WO2024049878A3 - Bioreducible polymer and use thereof - Google Patents

Bioreducible polymer and use thereof Download PDF

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Publication number
WO2024049878A3
WO2024049878A3 PCT/US2023/031502 US2023031502W WO2024049878A3 WO 2024049878 A3 WO2024049878 A3 WO 2024049878A3 US 2023031502 W US2023031502 W US 2023031502W WO 2024049878 A3 WO2024049878 A3 WO 2024049878A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymers
pdsa
bioreducible
engineered
nanoparticles
Prior art date
Application number
PCT/US2023/031502
Other languages
French (fr)
Other versions
WO2024049878A2 (en
Inventor
Jung Soo Suk
Gijung KWAK
Kai Zhang
Original Assignee
The Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Johns Hopkins University filed Critical The Johns Hopkins University
Publication of WO2024049878A2 publication Critical patent/WO2024049878A2/en
Publication of WO2024049878A3 publication Critical patent/WO2024049878A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/195—Chemokines, e.g. RANTES
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

Provided herein, inter alia, a composition or an engineered gene delivery composition including nanoparticles and polymers (e.g., poly(disulfide amine) or PDSA polymers) containing chemically distinct functional side chain groups and different amounts of bioreducible moi eties. Also provided is an engineered PEGylated nanoparticles including polymers (e.g., PDSA polymers).
PCT/US2023/031502 2022-08-30 2023-08-30 Bioreducible polymer and use thereof WO2024049878A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263373971P 2022-08-30 2022-08-30
US63/373,971 2022-08-30

Publications (2)

Publication Number Publication Date
WO2024049878A2 WO2024049878A2 (en) 2024-03-07
WO2024049878A3 true WO2024049878A3 (en) 2024-05-10

Family

ID=90098558

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/031502 WO2024049878A2 (en) 2022-08-30 2023-08-30 Bioreducible polymer and use thereof

Country Status (1)

Country Link
WO (1) WO2024049878A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190248957A1 (en) * 2018-02-07 2019-08-15 University Of Utah Research Foundation Bio-reducible polymers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190248957A1 (en) * 2018-02-07 2019-08-15 University Of Utah Research Foundation Bio-reducible polymers

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BULMUS ET AL.: "A new pH-responsive and glutathione-reactive, endosomal membrane- disruptive polymeric carrier for intracellular delivery of biomolecular drugs", JOURNAL OF CONTROLLED RELEASE, vol. 93, 2003, pages 105 - 120, XP004473631, DOI: 10.1016/j.jconrel.2003.06.001 *
KOO ET AL.: "Biodegradable branched poly(ethylenimine sulfide) for gene delivery", BIOMATERIALS, vol. 31, 2010, pages 988 - 997, XP026790428 *
OU ET AL.: "A Family of Bioreducible Poly(disulfide amine)s for Gene Delivery", BIOMATERIALS, vol. 30, no. 29, 2009, pages 5804 - 5814, XP026470007, DOI: 10.1016/j.biomaterials.2009.06.050 *

Also Published As

Publication number Publication date
WO2024049878A2 (en) 2024-03-07

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