field sensor to have a specific different one Magnetic field sensor is assigned as a partner to form a gradiometer, so that a sensor array of individual gradiometers results.
  • magnetometer units By using a number of vector magnetometer units in a geometric arrangement and gradiometer interconnection, these magnetometer units have a different orientation to the magnetic field of the heart.
  • the position and strength of the magnetic field exciter (heart) can be determined by the gradiometer connection, ie essentially vector arithmetic of what is measured. Since the much stronger background field is essentially the same in both magnetometer units (same strength and orientation), it can be eliminated. This eliminates the need for magnetic shielding, making magnetic field measurement possible in everyday environments.
  • Another advantage over classic gradiometer arrangements with one-dimensional magnetometers is the compact design this enables, as no distant reference magnetometer is required.
  • the invention is particularly suitable for unshielded measurement of weak magnetic fields.
  • the magnetic fields generated by the heart muscle usually have a strength in the range of 100 pT. These magnetic field strengths are well below typical magnetic field strengths in the environment.
  • the earth's magnetic field strength is approx. 50 pT.
  • the difference signal only the magnetic field generated by the heart remains in the form of the magnetic cardiogram signal, since the magnetic field generated by the heart has a high gradient between the two positions of the magnetic field sensors.
  • the difference signal can be generated directly by the magnetic field sensor device. However, it is also possible for the difference signal to be generated in the evaluation unit, in which case the measurement signals from the magnetic field sensors are transmitted to the evaluation unit.
  • Such a gradiometer structure makes it possible, in particular, to dispense with complex magnetic shielding during the implementation of the method.
  • the magnetic field sensors are nitrogen defect sensors, with each nitrogen defect sensor preferably comprising a diamond, optical filters and photodetectors, and more preferably a microwave resonator and / or a light source, in particular a laser.
  • the microwave resonator and/or the light source can also be arranged away from the magnetic field sensor device or from the magnetic field sensors.
  • the magnetic field sensors are nitrogen defect sensors.
  • the m s levels split In an external magnetic field, the m s levels split, the so-called Zeeman splitting, and when the fluorescence is plotted against the frequency of the microwave excitation, two dips appear in the fluorescence spectrum, the frequency spacing of which is proportional to the magnetic field strength.
  • the magnetic field sensitivity is defined by the minimally resolvable frequency shift and can reach up to 1 pT. Since the nitrogen vacancy center in single-crystalline diamond has four options for arranging itself in the crystal lattice, in the presence of a directed magnetic field, the nitrogen vacancy centers present in the crystal react to the external magnetic field with different strengths depending on their location in the crystal. As a result, in the maximum case, four associated pairs of fluorescence minima can appear in the spectrum, from whose shape and position relative to each other the amount and direction of the magnetic field can be clearly determined.
  • the structure and functionality of a nitrogen vacancy sensor are also known to those skilled in the art.
  • the magnetic cardiogram signals of a sensor group are filtered by the evaluation unit with a high pass and/or low pass, and/or that the evaluation unit detects a bias drift of the magnetic field sensors, in particular by averaging the magnetic cardiogram signals over a period of time which is greater than the heart rate is determined.
  • the evaluation unit uses the magnetic cardiogram signals to determine Vita Iparameter, preferably a heart rate, and/or a heart rate variability, and/or a duration and/or amplitude of ECG-equivalent signal changes, preferably P wave, QRS complex, T wave and corresponding combinations
  • the evaluation unit can determine a vital function and/or the assessment of a vital function of a person using the magnetic cardiogram signals of a specific sensor group. In this way, monitoring of the person's vital function can be ensured, especially if the person is on the support for a longer period of time, such as overnight.
  • further measures are taken on the basis of an assessment of the vital parameters, the further measures including, for example, making an emergency call and/or transmitting the vital functions to medical staff.
  • the assessment can be provided with a confidence value that reflects the statistical certainty of the classification result or assessment.
  • a device which is set up to determine cardiogram signals of one or more people using the method according to the invention.
  • the device comprises a support for people, at least one sensor device integrated into the support, which is designed to determine measurement signals of at least one person in a non-contact manner, the sensor device being a magnetic field sensor device, and the cardiogram signals being magnetic cardiogram signals.
  • the magnetic field sensor device has a plurality of magnetic field sensors, which are arranged as a sensor array in or on the support.
  • the device further comprises an evaluation unit which is designed to generate sensor groups of, in particular spatially adjacent, magnetic field sensors from the magnetic cardiogram signals obtained from the individual magnetic field sensors of the sensor to determine, wherein a sensor group is assigned to a signal source, in particular the heart of a person.
  • an evaluation unit which is designed to generate sensor groups of, in particular spatially adjacent, magnetic field sensors from the magnetic cardiogram signals obtained from the individual magnetic field sensors of the sensor to determine, wherein a sensor group is assigned to a signal source, in particular the heart of a person.
  • the support for people is designed, for example, as a mattress.
  • the support can be designed as a topper, i.e. a topper, or a lower, i.e. an underlay for a commercially available mattress.
  • the cushion can be designed as a blanket or a pillow or as a piece of clothing.
  • several supports with a device according to the invention can be present, for example two mattresses in one bed.
  • the sensor arrays of each individual support can be interconnected so that the evaluation unit takes into account all available magnetic field sensors when forming the sensor groups and thus the localization and signal separation can be guaranteed over the entire support surface.
  • the device has one or more additional sensor units, which are designed, for example, as temperature sensors and/or pressure sensors and/or microphones. These additional sensor units can provide additional information about where a person is located on the support through the measurement signals they generate. If nitrogen vacancy sensors are used as magnetic field sensors, the intrinsic temperature sensitivity of such magnetic field sensors can alternatively or additionally be used to determine where and how many people are based on the temperature distribution on the area that spans the sensor array formed by the magnetic field sensors the surface. Breathing sounds can also be recorded using one or more additional microphones and this information can be taken into account during the evaluation and the assignment and localization of the signal sources can be improved.
  • additional sensor units are designed, for example, as temperature sensors and/or pressure sensors and/or microphones.
  • Figure 1 shows a flowchart of a method according to the invention according to an exemplary embodiment of the invention.
  • Figure 2 shows an example of a bed with a mattress designed according to a possible embodiment of the invention.
  • Figure 3 shows examples of arrangements of magnetic field sensors as a sensor array for use in a method according to the invention or a device according to the invention.
  • Fig. 1 shows the sequence of a method 100 for determining magnetic cardiogram signals of one or more people.
  • measurement signals of at least one person are determined in a non-contact manner by a sensor device integrated in a support, in particular in a mattress, the sensor device being a magnetic field sensor device , which has a plurality of magnetic field sensors, which are arranged as a sensor array in or on the support and where the measurement signals are magnetic cardiogram signals.
  • the measurement signals are transmitted to an evaluation unit.
  • sensor groups of spatially adjacent magnetic field sensors are determined by evaluating the magnetic cardiogram signals of the individual magnetic field sensors of the sensor array by the evaluation unit.
  • they are previously assigned to specific sensor groups with a signal source, in particular the heart of a person.
  • a separate evaluation is now carried out person-specific magnetic cardiogram signals from each sensor group.
  • the person-specific magnetic cardiogram signals are subjected to pattern recognition and thus assigned to specific people.
  • Fig. 2 shows two examples of the arrangement of a device designed according to the invention in a mattress.
  • a bed 10 is shown in FIG. 2a).
  • the bed has a mattress 12 to support people.
  • two magnetic field sensor devices 3 Integrated into the mattress 12 are two magnetic field sensor devices 3, each of which has a plurality of magnetic field sensors.
  • two magnetic field sensor devices 3 are arranged along the longitudinal axis of the mattress in such a way that a person 1 who sleeps on the mattress comes to rest with his heart in the area of at least one of the magnetic field sensor devices 3.
  • the magnetic field sensor devices 3 are arranged near the surface or on the surface of the mattress 12 in order to ensure the smallest possible distance from the heart of the person 1.
  • the arrangement according to Fig. 2b) essentially corresponds to the arrangement from Fig. 2a) with the difference that an additional magnetic field sensor device 3 'is arranged at a deeper point on the mattress (approximately the underside of the mattress 12.
  • This arrangement offers the additional advantage Detect interference fields better and take them into account when measuring the magnetic cardiogram signals.
  • FIG. 3 shows examples of possible arrangements of the individual magnetic field sensors 4 of a magnetic field sensor device 3.
  • Fig. 3 a shows a linear sensor array of a total of ten magnetic field sensors 4, which are arranged in a row, for example transversely to the longitudinal axis of the mattress 12 of Fig. 2.
  • the magnetic field sensor device 3 is arranged.
  • the first person's heart 6a is approximately between the magnetic field sensors 4a and 4b
  • the second person's heart 6b is approximately at the position of the magnetic field sensor 4d
  • the pet's heart 6c is approximately between the magnetic field sensors 4f and 4g.
  • three sensor groups 5a, 5b and 5c can now be determined.
  • those magnetic field sensors 4 arranged adjacent to one another are combined into a sensor group, which deliver a measurement signal above a certain threshold value.
  • the magnetic field sensors 4a and 4b are determined to belong to a first sensor group 5a, with the sensor group 5a being assigned to the heart 6a of the first person as a signal source.
  • the magnetic field sensors 4c, 4d and 4e are determined to belong to a second sensor group 5b, with the sensor group 5b being assigned to the heart 6b of the second person as a signal source.
  • the magnetic field sensors 4f and 4g are determined to belong to a third sensor group 5c, with the sensor group 5c being assigned to the heart 6c of the pet as a signal source.
  • the distinction as to whether the signal source is the heart of a person or a pet can be derived, for example, by means of pattern recognition from the magnetic cardiogram signals of the respective sensor group 5a, 5b, 5c.
  • a dog typically has a much faster heart rate than a human.
  • Fig. 3 b shows a magnetic field sensor device 3 comprising a two-dimensional sensor array with five rows of ten magnetic field sensors 4, which are arranged alternately offset from one another, for example along the support surface of the mattress 12 of Fig. 2.
  • Such a two-dimensional arrangement offers an improved Accuracy of localizing a signal source.
  • three sensor groups 5d, 5e and 5f can in turn be determined.
  • those magnetic field sensors 4 arranged adjacent to one another are combined to form a sensor group, which deliver a measurement signal above a certain threshold value.
  • a first sensor group 5d is determined, which is assigned to the heart 6d of the first person as a signal source.
  • a second sensor group 5e is determined, which is assigned to the heart 6e of the second person as a signal source.
  • One Third sensor group 5f is determined, which is assigned to the heart 6f of the pet as a signal source.
  • the sensor array consists of between three and five magnetic field sensors 4 that contribute to a sensor group.
  • a sensor group always has to take into account the magnetic field sensors connected to the signal source, i.e. in particular to the heart, which deliver an even more significant measurement signal, in particular a measurement signal that is above the measurement noise and is stronger than the measurement signal from a more distant signal source.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un procédé de détermination de signaux de magnétocardiogramme d'une ou de plusieurs personnes, des signaux de mesure d'au moins une personne étant déterminés sans contact par au moins un dispositif de détection intégré dans une surface, par exemple un matelas, les signaux de mesure étant transférés à une unité d'évaluation, le dispositif de détection étant un dispositif de détection de champ magnétique et les signaux de mesure étant des signaux de magnétocardiogramme et le dispositif de détection de champ magnétique ayant une pluralité de capteurs de champ magnétique agencés sous la forme d'un réseau de capteurs dans ou sur la surface. Selon l'invention, par évaluation des signaux de capteur des capteurs de champ magnétique individuels du réseau de capteurs, des groupes de capteurs (appelés cellules) de capteurs champ magnétique, en particulier spatialement adjacents, sont formés, un groupe de capteurs étant associé à une source de signal, c'est-à-dire en particulier au cœur d'une personne. Par l'intermédiaire d'un examen séparé et d'un traitement ultérieur des signaux d'un groupe de capteurs respectif, différentes sources de signal peuvent être différenciées de cette manière et ainsi d'autres personnes qui sont simultanément présentes sur la surface pendant la mesure.
PCT/EP2023/072845 2022-09-09 2023-08-18 Procédé et dispositif de détermination de signaux de cardiogramme d'une ou de plusieurs personnes WO2024052089A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102022209446.8 2022-09-09
DE102022209446.8A DE102022209446A1 (de) 2022-09-09 2022-09-09 Verfahren und Einrichtung zur Bestimmung von Kardiogrammsignalen einer oder mehrerer Personen

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WO2024052089A1 true WO2024052089A1 (fr) 2024-03-14

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WO (1) WO2024052089A1 (fr)

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US8706204B2 (en) 2012-08-03 2014-04-22 Hyundai Motor Company System and method for observing heart rate of passenger
EP3308703A1 (fr) * 2016-10-11 2018-04-18 Biomagnetik Park GmbH Méthode magnétocardiographie et système magnétocardiographie
US20190167136A1 (en) * 2016-08-02 2019-06-06 National University Corporation Tokyo Medical And Dental University Biomagnetism measuring device
WO2020180949A1 (fr) * 2019-03-06 2020-09-10 GE Precision Healthcare LLC Procédés et systèmes permettant d'obtenir un signal d'électrocardiogramme d'un patient par l'intermédiaire d'un appareil d'électrode à contact direct non adhérent
US20210161420A1 (en) * 2018-08-22 2021-06-03 Asahi Kasei Microdevices Corporation Magnetic field measuring apparatus, magnetic field measuring method, and recording medium storing magnetic field measuring program
US20220228998A1 (en) * 2021-01-15 2022-07-21 X Development Llc Spin defect magnetometry imaging

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DE102021209759A1 (de) 2021-09-06 2023-03-09 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren und Einrichtung zur Bestimmung der Vitalfunktionen eines Fahrzeuginsassen
DE102022201690A1 (de) 2022-02-18 2023-08-24 Robert Bosch Gesellschaft mit beschränkter Haftung Sensoreinheit zur Messung von Magnetfeldern

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Publication number Priority date Publication date Assignee Title
US8706204B2 (en) 2012-08-03 2014-04-22 Hyundai Motor Company System and method for observing heart rate of passenger
US20190167136A1 (en) * 2016-08-02 2019-06-06 National University Corporation Tokyo Medical And Dental University Biomagnetism measuring device
EP3308703A1 (fr) * 2016-10-11 2018-04-18 Biomagnetik Park GmbH Méthode magnétocardiographie et système magnétocardiographie
US20210161420A1 (en) * 2018-08-22 2021-06-03 Asahi Kasei Microdevices Corporation Magnetic field measuring apparatus, magnetic field measuring method, and recording medium storing magnetic field measuring program
WO2020180949A1 (fr) * 2019-03-06 2020-09-10 GE Precision Healthcare LLC Procédés et systèmes permettant d'obtenir un signal d'électrocardiogramme d'un patient par l'intermédiaire d'un appareil d'électrode à contact direct non adhérent
US20220228998A1 (en) * 2021-01-15 2022-07-21 X Development Llc Spin defect magnetometry imaging

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SHIRAI YASUHIRO ET AL: "Magnetocardiography Using a Magnetoresistive Sensor Array", INTERNATIONAL HEART JOURNAL, vol. 60, no. 1, 31 January 2019 (2019-01-31), JP, pages 50 - 54, XP093098320, ISSN: 1349-2365, DOI: 10.1536/ihj.18-002 *

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